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13321
RETRACTED: Modern Subtype Classification and Outlier Detection Using the Attention Embedder to Transform Ovarian Cancer Diagnosis
Published 2024-01-01“…This study highlights how machine learning can revolutionize the medical field’s ability to classify ovarian cancer subtypes and identify outliers, giving doctors a valuable tool to lessen the severe effects of the disease. Adopting this novel method is likely to improve the practice of medicine and give people living with ovarian cancer worldwide hope.…”
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13322
A first evaluation of the efficacy of minibeam radiation therapy combined with an immune check point inhibitor in a model of glioma-bearing rats
Published 2025-03-01“…One possible strategy is to ally immunotherapy (IT) with novel RT approaches able to revert the immunosuppressive nature of GBM. …”
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13323
PICT: A low‐cost, modular, open‐source camera trap system to study plant–insect interactions
Published 2021-08-01“…Increased portability and image quality at lower costs allow for large‐scale deployment and the acquisition of novel insights into the reproductive biology of plants and their interactions with difficult to observe animals. …”
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13324
Exploring the molecular basis of efficient feed utilization in low residual feed intake slow-growing ducks based on breast muscle transcriptome
Published 2025-01-01“…These findings provide novel insights into the molecular changes underlying RFI variation in slow-growing ducks.…”
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13325
Importance of OsRac1 in Signalling of Pigm-1 Mediated Resistance to Rice Blast Disease
Published 2025-01-01“…Additionally, a transcriptional activator, RAI1, acts as an essential Pigm-1 interactor for blast resistance. Furthermore, a novel material 9311(<i>Pigm-1</i>) was prepared by using two-line restorer line 9311 as receptor and Shuangkang 77009 as donor with molecular marker-assisted technology, which improved blast resistance and yield. …”
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13326
Carthamin yellow-loaded glycyrrhetinic acid liposomes alleviate interstitial fibrosis in diabetic nephropathy
Published 2025-12-01“…The inhibitory effects were stronger than CY alone and were mediated by the inactivation of the TGFBR1/Smad2/Smad3 pathway, as confirmed by TGFBR1 overexpression studies.Conclusions CY-loaded GA liposomes demonstrated significant therapeutic efficacy in alleviating renal interstitial fibrosis in DN by targeting the TGFBR1/Smad2/Smad3 pathway. This novel drug delivery system provides a promising approach for the treatment of DN.…”
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13327
The PANORAMIC Survey: Pure Parallel Wide Area Legacy Imaging with JWST/NIRCam
Published 2025-01-01“…The survey includes ∼432 square arcmin of novel sky area not yet observed with JWST using at least six NIRCam broadband filters, increasing the existing area covered by similar Cycle 1 data by ∼60%. …”
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13328
miR-21 Overexpression Promotes Esophageal Squamous Cell Carcinoma Invasion and Migration by Repressing Tropomyosin 1
Published 2020-01-01“…These results suggest that miR-21 may be a novel predictive marker and therapeutic target for treatment of ESCC.…”
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13329
Individual mobility prediction by considering current traveling features and historical activity chain
Published 2025-01-01“…To fill this gap, we propose a novel method that incorporates current traveling features and historical activity chain to predict the coordinates of traveling destination. …”
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13330
The Bile Acid Metabolism of Intestinal Microorganisms Mediates the Effect of Different Protein Sources on Muscle Protein Deposition in <i>Procambarus clarkii</i>
Published 2024-12-01“…Our results demonstrated that the ‘<i>Bacteroides</i>-TCDCA-<i>MSTN</i>’ axis may mediate the effects of different protein sources on muscle development and protein deposition in <i>P. clarkii</i>, which was anticipated to represent a novel target for the muscle quality modulation in crustaceans.…”
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13331
Optimization of fatigue life of the seismic vibrator baseplate considering the coupling effect of welding residual stress
Published 2025-01-01“…Furthermore, multi-objective optimization algorithms and fusion decision-making methods were applied to the fatigue life optimization of the SVB, offering novel research approaches and methodologies. This study provides theoretical guidance for the structural design and optimization of the SVB, aligning with practical engineering needs and showing substantial application value.…”
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13332
20(S)-Ginsenoside Rg3 Protects Kidney from Diabetic Kidney Disease via Renal Inflammation Depression in Diabetic Rats
Published 2020-01-01“…The results of the current study suggest that 20(S)-Rg3 could potentially be used as a novel treatment against DKD.…”
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13333
OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review
Published 2021-01-01“…While central retinal thickness has been the most common and one of the first OCT identified biomarkers, today, other qualitative and quantitative biomarkers provide novel insight into disease activity and offer superior prognostic value and better guidance for tailored therapeutic management. …”
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13334
Adverse Events of the BCG (Bacillus Calmette–Guérin) and Rotavirus Vaccines in a Young Infant with Inborn Error of Immunity
Published 2020-01-01“…He also had “X-linked agammaglobulinemia” (MIM#300755) due to hemizygous missense variant, NM_001287344.1 (BTK):c.80G > A, p.Gly27Asp (novel). He had a sibling who passed away in infancy of unknown disease and family members with autoimmune disorders. …”
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13335
Neoadjuvant apatinib addition to sintilimab and carboplatin-taxane based chemotherapy in patients with early triple-negative breast cancer: the phase 2 NeoSAC trial
Published 2025-02-01“…Comparison of pre-neoadjuvant and post-surgery data revealed that the pCR group treated with this novel regimen exhibited an upregulation of distinct immune cell subsets, thereby activating the tumor microenvironment. …”
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13336
Metagenomic insights into the development of microbial communities of straw and leaf composts
Published 2025-01-01“…Using a comprehensive approach with chemical analyses of the substrates, amplicon, and full metagenome sequencing data, we have shown that such communities may be a source of identifying the highly effective decomposing species with novel PULs.…”
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13337
Genetic Background and Phenotypic Aspects of Light-Induced Carotenoid Biosynthesis in <i>Isosphaeraceae</i> Planctomycetes
Published 2024-12-01“…We examined the carotenogenesis and its genetic background in a novel planctomycete of the family <i>Isosphaeraceae</i>, <i>Singulisphaera</i> sp. …”
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13338
Zinc absorption from maize-based meals enriched with edible house crickets: a randomized crossover stable-isotope study in Kenyan pre-school children
Published 2025-01-01“…Abstract Edible insects have been proposed as a novel and sustainable source of protein and other essential nutrients for human consumption but nutrient absorption efficiency is still uncertain. …”
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13339
Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver DiseasesSummary
Published 2025-01-01“…This study explores the mechanisms underlying CRSDs in CLDs and novel therapies. Methods: We monitored the sleep of patients with CLD using actigraphic watch and established male mouse cholemia models by feeding with BA or bile duct ligation. …”
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13340
Rab21-Targeted Nano Drug Delivery System-Based FFPG for Efficient Paclitaxel Delivery to Inhibit Lung Cancer Progression
Published 2025-01-01“…<b>Conclusions</b>: In this study, a novel lung-targeted NDDS is proposed to enhance the therapeutic effect of chemotherapy drugs on lung cancer.…”
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