Identification of Key Genes and Prognostic Value Analysis in Hepatocellular Carcinoma by Integrated Bioinformatics Analysis by Meng Wang, Licheng Wang, Shusheng Wu, Dongsheng Zhou, Xianming Wang

“…This study is aimed at identifying novel key genes that may be used for hepatocellular carcinoma (HCC) diagnosis, prognosis, and targeted therapy. …”
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Reliability of Ultrasound Based Compressibility of the Lower Leg Anterior Tibial Muscle Compartment in Healthy Volunteers by Kay van Heeswijk, Daniëlle Spek, Jesse Muijsenberg, Loes Janssen, Michiel Winkes, Adwin R. Hoogeveen, Marc Scheltinga

“… # Purpose The purpose of this study was to investigate the reliability of a novel ultrasound compressibility technique using two distinct internal landmarks at the lower leg in a diverse group of asymptomatic adults…”
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lncRNA NEAT1 Downregulation Ameliorates the Myocardial Infarction of Mice by Regulating the miR-582-5p/F2RL2 Axis by Zhenhua Wu, Yunpeng Bai, Yujuan Qi, Chao Chang, Yan Jiao, Yaobang Bai, Zhigang Guo

“…NEAT1 downregulation ameliorates MI by regulating the miR-582-5p/F2RL2 axis, providing novel biomarkers for MI treatment.…”
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Correlation between MDA Level and Chitotriosidase-1 Activity in Seminal Fluid of Iraqi Infertile Males by Ali S. Abdul Aziz, Hedef D. Elyaseen, Hussain K. Kadhem

“…Conclusion: There is a correlation between seminal fluid Chitotriosidase-1 activity and malondialdehyde level in the Asthenospermia Group. Novel diagnostic and therapeutic approaches for the treatment of male infertility may result from our growing understanding of the roles played by Chitotriosidase-1 and malondialdehyde in male reproductive health. …”
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Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba by N. Datta

“…Therefore, there is an urgent need for more research on the pathogenesis of N. fowleri and the identification of novel targets for intervention. With the advances in genomic and proteomic technologies, new opportunities have emerged to explore the molecular biology of N. fowleri and its host response. …”
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The association between visceral fat metabolic score and stroke: mediation by declining kidney function by Yue Cao, Weixing Wen, Hao Zhang, Weiwen Li, Guolin Huang, Yuli Huang

“…Metabolic Score for Visceral Fat (METS-VF), a metric of visceral obesity, has emerged as a novel predictor of metabolic diseases. However, its association with stroke remains unclear. …”
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Digital Hydraulic Motor Characteristic Analysis for Heavy-Duty Vehicle Traction by Hao Zhang, Wenshu Wei, Hong Wang, Yang Zhang, Xiaochao Liu

“…Furthermore, the influence of the flow allocation method on efficiency and pressure pulsation is examined, leading to the proposal of a novel flow allocation strategy, the efficacy of which is substantiated through simulation. …”
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Variation in Botryosphaeriaceae from Eucalyptus plantations in YunNan Province in southwestern China across a climatic gradient by Guoqing Li, Bernard Slippers, Michael J. Wingfield, Shuaifei Chen

“…Eleven species were identified, including Botryosphaeria fusispora, B. wangensis, Lasiodiplodia pseudotheobromae, Neofusicoccum kwambonambiense, N. parvum, and six novel species described as B. puerensis, N. dianense, N. magniconidium, N. ningerense, N. parviconidium and N. yunnanense. …”
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Arabic translation, cultural adaptation, and validation of the BDDQ-AS for rhinoplasty patients by Ahmed S. Abdelhamid, Saad Elzayat, Mohamed A. Amer, Hossam S. Elsherif, Garyfalia Lekakis, Sam P. Most

“…This study aimed to translate, culturally adapt, and validate BDDQ-AS to Arabic as a novel tool for screening and detecting BDD in Arabic rhinoplasty individuals. …”
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3-Acetyldeoxynivalenol induces pyroptosis in leydig cells via METTL3-mediated N6-methyladenosine modification of NLRP3 by Yangyun Wang, Chaoliang Shi, Wei Jiao, Xiaoxiang Wan

“…Collectively, our findings reveal a novel mechanism by which 3-ADON exerts its reproductive toxicity, underscoring the pivotal role of METTL3-mediated m6A modifications in regulating Leydig cell dysfunction.…”
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Identification and Verification of Hub Mitochondrial Dysfunction Genes in Osteoarthritis Based on Bioinformatics Analysis by Hui Niu, Xingxing Deng, Qian Zhang, Yijun Zhao, Jinfeng Wen, Wenyu Li, Huan Liu, Xiong Guo, Cuiyan Wu

“…In conclusion, our study may provide novel mitochondrial dysfunction hub genes with potential clinical applications for understanding the pathology, diagnosis, and treatment of OA.…”
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Spline approximation of multivalued functions in linear structures routing by D. A. Karpov, V. I. Struchenkov

“…At the first stage, a novel mathematical model is developed to apply the dynamic programming method taking into account the constraints on the desired spline parameters. …”
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Endosperm culture-based allotriploid hybrid production from an interspecific cross of Haemanthus spp.: new insights into polyploidization and hybridization by Arisa Nakano, Masahiro Mii, Yoichiro Hoshino

“…Additionally, the study established a novel system for simultaneously producing diploid and allotriploid hybrids from a single seed, providing valuable materials to study the effects of polyploidization and hybridization in allopolyploid plants. …”
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Plasma CXCL3 Levels Are Associated with Tumor Progression and an Unfavorable Colorectal Cancer Prognosis by Can Cui, Rui Zhang, Feng Gu, Yunfeng Pei, Li Sun, Yueyang Huang, Guoping Niu, Jian Li

“…The results of this study suggest that plasma CXCL3 may be a novel diagnostic and prognostic biomarker for CRC.…”
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Altered Macular Vasculature in Migraine Patients without Aura: Is It Associated with Ocular Vasculature and White Matter Hyperintensities? by Nurdan Gamze Taşlı, Alevtina Ersoy

“…We suggest that for not only migraine with aura but also migraine without aura, neurovascular structures play an important role in pathogenesis, and novel studies are warranted to elucidate the alterations in these and determine the significance of WMHs in these patient groups.…”
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Exploring Glypican-3 targeted CAR-NK treatment and potential therapy resistance in hepatocellular carcinoma. by Lei Yang, Kien Pham, Yibo Xi, Qunfeng Wu, Dongfang Liu, Keith D Robertson, Chen Liu

“…Therefore, developing novel treatment options for patients with HCC is urgently needed. …”
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The resilience of parents and carers who administer medicines to children at home: a qualitative systematic review protocol by Stephen Morris, Simon Pini, Beth Fylan, Franki Wilson, Helen Faulkner, David P. Alldred

“…Discussion This protocol describes a novel method to address an important patient safety issue. …”
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Synthesis and Characterization of Green Zinc Oxide Nanoparticles with Antiproliferative Effects through Apoptosis Induction and MicroRNA Modulation in Breast Cancer Cells by Amir Hossein Aalami, Mohammad Mesgari, Amirhossein Sahebkar

“…Biological properties such as the antioxidant and antimicrobial activity of these novel ZnO-NPs were considered. MTT assays showed that the inhibitory concentration (IC50) of ZnO-NPs after 24 h was 11.16 μg/mL, 60.08 μg/mL, and 26.3 μg/mL on MCF7, MDA-MB-231, and HFF cells, respectively. …”
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The impact of trauma and how to intervene: a narrative review of psychotraumatology over the past 15 years by Miranda Olff, Irma Hein, Ananda B. Amstadter, Cherie Armour, Marianne Skogbrott Birkeland, Eric Bui, Marylene Cloitre, Anke Ehlers, Julian D. Ford, Talya Greene, Maj Hansen, Nathaniel G. Harnett, Debra Kaminer, Catrin Lewis, Alessandra Minelli, Barbara Niles, Nicole R. Nugent, Neil Roberts, Matthew Price, Anthony N. Reffi, Soraya Seedat, Antonia V. Seligowski, Anka A. Vujanovic

“…However, research on prevention is still scarce compared to treatment research where several evidence-based psychological, pharmacological and complementary/ integrative interventions exist, and novel forms of delivery have become available. Here, we focus on how best to address the range of negative health outcomes following trauma, how to serve individuals across the age spectrum, including the very young and old, and include considerations of sex/gender, ethnicity, and culture in diverse contexts, beyond Western, Educated, Industrialized, Rich, and Democratic (WEIRD) countries. …”
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Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model by Frida Wilske, Olof Eriksson, Rose-Marie Amini, Sergio Estrada, Helena Janols, Amina Khalil, Anders Larsson, Miklós Lipcsey, Sara Mangsbo, Jonathan Sigfridsson, Jan Sjölin, Paul Skorup, Anders Wall, Viola Wilson, Markus Castegren, Gunnar Antoni

“…Conclusion The neutrophil elastase PET-tracer [11C]NES is a novel and unique instrument to study the acute innate neutrophil immune response in sepsis and associated vital organ failure. …”
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