Effect over coagulation and fibrinolysis parameters of a prolonged release 24 + 4 daily use regime contraceptive formulation containing 2 mg dienogest/0.02 mg ethinylestradiol... by Pedro-Antonio Regidor, Alicyoy Angulo, Enrico Colli

“…Background A prolonged release combined oral contraceptive (COC) pill, containing 2 mg dienogest (DNG)/0.02 mg ethinylestradiol (EE) in a 24 + 4 daily dosing regimen has recently been approved in Europe.Objective To determine if this COC impacts coagulation and fibrinolytic factors in comparison to an immediate release COC containing 3 mg drospirenone (DRSP)/0.02 mg EE.Method Forty-four patients received the novel product, and forty-seven the comparator (immediate release formulation) during nine complete cycles. …”
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Genetic Variation of the DGAT1 gene in Dual-Purpose Dairy Cows and its Influence on Economically Important Breeding Traits by Mark E Armitage, Emma Swan, Denise O'Meara

“…MethodsDNA was extracted from hair samples, and the genotypes of the DGAT1 gene were determined using a combination of conventional PCR, restriction fragment length polymorphism (RFLP), gel electrophoresis, DNA sequencing and novel real-time PCR assays. ResultsThe three genotypes within the herd were: KK (n = 5), AA (n = 10), KA (n = 8). …”
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Plant genetic resources in India: management and utilization by K. Singh, K. Gupta, V. Tyagi, S. Rajkumar

“…Presently, our focus is on characterization of ex situ conserved germplasm and detailed evaluation of prioritized crops for enhanced utilization; assessment of impact of on-farm conservation practices on genetic diversity; genome-wide association mapping for identification of novel genes and alleles for enhanced utilization of PGR; identification and deployment of germplasm/landraces using climate analog data; validation of trait-specific introduced germplasm for enhanced utilization.…”
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A proposal to measure the resilience of the Andalusian Commnunity Social Services by Elena Ferri-Fuentevilla, Ana Vallejo-Andrada, Aleix Morilla-Luchena, Rocío Muñoz Moreno

“…Thus, the study’s objective was to create a resilience index based on accessible data to assess the extent to which Andalusia’s social services were capable of mitigating the effects of the pandemic. Methodology. A novel methodology, the HVCRA (Hazard, Vulnerability, Risk, and Capacity Analysis), is introduced in this paper. …”
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Evaluating SCUBE-1 as Predictive Biomarker for Hypertension-Mediated Organ Damage: A Comparative Study by Betül Ayça Yamak, Mustafa Candemir, Emrullah Kızıltunç, Hüseyin Baran Özdemir, Özlem Gülbahar, Asife Şahinarslan

“…Serum signal peptide, CUB (complement C1r/C1s, Uegf, and Bmp1) domain, and epidermal growth factor-like domain-containing protein 1 (SCUBE-1), a novel biomarker implicated in vascular pathology, shows promise for detecting HMOD. …”
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Optimal distribution modeling and multifractal analysis of wind speed in the complex terrain of Sichuan Province, China by Cun Zhan, Renjuan Wei, Lu Zhao, Shijun Chen, Chunying Shen

“…Considering these findings, the southwestern mountainous region emerges as the optimal area for wind farm development, given its stability (persistence) and moderate fluctuation complexity (multifractality), crucial for effective wind resource utilization in hydropower-dominated settings. Our study provides a novel approach to assessing wind resources and offers guidance for wind farm placement in complex terrain regions, supporting sustainable energy diversification in Sichuan Province.…”
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Prevention of Acute Radiation-Induced Skin Reaction with NPE® Camellia Sinensis Nonfermentatum Extract in Female Breast Cancer Patients Undergoing Postoperative Radiotherapy: A Sin... by Gabriela Näf, Urs E. Gasser, Hans E. Holzgang, Sandra Schafroth, Christoph Oehler, Daniel R. Zwahlen

“…This pilot study provides the first evidence on the potential pharmacological effectiveness of CSNF extract in prevention of RT-induced ARSR and recovery of skin irritation in patients undergoing postoperative whole breast RT and may reflect a novel concept for prevention of RT-induced ARSR and care of irritated skin.…”
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Stem Cell–Based Therapies via Different Administration Route for Stroke: A Meta-analysis of Comparative Studies by Gabriella Jeanne Mulia, Novelia Anna, John Chung-Che Wu, Hon-Ping Ma, Yung-Hsiao Chiang, Ju-Chi Ou, Kai-Yun Chen

“…Conventional therapies like tissue plasminogen activator are limited by narrow therapeutic windows and potential adverse effects, highlighting the urgency for novel treatments. Stem cell–based therapies, with their neuroprotective and regenerative properties, present a promising yet highly diverse alternative. …”
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Design and Test of a Cone Dielectric Elastomer Actuator Driving Hopping Robot by Yunguang Luan, Huaming Wang, Ling Zhou, Haichao Song

“…This research optimizes the performance by introducing a cone DEA with a novel type of semi-diamond preload mechanism. This type of preload mechanism can meet the requirements of a negative-stiffness preload and a light weight. …”
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Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer’s disease by regulating microglia homeostasis and inhibiting HMGB... by Yuan Xu, Naiyuan Shao, Feng Zhi, Ronghua Chen, Yilin Yang, Jiahui Li, Ying Xia, Ya Peng

“…Our in-vitro studies further confirmed that DOR overexpression mitigated microglial inflammatory response and rescued neurons from AD injury via HMGB1-NF-κB signaling pathway. Conclusions These novel findings uncover previously unappreciated roles of DOR in neuroprotection against AD injury via modulating microglia-related inflammatory responses.…”
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Simultaneous Determination of Mineral Nutrients and Toxic Metals in M. stenopetala from Southern Ethiopia: A Comparative Study of Three Cultivating Areas Using MP-AES by Ashenafi Shemnsa, Wondimeneh Dubale Adane, Merid Tessema, Endale Tesfaye, Gizaw Tesfaye

“…The samples were collected during the arid season, in 2019 from the three main M. stenopetala growing areas in southern Ethiopia (Chano Mile Kebele, Nechisar Kebele, and Konso Special Woreda). A novel digestion method for leaf and seed samples was developed using an optimized acid mixture (2.5 : 0.75 : 0.5 of HNO3, HClO4, and H2O2) at 240°C for 2 hrs and 30 min, resulting in clear and colorless solutions. …”
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Establishing a GRU-GCN coordination-based prediction model for miRNA-disease associations by Kai-Cheng Chuang, Ping-Sung Cheng, Yu-Hung Tsai, Meng-Hsiun Tsai

“…After preprocessing, data was trained with a novel model combining gated recurrent units (GRU) and graph convolutional network (GCN) to predict the level of miRNA-disease associations. …”
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Analytical and diagnostic performance characteristics of reverse-transcriptase loop-mediated isothermal amplification assays for dengue virus serotypes 1-4: A scoping review to inf... by Paul Arkell, Dumrong Mairiang, Adisak Songjaeng, Kenny Malpartida-Cardenas, Kerri Hill-Cawthorne, Panisadee Avirutnan, Pantelis Georgiou, Alison Holmes, Jesus Rodriguez-Manzano

“…Fourteen studies using previously described assays were identified, including those where reagents were lyophilised or 'printed' into microfluidic channels and where several novel detection methods were used. Serotype-specific DENV RT-LAMP assays are high-performing and have potential to be used in portable molecular diagnostic devices if they can be integrated with sample extraction and detection methods. …”
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Optimal rainwater harvesting locations for arid and semi-arid regions by using MCDM-based GIS techniques by Waqed H. Hassan, Karrar Mahdi, Zahraa K. Kadhim

“…The results of this study are novel in Karbala and help policymakers develop effective water management and resource allocation policies, promoting RWH as an alternative water supply in West Karbala and other water-scarce locations.…”
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Identification of the Highly Polymorphic Prion Protein Gene (<i>PRNP</i>) in Frogs <i>(Rana dybowskii</i>) by Chang-Su Han, Sae-Young Won, Sang-Hun Park, Yong-Chan Kim

“…To evaluate the impact of the SNPs on protein aggregation propensity and 3D structure, we utilized AMYCO and ColabFold. We identified 34 novel genetic polymorphisms including 6 non-synonymous SNPs in the frog <i>PRNP</i> gene. …”
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Barlow Twins deep neural network for advanced 1D drug–target interaction prediction by Maximilian G. Schuh, Davide Boldini, Annkathrin I. Bohne, Stephan A. Sieber

“…By reducing time and cost, machine learning and deep learning can accelerate this laborious discovery process. In a novel approach, BarlowDTI, we utilise the powerful Barlow Twins architecture for feature-extraction while considering the structure of the target protein. …”
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Empirical analysis of control models for different converter topologies from a statistical perspective by Hole Shreyas Rajendra

“…This text further proposes evaluation of a novel Converter Control Rank Metric (CCRM) that combines these metrics, and assists in identification of converter control models that showcase high conversion efficiency with low delay, low complexity, high scalability, and low deployment costs. …”
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The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development by Pralay Mukhopadhyay, Hesham A. Abdullah, Joanna B. Opalinska, Prani Paka, Eric Richards, Katja Weisel, Suzanne Trudel, Maria-Victoria Mateos, Meletios Athanasios Dimopoulos, Sagar Lonial

“…Abstract Patients with relapsed/refractory multiple myeloma (RRMM) have a poor prognosis and a need remains for novel effective therapies. Belantamab mafodotin, an anti–B-cell maturation antigen antibody-drug conjugate, was granted accelerated/conditional approval for patients with RRMM who have received at least 4 prior lines of therapy, based on response rates observed in DREAMM-1/DREAMM-2. …”
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How do electronic risk assessment tools affect the communication and understanding of diagnostic uncertainty in the primary care consultation? A systematic review and thematic synt... by Sarah Gerard Dean, Joshua Feyi-Waboso, Mark Tarrant, Raff Calitri, Elizabeth Shephard, Alex Burns, Brian Donnelly

“…Analytical themes were developed to describe separate aspects of the clinical consultation where risk and uncertainty are both central and altered via the use of an eRAT: ‘Novel risk’, ‘Risk refinement’, ‘Autonomy’, ‘Communication’, ‘Fear’ and ‘Mistrust’.Conclusion eRATs may improve the understanding and communication of risk in the primary care consultation. …”
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A survey study of physical activity participation in different organisational forms among groups of immigrants and descendants in Denmark by Eva Berthelsen Schmidt, Karsten Elmose-Østerlund, Bjarne Ibsen

“…By utilising a robust sample size and employing statistical analysis, we offer novel insights into participation patterns that have traditionally been explored more qualitatively. …”
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