Elevated and Correlated Expressions of miR-24, miR-30d, miR-146a, and SFRP-4 in Human Abdominal Adipose Tissue Play a Role in Adiposity and Insulin Resistance by Yury O. Nunez Lopez, Gabriella Garufi, Magdalena Pasarica, Attila A. Seyhan

“…This study suggests a novel association between the elevated levels of miRNAs miR-24, miR-30d, and miR-146a (apparently coregulated) and the level of SFRP4 transcript in AbdAT of subjects with obesity and T2DM. …”
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Food Insecurity Resilience Capacity of Rural Households in the Face of Induced-Weather Extremities in Bauchi State of Nigeria by Mohammed Sadiq, Muhammad Ahmad, Mahmood Bala, Invinder Singh

“…It is in lieu of the foregoing, that the researchers conceptualized a study that assessed rural households’ food insecurity resilience capacity in Nigeria’s Bauchi state using a resilience index measurement analysis (RIMA II), a novel methodological approach developed by FAO for studying such scenario, as literature review showed no evidence of its application in the study area. …”
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A Model of ESG-Transparency Index in Corporate Reporting by R. P. Bulyga, M. V. Melnik, I. V. Safonova, V. B. Gisin

“…Current "transparency indices" fall short in incorporating these factors, leading to methodological incomparability and gaps in assessing the "quality" and "reliability" of estimated values.To address this gap, the authors propose a novel mathematical model for the ESG transparency index in corporate reporting. …”
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Computer-Assisted Design Template Guided Percutaneous Radiofrequency Thermocoagulation through Foramen Rotundum for Treatment of Isolated V2 Trigeminal Neuralgia: A Retrospective C... by Ran Wang, Ying Han, Lijuan Lu

“…CAD template is a safe and precise navigation instrument for RFT treatment of isolated V2 trigeminal neuralgia via the foramen rotundum. Therefore, this novel tool is worthy of clinical promotion.…”
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Quantitative proteomic studies of the intestinal mucosa provide new insights into the molecular mechanism of ulcerative colitis by Yandong Guo, Dahal Pabitra, Lei Pan, Lanbo Gong, Aimin Li, Side Liu, Jing Xiong

“…Thus, there is a need for novel diagnostic and prognostic biomarkers for UC. …”
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Prevalence and correlates of burn-out among Nigerian medical doctors during the COVID-19 pandemic: a cross-sectional study by Ruth Eshikotse Pius, Janet Ngozi Ajuluchukwu, Alero Ann Roberts

“…Medical personnel have faced several clinical and non-clinical challenges because of the novel coronavirus (SARS-CoV-2) pandemic, which predisposes them to burn-out. …”
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Development and validation of the Michigan Chronic Disease Simulation Model (MICROSIM). by James F Burke, Luciana L Copeland, Jeremy B Sussman, Rodney A Hayward, Alden L Gross, Emily M Briceño, Rachael Whitney, Bruno J Giordani, Mitchell S V Elkind, Jennifer J Manly, Rebecca F Gottesman, Darrell J Gaskin, Stephen Sidney, Kristine Yaffe, Ralph L Sacco, Susan R Heckbert, Timothy M Hughes, Andrzej T Galecki, Deborah A Levine

“…This manuscript describes the design principles, implementation details, and population-level validation of a novel population-health microsimulation framework, the MIchigan ChROnic Disease SIMulation (MICROSIM), for The Effect of Lower Blood Pressure over the Life Course on Late-life Cognition in Blacks, Hispanics, and Whites (BP-COG) study of the effect of BP levels over the life course on dementia and cardiovascular disease. …”
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Phage display as a tool for identifying HIV-1 broadly neutralizing antibodies by A. N. Chikaev, A. P. Rudometov, Yu. A. Merkulyeva, L. I. Karpenko

“…Combinatorial biology methods offer a good solution for targeting interactions of specific molecules by a high-throughput screening and are widely used for drug development, diagnostics, identification of novel monoclonal antibodies, search for linear peptide mimetics of discontinuous epitopes for the development of immunogens or vaccine components. …”
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Gut colonization of Bacteroides plebeius suppresses colitis-associated colon cancer development by Hung-Lin Chen, Po-Yuan Hu, Chang-Shan Chen, Wei-Han Lin, Daniel K. Hsu, Fu-Tong Liu, Tzu-Ching Meng

“…By investigating the impact of Bacteroides plebeius that can be colonized in mouse gut by feeding the animal with seaweed diet, we unveil a novel mechanism through which this beneficial bacterium reshapes the gut microbial community and produces metabolites with anti-inflammatory and tumor-suppressive properties. …”
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Sybil-Resistant Self-Sovereign Identity Utilizing Attested Execution Secure Processors and Zero-Knowledge Membership Proofs by Koichi Moriyama, Akira Otsuka

“…In addition, we propose a novel scheme that enables users (holders) to request verifiers to verify their credentials without AESPs, and it further achieves unlinkability among credentials created for public verification. …”
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Drug Clues for the Treatment of Fungal Catheter-Related Bloodstream Infection With Antifungal Lock Therapy by Li X, Yu B, Li H, Liu Z, Fu X, Jiao P, Wang L

“…This will facilitate the development of novel treatments for catheter-related fungal infections, thereby improving clinical outcomes.Keywords: antifungal lock therapy, catheter-related bloodstream infections, Candida…”
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Clinical and Cost Burden of Primary Sjögren’s Syndrome: Descriptive Analysis Using a US Administrative Claims Database by Sue Perera, Liyuan Ma, Raj Punwaney, Sulabha Ramachandran

“…**Conclusion:** Patients with pSS experience a high disease burden despite treatment. This study provides novel insights in to the extent of the burden on healthcare resources among patients with pSS, in particular for patients with extra-glandular disease manifestations, when compared with sicca-free subjects.…”
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Balancing Privacy and Utility in Split Learning: An Adversarial Channel Pruning-Based Approach by Afnan Alhindi, Saad Al-Ahmadi, Mohamed Maher Ben Ismail

“…This research introduces a novel privacy-preserving split learning approach that integrates: 1) Adversarial learning and 2) Network channel pruning. …”
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Unraveling the Beneficial Role of Resveratrol in Fructose-Induced Non-Alcoholic Steatohepatitis with a Focus on the AMPK/Nrf2 Signaling Axis by Soha S. Zakaria, Safaa M. Hanafy

“…<i>Conclusions:</i> This study specifically examines resveratrol’s therapeutic effects in a high-fructose diet-induced NASH model, focusing on the AMPK/Nrf2 signaling pathway to address oxidative stress and autophagy, providing novel insights into its molecular mechanism of action. …”
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Opening Wedge High Tibial Osteotomy with Combined Use of Patient-Specific 3D-Printed Plates and Taylor Spatial Frame for the Treatment of Knee Osteoarthritis by Desheng Duan, Yang Cao, Renzeng Li, Guohui Wang, Yongfei Zhang, Kui Xiang, Yanli Hu, Yiqun Li, Peng Peng, Pan Zhang, Xianzhe Liu

“…However, shortcomings still exist in the current procedure, like unprecise creation, inability to correct knee rotation, and internal fixed failure. Here, we reported a novel procedure: patient-specific 3D-printed plates for opening wedge high tibial osteotomy (OWHTO) combined with Taylor spatial frame (TSF). …”
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Amelioration of liver fibrosis with autologous macrophages induced by IL-34-based condition by Yuichi Igarashi, Haruka Wada, Masato Muto, Ryohei Sone, Yoshinori Hasegawa, Ken-ichiro Seino

“…Abstract Background For the treatment of liver fibrosis, several novel cell therapies have been proposed. Autologous macrophage therapy has been reported as one of the promising treatments. …”
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Glucocorticoid receptor gene (NR3C1) methylation, childhood maltreatment, multilevel reward responsiveness and depressive and anxiety symptoms: A neuroimaging epigenetic study by Yajing Xu, Shan Yang, Cong Cao

“…Background: Although epigenomic and environment interactions (Epigenome × Environment; Epi × E) might constitute a novel mechanism underlying reward processing, direct evidence is still scarce. …”
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Development of Predictive Models for Progression from Diabetic Kidney Disease to End-Stage Renal Disease in Type 2 Diabetes Mellitus: A Retrospective Cohort Study by Hu H, Mu X, Zhao S, Yang M, Zhou H

“…The developed models offer improved accuracy over existing methods by incorporating renal pathology and novel inflammatory indices, making them more applicable in clinical settings.Conclusion: The predictive model proved to be effective in assessing the progression of DKD to ESRD. …”
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Predicting breast cancer recurrence using deep learning by Deepa Kumari, Mutyala Venkata Sai Subhash Naidu, Subhrakanta Panda, Jabez Christopher

“…This study introduces the BCR-HDL (Breast Cancer Recurrence using Hybrid Deep Learning) framework, a novel approach designed to predict breast cancer recurrence with high accuracy and interpretability. …”
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Caveolin-1 Knockdown Decreases SMMC7721 Human Hepatocellular Carcinoma Cell Invasiveness by Inhibiting Vascular Endothelial Growth Factor-Induced Angiogenesis by Zhi-Bo Zhang, Zheng Shi, Lan-Fang Yang, Hong-Bin Gao

“…Conclusion. Our results reveal a novel mechanism, whereby caveolin-1 positively regulates human HCC cell invasiveness by coordinating VEGF-induced angiogenesis.…”
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