The Synergistic Effects of Celastrol in combination with Tamoxifen on Apoptosis and Autophagy in MCF-7 Cells by Lijun Wang, Luqun Tang, Chengyun Yao, Chunyan Liu, Yongqian Shu

“…Considering the urgent need for novel therapeutic strategies in anticancer therapy, this combinatorial approach is worthy of further investigation.…”
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RETRACTED ARTICLE: Single-cell omics and machine learning integration to develop a polyamine metabolism-based risk score model in breast cancer patients by Xiliang Zhang, Hanjie Guo, Xiaolong Li, Wei Tao, Xiaoqing Ma, Yuxing Zhang, Weidong Xiao

“…Our findings offer new insights into tumor heterogeneity, and a novel framework to personalize prognosis. Single-cell technologies are being used in this context to enhance our understanding of the complex molecular terrain of breast cancer and support more effective clinical management.…”
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Imbalance of the Gut Microbiota May Be Associated with Missed Abortions: A Perspective Study from a General Hospital of Hunan Province by Bingsi Gao, Xingping Zhao, Xinyi Liu, Xuan Yang, Aiqian Zhang, Huan Huang, Yu-ligh Liou, Dabao Xu

“…Comprehensive insights regarding gut microbiota may facilitate improved understanding and the development of novel therapeutic and preventive strategies for MAs.…”
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A new approach to off-gas analysis for shaken bioreactors showing high CTR and RQ accuracy by Andreas Schulte, Janik Brockmann, Nina Müller, Tibor Anderlei, Jochen Büchs

“…Conclusions The developed TOM system showcases a novel approach to measuring OTR, CTR, and RQ in shaken bioreactors. …”
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Development of Chitosan-Polyacrylic Acid Complex Systems for Enhanced Oral Delivery of Lactobacillus Gasseri and Bifidobacterium Bifidum Probiotics by AL-Fawares O, Alshweiat A, Abuawad A

“…Box 206, Al-salt, 19117, Jordan, Tel +9627997622457, Email ola.alfawares@bau.edu.joIntroduction: The beneficial effects of probiotics are encountered by their low viability in gastrointestinal conditions and their insufficient stability during manufacturing, throughut the gastrointestinal transit, and storage. Therefore, novel systems are highly required to improve probiotics delivery.Methods: In this study, Lactobacillus gasseri (L), Bifidobacterium bifidum (B), and a combination of L+B were encapsulated in chitosan (CS)-polyacrylic acid (PAA) complex systems (CS-PAA). …”
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Perioperative Treatment with Rivaroxaban and Dabigatran on Changes of Coagulation and Platelet Activation Biomarkers following Left Atrial Appendage Closure by Yao Yao, Yanli Li, Qinchun Jin, Xiaoye Li, Xiaochun Zhang, Qianzhou Lv

“…Insufficient data exist regarding the investigation of the impact of novel oral anticoagulants (NOACs) on coagulation activation biomarkers in the context of left atrial appendage closure (LAAC) and device-related thrombosis (DRT). …”
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Technology Readiness Level of biodiversity monitoring with molecular methods – where are we on the road to routine implementation? by Tiina Laamanen, Veera Norros, Petteri Vihervaara, Jacqueline Jerney, Pirkko Kortelainen, Katharina Kujala, Stefan Lambert, Janne Mäyrä, Lilja Nikula, Ida Palmroos, Mikko Tolkkinen, Kristiina Vuorio, Kristian Meissner

“…Thus, implementation of novel molecular monitoring methods such as environmental DNA (eDNA) and DNA metabarcoding, are necessary. …”
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Antibody in Lymphocyte Supernatant (ALS) responses after oral vaccination with live Shigella sonnei vaccine candidates WRSs2 and WRSs3 and correlation with serum antibodies, ASCs,... by Malabi M Venkatesan, Cassandra Ballou, Shoshana Barnoy, Monica McNeal, Jill El-Khorazaty, Robert Frenck, Shahida Baqar

“…A recently completed trial of two novel S. sonnei live oral vaccine candidates WRSs2 and WRSs3 established that both candidates were safe, well tolerated and immunogenic in a vaccine dose-dependent manner. …”
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Introducing an integrated approach for fire safety assessment in healthcare facilities by interval valued neutrosophic-AHP and Fuzzy Inference System by Samaneh Salari, Ali Karimi

“…Subsequently, three main parameters – Potential Risk Level (PRL), Acceptance Risk Level (ARL) and Protection Level (PL) – were calculated as alternatives in IVN-AHP technique using novel mathematical equations. A fuzzy inference system (FIS) was then employed to estimate the risk magnitude and subsequently classify departments within the healthcare building based on their risk level. …”
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Metabolomics approach reveals key plasma biomarkers in multiple myeloma for diagnosis, staging, and prognosis by Xiaoxue Wang, Longhao Cheng, Aijun Liu, Lihong Liu, Lili Gong, Guolin Shen

“…Conclusion Our findings on key metabolites and metabolic pathways provide novel insights into the exploration of diagnostic and therapeutic targets for MM. …”
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Mechanically stable polymer networks incorporating polymeric ionic liquids for enhanced conductivity in solid-state electrolytes by Sezer Özenler, Nataliya Kiriy, Upenyu L. Muza, Martin Geisler, Anton Kiriy, Brigitte Voit

“…Enhancing both ionic conductivity and mechanical robustness remains a major challenge in designing solid-state electrolytes for lithium batteries. This work presents a novel approach in designing mechanically robust and highly conductive solid-state electrolytes, which involves ionic liquid-based cross-linked polymer networks incorporating polymeric ionic liquids (PILs). …”
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Enhanced detection of mild cognitive impairment in Alzheimer’s disease: a hybrid model integrating dual biomarkers and advanced machine learning by John Sahaya Rani Alex, R. Roshini, G. Maneesha, Jeetashree Aparajeeta, B. Priyadarshini, Chih-Yang Lin, Chi-Wen Lung

“…As a result, in this study, CerebroSpinal Fluid (CSF) biomarker information is combined with hippocampal volumes to differentiate between MCI and AD. For this, a novel two-stage hybrid learning model that leverages 3D CNN and the notion of a Fuzzy and Machine learning model is proposed. …”
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Are Trends in Economic Modeling of Pediatric Diabetes Mellitus up to Date with the Clinical Practice Guidelines and the Latest Scientific Findings? by Roque Cardona-Hernandez, Alberto de la Cuadra-Grande, Julen Monje, María Echave, Itziar Oyagüez, María Álvarez, Isabel Leiva-Gea

“…**Discussion:** Economic models designed for assessing interventions in diabetes in pediatric patients should be based on pediatric-specific data and include novel adjuvant glucose-monitoring metrics and latest evidence on prognostic factors (C-peptide, legacy effect, age at diagnosis, socioeconomic status) to provide a more faithful reflection of the disease. …”
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The Reaction Extraction Combining Crystallization for Growth of Sodium Chloride in a Spray Fluidized Bed Crystallizer by Dan Zheng, Jie Yan, Jun Chen, Zeqin Wang

“…At present, the crystal size of sodium chloride prepared by a traditional crystallization process (such as stirred crystallization) is inhomogeneous, and it has a great quantity of fine grains in crystallizer. This work presents a novel approach for the growth of sodium chloride from supersaturated solutions by reaction-extractive crystallization in a spray fluidized bed crystallizer (SFBC), in which sodium sulfate solution is transformed into potassium chloride and sulphuric acid based on a reactive extraction-crystallization process using triisooctylamine (TOL) in n-octanol as the extraction system. …”
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Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury by Rongzong Ye, Yating Wei, Jingwen Li, Yu Zhong, Xiukai Chen, Chaoqian Li

“…These findings suggest a novel mechanism of plasma-AM interaction in sepsis-induced ALI, offering a plausible strategy for assessing septic progression and treating lung injury.…”
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The genomes of Scedosporium between environmental challenges and opportunism by Francesco Venice, Federica Spina, Domenico Davolos, Stefano Ghignone, Giovanna Cristina Varese

“…However, unlike other fungal pathogens, little is known about the genome evolution of these organisms. We sequenced two novel genomes of Scedosporium aurantiacum and Scedosporium minutisporum isolated from extreme, strongly anthropized environments. …”
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Low Profile Planar Inverted-L Antenna (PILA) for UHF RFID Tag on Signal Absorption and Reflection Surfaces by Minh-Tan Nguyen, Yi-Fang Lin, Chien-Hung Chen, Hoang-Son Luong, Hua-Ming Chen

“…In this study, we propose a novel design incorporating six Planar Inverted-L Antennas (PILAs) to miniaturize Ultra-High Frequency Radio Frequency Identification (UHF-RFID) tags, thereby enhancing tag efficiency when mounted on various conductive surfaces. …”
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Quantitative Evaluation of Top Coal Caving Methods at the Working Face of Extra-Thick Coal Seams Based on the Random Medium Theory by Shi Jiulin, Zhang Quntao, Gao Xiaojin, Xue Jisheng

“…Accordingly, the optimal caving interval and caving sequences are determined, and a novel interval symmetrical coal caving method is proposed. …”
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Analysis of differentially expressed genes in hypertension and hypertensive cerebral hemorrhage via RNA-sequencing by Hongwu Qi, Min Qiao, Yansong Liu, Weijun Zeng, Lizhao Zhang, Hongjun Guo

“…Our study may make a contribution for the understanding of the specific mechanisms of HT and HCH and representing a potential novel strategy for HT and HCH treatment.…”
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Comparative analysis of correlation and causality inference in water quality problems with emphasis on TDS Karkheh River in Iran by Reza Shakeri, Hossein Amini, Farshid Fakheri, Man Yue Lam, Banafsheh Zahraie

“…Unlike correlations, causal relationships demonstrate directional and often unequal influences, highlighting Mg as a critical driver of TDS levels. This novel application of ML-based causal inference in water quality research provides a cost-effective and time-efficient alternative to traditional experimental methods. …”
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