DisCo P-ad: Distance-Correlation-Based <i><b>p</b></i>-Value Adjustment Enhances Multiple Testing Corrections for Metabolomics by Debmalya Nandy, Debashis Ghosh, Katerina Kechris

“…Conclusion: We propose the distance-correlation-based <i>p</i>-value adjustment (DisCo P-ad) as a novel modification that can enhance existing eigen-analysis-based multiple testing correction procedures by increasing power or reducing false positives. …”
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Evaluating Meaningful Changes in Patient‐Reported Outcome Measurement Information System–Fatigue Scores from Three Phase 3 Clinical Trials of Sarilumab for Patients With Rheumatoid... by Clifton O. Bingham, Emily Molina, Amy Praestgaard, Stefano Fiore, David Cella

“…This study demonstrates the ability to convert FACIT‐Fatigue score onto the PROMIS T score metric, the rapid reduction in fatigue with biologic therapies, and the use of novel eCDF curves to show individual patient‐level change.…”
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Carbon monoxide-oxidising Pseudomonadota on volcanic deposits by Robin A. Dawson, Nicola Fantom, Tamara Martin-Pozas, Patricia Aguila, Gary M. King, Marcela Hernández

“…Based on comparative metabolic and phylogenetic analyses, Cupriavidus strain CV2 is proposed as a novel species within the genus Cupriavidus with the name Cupriavidus ulmosensis sp. nov. for the type strain CV2T (= NCIMB 15506 T, = CECT 30956 T). …”
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Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis by Wenchang Yang, Yaxin Wang, Peng Zhang, Tao Wang, Chengguo Li, Xin Tong, Xiangyu Zeng, Yuping Yin, Kaixiong Tao, Ruidong Li

“…4-Octyl itaconate (OI) is a novel anti-inflammatory metabolite that exerts protective effects in many various disease models. …”
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A Low-Complexity Diversity-Preserving Universal Bit-Flipping Enhanced Hard Decision Decoder for Arbitrary Linear Codes by Praveen Sai Bere, Mohammed Zafar Ali Khan, Lajos Hanzo

“…By contrast, soft-decision decoding retains diversity order, albeit at the cost of increased computational complexity. We introduce a novel enhanced hard-decision decoder termed as the Diversity Flip decoder (DFD) designed for preserving the diversity order. …”
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Exploring the adoption of diaphragm and lung ultrasound (DLUS) by physiotherapists, physical therapists, and respiratory therapists: an updated scoping review by Simon Hayward, Camella Cardinael, Chloe Tait, Michael Reid, Andrew McCarthy

“…However, DLUS remains a novel and innovative imaging technique in the hands of physiotherapists, physical therapists, and respiratory therapists as its utility continues to grow in various research, clinical and educational settings.…”
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Characterization of Ti6Al4V powders produced by different methods for selective electron beam melting by Liu Z., Huang C., Gao C., Liu R., Chen J., Xiao Z.

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Myoelectric pattern recognition with virtual reality and serious gaming improves upper limb function in chronic stroke: a single case experimental design study by Maria Munoz-Novoa, Morten B. Kristoffersen, Katharina S. Sunnerhagen, Autumn Naber, Max Ortiz-Catalan, Margit Alt Murphy

“…This study aims to determine the feasibility and preliminary effectiveness of a novel intervention combining MPR, virtual reality (VR), and serious gaming to improve upper limb function in people with chronic stroke. …”
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Blood molecular subtypes to guide precision treatment strategies in systemic juvenile idiopathic arthritis by In-Woon Baek, Jung Woo Rhim, Kyung-Su Park, Ki-Jo Kim

“…The molecular signatures of three novel sJIA subgroups (designated as C1, C2, and C3) were investigated, focusing on their distinct features and treatment responses. …”
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Assessing the effects of therapeutic combinations on SARS-CoV-2 infected patient outcomes: A big data approach. by Hamidreza Moradi, H Timothy Bunnell, Bradley S Price, Maryam Khodaverdi, Michael T Vest, James Z Porterfield, Alfred J Anzalone, Susan L Santangelo, Wesley Kimble, Jeremy Harper, William B Hillegass, Sally L Hodder, National COVID Cohort Collaborative (N3C) Consortium

“…<h4>Background</h4>The COVID-19 pandemic has demonstrated the need for efficient and comprehensive, simultaneous assessment of multiple combined novel therapies for viral infection across the range of illness severity. …”
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Associations between Chinese Visceral Adiposity Index and the Risk of Metabolic Dysfunction-associated Steatotic Liver Disease and Liver Fibrosis: A Large Cross-sectional Study by Hui Liu, Mingming Deng, Gang Luo, Jie Chen

“…Conclusion: The CVAI was positively related to the risk of MASLD or liver fibrosis and could be a novel biomarker for predicting MASLD and fibrosis in the American population.…”
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Call to Action: Lead Pharmacy into the Next Decade by Kerry K Fierke, Gardner Lepp, Bridget McGugan, Marta Brooks

“…The evolving landscape of healthcare leadership demands novel perspectives, creative applications, and open-minded evaluations. …”
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Association of HLA-B27 Gene and Rheumatoid Arthritis: Analysis of Potential Role as a Predictive Biomarker by Karzan Ghafur Khidhir, Baban Ahmad, Dana Khdr Sabir

“…Our findings could lead to the discovery of novel diagnostic, preventive and therapeutic strategies. …”
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Investigation of Crinum solapurense leaves extract for antidiabetic activity and histopathological evaluation in an in-vivo experimental model by Sunayana Mali, Gaurav Jain, Jyotiram Sawale, Audumbar Mali

“…Background: This study investigates the biological activity of the newly discovered novel C. solapurense (Crinum solapurense) plant from the Solapur, Maharashtra region, addressing a literature gap on its properties. …”
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Development of Nutrient-Rich Injera Using Amaranthus Leaf/Grain and Teff Flours: A Study on Nutritional Value, Sensory Characteristics, and Storage Stability by Betelhem Abera, Ramesh Duraisamy, Tewodros Birhanu, Beyene Gurbo, Ketemaw Salelign

“…Furthermore, lower proportions of Amaranthus grain flour (2, 4, and 6 g blending) and leaf flour (2–10 g blending) significantly extended the storage period of blended flatbread up to 6–7 days, where higher proportions of Amaranthus grain (8 and 10 g blending) are expected to preserve the flatbread Injera up to 9–10 days, surpassing the 3–4 days of the control (100 g teff flour). Therefore, novel teff–Amaranthus blended food can be produced by means of a cost-effective and easy-to-produce new integrated teff–Amaranthus blended food that can enhance the nutritional value and shelf life of the existing teff Injera.…”
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Anatomical and physiological contributions of nasal turbinate vessels and lymphatics to the pathogenesis of nasal congestion in recurrent headaches: a pilot study by Jacob M. Chmielecki, Aishwarya Vemula, Joyce G. Schwartz, Jonathan A. Gelfond, William T. Phillips

“…This research highlights a novel diagnostic use of the whole-body blood pool scan for the assessment of nasal turbinate vasodilation as well as a possible new target for the treatment of recurrent headaches.…”
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Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study by Yunyi Yan, Nozomi Kondo, Kentaro Oniki, Hiroshi Watanabe, Tadashi Imafuku, Yuki Sakamoto, Takuro Shigaki, Akari Maruyama, Hitomi Nakazawa, Tetsuya Kaneko, Ayami Morita, Akira Yoshida, Hitoshi Maeda, Toru Maruyama, Hideaki Jinnouchi, Junji Saruwatari

“…Visit-to-visit variability of HbA1c was an independent risk factor of microalbuminuria in association with oxidative stress among type 2 diabetes mellitus patients. HbA1c-AUC, a novel index of HbA1c variability, may be a potent prognostic indicator in predicting the risk of microalbuminuria.…”
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Ideas of Multipolarity in the Conceptual Frame of the Soviet Diplomacy during the Final Phases of the Great Patriotic war (1943–1945) by I. E. Magadeev

“…Additionally, the essay introduces a novel dimension by surveying the viewpoints of other Soviet diplomats (S.A. …”
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Tissue-specific roles of de novo DNA methyltransferases by Dániel Márton Tóth, Flóra Szeri, Mária Ashaber, Muhyiddeen Muazu, Lóránt Székvölgyi, Tamás Arányi

“…DNMT3A and DNMT3B establish novel methylation patterns maintained by DNMT1 during replication. …”
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Experimental hypothermia by cold air: a randomized, double-blind, placebo-controlled crossover trial by Ane M. Helland, Sigurd Mydske, Jörg Assmus, Guttorm Brattebø, Øystein Wiggen, Haakon K. Kvidaland, Øyvind Thomassen

“…Shivering was effectively reduced, but not completely inhibited by the drug regimen, and core temperature declined at a rate of − 0.82 °C per hour. Conclusion The novel protocol utilizing cold air as a cooling method and drug-induced suppression of endogenous thermoregulation, is effective and enables future research projects. …”
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