Individualized gray matter morphological abnormalities unveil two neuroanatomical obsessive-compulsive disorder subtypes by Baohong Wen, Keke Fang, Qiuying Tao, Ya Tian, Lianjie Niu, Wenqing Shi, Zijun Liu, Jin Sun, Liang Liu, Xiaopan Zhang, Ruiping Zheng, Hui-Rong Guo, Yarui Wei, Yong Zhang, Jingliang Cheng, Shaoqiang Han

“…The identified subtypes offer novel insights into nosology and the heterogeneous nature of OCD.…”
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The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections by Mohamed, Moubarak, Keneth Iceland, Kasozi, Helal F., Hetta, Hazem M., Shaheen, Abdur, Rauf, Hayder M., Al-kuraishy, Safaa, Qusti, Eida M., Alshammari, Emmanuel Tiyo, Ayikobua, Fred, Ssempijja, Adam Moyosore, Afodun, Ritah, Kenganzi, Ibe Michael, Usman, Juma John, Ochieng, Lawrence Obado, Osuwat, Kevin, Matama, Ali I., Al-Gareeb, Emmanuel, Kairania, Monica, Musenero, Susan, Christina Welburn, Gaber, El-Saber Batiha

“…Novel therapies for the treatment of COVID-19 are continuing to emerge as the SARS-Cov- 2 pandemic progresses. …”
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Evaluating the efficacy of multi-incision and tube-dragging therapy combined with laser closure for high horseshoe-shaped anal fistula: Protocol of a prospective, randomized, contr... by Min Yang, Zubing Mei, Qingming Wang, Ye Han, De Zheng

“…We are presently investigating a novel surgical technique involving a combination of multi-incision and tube-dragging therapy, and laser closure (MITD-LaC) for the management of HHAF. …”
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GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway by Yaowen Zhang, Yixin Yang, Shanshan Kuang, Yang Zhang, Hancheng Qin, Jisheng Xie

“…This study aimed to identify novel prognostic biomarkers and potential therapeutic targets of amino acid metabolism-related genes for stomach adenocarcinoma (STAD). …”
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Distinctive Gut Microbiota Alteration Is Associated with Poststroke Functional Recovery: Results from a Prospective Cohort Study by Yini Dang, Xintong Zhang, Yu Zheng, Binbin Yu, Dijia Pan, Xiaomin Jiang, Chengjie Yan, Qiuyu Yu, Xiao Lu

“…Significant associations were detected between alterations of distinctive gut microbiota and global functional prognosis. It would facilitate novel treatment target selection in the context of stroke while the causal relationships between distinctive gut microbiota alterations and functional variations need to be further verified with well-designed studies.…”
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A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice by Peng Ma, Rongrong Huang, Yu Ou

“…Our data suggest that SGP8 may act as a novel and potent therapeutic agent against NAFLD.…”
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Advancements in Managing Anthracycline-Induced Cardiotoxicity: Insights from Interventional Clinical Trials by Zhao M, Zhang X, Zhou D, Song J

“…Advanced monitoring techniques, including global longitudinal strain (GLS)-guided echocardiography, cardiac magnetic resonance (CMR) and novel biomarkers (cfDNA, microRNA), showed promise in early AIC detection. …”
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A Single‐Center Retrospective Cohort Study of Biopterin Metabolism Disorders in the United Arab Emirates by Omar Jarrah, Mahmood Nouri, Aisha Al Shamsi

“…DHPR deficiency was most commonly reported among studied patients (50%), with five novel variants in the QDPR gene. The second prevalent disorder was PTPS deficiency and only one patient with SR deficiency. …”
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3D Web Application of Wind Prediction Under Typhoon on Coastal Cities Based on Ensemble k-NN and OpenFOAM by Mamad Tamamadin, Seong-Hoon Kee, Jurng-Jae Yee

“…To anticipate the impact, this study proposes a novel approach to integrate the typhoon track predictions generated by an ensemble k-Nearest Neighbors (k-NN) as the reference locations of the typhoon center. …”
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C3AR1 as a target for preeclampsia: from bioinformatics and network pharmacology to experimental validation by Yongfeng Hu, Shaoqiang Li, Yunhui Hong, Dongxian Peng

“…It is crucial for cellular functions and inflammation, with future studies aiming to leverage this for novel preeclampsia treatments. Clinical trial Not applicable.…”
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Delving into biomarkers and predictive modeling for CVD mortality: a 20-year cohort study by Zhen Wu, Abdullahi Mohamud Hilowle, Ying Zhou, Changlin Zhao, Shuo Yang

“…The integration of cardiac biomarkers, lipid profiles, and inflammatory markers significantly improves the accuracy of predictive models for CVD-related mortality. This novel approach offers enhanced prognostication, with potential for further optimization through the inclusion of additional clinical and lifestyle data.…”
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If Music is Ongoing Experience, What Might Music Theory Be? . A Suggestion from the Drastic by Christopher F. Hasty

“…If we take experience as essentially predetermined by the musical work or, in cognitivist information processing terms, by rule-governed mechanisms for manipulating internal representations (be these rules syntactic or semantic) we shall not be able to account for the creativity of music and the production of novel meaning. The complexity or messiness of such production may seem an impediment to understanding music – it would seem to lead to the vagaries of the merely subjective, to mere appearance, or to a hopeless relativism that would in the end leave us speechless. …”
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An automated adaptive trading system for enhanced performance of emerging market portfolios by Cristiana Tudor, Robert Sova

“…We conclude that with the right investment tools, EMs continue to offer compelling opportunities that should not be overlooked. The novel AATS proposed in this study is such a tool, providing active EM investors with substantial value-added through its ability to generate abnormal returns, and can help to enhance the resilience of EMs by mitigating the cost of crises for those countries.…”
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Association between the triglyceride glucose body mass index and asthma: evidence from NHANES 2011–2018 by Sijia Yu, Shiping Wu, Shouxin Wei

“…The triglyceride-glucose body mass index (TyG-BMI) is a novel biomarker used to evaluate insulin resistance; however, limited research exists on the relationship between TyG-BMI and asthma. …”
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Use of Minimal Residual Disease Status to Reduce Uncertainty in Estimating Long-term Survival Outcomes for Newly Diagnosed Multiple Myeloma Patients by Naomi van Hest, Peter Morten, Keith Stubbs, Nicola Trevor

“…**Discussion:** Alternative methods to estimate long-term survival outcomes, such as a response-based PSM, can reduce uncertainty in modeling predictions around cost-effectiveness estimates for health technology assessment bodies and payers, thereby supporting faster market access for novel therapies with immature survival data. **Conclusions:** Use of MRD status in a response-based PSM reduces uncertainty in modeling long-term survival in patients with NDMM and provides a greater number of clinically plausible extrapolations compared with a standard PSM.…”
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Expanding the clinical spectrum of 19p13.3 microduplication syndrome: a case report highlighting nephrotic syndrome and literature review by Wenjie Sun, Hong Yan, Mengxin Sun, Jie Wang, Kunxia Li

“…In this study, we report the case of a patient with 19p13.3 microduplication and novel clinical findings, specifically nephrotic syndrome. …”
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What behavior is important behavior? A systematic review of how wild and zoo-housed animals differ in their time-activity budgets by Robert Kelly, Marianne Freeman, Paul Rose, Paul Rose

“…Other species may adapt to captivity in novel ways, demonstrating flexibility in their behavior patterns without compromising welfare. …”
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Blood from septic patients with necrotising soft tissue infection treated with hyperbaric oxygen reveal different gene expression patterns compared to standard treatment by Julie Vinkel, Alfonso Buil, Ole Hyldegaard

“…Conclusion The global gene expression pattern in blood changed in response to HBO2 treatment in a direction associated with clinical biochemistry improvement, and the study provides potential novel biomarkers and pathways for monitoring HBO2 treatment effects and predicting an HBO2 responsive NSTI-sepsis profile. …”
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Integrative single-cell and multi-omics analyses reveal ferroptosis-associated gene expression and immune microenvironment heterogeneity in gastric cancer by Shupeng Zhang, Zhaojin Li, Gang Hu, Hekai Chen

“…Recently, ferroptosis, a novel mode of cell demise, has become a focal point in cancer research. …”
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Downregulation of FXYD2 Is Associated with Poor Prognosis and Increased Regulatory T Cell Infiltration in Clear Cell Renal Cell Carcinoma by Zedan Zhang, Yanlin Tang, Lei Li, Wuping Yang, Yawei Xu, Jingcheng Zhou, Kaifang Ma, Kenan Zhang, Hongkai Zhuang, Yanqing Gong, Kan Gong

“…This will probably provide a novel prognostic marker and potential therapeutic target for ccRCC.…”
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