GENOTYPIC DIVERSITY OF DENGUE VIRUS IN AEDES MOSQUITOES COLLECTED FROM DENGUE HOTSPOT AREAS IN KUALA LUMPUR AND SELANGOR, MALAYSIA by Wan Najdah Wan Mohamad Ali, Zurainee Mohamed Nor, Rafidah Ali, Rohani Ahmad, Yvonne Ai-Lian Lim

“…The findings from this study can be utilized to the search for novel genotypes, to the observation of potential genetic alterations in dengue viruses, and to the development of vaccines.…”
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Development of the pulmonary fibrosis, pulmonary vascular resistance, six minute walk distance, B-type natriuretic peptide, age (PVD-B65) risk score for patients with chronic lung... by Shameek Gayen, Jay Pescatore, Matthew Bittner, Mario Naranjo, Gerard J. Criner, Sheila Weaver, Temple Lung Center Pulmonary Vascular Disease Working Group

“…Conclusion The PVD-B65 risk assessment tool is a novel, internally validated one-year mortality risk calculator for patients with chronic lung disease and PH that encompasses factors related to pulmonary parenchymal and vascular remodeling. …”
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Special Staining of the Liquid-Based Cytopathology Test in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis with Nonneutropenic Patients by Yue Hu, Lin Zheng, Deng Pan, Lei Shao, Xianfa Xu, Yiming Yu, Qidong Zhuang, Zaichun Deng, Zhongbo Chen

“…This study showed that special staining of LCT in BAL fluid may be a novel method for the diagnosis of IPA, and the GMS of LCT had higher sensitivity and specificity, which was superior to PAS.…”
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Gap junction intercellular communications regulates activation of SARM1 and protects against axonal degeneration by Wen Jie Zhu, Jun Liu, Wan Hua Li, Zhi Ying Zhao, Chongquan Huang, Jian Yuan Yang, Hon Cheung Lee, Yong Juan Zhao

“…Our results demonstrate a novel intercellular regulation mechanism of SARM1 and reveal a protective role of healthy tissue against AxD induced by injury or neuroinflammation.…”
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H-AMR FORGE’d in FIRE. I. Magnetic State Transitions, Jet Launching, and Radiative Emission in Super-Eddington, Highly Magnetized Quasar Disks Formed from Cosmological Initial Cond... by Nicholas Kaaz, Matthew Liska, Alexander Tchekhovskoy, Philip F. Hopkins, Jonatan Jacquemin-Ide

“…This remapping generates magnetic monopoles, which we erase using a novel divergence cleaning approach. Despite the toroidal magnetic field's dominance at large radii, vertical magnetic flux builds up near the event horizon, leading to a magnetic state transition within the inner 200 gravitational radii of the disk. …”
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Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites by Thomas Kayser, MD, BS, Ronald Smulders, MD, PhD, Tomohiro Kusawake, PhD, Erik Wambre, PhD, Gurunadh R. Chichili, PhD, Mary B. Blauwet, DrPH, Anna Spence, MS, Melanie Patton, BS, Rima Tabash, PhD, Hannah A. DeBerg, PhD, Sugandhika Khosa, MS, Philipp Badorrek, MD, Jens M. Hohlfeld, MD, Brian C. Ferslew, PharmD, PhD

“…Background: House dust mite (HDM) allergies are prevalent, yet current treatments like allergen avoidance, pharmacotherapy, and conventional allergen immunotherapy present limitations. The novel LAMP (lysosomal-associated membrane protein)-based DNA vaccine ASP2390 targets major HDM allergens, potentially shifting immune responses toward nonallergic pathways and minimizing the risk of atopy, with positive safety and efficacy signals in preclinical models. …”
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Radiation-induced impacts on mitochondrial DNA and the transgenerational genomic instability by Ryosuke Seino, Haruka Kubo, Kai Nishikubo, Hisanori Fukunaga

“…Furthermore, to our knowledge, this is first to demonstrate the hereditary effects of radiation on the regulation of mitochondrial genome. These provide novel insights into the significance of radiation protection and preventive medicine for not only pre-pregnancy females but also the next generation.…”
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Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay by Linlin Dong, Susan Chen, Konstantin Piatkov, Dong Wei, Mark G. Qian

“…The successful implementation of this novel approach in discovery PK studies eliminates the need for tedious and costly generation of specific immunocapturing reagents for the LAGA mutants. …”
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Improving drug repositioning with negative data labeling using large language models by Milan Picard, Mickael Leclercq, Antoine Bodein, Marie Pier Scott-Boyer, Olivier Perin, Arnaud Droit

“…Results We proposed a novel strategy using Large Language Models (GPT-4) to analyze all clinical trials on prostate cancer and systematically identify true negatives. …”
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Landfill site selection in hilly terrains: An integrated RS-GIS approach with AHP and VIKOR by Shobhit Chaturvedi, Naimish Bhatt, Vatsal Shah, Keval H. Jodhani, Dhruvesh Patel, Sudhir Kumar Singh

“…This paper presents a novel integrated Geographic Information System-Multi-Criteria Decision Making (GIS-MCDM) framework for evaluating landfill site suitability in Shimla, India, a rapidly urbanizing hill station. …”
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Preclinical Efficacy and Proteomic Prediction of Molecular Targets for s-cal14.1b and s-cal14.2b Conotoxins with Antitumor Capacity in Xenografts of Malignant Pleural Mesothelioma by Angélica Luna-Nophal, Fernando Díaz-Castillo, Vanessa Izquierdo-Sánchez, Jesús B. Velázquez-Fernández, Mario Orozco-Morales, Luis Lara-Mejía, Johana Bernáldez-Sarabia, Noemí Sánchez-Campos, Oscar Arrieta, José Díaz-Chávez, Jorge-Ismael Castañeda-Sánchez, Alexei-Fedorovish Licea-Navarro, Saé Muñiz-Hernández

“…Some species of marine snails have been demonstrated to be potential sources of novel anticancer molecules. This study analyzed the anticancer effects in vitro and in vivo of two peptides found in <i>C. californicus</i>. …”
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Development of the Dutch translational knowledge agenda for inherited metabolic diseases by I. J. Hieltjes, J. H. van derLee, M. C. Groenendijk, G. vanHaaften, P. M. vanHasselt, R. J. Lunsing, G. J. J. vanProoijen, E. M. deRuiter, F. J. vanSpronsen, N. M. Verhoeven‐Duif, A. deVreugd, M. Wagenmakers, H. Zweers, H. Dekker, H. R. Waterham, C. D. vanKarnebeek, R. J. A. Wanders, R. A. Wevers

“…The resulting top 10 research questions cover multiple themes, i.e. prediction of disease progression, development of novel tools, mechanistic insights, improved diagnostics, therapeutic integration of multi‐omics techniques, assessment of impact on daily life, expanding treatment avenues, optimal study designs, effect of lifestyle interventions, and data utilization using FAIR principles. …”
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Driving brain state transitions via Adaptive Local Energy Control Model by Rong Yao, Langhua Shi, Yan Niu, HaiFang Li, Xing Fan, Bin Wang

“…Network control theory offers a novel framework for investigating the dynamic characteristics of brain state transitions. …”
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A Real-Time Human Pose Measurement System for Human-In-The-Loop Dynamic Simulators by Nicola Giulietti, Davide Todesca, Marco Carnevale, Hermes Giberti

“…The system exploits pre-trained 2D human pose detection models and integrates an <inline-formula> <tex-math notation="LaTeX">$\alpha \text {-}\beta \text {-}\gamma $ </tex-math></inline-formula> filter to reduce fluctuations in detected key points. It also introduces a novel Weighted Direct Linear Triangulation method, enhancing 3D reconstruction accuracy by assigning higher weights to key points consistent across current and previous frames. …”
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Effects of non-contact electric fields on the kidneys and livers of tumour-bearing rats [version 6; peer review: 1 approved, 2 approved with reservations, 1 not approved] by Luthfi Nurhidayat, Ahmad Ghitha Fadhlurrahman, Firman Alamsyah, Warsito Purwo Taruno, Nisrina Firdausi, Subekti Evi Dwi Nugraheni, Rarastoeti Pratiwi

“…Background A novel modality of cancer treatment based on exposure to non-contact electric fields called Electro-Capacitive Cancer Therapy (ECCT) has been developed. …”
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Characterization of meat quality, storage stability, flavor-related compounds, and their relationship in Korean Woorimatdag No. 2 chicken breast meat during cold storage by Yousung Jung, Soomin Oh, Sangrok Lee, Hee-Jeong Lee, Hyo-Jun Choo, Cheorun Jo, Ki-Chang Nam, Jun-Heon Lee, Aera Jang

“…We evaluated the quality, storage stability, and flavor-related compounds of breast meat from a novel Korean native chicken breed (Woorimatdag No. 2; WRMD2) and commercial broiler (CB) during seven days of aerobic cold storage. …”
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Sandpiper optimization with hybrid deep learning model for blockchain-assisted intrusion detection in iot environment by Mimouna Abdullah Alkhonaini, Manal Abdullah Alohali, Mohammed Aljebreen, Majdy M. Eltahir, Meshari H. Alanazi, Ayman Yafoz, Raed Alsini, Alaa O. Khadidos

“…This paper projects a novel sandpiper optimizer with hybrid deep learning-based intrusion detection (SPOHDL-ID) from the BC-assisted IoT platform. …”
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Advanced perspective on heavily phosphorus-doped diamond layers via optical emission spectroscopy by Kil-dong Sung, Stefan Andrei Irimiciuc, Michal Novotný, Zdeněk Weiss, Pavel Hubík, Jaromír Kopeček, Martin Vondráček, Vincent Mortet

“…Time-dependent control of precursor gas flow allowed modulation of IPH/ICH, improving control over phosphorus incorporation. This novel growth approach offers valuable insights for optimizing PDD synthesis, enabling more efficient phosphorus incorporation for electronic, electrochemical, and quantum applications.…”
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Efficiency of <i>in vitro</i> culture techniques applied to soybean (<i>Glycine max (L.) Merr.</i>) accessions from the VIR collection by E. S. Korshikova, K. M. Ershova, Yu. A. Moksheninova, Yu. V. Ukhatova

“…Successful application of novel methods also requires new approaches to studying soybean accessions, specifically their ability to regenerate and produce calluses for subsequent inclusion in biotechnological programs.Ten soybean accessions of various origin, contrasting in ripening schedules, were selected to study the possibility of effective introduction into in vitro culture and further assessment of their ability to produce calluses and regenerate in in vitro culture. …”
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Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4/JNK/ERK/NF-κB Pathway by Yu Long, Yan Xiang, Songyu Liu, Yulu Zhang, Jinyan Wan, Qiyue Yang, Mingquan Cui, Zhimin Ci, Nan Li, Wei Peng

“…However, BA has low solubility which may limit its clinical application. Hence, we prepared a novel drug delivery system—Baicalin liposome (BA-LP) in previous research—which can improve some physical properties of BA. …”
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