Interleukin-2/Anti-Interleukin-2 Immune Complex Expands Regulatory T Cells and Reduces Angiotensin II-Induced Aortic Stiffening by Beenish Majeed, Supannikar Tawinwung, Lance S. Eberson, Timothy W. Secomb, Nicolas Larmonier, Douglas F. Larson

“…To study the role of immune inhibitory cells, CD4+CD25+Foxp3+ regulatory T cells (Tregs), on vascular stiffness, we stimulated the proliferation of Treg lymphocytes in vivo using a novel cytokine immune complex of Interleukin-2 (IL-2) and anti-IL-2 monoclonal antibody clone JES6-1 (mAbCD25). …”
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MSC-Derived Extracellular Vesicle-Delivered L-PGDS Inhibit Gastric Cancer Progression by Suppressing Cancer Cell Stemness and STAT3 Phosphorylation by Benshuai You, Can Jin, Jiaxin Zhang, Min Xu, Wenrong Xu, Zixuan Sun, Hui Qian

“…In conclusion, our results imply that MSC-derived EVs could be utilized as an effective nanovehicle to deliver L-PGDS for gastric cancer treatment, which provides a novel idea for the EV-based cancer therapy.…”
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Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway by Jushuang Li, Lan Shu, Qianqian Jiang, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li, Jun Wu

“…These findings may provide the first line of evidence showing that Ori alleviates fibrosis in DN by inhibiting the Wnt/β-catenin signaling pathway and thereby reveal a novel therapeutic avenue for treating tubulointerstitial fibrosis.…”
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Bismuth-Remaining Cupellation Fire Assay Preconcentration Combined with Inductively Coupled Plasma Mass Spectrometry for the Simultaneous Determination of Ultratrace Au, Pt, Pd, Ru... by Wenshan Ni, Xiangju Mao, Mingxing Yao, Qiliang Sun, Xiaorui Guo, Hongli Zhang, Lu Liu

“…In this work, a novel method of bismuth fire assay (Bi-FA) combined with inductively coupled plasma mass spectrometry (ICP-MS) simultaneous determination of ultratrace gold (Au), platinum (Pt), palladium (Pd), ruthenium (Ru), rhodium (Rh), and iridium (Ir) in geologic samples was established. …”
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Caution when using network partners for target identification in drug discovery by Dandan Tan, Yiheng Chen, Yann Ilboudo, Kevin Y.H. Liang, Guillaume Butler-Laporte, J. Brent Richards

“…Summary: Identifying novel, high-yield drug targets is challenging and often results in a high failure rate. …”
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An Efficient and Hybrid Deep Learning-Driven Model to Enhance Security and Performance of Healthcare Internet of Things by Muhammad Babar, Muhammad Usman Tariq, Basit Qureshi, Zabeeh Ullah, Fahim Arif, Zahid Khan

“…Furthermore, reducing superfluous data and identifying effective fog nodes are difficult tasks. We provide a novel Software-Defined Networking (SDN)- driven Deep Learning (DL) approach to develop a secure, intelligent, and efficient framework for smart H-CIoT networks in order to address the aforementioned challenges. …”
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Intranasal Immunization with DNA Vaccine HA-CCL19/Polyethylenimine/Chitosan Composite Provides Immune Protection Against H7N9 Infection by Yuqing Xiang, Hongbo Zhang, Youcai An, Ze Chen

“…Background/Objectives: The H7N9 avian influenza virus (AIV) constitutes a novel subtype of influenza virus that has emerged within the past decade. …”
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Clinical Characteristics and Outcomes of COVID-19 in Children in Northern Iran by Leila Shahbaznejad, Hamed Rouhanizadeh, Mohammad Reza Navaeifar, Fatemeh Hosseinzadeh, Faeze Sadat Movahedi, Mohammad Sadegh Rezai

“…Since December 2019, the coronavirus disease 2019 (COVID-19) has been spread rapidly all over the world, infecting all age groups with this novel virus. In this manuscript, we report characteristics of children with COVID-19 in Mazandaran province, northern Iran. …”
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Bioprocess exploitation of microaerobic auto-induction using the example of rhamnolipid biosynthesis in Pseudomonas putida KT2440 by Jakob Grether, Holger Dittmann, Leon Willems, Tabea Schmiegelt, Elvio Henrique Benatto Perino, Philipp Hubel, Lars Lilge, Rudolf Hausmann

“…Conclusions Utilizing the inherent tolerance of P. putida to microaerobic conditions in combination with the application of homologous, low-oxygen inducible promoters is a novel and efficient strategy to control bioprocesses. …”
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Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome by Eva Drnovsek, Mojca Jensterle, Katja Goričar, Sara Redenšek, Andrej Janež, Irina Milisav, Vita Dolžan

“…Introduction Cholecystokinin (CCK) is involved in several metabolic pathways, and CCK agonists are considered as a potential novel treatment option in populations with increased metabolic risk, including polycystic ovary syndrome (PCOS). …”
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Color Stability and Surface Properties of PMMA/ZrO2 Nanocomposite Denture Base Material after Using Denture Cleanser by Mohammed M. Gad, Reem Abualsaud, Shaimaa M. Fouda, Ahmed Rahoma, Ahmad M. Al-Thobity, Soban Q. Khan, Sultan Akhtar, Khalid S. Al-Abidi, Mohamed S. Ali, Fahad A. Al-Harbi

“…Statement of Problem. Novel polymethyl methacrylate (PMMA) containing zirconium dioxide nanoparticles (nano-ZrO2) was suggested as a denture base material but there is a lack of information regarding denture cleanser effects. …”
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Pyrolysis and Dioxin Production Characteristics of Mineralized Waste in Landfills by Jian-Ying Fu, Han-Cheng Ma, Wen-Tao Jiao, Xu Xu, Xiao-Qing Lin, Xiao-Dong Li, Ming-Xiu Zhan

“…The experimental results of this study provide novel technical guidance for the resource utilization of MW.…”
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Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers by Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz

“…Ultimately, our findings reveal novel insights for the engineering of potent NKCEs triggering the NKp30 axis.…”
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Tropical cyclone intensity estimation based on YOLO-NAS using satellite images in real time by Priyanka Nandal, Prerna Mann, Navdeep Bohra, Ghadah Aldehim, Asma Abbas Hassan Elnour, Randa Allafi

“…This research presents a novel method for forecasting the strength of tropical storms using the You Only Look Once-Neural Architecture Search (YOLO-NAS) algorithm, leveraging real-time satellite imagery from the INSAT-3D platform. …”
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Synthesis and in vitro evaluation of spirobenzovesamicols as potential 11C-PET tracer alternatives to [18F]FEOBV for vesicular acetylcholine transporter (VAChT) imaging by Hugo Helbert, Winnie Deuther-Conrad, Michel de Haan, Barbara Wenzel, Gert Luurtsema, Wiktor Szymanski, Peter Brust, Rudi A. J. O. Dierckx, Ben L. Feringa, Philip H. Elsinga

“…Modern labelling techniques, in this case the [11C]MeLi cross-coupling methodology, expands labelling opportunities, allowing to explore novel vesamicol-based structures as potential PET-tracers. …”
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Dynamic Key Replacement Mechanism for Lightweight Internet of Things Microcontrollers to Resist Side-Channel Attacks by Chung-Wei Kuo, Wei Wei, Chun-Chang Lin, Yu-Yi Hong, Jia-Ruei Liu, Kuo-Yu Tsai

“…To address this critical vulnerability, this study proposes a novel dynamic key replacement mechanism specifically designed for lightweight IoT microcontrollers. …”
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Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled... by Eva Skovlund, Rune Haaverstad, Henrik Zetterberg, Jorunn L Helbostad, Rolf Busund, Johan Raeder, Theis Tønnessen, Torgeir Bruun Wyller, Melanie R Simpson, Nils Kristian Skjærvold, Bjørn Erik Neerland, Svein Aslak Landsverk, Ieva Martinaityte, Hilde Margrethe Norum, Geir Selbaek, Elisabeth Skaar, Arjen JC Slooter, Øyvind Sverre Svendsen, Alexander Wahba

“…We aim to study whether repurposing of clonidine can represent a novel treatment option for delirium, and the possible effects of dexmedetomidine and clonidine on long-term cognitive trajectories, motor activity patterns and biomarkers of neuronal injury, and whether these effects are associated with frailty status.Methods and analysis This five-centre, double-blind randomised controlled trial will include 900 cardiac surgery patients aged 70+ years. …”
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Deployment of next-generation sequencing approach for variant detection in myocardial infarction: A concise investigation by Desaraju Suresh Bhargav, Nadeem Siddiqui, Bhadra Murthy V, Vijaya Tartte, Vanaja V

“…Results: Variants in the APOB, MTHFR, WDR12, CELSR2, and MIA3 genes were identified as more predominant in the sequenced individuals and two novel variants were observed from CELSR2 which were not reported previously. …”
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Hooks, Lines, and Sinkers: How Active Galactic Nucleus Feedback and Cosmic-Ray Transport Shape the Far-infrared–Radio Correlation of Galaxies by Sam B. Ponnada, Rachel K. Cochrane, Philip F. Hopkins, Iryna S. Butsky, Sarah Wellons, N. Nicole Sanchez, Cameron Hummels, Yue Samuel Lu, Dušan Kereš, Christopher C. Hayward

“…Importantly, the indirect effect of AGN feedback on emergent observables highlights novel interpretations of outliers in the FRC. In particular, we find that in many cases “radio-excess” objects can be better understood as “IR-dim” objects with longer-lived radio contributions at low z from Type Ia supernovae and intermittent black hole accretion in quenching galaxies, though this is sensitive to the interplay of CR transport and AGN feedback physics. …”
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Entrepreneurship in Medical Education: Evaluation of the Entrepreneurship in Healthcare Seminar Series by Amanda Mac, Hayley McKee, Michael Balas, Aazad Abbas, Aida Ahrari, Pawandeep Sandhu, Dante Morra, Sarah McClennan, Alison Freeland

“…We created the Entrepreneurship in Healthcare Seminar Series (EHSS), a novel initiative designed to teach medical students about developing innovations and launching entrepreneurial ventures. …”
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