Prognostic Utility of the Combination of Platelet Count with Neutrophil-to-Lymphocyte Ratio in Aged Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Inter... by Xiao-Qing Quan, Hong-Yan Ji, Jie Jiang, Jia-Bao Huang, Cun-Tai Zhang

“…Our study was to investigate the role of a novel biomarker, the combination of platelet count, and neutrophil-to-lymphocyte ratio, for predicting in-hospital and long-term mortality of aged patients with acute myocardial infarction. …”
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Microbial keratitis in Southern Malawi: a microbiological pilot study by Timothy Neal, Dean Everett, Stephen B Kaye, Alistair Darby, Moira Gandiwa, Shaffi Mdala, Caroline E Corless, Rose Herbert, Nicholas A V Beare, Tobi F Somerville, Thokozani Zungu, Malcolm J Horsburgh, Petros C Kayange

“…We investigated the feasibility of using a novel corneal impression membrane (CIM) for obtaining and processing samples by culture, PCR and whole-genome sequencing (WGS) in patients presenting with suspected MK in Malawi.Methods and analysis Samples were collected from patients presenting with suspected MK using a 12 mm diameter polytetrafluoroethylene CIM disc. …”
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Amplitude Modulation Depth Coding Method for SSVEP-Based Brain–Computer Interfaces by Ruxue Li, Zhenyu Wang, Xi Zhao, Guiying Xu, Honglin Hu, Ting Zhou, Tianheng Xu

“…To address these issues, we proposed a novel amplitude modulation depth coding (AMDC) method that employs Amplitude Shift Keying (ASK) technique to modulate the luminance level of stimuli dynamically. …”
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Individualized prediction of multi-domain intelligence quotient in bipolar disorder patients using resting-state functional connectivity by Xiaoyu Li, Wei Wei, Linze Qian, Xiaojing Li, Mingli Li, Ioannis Kakkos, Qiang Wang, Hua Yu, Wanjun Guo, Xiaohong Ma, George K. Matsopoulos, Liansheng Zhao, Wei Deng, Yu Sun, Tao Li

“…It is a step toward the development of applicable techniques for quantitative and objective cognitive assessment in BD patients and contributes novel insights into understanding the complex neural mechanisms underlying different IQ domains.…”
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Significance of Linked Color Imaging for Predicting the Risk of Clinical Relapse in Ulcerative Colitis by Shuji Kanmura, Akihito Tanaka, Kazuki Yutsudou, Kosuke Kuwazuru, Fukiko Komaki, Yuga Komaki, Hiromichi Iwaya, Shiho Arima, Fumisato Sasaki, Shiroh Tanoue, Shinichi Hashimoto, Akio Ido

“…Linked color imaging (LCI) is a novel endoscopic system that enhances the color differences of the gastrointestinal mucosa. …”
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Realizing low voltage-driven bright and stable quantum dot light-emitting diodes through energy landscape flattening by Yiting Liu, Yingying Sun, Xiaohan Yan, Bo Li, Lei Wang, Jianshun Li, Jiahui Sun, Yaqi Guo, Weipeng Liu, Binbin Hu, Qingli Lin, Fengjia Fan, Huaibin Shen

“…Meanwhile, These LEDs show an unprecedented operation lifetime T95 (time for the luminance to decrease to 95%) of 72,968 h at 1,000 cd m-2. Our work points to a novel path to flatten energy landscape at the QD-related interface for solution-processed photoelectronic devices.…”
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Remote sensing assessment of dam impact on arid basins in Southern Saudi Arabia: A machine learning and space-for-time approach by Raid Almalki, Mehdi Khaki, Patricia M. Saco, Jose F. Rodriguez

“…The study introduces a novel framework that combines space-for-time substitution and Dynamic Time Warping (DTW) to assess temporal and spatiotemporal changes in key environmental factors such as NDVI, soil salinity, groundwater, and runoff. …”
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Chemical Fingerprint Analysis for Discovering Markers and Identifying Saussurea involucrata by HPLC Coupled with OPLS-DA by Qingdong Ma, Xiaoxiang Chen, Ke Zhang, Dahong Yao, Lu Yang, Hangyu Wang, Santai Bulemasi, Jian Huang, Jinhui Wang

“…., their dependence on personal experience and expertise, and it is a huge challenge to identify closely related species that share similar or identical morphological characteristics and chemical profiles. A novel and generally accepted identification strategy is urgently needed as a complement to regulations for protecting the public health interests. …”
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Occupational exposure to flame retardants following production replacement and their effect on thyroid function indicators by Ling Meng, Tingting Guo, Yizhi Liu, Han Wu, Kang An, Xizhu Xu, Yuancheng Li

“…With the ban of commercial Penta-BDEs, Octa-BDEs, and Deca-BDEs, many manufacturers have been transition to the production of novel brominated flame retardants (NBFRs), organophosphate ester flame retardants (OPFRs), and other alternatives. …”
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Intestinal schistosomiasis in remote areas of Southwest Ethiopia, a target region for large-scale mass drug administration by Yared Nigusu, Teshome Bekana, Eshetu Chilo, Sisay Teferi, Dereje Oljira Donacho, Dereje Gemeda, Tefera Darge, Abeza Mitiku, Abdi Geda Gedefa, Tadesse Sime, Wubishet Gezimu, Oda Gizaw, Gemechu Tadila, Miressa Bekana, Berhanu Erko

“…Strategies to end the disease as a public health threat, mainly in remote and endemic areas, should consider novel integrated strategies targeting the life cycle of schistosomes besides the large-scale mass drug administration.…”
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Strength and durability of indirect protection against SARS-CoV-2 infection through vaccine and infection-acquired immunity by Sophia T. Tan, Isabel Rodríguez-Barraquer, Ada T. Kwan, Seth Blumberg, Hailey J. Park, Justine Hutchinson, David Leidner, Joseph A. Lewnard, David Sears, Nathan C. Lo

“…However, indirect protection from SARS-CoV-2 infection-acquired immunity and its comparative strength and durability to vaccine-derived indirect protection in the current epidemiologic context of high levels of vaccination, prior infection, and novel variants are not well characterized. Here, we show that both vaccine-derived and infection-acquired immunity independently yield indirect protection to close social contacts with key differences in their strength and waning. …”
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Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion by Mehul Vora, Jonathan Dietz, Zachary Wing, Karen George, Jun Kelly Liu, Christopher Rongo, Cathy Savage-Dunn

“…Functional analysis of target genes revealed a novel role in body size for genes involved in one-carbon metabolism and in the endoplasmic reticulum (ER) secretory pathway, including the disulfide reductase dpy-11. …”
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Prospects for mine geological work in the intelligence age: Architecture of the intelligent geological guarantee technology system for mine exploitation by Yucheng XIA, Xueyang SUN, Lintian MIAO, Chen GUO, Rongjun DU

“…The technology system will surely become the novel productivity that boosts the quality and efficiency of mine geological work. …”
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Milestones and Timescale of Poststroke Recovery: A Cohort Study by Marianna Loi, Alberto Zaliani, Marta Abbamonte, Elena P. Ferrari, Roberto Maestri, Luigi Trojano, Pietro Balbi

“…In this observational monocentric cohort study, 176 poststroke inpatients at their first cerebrovascular event were consecutively enrolled. A novel measure based on the time needed to reach the main milestones of motor recovery was proposed. …”
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Fabrication of heteroatom-doped graphene-porous organic polymer hybrid materials via femtosecond laser writing and their application in VOCs sensing by Rasha Diab, Ganjaboy Boltaev, Mahmoud M. Kaid, Ahmad Fawad, Hani M. El-Kaderi, Mohammad H. Al-Sayah, Ali S. Alnaser, Oussama M. El-Kadri

“…This study demonstrates a novel approach to synthesize a composite material exclusively from a porous organic polymer (POP) by direct femtosecond laser writing on a compressed imide-linked porous organic polymer substrate. …”
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Osteoblastic Differentiation and Mitigation of the Inflammatory Response in Titanium Alloys Decorated with Oligopeptides by Aroa Álvarez-López, Raquel Tabraue-Rubio, Rafael Daza, Luis Colchero, Gustavo V. Guinea, Martine Cohen-Solal, José Pérez-Rigueiro, Daniel González-Nieto

“…These results highlight the potential of peptide decoration on R-THAB^® functionalized surfaces to expedite the development of novel metallic biomaterials with enhanced biocompatibility properties, thereby advancing the field of regenerative medicine.…”
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Low & Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2): study protocol for a phase 2, prospective, multicentre, open-label, multiarm, biomarker-direct... by Marshall Pitz, Eng-Siew Koh, Elizabeth H Barnes, Lucille Sebastian, Mandy L Ballinger, David M Thomas, Christopher O'Callaghan, John Simes, Hui K Gan, Sonia Yip, Hao-Wen Sim, Desma Spyridopoulos, Richard De Abreu Lourenco, Cynthia Hawkins, Kristen McParland, Benjamin Kong, Subotheni Thavaneswaran, Patrick J Wheeler

“…This study aims to improve outcomes by molecular profiling of patients at relapse, then matching them with the best available drug based on their molecular profile, maximising the chances of patient benefit while simultaneously testing multiple novel drugs.Methods and analysis Low & Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2) will be an international, phase 2, multicentre, open-label, biomarker-directed, umbrella clinical trial for recurrent isocitrate dehydrogenase mutant, histologically grade 2/3 gliomas. …”
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Influence of graphene nanoplatelets (GNPs) and aluminum-carbon layered double hydroxides (Al-C LDH) in polypropylene matrix of hybrid composite structures on the microstructure and... by R. Daulath Banu, R. Karunanithi, S. Sivasankaran, B. Subramanian, Abdullah A. Alhomidan

“…In this study, a polypropylene (PP) matrix was reinforced with ultra-fine graphene nanoplatelets (GNPs), aluminum-carbon layered double hydroxides (Al-C LDHs), and calcium carbonate (CaCO3) as hybrid reinforcements, along with polypropylene grafted maleic anhydride (PP-g-MA) compatibilizers to create a novel thermoplastic-based hybrid composite polymer. …”
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Antioxidant and Laxative Effects of Methanol Extracts of Green Pine Cones (<i>Pinus densiflora</i>) in Sprague-Dawley Rats with Loperamide-Induced Constipation by Hee-Jin Song, Ayun Seol, Jumin Park, Ji-Eun Kim, Tae-Ryeol Kim, Ki-Ho Park, Eun-Seo Park, Su-Jeong Lim, Su-Ha Wang, Ji-Eun Sung, Youngwoo Choi, Heeseob Lee, Dae-Youn Hwang

“…Overall, the finding of this study offers novel scientific evidence that MPC could be considered as a significant laxative for chronic constipation based on its antioxidant activity.…”
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The cancer-associated fibroblasts interact with malignant T cells in mycosis fungoides and promote the disease progression by Yige Zhao, Yong Li, Yong Li, Panpan Wang, Mengyan Zhu, Jiaqi Wang, Bo Xie, Chenyu Tang, Yangyang Ma, Shiwen Wang, Sha Jin, Jinhui Xu, Zhao Li, Xiaoyan Zhang, Liuyu Li, Xiuzu Song, Ping Wang

“…Target SOX4 may disrupt the interactions between tumor cells and CAFs.ConclusionOur study revealed the origin and evolution trajectory of MF and uncovered the intercellular interactions between malignant T cells and CAFs, providing new insights into the novel treatment targets of MF.…”
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