Allelic variation in an expansin, MdEXP-A1, contributes to flesh firmness at harvest in apples by Qiufang Su, Yifeng Feng, Xianglu Li, Zidun Wang, Yuanwen Zhong, Zhengyang Zhao, Huijuan Yang

“…These findings provide novel insight into the genetic control of flesh firmness by MdEXP-A1.…”
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Patients outcomes in lung adenocarcinoma transforming to small-cell lung cancer after tyrosine kinase inhibitor therapy by Shuai Wang, Yongsen Wang, Xuan Wu, Li Yang, Xiaoju Zhang

“…It carries a worse prognosis. Exploring novel therapeutic strategies for transformed SCLC is imperative.…”
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Synthesis and Characterization of TiO2 Modified with Polystyrene and Poly(3-chloro-2-hydroxypropyl Methacrylate) as Adsorbents for the Solid Phase Extraction of Organophosphorus Pe... by Enrique Alejo-Molina, A. Rafael Vilchis-Néstor, David Muñoz-Rodríguez, Cristian Carrera-Figueiras

“…Novel hybrid TiO2 particles were developed and assessed as an adsorbent for solid phase extraction (SPE) of organophosphorus pesticides (fensulfothion, parathion methyl, coumaphos, and diazinon) from spiked water. …”
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Investigation of the Feasibility and Safety of a Highly Intensive Penetration Technique for Recanalization in Severe Calcified Femoropopliteal Occlusive Lesions: A Retrospective Ob... by Shinsuke Mori, Keisuke Hirano, Yusuke Setonaga, Toshihiko Kishida, Tomoya Fukagawa, Kohei Yamaguchi, Masafumi Mizusawa, Masakazu Tsutsumi, Norihiro Kobayashi, Yoshiaki Ito

“…To address this issue, we employed a novel highly intensive penetration (HIP) technique. …”
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Inhibition of Mitochondrial Fission Reverses Simulated Microgravity-Induced Osteoblast Dysfunction by Enhancing Mechanotransduction and Epigenetic Modification by Qiusheng Shi, Yaxin Song, Jingqi Cao, Jing Na, Zhijie Yang, Xinyuan Chen, Ziyi Wang, Yubo Fan, Lisha Zheng

“…Therefore, targeting mitochondrial fission emerges as a promising therapeutic strategy to alleviate osteoblast dysfunction under SMG conditions, providing novel approaches to maintain bone health during prolonged space missions and safeguard the astronaut well-being.…”
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PGTransNet: a physics-guided transformer network for 3D ocean temperature and salinity predicting in tropical Pacific by Song Wu, Senliang Bao, Wei Dong, Senzhang Wang, Xiaojiang Zhang, Chengcheng Shao, Junxing Zhu, Xiaoyong Li

“…In this paper, we proposed PGTransNet, a novel physics-guided transformer network for 3D Ocean temperature and salinity forecasting. …”
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Signature for Pain Recovery IN Teens (SPRINT): protocol for a multisite prospective signature study in chronic musculoskeletal pain by Fiona Campbell, Jennifer Stinson, Sara E Williams, Christopher D King, Laura Simons, Massieh Moayedi, Robert C Coghill, Martin S Angst, Nima Aghaeepour, Brice Gaudilliere, Marina López-Solà, Marie-Eve Hoeppli, Emma Biggs, Ed Ganio, Kenneth R Goldschneider, Danielle Ruskin, Elliot J Krane, Suellen Walker, Gillian Rush, Marissa Heirich

“…Discovery of robust prognostic markers separating patients who recover from patients with persistent pain and disability is critical for developing patient-specific treatment strategies and conceiving novel approaches that benefit all patients. Given that chronic pain is a biopsychosocial process, this study aims to discover and validate a robust prognostic signature that measures across multiple dimensions in the same adolescent patient cohort with a computational analysis pipeline. …”
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Edge-Preserving Probabilistic Downsampling for Reliable Medical Segmentation in Resource-Constrained Environments by Shahzad Ali, Yu Rim Lee, Soo Young Park, Won Young Tak, Soon Ki Jung

“…This study introduces a novel approach, Edge-Preserving Probabilistic Downsampling (EPD), designed to retain critical details and bridge the performance gap between networks trained on original and downsampled resolutions. …”
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Exploring Azithromycin’s Neuroprotective Role in Traumatic Brain Injury: Insights into Cognitive and Motor Recovery and Neuroinflammatory Modulation by Mohannad A. Almikhlafi, Nehad A. Abdallah, Aakash Kumar, Tarun Sharma, Zuber Khan, Haifa A. Fadil, Sultan Althagfan, Ahmed K. B. Aljohani, Sara A. Almadani, Samar F. Miski, Tahani Saeedi, Rayan S. Alharbi, Abdulrahman M. Al-Harthe, Mohammed H. Alsubhi, Hanaa Wanas, Ahmed Aldhafiri, Sidharth Mehan, Hossein M. Elbadawy

“…This research supports the potential re-purposing of AZI as a novel treatment strategy for TBI and related neurodegenerative disorders.…”
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De Novo or inherited: gonosomal mosaicism in hereditary angioedema due to C1 inhibitor deficiency by Laura Batlle-Masó, Laura Batlle-Masó, Laura Batlle-Masó, Janire Perurena-Prieto, Janire Perurena-Prieto, Janire Perurena-Prieto, Laura Viñas-Giménez, Laura Viñas-Giménez, Laura Viñas-Giménez, Aina Aguiló-Cucurull, Aina Aguiló-Cucurull, Paula Fernández-Álvarez, Johana Gil-Serrano, Johana Gil-Serrano, Johana Gil-Serrano, Mar Guilarte, Mar Guilarte, Mar Guilarte, Roger Colobran, Roger Colobran, Roger Colobran, Roger Colobran

“…In the patient, we identified a novel splice site mutation in SERPING1 (c.890-1G>C) and, by cDNA analysis, we confirmed its pathogenicity. …”
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e-GLR Score Predicts Early Graft Loss in Adult Live-Donor Liver Transplantation by Viniyendra Pamecha, MS, MRCS, FRCS, FEBS, Nilesh Sadashiv Patil, MS, MCh, Tharun Gattu, MS, Guresh Kumar, MSc, MPhil, PhD, Bramhadatta Pattnaik, MS, MCh, Nihar Mohapatra, MS, MCh, Gaurav Sindwani, MD, PDCC, Ashok Choudhury, MD, DM

“…Internal cross-validation revealed a high predictive value (C-statistic = 0.858). Conclusions:. Our novel risk score can efficiently predict early allograft loss following graft dysfunction, which enables donor-recipient matching, evaluation, and prognostication simply and reliably in adult LDLT.…”
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Impact of advanced lung cancer inflammation index on all-cause mortality among patients with heart failure: a systematic review and meta-analysis with reconstructed time-to-event d... by Ahmed Mazen Amin, Ramy Ghaly, Hossam Elbenawi, Abdelrahman Ewis, Ubaid Khan, Khaled S. M. Elshaer, Mohamed Abuelazm, Basel Abdelazeem, Brijesh Patel, Farris K. Timimi, Islam Y. Elgendy

“…The advanced lung cancer inflammation index (ALI) is a novel inflammatory and nutritional biomarker. We aimed to investigate the prognostic role of ALI in patients with HF. …”
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Exploring the paradigm shift towards sustainability: A systematic literature review on circular economy and eco-innovation by Ruchira R N Ghormare, Sana Fatima, Priya Grover, Nidhi Phutela, Vinay Kandpal, Ernesto D. R. Santibanez Gonzalez

“…Therefore, this research is novel, and we explored the role of circular economy and eco-innovation towards sustainability through a systematic literature review. …”
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A systematic investigation on microstructure evolution, phase transformation and dynamic recrystallization mechanisms of hot isostatic pressed Ti–45Al–2Mn–2Nb–1B alloy during hot d... by Meiyi Ba, Hongkui Tang, Lianxi Hu, Yu Sun, Fei Gao

“…This comprehensive analysis offers novel insights into DRX mechanisms, providing valuable guidance for optimizing the hot working process of Ti–45Al–2Mn–2Nb–1B (at%) alloy.…”
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High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response by Tianzhu Tao, Lulong Bo, Teng Li, Longbao Shi, Hui Zhang, Bo Ye, Yuhai Xu, Qingqing Ma, Xiaoming Deng, Guorong Zhang

“…The present study identified VISTA as a novel immune checkpoint in the regulation of T cell and macrophage response during sepsis. …”
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QUIET WARRIOR – Rationale and design: An ancillary study to the Women's IschemiA TRial to Reduce Events in Nonobstructive CAD (WARRIOR) by Osama Dasa, Eileen Handberg, Damini Dey, Pinaki Sarder, Margaret C. Lo, Balaji K. Tamarappoo, Steven M. Smith, Leslee J. Shaw, C. Noel Bairey Merz, Carl J. Pepine

“…Anticipated findings include correlations of specific plaque attributes with angina severity and novel insights into inflammatory markers. Socioeconomic variables will also be examined for their impact on cardiovascular risk. …”
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Preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomy by Wassapol Sornthai, Achiraya Teyateeti, Tawatchai Taweemonkongsap, Siros Jitpraphai, Varat Woranisarakul, Kantima Jongjitaree, Katunyou Mahamongkol, Nattaporn Wanvimolkul, Thitipat Hansomwong

“…Preoperative body composition was assessed using CT scans at the L3 vertebral level to measure psoas muscle density (PMD), skeletal muscle density (SMD), axial muscle density (AMD), and muscle indices. Novel inflammatory and nutritional markers, including serum chloride levels within 24 h post-surgery, were also evaluated. …”
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Contrasting Seasonal Distribution Patterns of Two Boreal Aerial Hawking Bat Species in Finland by Piia Lundberg, Miika Kotila, Katarina Meramo, Kati M. Suominen, Miina Suutari, Tia‐Marie Pietikäinen, Ville Vasko, Thomas M. Lilley

“…ABSTRACT Climate change poses significant consequences for temperate bat species, potentially altering their distribution ranges and generating novel interactions among species sharing similar ecological niches. …”
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L-Citrulline in Neonates: From Bench to Bed Side by Dwayne Mascarenhas, Atefeh Mohammadi, Randa Higazy, Julijana Ivanovska, Estelle Gauda, Bonny Jasani

“…While L-CIT shows promise in the treatment of various neonatal conditions, adequately powered studies to evaluate the safety and efficacy of L-CIT supplementation post-surgical NEC and BPD ± PH in the extremely preterm population are needed to translate this novel therapy to clinical practice.…”
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Enhanced penetration and biofilm eradication by sophorolipid micelles encapsulating Honokiol: a comprehensive solution for biofilm-associated lung infections by Shiyu Lin, Xiaojuan Li, Wei Zhang, Gang Shu, Tim Tolker-Nielsen, Haohuan Li, Funeng Xu, Juchun Lin, Guangneng Peng, Li Zhang, Hualin Fu

“…Conclusions HK-SL Ms offers a novel strategy for the clinical treatment of biofilm-associated infections by dispersing and removing S. aureus biofilms and preventing new infections. …”
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