Cross-Talk between NOK and EGFR: Juxtamembrane and Kinase domain interactions enhancing STAT3/5 signaling in breast cancer tumorigenesis by Yinyin Wang, Bingdong Zhang, Chunhua He, Bo Tian, Sihan Liu, Jianghua Li, Jiayu Wang, Shigao Yang, Bingtao Zhu, Xiaoguang Wang, Zhijie Chang, Chenxi Cao

“…Here we report that NOK (also known as STYK1), a novel tyrosine kinase cross-talks with EGFR to promote tumorigenesis and metastasis of breast cancer cells. …”
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Effects of Retinol, Natural Pea Peptide and Antioxidant Blend in a Topical Formulation: In Vitro and Clinical Evidence by Brian Cook, Melanie Riggs, K. C. Holley, Helen Knaggs, Ganesh Diwakar, Edwin D. Lephart

“…The present study assessed the effectiveness of a novel topical formulation, referred to as retinol topical formulation (RTF), to improve the quality of skin health. …”
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Designing smartphone-based cognitive assessments for schizophrenia: Perspectives from a multisite study by Aishwarya Raje, Abhijit R. Rozatkar, Urvakhsh Meherwan Mehta, Ritu Shrivastava, Ameya Bondre, Manaal Amir Ahmad, Anshika Malviya, Yogendra Sen, Deepak Tugnawat, Anant Bhan, Tamonud Modak, Nabagata Das, Srilakshmi Nagendra, Erlend Lane, Juan Castillo, John A. Naslund, John Torous, Soumya Choudhary

“…Thematic analysis reinforces the importance of feedback and data sharing, although this presents a challenge, given the novel nature of smartphone-based cognitive measures that have not yet been standardized or validated.…”
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Fluidization of fine coal particles in an ultrasound enhanced gas-solid fluidized bed by Sayuri Naicker, Neeraj Kuarsingh, Milan Carsky, David Lokhat

“…The reduction in minimum fluidization velocity shows promise for reduced energy consumption, and increased production throughput, of the fine coal particle processing industry. Overall the novel application of ultrasound improved the quality and operability of the fluidization of fine coal particles.…”
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A hyperspectral and multi-angular synthetic dataset for algorithm development in waters of varying trophic levels and optical complexity by J. Pitarch, V. E. Brando, V. E. Brando

“…Bio-optical modeling benefited from knowledge and data accumulated over the past 3 decades, enabling the imposition of rigorous quality standards and the definition of novel bio-optical relationships that are significant contributions on their own. …”
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Non3 is an essential Drosophila gene required for proper nucleolus assembly by E. N. Andreyeva, A. A. Ogienko, A. A. Yushkova, J. V. Popova, G. A. Pavlova, E. N. Kozhevnikova, A. V. Ivankin, M. Gatti, A. V. Pindyurin

“…Here, we report the characterization of the Drosophila Non3 (Novel nucleolar protein 3) gene, which encodes a protein homologous to the human Brix domain-containing Rpf2 that has been shown to control ribosomal RNA (rRNA) processing. …”
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Breast cancers with neuroendocrine differentiation: Retrospective case studies series from a single institution based on the 2019 WHO classification by Youngkyung Jeon, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Kyuehee Choi, Sun Young Jeong, Yeji Jung, Jaeyeon Jang, Dae-Ho Choi, Joohyun Hong, Hyo Jung Kim, Soo Youn Cho, Yeon Hee Park

“…Among them, primary breast NEC was associated with poor overall survival. Novel treatments are thus required to improve the prognosis of primary breast NEC.…”
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Development of Spray-Dried Micelles, Liposomes, and Solid Lipid Nanoparticles for Enhanced Stability by Shradha Dattani, Xiaoling Li, Charina Lampa, Amanda Barriscale, Behzad Damadzadeh, David Lechuga-Ballesteros, Bhaskara R. Jasti

“…The objective of this study was to compare the potential of lipid-based micelles, liposomes, and SLNs for producing stable re-dispersible spray-dried powders with trehalose or a combination of trehalose and L-leucine. This study provides novel insights into the implementation of spray drying as a technique to enhance long-term stability for these lipid-based nanocarriers. …”
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Polymeric Multivalent Fc Binding Peptides‐Fabricated Clinical Compounding Bispecific Antibody Potentiates Dual Immunotherapy Targeting PD1 and CTLA‐4 by Zongyu Liu, Hongyu Chu, Weidong Zhao, Chenguang Yang, Tongjun Liu, Na Shen, Zhaohui Tang

“…Thus, these findings provide a novel approach to enhance antitumor therapy using aPD1 and aCTLA‐4.…”
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Effect of epigallocatechin-3-gallate (EGCG) on cognitive functioning and the expression of APP and BDNF in the hippocampus of rats with streptozotocin -induced Alzheimer-like disea... by Farnaz Ghayour Babaei, Ehsan Saburi, Fatemeh Forouzanfar, Mohadese Asgari, Zakieh Keshavarzi, Vahid Hajali

“…These findings could provide a beneficial insight for developing novel, safe, and efficient natural compounds for preventing or alleviation AD symptoms in humans.…”
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High nature value farming systems in Europe: A dataset encompassing the environmental impact assessment of farms and extensive ruminant food productsFigshare by M. Torres-Miralles, P. Jeanneret, M. Lamminen, F. Joly, B. Dumont, H. Tuomisto, I. Herzon

“…The main outcome is a unique and novel dataset for HNV farming systems, addressing critical gaps in available information. …”
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miR-129-5p Regulates the Immunomodulatory Functions of Adipose-Derived Stem Cells via Targeting Stat1 Signaling by He-Yang Zhang, Yu-Han Wang, Yan Wang, Yan-Nv Qu, Xiao-Hui Huang, Hui-Xin Yang, Chang-Ming Zhao, Youdi He, Si-Wei Li, Jin Zhou, Changyong Wang, Xiao-Xia Jiang

“…Collectively, these results reveal a new role for miR-129-5p in regulating the immunomodulatory activities of ASCs by targeting Stat1 activation. These novel insights into the mechanisms of ASC immunoregulation may lead to the consistent production of ASCs with strong immunosuppressive functions and thus better clinical utility of these cells.…”
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Mapping decision-making pathways: Determination of intervention entry points for diagnostic tests in suspected serious infection [version 2; peer review: 2 approved] by Raasti Naseem, Sara Pretorius, Nicola Howe, Clare Lendrem, Cameron Williams, Enitan D Carrol, Philip Pallmann

“…Background PROTECT (Platform Randomised evaluation of clinical Outcomes using novel TEChnologies to optimise antimicrobial Therapy) has brought together a team of researchers to design a platform trial to rapidly evaluate and adopt into care multiple diagnostic technologies, bringing immediate benefit to patients. …”
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A dynamic co-expression approach reveals Gins2 as a potential upstream modulator of HNSCC metastasis by Nasibeh Khayer, Samira Shabani, Maryam Jalessi, Mohammad Taghi Joghataei, Frouzandeh Mahjoubi

“…In the present study, a novel three-way interaction approach was employed to uncover dynamic co-expression relationships underlying the metastatic nature of HNSCC. …”
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Strain rebound and inhomogeneity in glass-to-metal seals: Radial vs axial strain evolution by Keqian Gong, Zheng Liu, Zifeng Song, Chao Zhou, Zhangjing Shi, Siyue Nie, Weisong Zhou, He Yan, Zhichun Fan, Yong Zhang

“…This study employs advanced fiber Bragg grating (FBG) in situ monitoring to decouple and independently analyze radial and axial strain evolution, providing novel insights into the mechanical anisotropy of sealing glass. …”
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The virome composition of respiratory tract changes in school-aged children with Mycoplasma pneumoniae infection by Dianqi Zhang, Yang Cao, Biao Dai, Teng Zhang, Xing Jin, Qingyue Lan, Chaoying Qian, Yumin He, Yi Jiang

“…In addition, some new viruses, such as rhinovirus, respirovirus, dependoparvovirus, and a novel gemykibvirus, were also detected in the BALF of the disease cohort. …”
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Zebularine Promotes Hepatic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells by Interfering with p38 MAPK Signaling by Yong-Heng Luo, Juan Chen, En-Hua Xiao, Qiu-Yun Li, Yong-Mei Luo

“…The present study investigated the effects of zebularine on hepatic differentiation of rabbit BMMSCs, as well as the role of p38 on DNMT1 and hepatic differentiation, with the aim of developing a novel strategy for improving derivation of hepatocytes. …”
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Pegylated NIR Fluorophore-Conjugated OBHSA Prodrug for ERα-Targeted Theranostics with Enhanced Imaging and Long-Term Retention by Xiaohua Wang, Xiaofei Deng, Lilan Xin, Chune Dong, Guoyuan Hu, Hai-Bing Zhou

“…This study aims to integrate the pegylation strategy with a tumor microenvironment-responsive approach. A novel esterase-activated EPR strategy prodrug, OBHSA-PEG-DCM, was designed. …”
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Constructing meaningful code changes via graph transformer by Shikai Guo, Mengxuan Li, Xin Ge, Hui Li, Rong Chen, Tingting Li

“…To solve these limitations, a novel method is proposed, named Graph Transformer for learning meaningful Code Transformations (GTCT), to provide developers with preliminary and quick feedback when developers submit code changes, which can improve the quality of code changes and improve the efficiency of code review. …”
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Construction process optimisation of graphene-basalt fibre asphalt mixtures by Huzhu Zhang, Wenjia Yang, Huimin Li, Chunyu Zheng, Lijuan Sun

“…Graphene-basalt fibre asphalt mixture (GBFAM) is a novel composite-modified material. However, there is currently a lack of an effective basis for selecting appropriate construction processes and parameters in practical engineering applications. …”
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