An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors by Russell J. Schilder, Drew Rasco, Manish R. Sharma

“…This first-in-human trial evaluates ESK-440, a dual inhibitor of ALK and focal adhesion kinase, as a novel strategy for cancers with resistance to ALK-targeting TKIs. …”
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Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance by Tianming Qiu, Yu Zhi, Jingyuan Zhang, Ningning Wang, Xiaofeng Yao, Guang Yang, Liping Jiang, Li Lv, Xiance Sun

“…This discovery could provide novel insights into therapeutic strategies for T2D provoked by environmental toxicants.…”
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Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3 by Alexander J. D. Snow, Tharushi Wijesiriwardena, Benjamin J. Lane, Brendan Farrell, Polly C. Dowdle, Matilda Katan, Stephen P. Muench, Alexander L. Breeze

“…Here, functional FGFR3-TACC3 was expressed through a novel cell-free expression system in under 48 h. …”
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Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons by Eduardo Pérez-Palma, Víctor Andrade, Mario O. Caracci, Bernabé I. Bustos, Camilo Villaman, Matías A. Medina, Miguel E. Ávila, Giorgia D. Ugarte, Giancarlo V. De Ferrari

“…RNAseq experiments allowed the identification of 170 differentially expressed genes, including known Wnt/β-catenin target genes such as Notum, Axin2, and Lef1, as well as novel potential candidates Fam84a, Stk32a, and Itga9. …”
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A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor by Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret

“…To address this issue, we designed and synthesised a novel lipidated phosphomimetic peptide inhibitor targeting β-arrestins, called ARIP, which was developed based on the C-terminal tail (A343-S371) of the vasopressin V2 receptor. …”
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Direct Photocoagulation Guided by Merged Retinal Images for the Treatment of Focal Diabetic Macular Edema by Yoshihiro Takamura, Takehiro Matsumura, Shogo Arimura, Makoto Gozawa, Masakazu Morioka, YutakaYamada, Masaru Inatani

“…Purpose. To introduce a novel laser photocoagulation (PC) protocol named merged image-guided PC (MIG-PC), which included merging the images of the fundus, optical coherence tomography (OCT) map, and fluorescein angiography (FA). …”
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Multiomics unravels the complexity of male obesity: a prospective observational study by Georgios E. Papadakis, Lucie Favre, Yassine Zouaghi, Nathalie Vionnet, Nicolas J. Niederländer, Michela Adamo, James S. Acierno, Dassine Berdous, Alexia Boizot, Jenny Meylan, Julijana Ivanisevic, Emmanuelle Paccou, Hector Gallart-Ayala, Tim Reyns, Elise Van Caeneghem, Bruno Lapauw, Jérôme Pasquier, Yasser Aleman, Styliani Mantziari, Olivier Salamin, Raul Nicoli, Tiia Kuuranne, Tom Fiers, Patric Hagmann, Federico Santoni, Andrea Messina, Nelly Pitteloud

“…Conclusions Combining clinical, biochemical, and molecular markers allows adequate stratification of metabolic risk in men with obesity and provides novel tools for personalized care.…”
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Machine learning model and nomogram to predict the risk of heart failure hospitalization in peritoneal dialysis patients by Liping Xu, Fang Cao, Lian Wang, Weihua Liu, Meizhu Gao, Li Zhang, Fuyuan Hong, Miao Lin

“…For all the above endpoints, the ML models demonstrated better discrimination than Cox regression.Conclusions We developed and validated a novel method to predict the risk factors of HF and all-cause mortality that integrates readily available clinical, laboratory, and electrocardiographic variables to predict the risk of HF among PD patients.…”
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High-level biosynthesis and purification of the antimicrobial peptide Kiadin based on non-chromatographic purification and acid cleavage methods by Liangjun Zheng, Fengyi Yang, Chen Wang, Muhammad Zafir, Zishuo Gao, Pilong Liu, Fatma A. El-Gohary, Xin Zhao, Huping Xue

“…This study presents a novel approach for the biosynthesis of the antimicrobial peptide Kiadin by engineering a DAMP4–DPS–Kiadin fusion protein to mitigate host cell toxicity and achieve high-level expression. …”
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Loss of protein C vs protein S results in discrepant thrombotic phenotypes by Chia-Jui Ku, Xinge Yu, Queena Y. Zhao, Steven J. Grzegorski, Jeffrey G. Daniel, Allison C. Ferguson, Jordan A. Shavit

“…Transcriptomic analysis and gene knockdown identified novel proc genetic interactions with adgrf7, a G protein-coupled receptor (GPCR) not previously known to be involved in coagulation. …”
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Quad-Band 3D Rectenna Array for Ambient RF Energy Harvesting by Fatima Khalid, Warda Saeed, Nosherwan Shoaib, Muhammad U. Khan, Hammad M. Cheema

“…In order to maintain stable rectenna output at varying input power levels and load resistances, a novel transmission line based matching network using closed form equations is proposed. …”
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Digital Twin-Empowered Green Mobility Management in Next-Gen Transportation Networks by Kubra Duran, Lal Verda Cakir, Achille Fonzone, Trung Q. Duong, Berk Canberk

“…Therefore, we propose a DT-empowered Eco-Regulation (DTER) framework with a novel twinning approach. We define a transport-specific twin sampling rate to catch right-time data in a transportation network. …”
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The Feasibility and Acceptability of an HIV Web- Based Screening Program in Iran by Roya Sahebi, Hossein Dehghanian, Alireza Mirahmadizadeh, Leyla Sahebi, Reza Yousefi Farkhad, Simin Khayatzadeh-Safaie, Nazila Sattari, Leila Jahangiry, Hamid Sharifi

“…A web-based screening programcould provide a novel approach to address this challenge. This study aimed to evaluate the feasibility and acceptability of a web-based HIV screening program for identifying individuals with high-risk HIV behaviors in Iran.Methods: A cross-sectional study was conducted using an educational website where individuals could anonymously complete a risk assessment questionnaire. …”
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SGCL-LncLoc: An Interpretable Deep Learning Model for Improving lncRNA Subcellular Localization Prediction with Supervised Graph Contrastive Learning by Min Li, Baoying Zhao, Yiming Li, Pingjian Ding, Rui Yin, Shichao Kan, Min Zeng

“…In the study, we develope SGCL-LncLoc, a novel interpretable deep learning model based on supervised graph contrastive learning. …”
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Gut Microbiota as Mediator and Moderator Between Hepatitis B Virus and Hepatocellular Carcinoma: A Prospective Study by Bingren Hu, Yi Yang, Jiangqiao Yao, Ganglian Lin, Qikuan He, Zhiyuan Bo, Zhewei Zhang, Anlvna Li, Yi Wang, Gang Chen, Yunfeng Shan

“…We aimed to evaluate the potential correlation between gut microbiome and HBV‐related HCC and introduced novel machine learning (ML) signatures based on gut microbe to predict the risk of HCC. …”
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Audio-visual event localization with dual temporal-aware scene understanding and image-text knowledge bridging by Pufen Zhang, Jiaxiang Wang, Meng Wan, Song Zhang, Jie Jing, Lianhong Ding, Peng Shi

“…To address these challenges, a novel Dual Temporal-aware scene understanding and image-text Knowledge Bridging (DTKB) model is proposed in this paper. …”
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Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes by Jin Lin, Ye Yu, Xuanwei Wang, Yini Ke, Chuanyin Sun, Lihuan Yue, Guanhua Xu, Bei Xu, Liqin Xu, Heng Cao, Danyi Xu, Nancy Olsen, Weiqian Chen

“…Objective. Iguratimod, a novel disease-modifying anti-rheumatic drug for the treatment of rheumatoid arthritis, has been approved in China and Japan. …”
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Advantages of using T1-mapping in cardiac magnetic resonance imaging in patients with acromegaly by Alina A. Almaskhanova, Konstantin V. Melkozerov, Elena G. Przhiyalkovskaya, Natalia V. Tarbaeva, Anastasya Y. Korneluk, Raisa S. Kosharnaia, Victor Y. Kalashnikov, Zhanna E. Belaya, Galina A. Mel'nichenko, Natalia G. Mokrysheva

“…Myocardial T1-mapping is a novel MRI method that allows to assess the degree of MF without the need for myocardial biopsy. …”
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Dysbiosis of Gastric Mucosal Fungal Microbiota in the Gastric Cancer Microenvironment by Zhenzhan Zhang, Hao Feng, Yaopeng Qiu, Zhou Xu, Qingfeng Xie, Wenfu Ding, Hao Liu, Guoxin Li

“…This study revealed a novel perspective on the role of Solicoccozyma in tumors and a theoretical basis for therapeutic targets against GC.…”
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DGL-STFA: Predicting lithium-ion battery health with dynamic graph learning and spatial–temporal fusion attention by Zheng Chen, Quan Qian

“…To address these challenges, we propose a novel framework, Dynamic Graph Learning with Spatial–Temporal Fusion Attention (DGL-STFA), which transforms health indicator time-series data into time-evolving graph representations. …”
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