Modulation of adiposity and adipocyte inflammation by methanol extracts of Alpinia calcarata leaf in high-fat-diet induced-obese mice: Involvement of COX-2 and PPAR-γ by Imtiaz Ahmad, Maruful Hasan, Dipty Rani Bhowmik, Rahima Begum, Sourav Roy, Md Monirul Islam, Md Abdur Rahman Ripon, Mohammad Salim Hossain

“…Taking it all together, it is noteworthy to report this novel function of A. calcarata leaf in reducing adiposity and adipocyte inflammation.…”
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Mitigation of PFOA/PFOS toxicity in zebrafish (Danio rerio) by oxidative stress modulation and gut microbial metabolism through the use of aquatic probiotic Lactobacillus rhamnosus by Chun Wang, Guanyi Li, Sibao Chen, Ruixuan Li, Mengyan Wang, Xia Wang, Ning Ding, Yingxue Sun

“…Notably, through the analysis of metabolic pathway differences, it was observed that the PFOA-exposure group exhibited a higher proportion of Rhodococcus in the PWY-7315 pathway, whereas L. rhamnosus mitigated this trend. These novel findings not only elucidate the mechanism by which L. rhamnosus efficiently reduces PFOS and PFOA toxicity in zebrafish but also provide a theoretical basis and practical recommendations for utilizing probiotics in aquaculture.…”
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Genomic patterns of strain-specific genetic structure, linkage, and selection across fall armyworm populations by Ashley E. Tessnow, Rodney N. Nagoshi, Robert L. Meagher, Todd M. Gilligan, Ben M. Sadd, Yves Carrière, Holly N. Davis, Shelby J. Fleischer, Kelly Richers, John C. Palumbo, Patrick Porter, Jose Carlos Verle Rodrigues, Gregory A. Sword

“…Here, we used whole genome sequencing population genomics to unravel novel patterns of population structure, linkage, and selection across the genome of a notorious agricultural pest, the fall armyworm. …”
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Exploring molecular determinants and pharmacokinetic properties of IgG1-scFv bispecific antibodies by Kristina M.J. Aertker, Minu Ravindra Pilvankar, Tobias M. Prass, Michaela Blech, Fabian Higel, Srinath Kasturirangan

“…These findings highlight that the PK properties of BsAbs may be governed by novel determinants, owing to their increased structural complexity compared to immunoglobulin G (IgG) 1 antibodies.…”
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Enhancement of chemotherapy using oncolytic virotherapy: Mathematical and optimal control analysis by Joseph Malinzi, Rachid Ouifki, Amina Eladdadi, Delfim F. M. Torres, K. A. Jane White

“…Oncolytic virotherapy has been emerging as a promising novel cancer treatment which may be further combined with the existing therapeutic modalities to enhance their effects. …”
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Optimization of photocatalytic degradation of Eriochrome Black T from aqueous solution using TiO2-biochar composite by Mohammednur Abdu, Solomon Tibebu, Saeideh Babaee, Abebe Worku, Titus A.M. Msagati, Jemal Fito Nure

“…This study aims to optimize the photocatalytic degradation of Eriochrome Black T dye in aqueous solutions using a novel composite of TiO2 and biochar (BC) as a photocatalyst under UV irradiation. …”
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Carbon finance for forest resilience in California by Micah Elias, Ethan Yackulic, Katharyn Duffy, Katharyn Duffy, Phil Saksa, Daniel L. Sanchez, Nicholas Pevzner, Spencer Plumb, Jillian Dyszynski, Carina Bracer

“…This study shows that carbon revenue from traditional markets or novel carbon contribution programs can help close the funding gap for forest restoration in California while underscoring the need for innovative conservation finance mechanisms to support ecosystem resilience and climate mitigation goals.…”
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A Lightweight Network for Ship Detection in SAR Images Based on Edge Feature Aware and Fusion by Yuming Li, Jin Liu, Xingye Li, Xiliang Zhang, Zhongdai Wu, Bing Han

“…To address these issues, we propose a novel lightweight detection method based on edge feature aware and fusion. …”
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Study protocol for a randomised controlled trial on the use of intraoperative ultrasound-guided laparoscopic ovarian cystectomy (UGLOC) as a method of fertility preservation in the... by Srdjan Saso, Sadaf Ghaem-Maghami, Jan Yvan Jos Verbakel, Benjamin P Jones, Joseph Yazbek, Mona El-Bahrawy, Lorraine S Kasaven

“…This study will evaluate the effect on ovarian reserve following two different surgical interventions for the management of benign ovarian cysts.Methods and analysis We will conduct a two-armed randomised controlled trial comparing laparoscopic ovarian cystectomy, considered gold standard treatment as per the Royal College of Obstetricians and Gynaecologists (RCOG) Green Top guidelines for the management of benign ovarian cysts, with ultrasound-guided laparoscopic ovarian cystectomy (UGLOC), a novel method of FPS. The study commencement date was October 2021, with a completion date aimed for October 2024. …”
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Development of a patient reported outcome instrument for chronic sialadenitis by Fatemeh Ramazani, Amr Hamour, Caroline C. Jeffery, Vincent Biron, Yaser Alrajhi, Daniel O’Connell, David W. J. Côté

“…Conclusion Clinical application of the novel questionnaire produced by this study will allow for a patient-centered assessment of the patient reported effectiveness of sialendoscopy assisted therapies for management of chronic sialadenitis. …”
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A self-configuration framework for balancing services in the fog of things by Edson Mota, Jurandir Barbosa, Gustavo B. Figueiredo, Maycon Peixoto, Cássio Prazeres

“…Within this context, this paper presents a novel self-organizing environment based on the Fog of Things approach, designed to address these challenges. …”
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Association of Immune Nutrition Indices with the Risk of All-Cause Mortality and Cardiovascular Mortality in Patients with Heart Failure in the NHANES (1999–2018) by Feifei Zhang, Yuetao Xie, Litian Liu, Huiliang Liu, Ohua Feng, Yingxiao Li, Yi Dang

“…Malnutrition is prevalent in patients with HF and disrupts the equilibrium of immune and inflammatory responses, resulting in further deterioration of the HF. Novel indicators emerge as immune nutrition indices, including the prognostic nutritional index (PNI), neutrophil-to-lymphocyte ratio (NLR), Controlling Nutritional Status (CONUT) score, and cholesterol-modified prognostic nutritional index (CPNI). …”
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Multifunctional properties of cotton fabric tailored via green synthesis of TiO2/curcumin composite by Barbara Simončič, Brigita Tomšič, Marija Gorjanc, Mateja Kert

“… In this study, a novel green process was developed to produce a multifunctional cotton (CO) fabric incorporating TiO2/curcumin composites that simultaneously provides UV protection and photocatalytic performance. …”
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TT Mutant Homozygote of Is a Key Factor for Increasing Basal Metabolic Rate and Resting Metabolic Rate in Korean Elementary School Children by Jung Ran Choi, In-Su Kwon, Dae Young Kwon, Myung-Sunny Kim, Myoungsook Lee

“…In the high-BMR group, we observed that higher muscle, fat mass, and C-peptide affect the increase of BMR in children with TT (p < 0.001, p < 0.001, and p = 0.018, respectively), while Rohrer's index could explain the usual decrease in BMR (adjust r2 = 1.000, p < 0.001, respectively). We identified a novel association between TT of KLF5 rs3782933 and BMR in Korean children. …”
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Pioglitazone Attenuates Drug-Eluting Stent-Induced Proinflammatory State in Patients by Blocking Ubiquitination of PPAR by Zhongxia Wang, Tao Zhang, Lizhe Sun, Ruifeng Li, Yuanyuan Wei, Xiaojuan Fan, Zuyi Yuan, Junhui Liu, Tao Chen

“…PIO treatment attenuated DES-induced PPAR loss, NF-κB activation, and proinflammation, indicating that PIO may have a novel direct protective role in modulating proinflammation in DES era.…”
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ReliefF guided variable spiral tuna swarm optimization algorithm with somersault foraging for feature selection by Yu-Cai Wang, Jie-Sheng Wang, Min Zhang, Hao-Ming Song, Jia-Ning Hou, Yu-Liang Qi, Yu-Wei Song

“…Firstly, inspired by the sudden flipping behavior of manta rays when capturing plankton, a novel somersault foraging strategy is introduced to help the TSO algorithm escape from local optima. …”
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Staphylococcus aureus nt5 gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion by Xinpeng Liu, Lan Huang, Yang Ye, Haiyi Wang, Min Tang, Fuqiang He, Zijing Xia, Shi Deng, Peng Zhang, Ruiwu Dai, Shufang Liang

“…It is essential to explore key pathogenicity-driven genes/proteins in bacterial infection and antibiotics resistance, which contributes to develop novel therapeutic strategies against S. aureus infections. …”
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Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation by Mohammad Alhashmi, Abdulrahman M. E. Gremida, Santosh K. Maharana, Marco Antonaci, Amy Kerr, Shijian Fu, Sharna Lunn, David A. Turner, Noor A. Al-Maslamani, Ke Liu, Maria M. Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N. Wheeler, Robert J. van ‘t Hof, George Bou-Gharios, Kazuhiro Yamamoto

“…We propose that in skeletal progenitors, LRP1 plays a critical role in formation and maturity of multiple bones and joints by regulating Wnt signalling, providing novel insights into the fundamental processes of morphogenesis and the emergence of skeletal pathologies.…”
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Deciphering the pseudouridine nucleobase modification in human diseases: From molecular mechanisms to clinical perspectives by Shiheng Jia, Xue Yu, Na Deng, Chen Zheng, Mingguang Ju, Fanglin Wang, Yixiao Zhang, Ziming Gao, Yanshu Li, Heng Zhou, Kai Li

“…Additionally, it explores the therapeutic potential of targeting pseudouridylation, presenting novel strategies for disease treatment. Highlights Methods to detect pseudouridine were introduced from classic mass spectrometry‐based methods to newer approaches such as nanopore‐based technologies and BID sequencing, each with its advantages and limitations. …”
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Modeling dose uncertainty in cone-beam computed tomography: Predictive approach for deep learning-based synthetic computed tomography generation by Cédric Hémon, Lucía Cubero, Valentin Boussot, Romane-Alize Martin, Blanche Texier, Joël Castelli, Renaud de Crevoisier, Anaïs Barateau, Caroline Lafond, Jean-Claude Nunes

“…This approach also provides a novel method for estimating dose uncertainty by defining a confidence interval around the CT DVH using the estimated sCT uncertainty.…”
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