Exploring the expression of DLL3 in gastroenteropancreatic neuroendocrine neoplasms and its potential diagnostic value by L. Yin, R. Wang, X. Ma, K. Jiang, Y. Hu, X. Zhao, L. Zhang, Z. Wang, T. Long, M. Lu, J. Li, Y. Sun

“…Abstract Delta-like protein (DLL3) is a novel therapeutic target. DLL3 expression in gastroenteropancreatic neuroendocrine tumors (GEP-NECs) is poorly understood, complicating the distinction between well-differentiated neuroendocrine tumors G3 (NET G3) and poorly differentiated NEC. …”
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Transcriptomic signatures of severe acute mountain sickness during rapid ascent to 4,300 m by Ruoting Yang, Aarti Gautam, Rasha Hammamieh, Robert C. Roach, Beth A. Beidleman

“…The differential regulation of these pathways provides novel insights into the biological mechanisms underlying AMS. …”
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Integrative bioinformatics and machine learning approach unveils potential biomarkers linking coronary atherosclerosis and fatty acid metabolism-associated gene by Hong Li, Yongyun Xu, Aiting Wang, Chuanxin Zhao, Man Zheng, Chunyan Xiang

“…Conclusions This research has successfully identified seven key FAMGs implicated in AS, offering novel insights into the pathophysiology of the disease. …”
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Visual and High-Efficiency Secretion of SARS-CoV-2 Nanobodies with <i>Escherichia coli</i> by Shuai Zhao, Wanting Zeng, Fang Yu, Pingping Xu, Chin-Yu Chen, Wanping Chen, Yanming Dong, Fei Wang, Lixin Ma

“…Notably, Fu2-sfGFP-ANTE can be normally secreted into the culture medium and outer membrane. The novel nanobody production system enhances the efficiency of nanobody expression and streamlines the downstream purification process, enabling large-scale, cost-effective nanobody production. …”
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SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation by Ryan T. Wagner, Ryan A. Hlady, Xiaoyu Pan, Liguo Wang, Sungho Kim, Xia Zhao, Louis Y. El Khoury, Shafiq Shaikh, Jian Zhong, Jeong-Heon Lee, Jolanta Grembecka, Tomasz Cierpicki, Thai H. Ho, Keith D. Robertson

“…Conclusions These findings unify genome-wide screening approaches with the latest genetic and pharmacologic modeling methodologies to reveal an entirely novel epigenetic approach to individualize therapies against a challenging loss-of-function SETD2 mutation in cancer.…”
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A life stage resolved habitat model for guiding seagrass restoration in coastal lagoons by Sherry Y. Zhai, Michelle Waycott, Ryan Lewis, Emma O’Loughlin, Paul L.A. Erftemeijer, Peisheng Huang, Justin D. Brookes, Claire Sims, Zhenming Zhang, Matthew R. Hipsey

“…This study aimed to develop a novel phenology-based habitat suitability model for quantifying the overall probability of reproductive success, based on salinity, water depth, light availability, temperature and filamentous algae presence. …”
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Assessment of the Vanillin Anti-Inflammatory and Regenerative Potentials in Inflamed Primary Human Gingival Fibroblast by Erica Costantini, Bruna Sinjari, Katia Falasca, Marcella Reale, Sergio Caputi, Srinivas Jagarlapodii, Giovanna Murmura

“…Therefore, Vanillin shows a potential therapeutic interest as an inflammatory modulator molecule with novel application in periodontal regeneration and oral health.…”
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CFD analysis of heat transfer enhancement in impinging jet array by varying number of jets and spacing by Zakia Rachdi, Nidhal Hnaien, Aboulbaba Eladeb, Badr M. Alshammari, Lioua Kolsi, Hacen Dhahri

“…Abstract Using the RANS approach with the standard k-ω turbulence model, this study offers a novel investigation into the dynamic and thermal properties of turbulent impinging jet arrays. …”
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IGF-1 impacts neocortical interneuron connectivity in epileptic spasm generation and resolution by Carlos J. Ballester-Rosado, John T. Le, Trang T. Lam, Anne E. Anderson, James D. Frost, Jr., John W. Swann

“…Results point to (1–3)IGF-1 and its analogues as potential novel disease-modifying therapies for this neurodevelopmental disorder.…”
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ViT-Based Face Diagnosis Images Analysis for Schizophrenia Detection by Huilin Liu, Runmin Cao, Songze Li, Yifan Wang, Xiaohan Zhang, Hua Xu, Xirong Sun, Lijuan Wang, Peng Qian, Zhumei Sun, Kai Gao, Fufeng Li

“…This study proposes a novel method using face diagnosis images based on traditional Chinese medicine principles, providing a non-invasive, efficient, and interpretable alternative for SZ detection. …”
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CD300E+ macrophages facilitate liver regeneration after splenectomy in decompensated cirrhotic patients by Tao Yang, Yuan Zhang, Chujun Duan, Hui Liu, Dong Wang, Qingshan Liang, Xiao Chen, Jingchang Ma, Kun Cheng, Yong Chen, Ran Zhuang, Jikai Yin

“…CD300E+ macrophages are anticipated to emerge as a novel therapeutic strategy for the treatment of liver cirrhosis.…”
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Tanshinone IIA Sodium Sulfonate Attenuates LPS-Induced Intestinal Injury in Mice by Xin-Jing Yang, Jin-Xian Qian, Yao Wei, Qiang Guo, Jun Jin, Xue Sun, Sheng-Lan Liu, Chun-Fang Xu, Guo-Xing Zhang

“…The present study may provide novel insight into the molecular mechanisms of TSS on the treatment of intestinal injury.…”
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Glucose Supplementation Enhances the Bactericidal Effect of Penicillin and Gentamicin on <i>Streptococcus sanguinis</i> Persisters by Kazuya Takada, Yoshie Yoshioka, Kazumasa Morikawa, Wataru Ariyoshi, Ryota Yamasaki

“…Taken together, these findings may facilitate the development of novel therapeutic strategies against IE caused by oral streptococcal infection.…”
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Develop Reusable Carbon Sub‐Micrometer Composites with Record‐High Cd(II) Removal Capacity by Mengke Cui, Huiting Jiao, Shijie Yuan, Bin Dong, Zuxin Xu

“…Nevertheless, achieving ultra‐efficient and cost‐effective treatment of trace amounts of heavy metals remains a major challenge. Herein, the novel carbon sub‐micrometer composites (CSMCs) supported Fe0@γ‐Fe2O3 core‐shell clusters nanostructures are designed and synthesized through a series of universally applicable methods. …”
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In-vitro accuracy of the virtual patient model with maxillomandibular relationship at centric occlusion using 3D-printed customized transfer key by Anh Ho-Quynh Nguyen, Nam Cong-Nhat Huynh, Oanh Ngoc-Hoang Nguyen, Nhat Dinh-Minh Nguyen, Hai Hoang Phan, Jong-Eun Kim, Gan Jin, Khanh Hung Nguyen, Hung Trong Hoang

“…Conclusions The 3D-printed customized transfer key effectively enhanced the virtual patient model’s accuracy, surpassing traditional trueness and precision methods. This novel approach offers a streamlined, patient-friendly solution for digital dental workflows.…”
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Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer by Yaojun Ren, Min Xue, Xinhui Hui, Xiuyu Liu, Muhammad Asad Farooq, Yiran Chen, Yuzhou Ji, Yixin Duan, Iqra Ajmal, Jie Yao, Wenzheng Jiang

“…This study aims to tackle the challenge of TGF-β-mediated tumor immune evasion within the immunosuppressive tumor microenvironment by designing a novel chimeric cytokine receptor TRII/21 R, which consists of extracellular domains of TGF-β receptor II (TRII) and transmembrane and intracellular domains of IL-21 receptor (21 R) and can convert the immunosuppressive signal from TGF-β in the tumor microenvironment (TME) into an NK cell activation signal through the IL-21R-STAT3 pathway. …”
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Efficacy and safety of an algorithm using C-reactive protein to guide antibiotic therapy applied through a digital clinical decision support system: a study protocol for a randomis... by Vandack Nobre, Pedro R Povoa, Vitoria Moura Leite Rabelo Rezende, Isabela Nascimento Borges, Cecilia Gomez Ravetti, Renan Pedra De Souza, Paula Frizera Vassalo, Ana Clara de Paula Caldas, Felipe Rodrigues Gatto, Getulio Hideyoshi Okamura, Raquel Lopes de Brito Lacerda

“…While CRP is less studied, it offers advantages such as lower cost and broader availability compared with PCT.Methods and analysis This randomised clinical trial aims to evaluate a novel algorithm for non-critically ill adult patients. …”
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Pharmacological Modulation of the Unfolded Protein Response as a Therapeutic Approach in Cutaneous T-Cell Lymphoma by Nadia St. Thomas, Benjamin N. Christopher, Leticia Reyes, Reeder M. Robinson, Lena Golick, Xiaoyi Zhu, Eli Chapman, Nathan G. Dolloff

“…To understand the significance of these two factors, we used a novel isoform selective small-molecule inhibitor of HSPA5/6 (JG-023). …”
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Geological disaster risk assessment based on ecological niche model: A case study of Longhui County, Shaoyang City by Yun ZHANG, Feng ZI, Jiehua GUO, Yunjiang CAO, Jiuling DUAN, Zhigang GUO, Long TANG

“…This study introduces a novel method for the risk assessment of geological disasters in Longhui County and provides a theoretical basis for the government’s risk management strategy.…”
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Metformin in COVID-19: a magical role beyond the hyperglycemia by Gaurav Kumar Chaubey, Rahul Dilawari, Radheshyam Modanwal, Sharmila Talukdar, Asmita Dhiman, Manoj Raje

“…Researchers confront a worrying situation to rapidly develop effective strategies to combat this novel infection and its long-term aftereffects. To date, there have been myriad reports ranging from the repurposing of the classical antimalarial drug hydroxychloroquine to several other antiviral and anti-bacterial agents like remdesivir, favipiravir, and most recently azithromycin, which has entered clinical use in many countries for combating COVID-19 infections. …”
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