Serum microRNAs as Diagnostic Markers in Polycystic Ovary Syndrome: A Narrative Review by K Lavanya, N Palaniappan, VM Vinodhini, Santhi Silambanan

“…Since serum microRNAs are present in various bodily fluids, they are novel markers for diseases like PCOS. The microRNA profile constantly changes depending on the pathogenic stage of the disease. …”
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Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis by Jiaqi Yao, Yuhong Jiang, Pengcheng Zhang, Yifan Miao, Xiajia Wu, Hang Lei, Zhijun Xie, Yong Tian, Xianlin Zhao, Juan Li, Lv Zhu, Meihua Wan, Wenfu Tang

“…Overall, these results uncover a previously unexplored role for HINT2 in maintaining mitochondrial energy metabolism in pancreatic acinar cells and reveals novel mechanism and target for Emo-mediated AP remission.…”
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Magnetohydrodynamic Peristaltic Propulsion of Casson Nanofluids With Slip Effects Over Heterogeneous Rough Channel by Hanumesh Vaidya, Fateh Mebarek‐Oudina, Rakesh Kumar, C. Rajashekhar, Kerehalli Vinayaka Prasad, Sangeeta Kalal, Kottakkaran Sooppy Nisar

“…In this context, the aim of the present work focuses on modeling the magnetohydrodynamic peristaltic slip flow of Casson nanofluid and analyzing the role of multiple slip effects over a non‐uniform rough channel. A novel rough non‐uniform model is effectively governed by a set of nonlinear coupled governing partial differential equations, which are simplified under long wavelength and creeping flow approximations. …”
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Lucidin from <i>Rubia cordifolia</i> Outperforms FDA-Approved Lapatinib as a Potential Multitargeted Candidate for Breast Cancer Signalling Proteins by Akram Ahmed Aloqbi, Hadil Alahdal, Amany I. Alqosaibi, Mashael M. Alnamshan, Ibtesam S. Al-Dhuayan, Ahood A. Al-Eidan, Hind A. S. Alzahrani, Nouf K. ALaqeel, Fatmah Hazza Alsharif, Abeer Al Tuwaijri

“…<b>Conclusions:</b> Lucidin shows promise as a novel, multitargeted anti-breast cancer agent with improved efficacy over Lapatinib. …”
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KE-RSIC: Remote Sensing Image Captioning Based on Knowledge Embedding by Kangda Cheng, Erik Cambria, Jinlong Liu, Yushi Chen, Zhilu Wu

“…This article proposes a novel knowledge-embedded remote sensing image captioning model. …”
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Gaussian process latent variable models-ANN based method for automatic features selection and dimensionality reduction for control of EMG-driven systems by Maham Nayab, Asim Waris, Muhammad Jawad Khan, Dokhyl AlQahtani, Ahmed Imran, Syed Omer Gilani, Umer Hameed Shah

“…To overcome such issues, this paper proposes a novel approach that integrates feature reduction techniques with an artificial neural network (ANN) classifier to enhance the accuracy of high-dimensional EMG classification. …”
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Crop protection by RNA interference: a review of recent approaches, current state of developments and use as of 2013 by Kirsten Germing, Cecilia Andrea Díaz Navarrete, Andreas Schiermeyer, Udo Hommen, Luise Zühl, Sebastian Eilebrecht, Elke Eilebrecht

“…RNAi applications were identified to be an upcoming topic in crop protection and, therefore, are becoming increasingly relevant for environmental risk assessment, due to the high number of targeted pest species as well as the variety of novel application types. With this review, we inform future work aimed to develop further adequate concepts and methods for environmental risk assessment of RNAi-based applications.…”
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Prevalence and Risk Factors for Opioid-Induced Constipation in an Older National Veteran Cohort by Fern FitzHenry, Svetlana K. Eden, Jason Denton, Hui Cao, Aize Cao, Ruth Reeves, Guanhua Chen, Glenn Gobbel, Nancy Wells, Michael E. Matheny

“…Conclusions. There were several novel covariates found that are seen in the all-cause chronic constipation literature but have not been reported for opioid-induced constipation. …”
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Fc-binding nanodisc restores antiviral efficacy of antibodies with reduced neutralizing effects against evolving SARS-CoV-2 variants by Jaehyeon Hwang, Soyun Choi, Beom Kyu Kim, Sumin Son, Jeong Hyeon Yoon, Kyung Won Kim, Wonbeom Park, Hyunjoo Choo, Suhyun Kim, Soomin Kim, Seokhyeon Yu, Sangwon Jung, Sang Taek Jung, Min-Suk Song, Sang Jick Kim, Dae-Hyuk Kweon

“…To overcome these challenges, we propose a novel prophylactic strategy involving the intranasal delivery of an antibody in combination with an Fc-binding nanodisc. …”
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Finite-Time Output Robust Control for Restricted Joint Flight Emulator Robotic Arm With Adaptive Tangent Barrier Gains by Isaac Chairez, Alejandra Hernandez-Sanchez, Caridad Mireles, Arthur Mukhamedov, Grigory Bugriy, Stepan Lemak, Viktor Chertopolokhov

“…This research presents a novel, robust controller for acceleration tracking in robotic manipulators with time-varying joint limitations, accounting for articulation constraints. …”
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Simultaneous detection of human neutrophil elastase and cathepsin G on a single substrate using a fluorometric quantum dots probe and chemometric models by Fátima A.R. Mota, Rafael C. Castro, David S.M. Ribeiro, João L.M. Santos, Ricardo N.M.J. Páscoa, Marieta L.C. Passos, M. Lúcia M.F.S. Saraiva

“…In this study, we propose a novel method combining distinctly sized CdTe quantum dots (QDs) as a fluorescent probe to implement a platform for simultaneous discrimination and quantification of HNE and CatG, applying chemometric analysis.The fluorometric response was acquired using two different methods: kinetic and excitation/emission matrices (EEM). …”
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Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies by Niloofar Javid, Ali Asadipour, Ehsan Salarkia, Mohammad Amin Langarizadeh, Fatemeh Sharifi, Mohammad Mahdavi, Bagher Amirheidari, Aida Iraji, Hojjat Rezaiezadeh, Gholamreza Hassanpour, Yaghoub Pourshojaei

“…This study endeavors to address this critical need by focusing on the design and synthesis of a series of novel compounds. Fifteen derivatives incorporating the nitrochromene pharmacophore were meticulously synthesized using the Henry reaction. …”
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Molecular Mechanisms Underlying Substance Transport, Signal Transduction, and Anti-Stress Regulation, as Well as Anti-Alkaline Regulation via <i>Bursicon</i> in the Cerebral Gangli... by Meiyao Wang, Jun Zhou, Jiachun Ge, Gangchun Xu, Yongkai Tang

“…Furthermore, it was discovered for the first time that <i>bursicon</i> plays a positive regulatory role in the adaptation of <i>E. sinensis</i> to alkalinity. (4) Conclusions: The present study elucidates the molecular regulatory pattern of the cerebral ganglion in <i>E. sinensis</i> under acute alkaline stress as well as revealing a novel role of <i>bursicon</i> in facilitating adaptation to alkalinity in <i>E. sinensis</i>, providing valuable theoretical insights into the molecular regulatory mechanisms underlying the responses of cerebral ganglia to saline–alkali environments. …”
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Predictive models for the surface roughness and subsurface damage depth of semiconductor materials in precision grinding by Shang Gao, Haoxiang Wang, Han Huang, Zhigang Dong, Renke Kang

“…This paper introduces novel models for predicting both surface roughness and SDD in hard and brittle semiconductor materials. …”
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Mitotane-Induced Hyperlipidemia: A Retrospective Cohort Study by Hassan Shawa, Ferhat Deniz, Hadil Bazerbashi, Mike Hernandez, Rena Vassilopoulou-Sellin, Camilo Jimenez, Mouhammed Amir Habra

“…Understanding the mechanism of HDL change may lead to the discovery of novel HDL-c-elevating drugs.…”
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Anomaly Detection in High Mobility MDT Traces Through Self-Supervised Learning by J. M. Sanchez-Martin, C. Gijon, M. Toril, S. Luna-Ramirez, V. Wille

“…Unfortunately, labeling MDT data is a labor-intensive task, that can be alleviated by using Self-Supervised Learning (SSL). This work presents a novel SSL method to detect MDT measurements with abnormal position information in road scenarios. …”
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Degradation kinetics, pathways, transformation products, and toxicity assessment of fluorochloridone in agricultural soils by Dong Zhao, Hongyu Chen, Shuo Shen, Enyu Lu, Junlong Feng, Hui Zhi, Lei Wang, Wei Li

“…Predictive assessments via ECOSAR, alongside empirical laboratory experiments, revealed that most novel TPs exhibit significantly lower acute toxicity towards Danio rerio, Daphnia magna Straus, and Algae compared to FLC. …”
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Anatomy-Informed Multimodal Learning for Myocardial Infarction Prediction by Ivan-Daniel Sievering, Ortal Senouf, Thabo Mahendiran, David Nanchen, Stephane Fournier, Olivier Muller, Pascal Frossard, Emmanuel Abbe, Dorina Thanou

“…In this work, we propose a novel anatomy-informed multimodal deep learning framework to predict future MI from clinical data and Invasive Coronary Angiography (ICA) images. …”
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IL-6-Inducing Peptide Prediction Based on 3D Structure and Graph Neural Network by Ruifen Cao, Qiangsheng Li, Pijing Wei, Yun Ding, Yannan Bin, Chunhou Zheng

“…In this study, we propose a novel IL-6-inducing peptide prediction method called DGIL-6, which integrates 3D structural information with graph neural networks. …”
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SumGPT: A Multimodal Framework for Radiology Report Summarization to Improve Clinical Performance by Tipu Sultan, Mohammad Abu Tareq Rony, Mohammad Shariful Islam, Samah Alshathri, Walid El-Shafai

“…In this study, we propose a novel model, SumGPT, which integrates T5 with a Vision Transformer to harness the power of transformer-based architectures for enhanced radiology report summarization. …”
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