ENO1 promotes PDAC progression by inhibiting CD8+ T cell infiltration through upregulating PD-L1 expression via HIF-1α signaling by Aziguli Tulamaiti, Shu-Yu Xiao, Yan Yang, Musitaba Mutailifu, Xia-Qing Li, Shi-Qi Yin, Hong-Tai Ma, Hong-Fei Yao, Lin-Li Yao, Li-Peng Hu, Jun Li, Shu-Heng Jiang, Zhi-Gang Zhang, Yan-Miao Huo, Dong-Xue Li, Xue-Li Zhang

“…Mechanistic studies revealed that ENO1 upregulated PD-L1 to prevent CD8+ T cells infiltration through the hypoxia-inducible factor (HIF)-1α signaling pathway, leading to PDAC progression.In conclusion, our findings indicate that ENO1 might serve as a potential biomarker for PDAC and a novel onco-immunotherapeutic target via its role in altering the TIME.…”
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Serum Levels of IL-33 and Correlation with IL-4, IL-17A, and Hypergammaglobulinemia in Patients with Autoimmune Hepatitis by Ma Liang, Zhang Liwen, Zhuang Yun, Ding Yanbo, Chen Jianping

“…Our findings highlight the possible role of the IL-33/sST2 axis in the progression of AIH, opening a new door for developing a novel therapeutic strategy for AIH.…”
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Oncogenic RIT1 mutations confer ferroptosis vulnerability in lung adenocarcinoma by Ruilan Ma, Dian Yang, Peng Wang, Ziyi Zhang, Xuehong Zhang, Jialiang Song, Han Liu, Shuyan Liu, Yingqiu Zhang, Lijuan Zou

“…Hence, our study unravels a novel aspect of RIT1 mutations in lung cancer and suggests ferroptosis induction as a potential therapeutic strategy to treat lung cancer patients carrying RIT1 mutations.…”
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Perinatal midwifery care demand in a tertiary hospital: A time-series analysis by Luisa C. Eggenschwiler, Giusi Moffa, Valerie Smith, Michael Simon

“…To determine care demand, we approached it in a novel way, accounting for both the number of women on each unit and each case's expected complexity. …”
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EMC2 suppresses ferroptosis via regulating TFRC in nasopharyngeal carcinoma by Xianghui Chen, Xiaoyan Wang, Yuxia Zou, Yan Wang, Tingting Duan, Zijie Zhou, Yi Huang, Qing Ye

“…Conclusions: EMC2 suppresses ferroptosis and promotes tumor progression, and the EMC2-TFRC axis is a novel ferroptosis regulatory pathway. EMC2 is a potentially biomarker and therapeutic target for NPC.…”
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Friction Properties of Alumina–Silicon Carbide–Silver–Graphene Nanoplatelet Self-Lubricating Composite Prepared by SPS Technique by Viktor Puchý, Jana Andrejovská, Richard Sedlák, Róbert Džunda, František Kromka, Ivan Petryshynets, Mária Podobová, Ladislav Falat

“…The findings of this study propose a novel material design approach for developing self-lubricating ceramic composites with hybrid solid lubricants.…”
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EARice10: a 10 m resolution annual rice distribution map of East Asia for 2023 by M. Song, M. Song, M. Song, L. Xu, L. Xu, J. Ge, J. Ge, J. Ge, H. Zhang, H. Zhang, H. Zhang, L. Zuo, L. Zuo, J. Jiang, J. Jiang, J. Jiang, Y. Ding, Y. Ding, Y. Ding, Y. Xie, Y. Xie, Y. Xie, F. Wu, F. Wu

“…Therefore, to acquire the latest rice distribution of the EA, this study proposed a novel rice distribution mapping method based on the Google Earth Engine (GEE) platform, producing a 10 m resolution annual rice distribution map (EARice10) of EA for 2023. …”
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Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells by Methi Wathikthinnakon, Piriya Luangwattananun, Nunghathai Sawasdee, Chutipa Chiawpanit, Vannajan Sanghiran Lee, Piyarat Nimmanpipug, Yingmanee Tragoolpua, Siriphorn Rotarayanont, Thanich Sangsuwannukul, Nattaporn Phanthaphol, Yupanun Wutti-in, Chalermchai Somboonpatarakun, Thaweesak Chieochansin, Mutita Junking, Jatuporn Sujjitjoon, Pa-thai Yenchitsomanus, Aussara Panya

“…Abstract Cholangiocarcinoma (CCA) is a lethal cancer with rapid progression and poor survival. Novel and more effective therapies than those currently available are, therefore, urgently needed. …”
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Forecasting insect abundance using time series embedding and machine learning by Gabriel R. Palma, Rodrigo F. Mello, Wesley A.C. Godoy, Eduardo Engel, Douglas Lau, Charles Markham, Rafael A. Moral

“…Based on Random Forests, Lasso-regularised linear regression, and LightGBM regression algorithms, we showed the feasibility of our novel approach, which yields competitive forecasts while automatically selecting insect abundances, climate time series and their lags to aid forecasting.…”
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Genome-wide association study analysis of single nucleotide variants in L. infantum associated with IL-6 inflammatory response in visceral leishmaniasis by Amanda Miranda da Silva, Kátia Silene Sousa Carvalho, Caio Andrey Bezerra Januário, Raquel Gomes de Sena Carneiro Caldas, Bianka Lopes da Silva Paulino, Débora Cavalcante Braz, Dorcas Lamounier Costa, Gabriel da Luz Wallau, Wilson Jose da Silva Junior, Carlos Henrique Nery Costa

“…These findings demonstrate that IL-6 levels tended to be associated with the fatal outcome of VL and highlight 35 novel genetic variants that could serve as potential biomarkers for prognosis. …”
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The mirror preference test: A reverse translational approach to study anomalous subjective experience in rats by Daria Chestnykh, Liubov S. Kalinichenko, Stephan von Hörsten, Johannes Kornhuber, Christian P. Müller

“…We propose that limited visual perception that meets brain monoamine sensitization may trigger visual illusions as part of a psychotic-like state in rats. This novel approach can be utilized to test intervention strategies for psychosis in rats.…”
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Multi-Temporal Analysis and Techno-Economic Evaluation of Offshore Wind Energy Integration to the Western Interconnection by Li He, Shahnawaz Siddiqui, Sameer Nekkalapu, Sohom Datta, Travis Douville, Konstantinos Oikonomou, Manisha Maharjan

“…Three generation and transmission scenarios across two future representations of the Western Interconnection (WI) are modeled, and detailed production cost modeling (PCM) and power flow (PF) models of each topology were constructed. A novel multi-terminal high voltage direct current (MTDC) model was developed and utilized, and its performance is compared with conventional high voltage direct current (HVDC) radial topology. …”
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The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction by Kecheng Zhu, Chunxiang Sheng, Linlin Zhang, Yuying Yang, Xiaojing Chen, Tao Jiang, Jiaxi Song, Deng Zhang, Xiao Wang, Hongyan Zhao, Lihao Sun, Libin Zhou, Bei Tao, Jianmin Liu

“…Taken together, the results of this study reveal that the SIRT5-JIP4 axis is a novel positive regulator that finely regulates RANKL-induced osteoclast differentiation and suggest that targeting this axis is a therapeutic strategy for preventing osteoporotic bone loss. …”
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The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway by Yankun Shao, Yilin Xu, Huang Di, Xinxiu Shi, Yingying Wang, Hongyu Liu, Lina Song

“…Collectively, these data suggested that ORMDL3 promoted oxidative response and ferroptosis in a model of AD by the PERK/ATF4/HSPA5 pathway, which might be a novel target spot mechanism of ferroptosis in AD and may serve as a regulator of AD‐induced ferroptosis.…”
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Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency by Xiaofei Zhang, Linzi Ma, Xiaotong Liu, Xingyu Zhou, Ao Wang, Yunhui Lai, Jun Zhang, Ying Li, Shiling Chen

“…These findings provide a novel and promising treatment strategy for POI patients.…”
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Analysis of GAA Junction Less NS FET Towards Analog and RF Applications at 30 nm Regime by Asisa Kumar Panigrahy, Sudheer Hanumanthakari, Shridhar B. Devamane, Shruti Bhargava Choubey, M. Prasad, D. Somasundaram, N. Kumareshan, N. Arun Vignesh, Gnanasaravanan Subramaniam, Durga Prakash M, Raghunandan Swain

“…This research focuses on a quantum model created using an entirely novel nanosheet FET. The standard model describes the performance of a Gate-all-around (GAA) Junction-less (JL) nanosheet device with a gate dielectric of SiO₂ and HfO₂, each having a thickness of 1 nm. …”
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Applying YOLOv6 as an ensemble federated learning framework to classify breast cancer pathology images by Chhaya Gupta, Nasib Singh Gill, Preeti Gulia, Noha Alduaiji, J. Shreyas, Piyush Kumar Shukla

“…A new homomorphic encryption and decryption algorithm is also proposed to retain data privacy. A novel pruned YOLOv6 model with FedL is introduced in this study to differentiate benign and malignant tissues. …”
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Infiltration and subtype analysis of CD3 + CD20 + T cells in lung cancer by Liping Luo, Juan Ji, Juan Dong, Maotao He, Wenjun Jiang, Yang Liu, Weidong Wang

“…This finding could facilitate the advancement of novel cancer treatment strategies.…”
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Prognostic prediction for inflammatory breast cancer patients using random survival forest modeling by Yiwei Jia, Chaofan Li, Cong Feng, Shiyu Sun, Yifan Cai, Peizhuo Yao, Xinyu Wei, Zeyao Feng, Yanbin Liu, Wei Lv, Huizi Wu, Fei Wu, Lu Zhang, Shuqun Zhang, Xingcong Ma

“…Thus, it is necessary to establish a novel predictive model of high accuracy for the prognosis of IBC patients. …”
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Imaging the large‐scale and cellular response to focal traumatic brain injury in mouse neocortex by Yelena Bibineyshvili, Thomas J. Vajtay, Shiva Salsabilian, Nicholas Fliss, Aastha Suvarnakar, Jennifer Fang, Shavonne Teng, Janet Alder, Laleh Najafizadeh, David J. Margolis

“…Our results in unanaesthetized mice describe novel spatial and temporal neural adaptations that occur at cortical sites remote to a focal brain injury.…”
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