Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESS by Mingqun Deng, Han Wu, Miao Yu, Yi Tian, Yuxiu Li, Xinhua Xiao

“…This study indicated that DIHS/DRESS could lead to APS, especially APS III, providing novel insights into the etiological factors of APS.…”
Get full text

Development and validation of a nomogram to predict recurrence in epithelial ovarian cancer using complete blood count and lipid profiles by Xi Tang, Jingke He, Qin Huang, Yi Chen, Ke Chen, Jing Liu, Yingyu Tian, Hui Wang

“…Grade, International Federation of Gynecology and Obstetrics (FIGO) stage, platelet-to-lymphocyte ratio, red blood cell distribution width-coefficient of variation, triglycerides, and human epididymal protein 4 were identified as independent prognostic factors. The novel nomogram displayed a good predictive performance, with a concordance index (C-index) of 0.787 in the training group and 0.807 in the validation group. …”
Get full text

A qualitative study exploring depressed participants’ experiences of receiving Augmented Depression Therapy (ADepT) by Rebecca Watson, Kim A Wright, Nigel Reed, Barney Dunn, Emily Widnall, Kalliopi Demetriou, Laura Warbrick, Katie Marchant, Nicole Geschwind, Isabella Magner-Parsons, Rachel Barter

“…Objectives The current study aimed to explore participants’ views on the acceptability, impact and mechanisms of change of Augmented Depression Therapy (ADepT), a novel wellbeing-focused and recovery-oriented psychological therapy for depression.Design A semi-structured qualitative interview design was used, with data analysed using the framework approach.Participants 20 participants with anhedonic depression who had received up to 20 sessions of ADepT, sampled from a pilot randomised controlled trial of ADepT versus Cognitive Behavioural Therapy (CBT).Setting A primary care psychological therapy clinic in Devon, UK, with interviews occurring between May 2018 and February 2020.Results Participants found the wellbeing focus of ADepT acceptable. …”
Get full text

MXenes in biosensing: Enhancing sensitivity and flexibility – A review of properties, applications, and future directions by Ali Mohammad Amani, Lobat Tayebi, Ehsan Vafa, Alireza Jahanbin, Milad Abbasi, Ahmad Vaez, Hesam Kamyab, Lalitha Gnanasekaran, Shreeshivadasan Chelliapan

“…MXenes are a novel type of nanostructured material that has received a lot of attention for their potential applications in bioanalysis owing to their unique features. …”
Get full text

The Anti-Inflammatory Effects of Shinbaro3 Is Mediated by Downregulation of the TLR4 Signalling Pathway in LPS-Stimulated RAW 264.7 Macrophages by Hwa-Jin Chung, Wonil Koh, Won Kyung Kim, Joon-Shik Shin, Jinho Lee, Sang Kook Lee, In-Hyuk Ha

“…Shinbaro3 exerted anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophage cells through modulation of the TLR4/MyD88 pathways, suggesting that Shinbaro3 is a novel anti-inflammatory therapeutic candidate in the field of pharmacopuncture.…”
Get full text

Variants of the Sliding Mode Control in Presence of External Disturbance for Quadrotor by Irfan Ahmad, Muwaida Liaquat, Fahad Mumtaz Malik, Hameed Ullah, Usman Ali

“…The main focus of this article is to design two flight control strategies for a quadrotor. Firstly, a novel IIPRERL-SMC is designed through Improved Integral Sliding Mode Control (II-SMC) via proper gain scheduling by system Eigenvalues. …”
Get full text

Development of an Efficient and Generalized MTSCAM Model to Predict Liquid Chromatography Retention Times of Organic Compounds by Mengdie Fan, Chenhui Sang, Hua Li, Yue Wei, Bin Zhang, Yang Xing, Jing Zhang, Jie Yin, Wei An, Bing Shao

“…Finally, by training the optimal quantitative structure–retention relationship (QSRR) models for each category of compounds and selecting the best-fitting model for prediction via discriminant analysis during the prediction period, a novel and universal high-throughput retention time prediction model was established. …”
Get full text

Examining anti-inflammatory therapies in the prevention of cardiovascular events: protocol for a systematic review and network meta-analysis of randomised controlled trials by George A Wells, Kevin Emery Boczar, Sheojung Shin, Kathryn A Bezzina, Aishwarya Geejo, Alexander Liam Pearson, Saba Shahab, Christophe A Fehlmann, Sarah Visintini, Rob Beanlands

“…Introduction Inflammation is emerging as an important risk factor for atherosclerotic cardiovascular disease and has been a recent target for many novel therapeutic agents. However, comparative evidence regarding efficacy of these anti-inflammatory treatment options is currently lacking.Methods and analysis This systematic review will include randomised controlled trials evaluating the effect of anti-inflammatory agents on cardiovascular outcomes in patients with known cardiovascular disease. …”
Get full text

Long noncoding RNA GDIL acts as a scaffold for CHAC1 and XRN2 to promote platinum resistance of colorectal cancer through inhibition of glutathione degradation by Xuan Deng, Lu Chang, Lingyu Tang, Haoqin Jiang, Xiao Xu, Xinju Zhang, Jian Chen, Liu Dong, Qianqian Xu, Ruoshui Cao, Jianbin Xiang, Ming Guan

“…Thus, lncRNA GDIL is a novel target to promote GSH degradation and augment platinum therapy.…”
Get full text

Single-cell transcriptomic analysis reveals characteristic feature of macrophage reprogramming in liver Mallory-Denk bodies pathogenesis by Zixuan Fang, Bei Zhong, Yi Shi, Wanmei Zhou, Maoping Huang, Samuel W. French, Xiaoping Tang, Hui Liu

“…Particularly, we identified a novel Gpnmbhigh KCs subset as lipid-associated macrophage (LAM) with high expression of Trem2, CD63, and CD9. …”
Get full text

Pretreatment of Ascorbic Acid Inhibits MPTP-Induced Astrocytic Oxidative Stress through Suppressing NF-κB Signaling by Xiaokang Zeng, Kai Xu, Ji Wang, Yunqi Xu, Shaogang Qu

“…Hence, our findings elucidate a novel protective mechanism of AA in astrocytes.…”
Get full text

Light and dark biofilm adaptation impacts larval settlement in diverse coral species by Paul A. O’Brien, Sara C. Bell, Laura Rix, Abigail C. Turnlund, Shannon R. Kjeldsen, Nicole S. Webster, Andrew P. Negri, Muhammad A. Abdul Wahab, Inka Vanwonterghem

“…Conclusions Our work identifies novel microbial groups that significantly influence coral larval settlement, which can be targeted for the discovery of settlement-inducing metabolites for implementation in reef restoration programs. …”
Get full text

Clinical symptoms and functional impairment in attention deficit hyperactivity disorder (ADHD) co-morbid tic disorder (TD) patients: a cluster-based investigation by Zhongliang Jiang, Hui Xu, Anyi Zhang, Liping Yu, Xianbin Wang, Wenyan Zhang, Yonghua Cui, Ying Li

“…Cluster analysis provides a novel perspective on the heterogeneity of these commonly observed clinical disorders. …”
Get full text

Health State Utility Values in Children and Adolescents with Disabilities: A Systematic Review by Lucy Kanya, PhD, Nana Anokye, PhD, Ahmad Hecham Alani, PharmD, Nandini Jayakumar, MSc, Jennifer M. Ryan, PhD

“…Studies quality was assessed using a novel tool derived from 3 validated checklists. Results: Of the 3541 screened articles, 31 met inclusion criteria. …”
Get full text

Mountain sentinels in a changing world: Review and conservation implications of weather and climate effects on mountain goats (Oreamnos americanus) by Kevin S. White, Becky Cadsand, Steeve D. Côté, Tabitha Graves, Sandra Hamel, Richard B. Harris, Forest P. Hayes, Eran Hood, Kevin Hurley, Tyler Jessen, Bill Jex, Erich Peitzsch, Wesley Sarmento, Helen Schwantje, Joel Berger

“…Specifically, spatiotemporal (and other) aspects of monitoring and management may need to be adjusted to accommodate emerging and novel conservation challenges. Yet, key data and knowledge gaps remain and should be addressed to advance conservation and decision-making capabilities. …”
Get full text

Combining interictal intracranial EEG and fMRI to compute a dynamic resting-state index for surgical outcome validation by Varina L. Boerwinkle, Kristin M. Gunnarsdottir, Bethany L. Sussman, Sarah N. Wyckoff, Emilio G. Cediel, Belfin Robinson, William R. Reuther, Aryan Kodali, Sridevi V. Sarma

“…IntroductionAccurate localization of the seizure onset zone (SOZ) is critical for successful epilepsy surgery but remains challenging with current techniques. We developed a novel seizure onset network characterization tool that combines dynamic biomarkers of resting-state intracranial stereoelectroencephalography (rs-iEEG) and resting-state functional magnetic resonance imaging (rs-fMRI), vetted against surgical outcomes. …”
Get full text

Availability in ECMO Reduces the Failure to Rescue in Patients With Pulmonary Embolism After Major Surgery: A Nationwide Analysis of 2.4 Million Cases by Johannes Diers, MD, Nikolas Baumann, MD, Philip Baum, MD, Konstantin L. Uttinger, MD, Johanna C. Wagner, MD, Peter Kranke, MD, Patrick Meybohm, MD, Christoph-Thomas Germer, MD, Armin Wiegering, MD

“…Postoperative pulmonary embolism (PE) is a rare but potentially life-threatening complication, which can be treated with extracorporeal membrane oxygenation (ECMO) therapy, a novel therapy option for acute cardiorespiratory failure. …”
Get full text

GTPase GPN3 facilitates cell proliferation and migration in non-small cell lung cancer by impeding clathrin-mediated endocytosis of EGFR by Linlin Xu, Jiankun Guo, Xinsheng Xie, Hailong Wang, Alan Jiang, Changhua Huang, Hua Yang, Shiwen Luo, Limin Chen

“…These results suggest that targeting GPN3 could serve as a novel prognostic biomarker and therapeutic strategy for NSCLC treatment.…”
Get full text

Deep Joint Demosaicking and Super-Resolution for Spectral Filter Array Images by Abdelhamid N. Fsian, Jean-Baptiste Thomas, Jon Y. Hardeberg, Pierre Gouton

“…To this end, we use a two-branch framework, namely a pseudo-panchromatic image network and a pre-demosaicking sub-branch coupled with a novel deep residual demosaicking and super resolution module. …”
Get full text

ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy by Yuexiu Wu, Yufeng Zuo, Rana Chakrabarti, Biao Feng, Shali Chen, Subrata Chakrabarti

“…Several signaling mechanisms are activated secondary to hyperglycemia in diabetes, leading to activation of vasoactive factors. We investigated a novel pathway, namely extracellular signal regulated kinase 5 (ERK5) mediated signaling, in modulating glucose-induced vascular endothelial growth factor (VEGF) expression. …”
Get full text