Directional Topography Influences Adipose Mesenchymal Stromal Cell Plasticity: Prospects for Tissue Engineering and Fibrosis by Gabriel Romero Liguori, Qihui Zhou, Tácia Tavares Aquinas Liguori, Guilherme Garcia Barros, Philipp Till Kühn, Luiz Felipe Pinho Moreira, Patrick van Rijn, Martin C. Harmsen

“…These data suggest that nanotopography may be a novel tool for inhibiting fibrosis.…”
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PZS‐Net: Incorporating of Frame Sequence and Multi‐Scale Priors for Prostate Zonal Segmentation in Transrectal Ultrasound by Jianguo Ju, Qian Zhang, Pengfei Xu, Tiange Liu, Cheng Li, Ziyu Guan

“…To overcome the limitation, a novel Prostate Zonal Segmentation Network (PZS‐Net), based on U‐Net, which learns critical cross‐frame information and multi‐scale features from sequential frames, is proposed. …”
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Multiscale Attention Feature Fusion Based on Improved Transformer for Hyperspectral Image and LiDAR Data Classification by Aili Wang, Guilong Lei, Shiyu Dai, Haibin Wu, Yuji Iwahori

“…This article proposes a novel multiscale attention feature fusion network, composed of hierarchical convolutional neural networks and transformer to enhance joint classification accuracy of hyperspectral image (HSI) and light detection and ranging (LiDAR) data. …”
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Efficacy and safety of Xiongzhitongluo granules in the treatment of acute ischemic stroke: study protocol for a randomized controlled trial by Yunmeng Chen, Jingjing Wei, Xiao Liang, Yue Liu, Lina Miao, Di Zhao, Yunfan Zhang, Hongxi Liu, Yunling Zhang

“…However, their efficacy is often limited by stringent time constraints and contraindications, restricting accessibility for certain patient populations. Investigating novel therapeutic strategies is, therefore, crucial. …”
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A pH-responsive PROTAC-based nanosystem triggers tumor-specific ferroptosis to construct in situ tumor vaccines by Linghong Huang, Xinyuan Sun, Qinhua Zuo, Ting Song, Ning Liu, Zonghua Liu, Wei Xue

“…This antigen capture system provides a novel strategy to improve the anti-tumor efficacy of in situ tumor vaccines.…”
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Restriction of mitochondrial oxidation of glutamine or fatty acids enhances intracellular growth of Mycobacterium abscessus in macrophages by Ho Won Kim, Ji Won Lee, Hoe Sun Yoon, Hwan-Woo Park, Young Ik Lee, Sung Ki Lee, Jake Whang, Jong-Seok Kim

“…These insights advance our understanding of Mab’s impact on host cell metabolism and propose a novel avenue for therapeutic intervention. By manipulating host mitochondrial metabolism, we identify a potential host-directed therapeutic strategy against Mab, offering a promising alternative to conventional treatments beleaguered by drug resistance. …”
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Expert Comment Generation Considering Sports Skill Level Using a Large Multimodal Model with Video and Spatial-Temporal Motion Features by Tatsuki Seino, Naoki Saito, Takahiro Ogawa, Satoshi Asamizu, Miki Haseyama

“…To address this issue, we propose a novel approach to generate skill-level-aware expert comments by leveraging a Large Multimodal Model (LMM) and spatial-temporal motion features. …”
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Using Image-based AI for insect monitoring and conservation - InsectAI COST Action by Tom August, Mario Balzan, Paul Bodesheim, Gunnar Brehm, Lisette Cantú-Salazar, Sílvia Castro, Joseph Chipperfield, Guillaume Ghisbain, Alba Gomez-Segura, Jérémie Goulnik, Quentin Groom, Laurens Hogeweg, Chantal Huijbers, Andreas Kamilaris, Karolis Kazlauskis, Wouter Koch, Dimitri Korsch, João Loureiro, Youri Martin, Angeliki Martinou, Kent McFarland, Xavier Mestdagh, Denis Michez, Charlie Outhwaite, Luca Pegoraro, Nadja Pernat, Lars Pettersson, Pavel Pipek, Cristina Preda, David Rolnick, Tobias Roth, David Roy, Helen Roy, Veljo Runnel, Martina Sasic, Dmitry Schigel, Julie Sheard, Cecilie Svenningsen, Heliana Teixeira, Nicolas Titeux, Thomas Tscheulin, Elli Tzirkalli, Marijn van der Velde, Roel van Klink, Nicolas Vereecken, Sarah Vray, Toke Thomas Høye

“…These groups will address how image-based insect AI technologies can best address Societal Needs, support innovation in Image Collection hardware, create standardised approaches for Image Processing and develop novel Data Analysis and Integration methods for turning data into actionable insights.…”
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Towards Reliable Participation in UAV-Enabled Federated Edge Learning on Non-IID Data by Youssra Cheriguene, Wael Jaafar, Halim Yanikomeroglu, Chaker Abdelaziz Kerrache

“…Hence, we propose in this article a novel client selection scheme that enhances convergence by prioritizing fast UAVs with high-reliability scores, while eliminating malicious UAVs from training. …”
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SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling by Antonio Michelucci, Luigi Sforna, Riccardo Focaia, Maria Vittoria Leonardi, Angela Di Battista, Giorgia Rastelli, Simone Vespa, Simona Boncompagni, Manlio Di Cristina, Luigi Catacuzzeno

“…Finally, ORF3a expression in HEK293 cells leads to lysosomal volume increase, mitochondrial damage, and accumulation of intracellular membranes, all alterations reverted by the N82W mutation. We propose a novel function for ORF3a as a lysosomal water-permeable channel, essential for lysosome deacidification and inactivation, key steps to promote virus egress.…”
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Statistically Coherent Calibration of X-Ray Fluorescence Spectrometry for Major Elements in Rocks and Minerals by Surendra P. Verma, Sanjeet K. Verma, M. Abdelaly Rivera-Gómez, Darío Torres-Sánchez, Lorena Díaz-González, Alejandra Amezcua-Valdez, Beatriz Adriana Rivera-Escoto, Mauricio Rosales-Rivera, John S. Armstrong-Altrin, Héctor López-Loera, Fernando Velasco-Tapia, Kailasa Pandarinath

“…Similar sensitivity (∼2.69–46.17 kc·s−1·%−1 for the OLR and ∼2.78–59.69 kc·s−1·%−1 for the UWLR) also indicated that the UWLR could advantageously replace the OLR model. Another novel aspect is that the total uncertainty can be reported for individual chemical data. …”
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Humanising nanotoxicology: replacement of animal-derived products in the application of integrated approaches to testing and assessment of nanomaterial inhalation hazard by Roma Fraser, Keira Campbell, Pawel Pokorski, Eve MacKinnon, Katie McAllister, Karla B. Neves, Fiona Murphy

“…This has prompted the design of Novel Approach Methods (NAMs) to streamline risk assessment and predict human hazards without relying on animal testing. …”
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Case report: Clinical characteristics and Genetical analysis of HSD11B2 in three Chinese children with apparent mineralocorticoid excess: a case series by Yuan Ding, Yuan Ding, Ming Cheng, Ming Cheng, Bingyan Cao, Bingyan Cao, Min Liu, Min Liu, Xuyun Hu, Xuyun Hu, Di Wu, Di Wu, Di Wu

“…Through our analysis, four novel variants of the HSD11B2 gene were identified, thereby enhancing the genotype-phenotype spectrum associated with AME. …”
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Bisphenol A induces apoptosis and disrupts testosterone synthesis in TM3 cells via reactive oxygen species-mediated mitochondrial pathway and autophagic flux inhibition by Wenzhe Yang, Feilong Pan, Tong Zhao, Fangfang Chen, Wenqi Shao, Jinhao Wang, Shirui Wang, Zichen Zhao, Kexiang Liu, Shuchen Zhao, Lijia Zhao

“…These findings provide novel mechanistic insights into male reproductive toxicity caused by BPA exposure.…”
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Performance improvements and increased ruminal microbial interactions in Angus heifers via supplementation with native rumen bacteria during high-grain challenge by Fan Yang, Madison T. Henniger, Andrew S. Izzo, Emily A. Melchior, Brooke A. Clemmons, Mary A. Oliver, James R. Gaffney, Cameron Martino, Taylor B. Ault-Seay, Miranda L. Striluk, Jordan J. Embree, Juan F. Cordero-Llarena, Pierre-Yves Mulon, David E. Anderson, Mallory M. Embree, Phillip R. Myer

“…Abstract Feedlot cattle may be subjected to digestive disorders, including ruminal acidosis, due to high concentration of grain in their diet. Therefore, novel feeding strategies are required to maximize animal performance and mitigate economic losses in the operation. …”
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The OXT rs6133010 variant modulates susceptibility to psychiatric symptoms during withdrawal in patients with alcohol dependence by Guanghui Shen, Wei Wang, Yuyu Wu, Xinguang Luo, Kexin Wang, Yu-Hsin Chen, Yimin Kang, Yanlong Liu, Fan Wang, Li Chen

“…Conclusion This study presents novel evidence that OXT rs6133010 specifically modulates psychiatric symptoms in AD. …”
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Exploration of Digital Twin Design Mechanism of the Deep in Situ Rock Insulation Coring Device by Bo Yu, Heping Xie, Ling Chen, Wu Zhao, Zhiqiang He

“…The exploration of the novel design model combined digital twin technology with innovative design theory. …”
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Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells by Xu Zhou, Wen-Ming Liu, Han-Yong Sun, Yuan Peng, Ren-Jie Huang, Cai-Yang Chen, Hong-Dan Zhang, Shen-Ao Zhou, Hong-Ping Wu, Dan Tang, Wei-Jian Huang, Han Wu, Qi-Gen Li, Bo Zhai, Qiang Xia, Wei-Feng Yu, He-Xin Yan

“…Amphiregulin and FGF19 are key factors responsible for STAT1 activation, representing promising novel therapeutic targets for the treatment of liver cirrhosis.…”
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Development of Modified-Release Diclofenac Sodium Capsules Using Blends of Pectin-Clay Multiparticulate Hybrid Systems as Release Retardants by Ofosua Adi-Dako, Frederick William Akuffo Owusu, Isaac Yaw Attah, Doris Kumadoh, Prince George Acquah Jnr, Issaka Nelson, Nii Odartey Hutton-Mills, Karen Yaa Yeboaa Obese, Joseph Adusei Sarkodie, Benoit Banga N’guessan, Awo Afi Kwapong, Christina Osei-Asare, Emmanuel Adase, Mary-Ann Archer

“…A combination of inorganic and organic hybrid systems is of high research interest as they provide novel hybrid systems for the improvement of existing properties, overcoming limitations of the parent materials, and for the optimization of their controlled release potential. …”
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Design, Synthesis, and Antioxidant and Anti-Tyrosinase Activities of (<i>Z</i>)-5-Benzylidene-2-(naphthalen-1-ylamino)thiazol-4(5<i>H</i>)-one Analogs: In Vitro and In Vivo Insight... by Hee Jin Jung, Hye Jin Kim, Hyeon Seo Park, Hye Soo Park, Jeongin Ko, Dahye Yoon, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon

“…Fifteen compounds (<b>1</b>–<b>15</b>) constructed on a hybrid structure combining a β-phenyl-α,β-unsaturated carbonyl template and a 2-aminothiazol-4(5<i>H</i>)-one scaffold were designed and synthesized as potential novel anti-tyrosinase substances. Two compounds (<b>10</b> and <b>15</b>) showed more potent inhibition against mushroom tyrosinase than kojic acid, and the inhibitory activity of <b>10</b> (IC₅₀ value: 1.60 μM) was 11 times stronger than that of kojic acid. …”
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