Association between weight-adjusted waist index and cognitive impairment in Chinese older men: a 7-year longitudinal study by Jie Lin, Hongchen Shen, Wenjuan Yang, Guojun Zhang, Jie Sun, Wenqin Shen, Li Huang, Huajian Chen

“…Weight-adjusted waist index (WWI) is a novel measure of obesity that may offer more precise assessments of muscle and fat mass. …”
Get full text

Real world data on outcomes of anti-CD38 antibody treated, including triple class refractory, patients with multiple myeloma: a multi-institutional report from the Canadian Myeloma... by A. Visram, A. De La Torre, D. White, J. Su, E. Masih-Khan, M. Chu, V. Jimenez-Zepeda, A. McCurdy, R. LeBlanc, K. Song, H. Mian, M. Louzada, M. Sebag, D. Bergstrom, J. Stakiw, A. Reiman, R. Kotb, M. Aslam, C. Venner, R. Kaedbey, E. Gul, D. Reece

“…Abstract Multiple myeloma (MM) remains incurable despite the availability of novel agents. This multi-center retrospective cohort study used the Canadian Myeloma Research Group Database to describe real-world outcomes of patients withanti-CD38 monoclonal antibody (mAb) refractory MM subsequently treated with standard of care (SoC) regimens. …”
Get full text

Extracellular vesicles display distinct glycosignatures in high-grade serous ovarian carcinoma by Kristina Mae Bienes, Akira Yokoi, Masami Kitagawa, Hiroaki Kajiyama, Morten-Thaysen Andersen, Rebeca Kawahara

“…Our study provides insights into the EV glycoproteome of HGSOC and the underlying changes in the glycosylation machinery in HGSOC tissues, opening new avenues for the discovery of novel markers against HGSOC.…”
Get full text

Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6 by Huan Yi, Yan-zhao Su, Rong Lin, Xiang-qin Zheng, Diling Pan, Dan-mei Lin, Xiang Gao, Rong Zhang

“…This finding may provide a novel diagnostic and therapeutic target for improving the poor prognoses of OC patients.…”
Get full text

Thromboelastography in Patients with Inflammatory Bowel Disease by Yonghua Shen, Liangliang Shi, Juanjuan Zhang, Hao Zhu, Yuling Yao, Zhenqing Liu, Xiaoping Zou, Xiaoqi Zhang

“…This study was conducted to discover novel thrombophilic markers using thromboelastography (TEG) and to evaluate the relation between the predisposing factors and the activity of disease in Chinese patients with Crohn’s disease (CD) and ulcerative colitis (UC). …”
Get full text

A new potential of sodium anthraquinone-2-sulfonate as a corrosion inhibitor for carbon steel in 0.5 M H2SO4 by Nikolay Akatyev, Roza Kenzhegalieva, Meruyet Khapiyeva, Gauhar Uzakbay, Aruzhan Talapova, Ruben Vardanyan

“…The results highlight the novel potential of AQ2SNa as an effective corrosion inhibitor to provide an effective solution for enhancing the protection of carbon steel in acidic media. …”
Get full text

Leakage of Octyl(Phenyl)--Di-Isobutylcarbamoylmethylphosphine Oxide from a Macroporous Silica-Based Chelating Polymeric Adsorption Material and its Recovery by Some Selected Porous... by Anyun Zhang, Yuezhou Wei, Harutaka Hoshi, Mikio Kumagai, Yoshikazu Koma

“…The leakage behaviour of a neutral chelating agent, i.e. octyl(phenyl)- N,N -di-isobutylcarbamoylmethylphosphine oxide (CMPO), from its macroporous silica-based (CMPO/SiO 2 -P) extraction resin (a novel polymeric adsorption material developed in the MAREC process) and the recovery of CMPO by some selected polymer- and silica-based porous adsorbents were investigated by column operation in 0.01 M HNO 3 at 25°C or 50°C. …”
Get full text

Isolation of a tumor neoantigen specific CD8+ TCR from a skin biopsy of a vaccination site by Maria Paula Roberti, Pornpimol Charoentong, Yanhong Lyu, Marten Meyer, Stefan B. Eichmüller, Patrick Schmidt, Frank Momburg, Miray Cetin, Felix Hartmann, Nektarios A. Valous, Albrecht Stenzinger, Laura Michel, Peter Lichter, Andreas Schneeweiss, Verena Thewes, Carlo Fremd, Inka Zörnig, Dirk Jäger

“…However, their challenging identification and isolation limits their use in clinical practice. Therefore, novel approaches to isolate tumor-specific T cells are needed. …”
Get full text

The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target by Reem Alharthi, Monica Sueiro-Olivares, Isabelle Storer, Hajer Bin Shuraym, Jennifer Scott, Reem Al-Shidhani, Rachael Fortune-Grant, Elaine Bignell, Lydia Tabernero, Michael Bromley, Can Zhao, Jorge Amich

“…Fungal sulfur metabolism comprises anabolic and catabolic routes that are not well conserved in mammals, therefore is considered a promising source of prospective novel antifungal targets. To gain insight into Aspergillus fumigatus sulfur-related metabolism during infection, we used a NanoString custom nCounter-TagSet and compared the expression of 68 key metabolic genes in different murine models of invasive pulmonary aspergillosis, at 3 time-points, and under a variety of in vitro conditions. …”
Get full text

A dataset on bathymetry and hydrology of an emerging periglacial lagoon in Svalbard, ArcticMendeley Data by Andrius Šiaulys, Aleksej Šaškov, Greta Kilmonaitė, Dzmitry Lukashanets, Tobia Politi, Aurelija Samuilovienė, Anastasija Zaiko, Sergej Olenin

“…There is limited data on the geomorphology and hydrology of these novel formations, primarily because conducting research in remote polar regions is logistically challenging and expensive.We present hydrological and bathymetric data collected in 2022-2024 in a newly formed lagoon located in the western part of Spitsbergen (Svalbard), between Eidembreen glacier and Eidembukta bay. …”
Get full text

Adaptive modification of antiviral defense systems in microbial community under Cr-induced stress by Dan Huang, Jingqiu Liao, Jose Luis Balcazar, Mao Ye, Ruonan Wu, Dongsheng Wang, Pedro J. J. Alvarez, Pingfeng Yu

“…These findings advance our understanding of microbial adaptation in stressful environments and may inspire novel approaches for microbiome manipulation and bioremediation. …”
Get full text

Pan-cancer characterization of m6A-mediated regulation of T cell exhaustion dynamics and clinical relevancies in human cancers by Weiping Ji, Ye Fang, Liwei Chen, Yitong Zheng, Yifei Pei, Changqiu Mei, Meng Zhou

“…Moreover, m6A-TEX crosstalk influenced responses to immune checkpoint blockade therapies. Our findings provide novel insights into the role of m6A in TEX regulation and underscore the potential of m6A regulators as biomarkers and therapeutic targets for advancing cancer immunotherapy.…”
Get full text

SELP+ TEC:CD8+ T cell crosstalk associates with improved radiotherapy efficacy in cervical cancer by Qingyu Huang, Wenhui Yang, Fuhao Wang, Rui Huang, Qian Wang, Xiaohui Li, Tianyu Lei, Shengqin Yue, Wenxue Zou, Qi An, Jinbo Yue, Qinyong Hu, Chao Liu

“…Targeting this crosstalk may offer novel therapeutic strategies to mitigate treatment resistance and improve patient survival.…”
Get full text

Multi-Task Learning for Alzheimer’s Disease Diagnosis and Mini-Mental State Examination Score Prediction by Jin Liu, Xu Tian, Hanhe Lin, Hong-Dong Li, Yi Pan

“…To address this challenging problem, we propose a novel multi-task learning method, which uses feature interaction to explore the relationship between Alzheimer’s disease diagnosis and mini-mental state examination score prediction. …”
Get full text

Cooperative maximum adhesion tracking control for multi-motor electric locomotives by Leiting Zhao, Yongxiang Wang, Kan Liu, Liran Li, Jingyuan Zhan, Qingliang Liu

“…Originality/value – This study presents a novel cooperative adhesion tracking control scheme. …”
Get full text

AdipoR1 enhances the radiation resistance via ESR1/CCNB1IP1/cyclin B1 pathway in hepatocellular carcinoma cells by Yuhan Gan, Linhui Zhu, Yimo Li, Ruoting Ge, Jiahe Tian, Yuxin Chen, Xiang He, Shumei Ma, Xiaodong Liu

“…This study will promote the development of novel targeted radiosensitizing drugs.…”
Get full text

Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice by Jing Ye, Ling Liu, Qingwei Ji, Ying Huang, Ying Shi, Lei Shi, Jianfang Liu, Menglong Wang, Yao Xu, Huimin Jiang, Zhen Wang, Yingzhong Lin, Jun Wan

“…The downregulation of IL-22 may be a novel therapeutic strategy to prevent cardiac hypertrophy.…”
Get full text

Enhanced Optical and Thermal Stability of Blue Pyrrole Derivatives for Color Filter in Image Sensors by Sunwoo Park, Sangwook Park, Saeyoung Oh, Hyukmin Kwon, Hayoon Lee, Kiho Lee, Chun Yoon, Jongwook Park

“…We designed and synthesized two novel blue pyrrole derivatives, 2-(3-cyano-4-(4-(dibutylamino)phenyl)-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)malononitrile (BAPCP) and 2-(3-cyano-4-(4-(dihexylamino)phenyl)-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)malononitrile (HAPCP), as potential candidates for use in image sensor color filters. …”
Get full text

Magnetic-responsive triple shape memory polymer from bio-based benzoxazine/urethane polymer alloys with iron oxide nanoparticles by Kullanard Ruenpanya, Phattarin Mora, Panagiotis Karagiannidis, Kittipon Bunyanuwat, Sarawut Rimdusit

“…Novel magnetic-responsive triple shape memory polymers (SMPs) derived from bio-based benzoxazine-urethane (V-fa/PU) polymer alloys containing iron oxide nanoparticles (Fe3O4 NPs) were developed in this work. …”
Get full text

Simultaneous Inference of Past Demography and Selection from the Ancestral Recombination Graph under the Beta Coalescent by Korfmann, Kevin, Sellinger, Thibaut Paul Patrick, Freund, Fabian, Fumagalli, Matteo, Tellier, Aurélien

“…We tackle these limitations by developing two novel and different approaches to infer multiple merger events from sequence data or the ancestral recombination graph (ARG): a sequentially Markovian coalescent (SMβC) and a graph neural network (GNNcoal). …”
Get full text