Genetics of Primary Adrenal Insufficiency Beyond CAH in Saudi Arabian Population by Mohamed H. Al‐Hamed, Alya Qari, Lamya Alrayes, Mohammed Alotaibi, Zainab Al Masseri, Afaf Alotaibi, Abdullah AlAshwal, Zuhair N. AlHassnan, Afaf Alsagheir

“…Hemizygous variants in ABCD1 were the most common cause of PAI in this cohort (16 families) leading to adrenoleukodystrophy. A total of six novel variants were detected, of which four were predicted to be pathogenic (P) / likely pathogenic (LP) and two were VUS. …”
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Comprehensive analysis of publications concerning combinations of immunotherapy and targeted therapies for hepatocellular carcinoma: a bibliometric study by Biling Gan, Lei Wu, Shunan Zhou, Zhihong Chen, Fan Wu, Lianqun Xu, Zhenrong Chen, Honghui Ma, Peijia He, Dan Fang, Ning Shi

“…Early research primarily focused on angiogenesis, dendritic cells, and expression markers, while recent trends have shifted towards phase III trials, adverse reactions, and checkpoint inhibitors, underscoring the field’s dynamic progression.ConclusionFuture research will expand on the pathological mechanisms underlying these therapies and novel interventions and combination strategies. Addressing adverse events and treatment discontinuation will remain central to advancing clinical applications.…”
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Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future Perspectives by Domenica Lucia D’Antonio, Anna Zenoniani, Samia Umme, Adriano Piattelli, Maria Cristina Curia

“…Furthermore, this review underscores the clinical research significance of <i>Fn</i> as a potential tumor biomarker and therapeutic target, offering a novel outlook on its applicability in cancer detection and prognostic assessment. …”
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The SERPINB4 gene mutation identified in twin patients with Crohn’s disease impaires the intestinal epithelial cell functions by Xiao-Mei Ouyang, Jun-Hui Lin, Ying Lin, Xian-Ling Zhao, Ya‐Ni Huo, Lai-Ying Liang, Yong-Dong Huang, Gui-Jing Xie, Peng Mi, Zhen-Yu Ye, Bayasi Guleng

“…The activation of SERPINB4 might represent a novel therapeutic target for inflammatory bowel disease.…”
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Evaluation of a user‐friendly CSDS cage apparatus for studying depressive‐like behaviors in rodents by Hao Zhang, Dongmei Gao, Minghu Hu, Wanqing Zhou, Muxuan Han, Ya Sun, Yang Zhang, Jieqiong Wang, Mingzhou Gao

“…Our study team developed a novel, standardized apparatus to induce CSDS in rodents and assessed the model's practical adaptability. …”
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Neuron-inspired CsPbBr3/PDMS nanospheres for multi-dimensional sensing and interactive displays by Junhu Cai, Xiang Zhang, Yu Chen, Wenzong Lai, Yun Ye, Sheng Xu, Qun Yan, Tailiang Guo, Jiajun Luo, Enguo Chen

“…Drawing inspiration from neurons, a novel multifunctional CsPbBr3/PDMS nanosphere is devised to sense humidity, temperature, and pressure simultaneously with unique interactive responses. …”
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Physiochemical and functional evaluation of the first-in-class anti-cancer IgE antibody drug, MOv18, through process development and good manufacturing practice production by Heather J Bax, Jitesh Chauhan, Alexandra J McCraw, Melanie Grandits, Chara Stavraka, Heike Lentfer, Tim Hillyer, Simon Carroll, Kim Vigor, Chris Selkirk, Mariangela Figini, Jack Cheeseman, Paulina A Urbanowicz, Richard A Gardner, Daniel I R Spencer, Nigel Westwood, Sarah Mellor, James Spicer, Debra H Josephs, Sophia N Karagiannis

“…We confirm the suitability of the pipeline described for generating intact, functionally active, clinical-grade material for this novel therapeutic class as an Investigational Medicinal Product (IMP), with comparable characteristics to the original research-grade antibody. …”
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Energy and CO2 fluxes in the early stage development of reclaimed and unreclaimed post-mining areas by Aysan Badraghi, Ondřej Mudrák, Jiří Kučera, Leonardo Montagnani, Jan Frouz

“…To address this gap, we conducted the first direct measurements of net ecosystem exchange (NEE), latent heat (LE), and sensible heat (H) using paired eddy covariance towers at both reclaimed and unreclaimed sites during the growing seasons of 2020, 2021, and 2023 in the early stage of succession in Czechia. Our novel results show that early post-coal mining sites were net sources of CO2 but became carbon sinks on a monthly scale within four years, highlighting the rapid ecosystem recovery at both sites. …”
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Optimal timing of organs-at-risk-sparing adaptive radiation therapy for head-and-neck cancer under re-planning resource constraints by Fatemeh Nosrat, Cem Dede, Lucas B. McCullum, Raul Garcia, Abdallah S.R. Mohamed, Jacob G. Scott, James E. Bates, Brigid A. McDonald, Kareem A. Wahid, Mohamed A. Naser, Renjie He, Aysenur Karagoz, Amy C. Moreno, Lisanne V. van Dijk, Kristy K. Brock, Jolien Heukelom, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Andrew J. Schaefer, Clifton D. Fuller

“…Materials and methods: A novel Markov decision process (MDP) model was developed to determine optimal timing of re-planning based on the patient’s expected toxicity, characterized by normal tissue complication probability (NTCP), for four toxicities. …”
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Data-driven prediction of critical diameter for deterministic lateral displacement devices: an integrated DPD-ML approach by Shuai Liu, Peng Zhang, Anbin Wang, Keke Tang, Shuo Chen, Chensen Lin

“…To address this challenge, this paper proposes a novel integrated approach that combines Dissipative Particle Dynamics (DPD) simulation with various machine learning (ML) models to rapidly predict the critical diameter of DLD devices with arbitrary pillar shapes considering fluid dynamics. …”
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Cytotoxic Activity of Bisphosphonic Derivatives Obtained by the Michaelis–Arbuzov or the Pudovik Reaction by Zsuzsanna Szalai, Janka Bednárik, Boldizsár Szigfrid Tóth, Angéla Takács, Szilárd Tekula, László Kőhidai, Konstantin Karaghiosoff, László Drahos, György Keglevich

“…<b>Conclusions:</b> The new families of compounds synthesized by our novel approaches may be of practical importance due to the significant cytotoxic activity on the cell cultures investigated. …”
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Selective JAK2 pathway inhibition enhances anti-leukemic functionality in CD19 CAR-T cells by Kohei Mitsuno, Masaya Suematsu, Yuki Naito, Azusa Mayumi, Hideki Yoshida, Shinya Osone, Toshihiko Imamura, Yozo Nakazawa, Shigeki Yagyu, Tomoko Iehara

“…Abstract The integration of molecular targeted therapeutics with chimeric antigen receptor T (CAR-T) cell therapy represents a novel strategy to amplify the anti-tumor efficacy of immunotherapy. …”
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Modified CD15/CD16-CLL1 inhibitory CAR-T cells for mitigating granulocytopenia toxicities in the treatment of acute myeloid leukemia by Rui Zhang, Yifan Zhao, Xiao Chai, Yingshuai Wang, Mohan Zhao, Shujing Guo, Yu Zhang, Mingfeng Zhao

“…Considering the distinct expression levels of CD15/CD16 on neutrophils and AML blasts, we have devised novel modified CD15 /CD16-CLL1 iCAR structures incorporating diverse inhibitory elements. …”
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Designing EV Charging Energy Hubs to Meet Flexibility Requirements in Smart Grids by Walied Alfraidi, Fahad Alaql, Khalid AlMuhanna, Hassan M. Hussein Farh, Abdullrahman A. Al-Shamma’a

“…This study introduces a novel mathematical optimization model designed to maximize the operational flexibility of EV charging stations by transforming them into fully functional energy hubs. …”
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Multiphoton imaging-based quantifiable collagen signatures for predicting outcomes in patients with pancreatic ductal adenocarcinoma by Xiwen Chen, Jikui Miao, Xingxin Huang, Xiahui Han, Liqin Zheng, Jianxin Chen, Linying Chen, Lianhuang Li

“…A combination of label-free multiphoton imaging technique and computer-aided image processing method may offer a novel and promising approach for finding new biomarkers to improve prognosis prediction and thereby tailor treatment strategies more effectively.…”
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Harnessing the power of proteins in modulation of miRNAs for targeting Iron deficiency Anemia: Opinion for future implications and strategies by Ray Wagiu Basrowi, Ray Wagiu Basrowi, Ray Wagiu Basrowi, Tonny Sundjaya, Tonny Sundjaya, Dessy Pratiwi, Nurlinah Amalia, Nurlinah Amalia, Nurlinah Amalia, Yosi Yohanes Putra Tandi, Muhammad Yasir Syafa’atulloh, Garuda Nusantara Putra Utomo, Muhammad Abdir Rahman Albarok, Fahrul Nurkolis

“…This review explores the cutting-edge interplay between microRNAs (miRNAs) and proteins in erythropoiesis, highlighting novel therapeutic strategies for IDA. Emerging evidence underscores the pivotal role of miRNAs—such as miR-15a, miR-24, miR-150, and miR-223—in regulating erythropoiesis, with dysregulation linked to hematologic and systemic diseases. …”
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Sodium-glucose cotransporter-2 inhibitors increase urinary tract infections?—a cross sectional analysis of a nationwide Japanese claims database by Go Anan, Daisuke Kikuchi, Kenji Omae, Takuo Hirose, Kouji Okada, Takefumi Mori

“…Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a novel class of antidiabetic drugs. Guidelines for the proper use of SGLT2 inhibitors recommend caution regarding urinary tract infections (UTIs). …”
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Event-Type Identification in Power Grids Using a Spectral Correlation Function-Aided Convolutional Neural Network by Ozgur Alaca, Ali Riza Ekti, Jhi-Young Joo, Nils Stenvig

“…This study introduces a novel event-type identification method, utilizing a Spectral Correlation Function (SCF)-aided Convolutional Neural Network (CNN). …”
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Pleiotropic effects of mutant huntingtin on retinopathy in two mouse models of Huntington's disease by Hui Xu, Anakha Ajayan, Ralf Langen, Jeannie Chen

“…In addition, we present novel findings that mHTT disrupts cell polarity in the photoreceptor cell layer and the retinal pigment epithelium (RPE). …”
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High-performance UWB Vivaldi antenna on FR4: A cost-effective solution for wearable technologies by Sahar Saleh, Tale Saeidi, Nick Timmons, Bader Alali, Faroq Razzaz, Ayman A. Althuwayb

“…This paper introduces a novel Vivaldi Tapered Slot Antenna (VTSA) designed for wearable Ultra-Wideband (UWB) applications, utilizing a cost-effective FR4 substrate with a thickness of 0.8 mm. …”
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