Design and assessment of lipase-CuO nanoparticle conjugates for enhanced antimicrobial efficacy against clinical pathogens by Eman M. Handak, Dina H. Amin, Mai M. Elhateir

“…These findings suggest that Lipase-CuO nanoparticle conjugates hold great promise as a novel antimicrobial strategy, offering a potential solution to combat bacterial infections, especially those caused by multidrug-resistant strains. …”
Get full text

An UPLC-MS/MS Method for Determination of Osimertinib in Rat Plasma: Application to Investigating the Effect of Ginsenoside Rg3 on the Pharmacokinetics of Osimertinib by Zhenzhen Ying, Jingyao Wei, Ruijuan Liu, Fang Zhao, Yifang Yu, Xin Tian

“…Osimertinib is a novel oral, potent, and irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for treatment of advanced T790M mutation-positive advanced non-small cell lung cancer, which is commonly combined with ginsenoside Rg3 in clinic to enhance the efficacy and minimize adverse reactions. …”
Get full text

Prone Position after Liberation from Prolonged Mechanical Ventilation in COVID-19 Respiratory Failure by Andrei Karpov, Anish R. Mitra, Sarah Crowe, Gregory Haljan

“…The sessions were well tolerated by patients, nursing, and the allied health team. Conclusions. The novel practice of PEPP after liberation from prolonged mechanical ventilation in patients with COVID-19 respiratory failure is feasible and well tolerated, and may be associated with favourable clinical outcomes including improvement in oxygenation and respiratory rate and a low rate of reintubation. …”
Get full text

Golgin Subfamily A Member 5 Is Essential for Production of Extracellular Matrix Proteins during TGF-β1-Induced Periodontal Ligament-Fibroblastic Differentiation by Hyun-Jin Kim, Seong-Min Kim, Min-Jeong Choi, Young-Joo Jang

“…Our study was to investigate the mechanism of the fibroblastic process in the periodontal ligament differentiation of hPDLSCs through the discovery of novel markers. One of the monoclonal antibodies previously established through decoy immunization was the anti-LG11 antibody, which recognized Golgi subfamily A member 5 (GOLGA5) as a PDL-fibroblastic progenitor-specific antigen. …”
Get full text

Generation of American mink induced pluripotent stem cells: a protocol by I. E. Pristyazhnyuk, A. G. Menzorov

“…In 2015 we produced American mink iPS cells and showed fibro-blast genome reprogramming at the level of gene expression and divided genes into four groups: reprogrammed, with intermediate expression, non-reprogrammed, and the ones with a “novel” expression pattern. Thus, an opportunity to study pluripotency and differentiation on two pluripotent cell types, ES and iPS cells, was added for one more species. …”
Get full text

Bipolar membrane/hydrophobic gas permeable membrane electrochemical systems for highly efficient removal of ammonium nitrogen in wastewater by YAN Zhang, KUANG Wenjie, JIANG Zhuwu, FENG Chunhua*

“…The combination of recovery and removal presents a novel approach to address challenges associated with ammonia-containing wastewater treatment.…”
Get full text

Use of Graph Database for the Integration of Heterogeneous Biological Data by Byoung-Ha Yoon, Seon-Kyu Kim, Seon-Young Kim

“…Moreover, querying a graph database in diverse ways has the potential to reveal novel relationships among heterogeneous biological data.…”
Get full text

IAR 2.0: An Algorithm for Refining Inconsistent Annotations for Time-Series Data Using Discriminative Classifiers by Einari Vaaras, Manu Airaksinen, Okko Rasanen

“…To address this, we propose a novel algorithm, iterative annotation refinement (IAR) 2.0, for refining inconsistent annotations for time-series data. …”
Get full text

Comparison Of Glucagon Like Peptide/1 Levels In Diabetic Women With Ovarian Polycystic Syndrome And Healthy Women by Namra Iqtidar, Imran Ali Zaidi, Sobia Niaz, Javaria Latif, Amir Naveed, Ayesha Yousaf

“… Objective: The aim of the study is to compare Glucagon-Like Peptide-1 levels in polycystic ovarian syndrome patients having diabetes mellitus (DM) and healthy women.Polycystic ovarian syndrome (PCOS) is one of the routine endocrinological disorders of reproductive-aged women and it is associated with many problems and complications later in life. A relatively novel peptide hormone which is included in incretins (Gut-derived hormones) is Glucagon-like peptide-1(GLP-1). …”
Get full text

Design and Optimization of a Hybrid Gas Generator for Hydrogen Peroxide Tank Pressurization by Mykhailo Vorobei, Mykola Bondarenko

“…This study presents a novel hybrid gas generator approach using hydrogen peroxide, showing how innovative materials enhance rocket system reliability and efficiency. …”
Get full text

Harris Harks Optimization Based Clustering With Fuzzy Routing for Lifetime Enhancing in Wireless Sensor Networks by Di Jing

“…In HHOCFR, an improved Harris harks optimization (HHO) algorithm is utilized to select the best cluster heads (CHs) and form optimal clusters simultaneously by a novel encoding mechanism. Moreover, good point set based population initialization and neighborhood centroid opposition based learning mechanism are used to accelerate convergence and avoid being trapped into local optima. …”
Get full text

Specialized Medical Weight Management Intervention for High-Risk Obesity by Gitanjali Srivastava, Chelsea Paris, Jessica Johnson, Emma Barnes, Brittany L. Cunningham, C. J. Stimson, Kevin D. Niswender, Sabrina J. Poon

“…Our institution’s Episodes of Care team partnered with its tertiary care obesity center to design a novel medical weight management bundle for employers that would collectively deliver high value obesity services. …”
Get full text

Design and Development of Monolithic Microwave Integrated Amplifiers and Coupling Circuits for Telecommunication Systems Applications by R. Makri, M. Gargalakos, N. K. Uzunoglu

“…Due to high cost of MMIC fabrication only the first subunit was manufactured and tests verified the simulation results. Additionally, novel techniques have been used for the design of two coupling networks at 10 GHz in order to minimize the area occupied. …”
Get full text

Algorithm and Architecture Optimization for 2D Discrete Fourier Transforms with Simultaneous Edge Artifact Removal by Faisal Mahmood, Märt Toots, Lars-Göran Öfverstedt, Ulf Skoglund

“…In this paper we present a novel FPGA-based solution to calculate 2D DFTs with simultaneous edge artifact removal for high-performance applications. …”
Get full text

Mechanical properties and macro–micro failure mechanisms of granite under thermal treatment and inclination by Yue Cao, Xiaowu Zhang, Lei Sun, Yadong Zheng, Chong Li

“…This study is built on a novel combined compression and shear test system, investigating granite’s physical and mechanical properties and macroscopic failure characteristics under varying temperatures and inclination angles. …”
Get full text

Confidence-Aware Embedding for Knowledge Graph Entity Typing by Yu Zhao, Jiayue Hou, Zongjian Yu, Yun Zhang, Qing Li

“…To address this problem, we propose ConfE, a novel confidence-aware embedding approach for modeling the (entity, entity type) tuples, which takes tuple confidence into consideration for learning better embeddings. …”
Get full text

The interaction of Adipose Derived Stem Cells and Breast Cancer by Natasha Cunningham, Ava O'Meara, Cathy L. Brougham

“…Which in future could be a target for novel treatment therapies, thus giving patients a better prognosis and survival rate by providing a personalised molecular approach of treatment.…”
Get full text

Pesticidal Activity of Sundarban Mangrove Plant Extracts against Sitophilus Pests and Identification of Active Constituents Using LC-MS by Md. Abdur Rahman, Rinku Rani Paul, Chaina Biswas, Hakima Akter, Razina Rouf, Sushmita Nath, Jamil A. Shilpi, Lutfun Nahar, Stayajit D. Sarker, Shaikh Jamal Uddin

“…Plants act as a rich source of novel natural pesticides. In the backdrop of the recent revival of interest in developing plant-based insecticides, this study was carried out to investigate the pesticidal activity of Sundarban mangrove plants. …”
Get full text

RNA modification writer-based immunological profile and genomic landscape of tumor microenvironment in lung adenocarcinoma by Qiang Xu, Lingyu Kong, Zhezhu Han, Xiuying Jin, Mingyan Ding, Zhengri Piao, Songnan Zhang

“…The potential for undoing epigenetic changes may develop novel therapeutic and prognostic approaches. However, the roles of these RNA modifications in the tumor microenvironment (TME) are still unknown. …”
Get full text

Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults by Ya-Nan Zhang, Qin-Qiu Wang, Yi-Shu Chen, Chao Shen, Cheng-Fu Xu

“…UHR was significantly associated with NAFLD and may serve as a novel and reliable marker for NAFLD in lean adults.…”
Get full text