Myeloid cell-derived apCAFs promote HNSCC progression by regulating proportion of CD4+ and CD8+ T cells by Feilong Ren, Lin Meng, Shize Zheng, Jiasen Cui, Shaoyi Song, Xing Li, Dandan Wang, Xing Li, Qilin Liu, Wenhuan Bu, Hongchen Sun

“…Significance: ApCAFs derived from myeloid cells promote the progression of HNSCC by increasing the ratio of CD4+/CD8+ cells, indicating potential novel targets to be used to treat the human HNSCC. …”
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Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy by Cetin Akpolat, Muhammed M. Kurt, Merve Yılmaz, Fikriye Ordulu, Ferhat Evliyaoglu

“…Optical coherence tomography angiography could be a novel and promising noninvasive diagnostic technique in patients with inactive Graves’ ophthalmopathy to detect foveal and parafoveal vessel density changes compared to healthy subjects. …”
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Network pharmacology combined with experimental verification for exploring the potential mechanism of phellodendrine against depression by Lili Hu, Na Wu, Jue Wang, Donghui Cai

“…The mRNA levels of CHRM1, HTR1A and key targets of the PI3K/Akt signalling pathway were also influenced. Our research reveals novel mechanisms underlying the anti-MDD effects of PHE through network pharmacology and experiments, which provides a new direction for the development of antidepressants.…”
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Characteristics and Clinical Course of Patients with Acute Myocardial Infarction and ST-segment Elevation with and without Interatrial Block by Francisco de Jesús Valladares Carvajal, Verónica Mercedes Carretero Acosta, Raimundo Carmona Puerta, Aymara Marcia Hernández Cardoso, Ernesto Julio Bernal Valladares

“…<strong>Foundation:</strong> it is novel to establish the relationship between interatrial block and acute myocardial infarction with ST-segment elevation due to the few studies that address the subject. …”
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MONITORING AND ANALYSIS OF STUDENTS' PERFORMANCE DURING SOFTWARE DEVELOPMENT by Oleksandr Sharyhin, Vasyl Fedorets, Oksana Klochko

“…The primary focus is on the development of novel performance metrics that effectively capture the level of control required from the Team Leader and the quality of work assessed by the QA Engineer. …”
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Identified VCAM1 as prognostic gene in gastric cancer by co-expression network analysis by Wenjuan Li, Hong Gao, Jianjun Liu

“…In conclusion, this study identifies VCAM1 as a promising diagnostic and prognostic factor, suggesting novel avenues for diagnostic and therapeutic approaches in gastric cancer.…”
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Beyond Text Generation: Assessing Large Language Models’ Ability to Reason Logically and Follow Strict Rules by Zhiyong Han, Fortunato Battaglia, Kush Mansuria, Yoav Heyman, Stanley R. Terlecky

“…However, a neglected issue in the debate concerning the applications of LLMs is whether they can reason logically and follow rules in novel contexts, which are critical for our understanding and applications of LLMs. …”
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Experimental study on the simultaneous effect of smart water and clay particles on the stability of asphaltene molecule and emulsion phase by Mina Sadat Mahdavi, Amir Hossein Saeedi Dehaghani

“…In this study, we investigated the synergistic roles of asphaltene and clay in the smart water flooding process using a novel experimental approach. Our results provide new insights into how the behavior and properties of water in heavy oil emulsions are affected by changes in ion-tuned water in clay-rich sandstone reservoirs. …”
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Green awakening: The rising influence of minority shareholders And ESG in shaping China's sustainable future by Shanshan Yue, Norkhairul Hafiz Bajuri, Guang Ye, Farid Ullah

“…Second, it introduces the novel moderating role of ESG ratings, showing how they can shift minority shareholders’ focus toward long-term sustainability goals. …”
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Integrating piecewise and symbolic regression with remote sensing data for spatiotemporal analysis of surface water total dissolved solids in the Karun River, Iran by Javad Zahiri, Mohammad Reza Nikoo, Adell Moradi-Sabzkouhi, Mitra Cheraghi, Nazmi Mat Nawi

“…This study presents a novel hybrid modeling approach that combines piecewise and symbolic regression (SR) models with Landsat imagery to predict TDS levels in river systems. …”
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Navigating uncertainty in environmental DNA detection of a nuisance marine macroalga. by Patrick K Nichols, Kaʻuaʻoa M S Fraiola, Alison R Sherwood, Brian B Hauk, Keolohilani H Lopes, Colt A Davis, James T Fumo, Chelsie W W Counsell, Taylor M Williams, Heather L Spalding, Peter B Marko

“…Detecting nuisance species at low abundances with minimal uncertainty is vital for successful containment and eradication. We developed a novel eDNA assay to detect a nuisance marine macroalga across its colonization front using surface seawater samples from Papahānaumokuākea Marine National Monument (PMNM), one of the world's largest marine reserves. …”
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Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment by Li G, He F, Feng J, Xu G, Wu C, Qiao Y, Liu Y, Chen H, Du P, Wang J

“…In an enzymolysis model of rat OA, PAs/PF127 nanospheres significantly reduce joint space swelling in the early stages of cartilage destruction and accelerate the formation of subchondral bone and cartilaginous surface.Implication: This study offers valuable insights into the preparation of novel PA nanospheres for effective repair of OA.Keywords: procyanidin, self-assembling nanospheres, injectable, osteoarthritis treatment…”
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IM-OFDM ISAC Outperforms OFDM ISAC by Combining Multiple Sensing Observations by Hugo Hawkins, Chao Xu, Lie-Liang Yang, Lajos Hanzo

“…The existing solutions either insert a radar signal into the deactivated subcarriers, thereby using a radar signal for sensing, or employ compressed sensing, which leads to a lower sensing performance than OFDM ISAC. Hence, a novel low complexity algorithm is proposed for ensuring that an IM-OFDM ISAC system outperforms its OFDM ISAC counterpart for both communication and sensing. …”
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Eigen Solution of Neural Networks and Its Application in Prediction and Analysis of Controller Parameters of Grinding Robot in Complex Environments by Shixi Tang, Jinan Gu, Keming Tang, Wei Ding, Zhengyang Shang

“…Lastly, to verify the eigen solution theory of neural networks, the proposed theory was applied to a novel prediction and analysis model of controller parameters of grinding robot in complex environments with deep neural networks and then build prediction model with deep learning neural networks for controller parameters of grinding robot. …”
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InceptionDTA: Predicting drug-target binding affinity with biological context features and inception networks by Mahmood Kalemati, Mojtaba Zamani Emani, Somayyeh Koohi

“…In this paper, we introduce InceptionDTA, a novel drug-target binding affinity prediction model that leverages CharVec, an enhanced variant of Prot2Vec, to incorporate both biological context and categorical features into protein sequence encoding. …”
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Research on Feature Extracted Method for Flutter Test Based on EMD and CNN by Hua Zheng, Zhenglong Wu, Shiqiang Duan, Jiangtao Zhou

“…Inspired by deep learning concepts, a novel feature extraction method for flutter signal analysis was established in this study by combining the convolutional neural network (CNN) with empirical mode decomposition (EMD). …”
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Navigating large-volume subcutaneous injections of biopharmaceuticals: a systematic review of clinical pipelines and approved products by Philip Green, Andreas Schneider, Jakob Lange

“…These findings highlight the importance of developing large-volume drug delivery systems and novel formulations to reduce injection volumes. The analysis provides valuable guidance for new product development, as well as for marketing and commercialization strategies in the rapidly evolving LVSC landscape.…”
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Triple Endobutton with Coracoacromial Ligament Transfer: A Modified Technique for Fixation of Acromioclavicular Joint Dislocation by Vikas Kesari, Jatin Prakash, Jyoti Garg, Divesh Jalan, Karan Maggo, Naval Bhatia

“…Introduction: The study explores a novel technique for the fixation of acromioclavicular joint (ACJ) dislocation utilizing triple Endobutton and coracoacromial ligament (CAL) transfer. …”
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DA5-CH and Semaglutide Protect against Neurodegeneration and Reduce α-Synuclein Levels in the 6-OHDA Parkinson’s Disease Rat Model by Lingyu Zhang, Chun Li, Zijuan Zhang, Zhenqiang Zhang, Qian-Qian Jin, Lin Li, Christian Hölscher

“…Insulin desensitization has been observed in the brains of patients with Parkinson’s disease (PD), which is a progressive neurodegenerative disorder for which there is no cure. Semaglutide is a novel long-actingglucagon-likepeptide-1 (GLP-1) receptor agonist that is on the market as a treatment for type 2 diabetes. …”
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Prognostic value of albumin-bilirubin grade in patients with cholangiocarcinoma: a systematic review and meta-analysis by Mahyaar Omouri-Kharashtomi, Seyedeh Yasaman Alemohammad, Negin Moazed, Inas Afzali Nezhad, Hamed Ghoshouni

“…This systematic review and meta-analysis aims to assess the prognostic value of the novel hepatic function assessment measure known as albumin-bilirubin (ALBI) grade in patients with CCA. …”
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