Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study by Esra Cataltepe, Eda Ceker, Ayse Fadiloglu, Fatih Gungor, Nermin Karakurt, Zekeriya Ulger, Hacer Dogan Varan

“…Conclusion SII is significantly associated with sarcopenia in a geriatric outpatient population, and a population-specific SII cut-off may serve as a novel, simple, and practical biomarker for diagnosing sarcopenia.…”
Get full text

Replication-transcription complex of coronaviruses: functions of individual viral non-structural subunits, properties and architecture of their complexes by E. L. Mishchenko, V. A. Ivanisenko

“…Severe acute respiratory syndrome CoV (SARS-CoV), Middle East respiratory syndrome CoV (MERS-CoV), and the novel coronavirus (2019-nCoV, SARS-CoV-2) have been identif ied as causing global pandemics. …”
Get full text

A review on intrathecal administration of medications for leptomeningeal metastases in solid tumors by Xuemei Wang, Chi Yao, Li Quan, Junxiang Zhou

“…In recent years, the advent of novel anti-tumor drugs has led to a growing number of agents being employed for IT administration in the treatment of malignant tumors with LMD. …”
Get full text

Differentially Expressed MicroRNAs in the Development of Early Diabetic Retinopathy by Qiaoyun Gong, Jia’nan Xie, Yang Liu, Ying Li, Guanfang Su

“…Therefore, miRNA modulation and the targeting of miRNA effects on transcription factors could represent novel and effective DR-treatment strategies.…”
Get full text

Multimodal heterogeneous graph fusion for automated obstructive sleep apnea-hypopnea syndrome diagnosis by Haoyu Wang, Xihe Qiu, Bin Li, Xiaoyu Tan, Jingjing Huang

“…This study presents a novel heterogeneous graph convolutional fusion network (HeteroGCFNet) leveraging multimodal physiological signals and domain knowledge for automated OSAHS diagnosis. …”
Get full text

Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System by Yuji Tsuchikawa, Naosuke Kamei, Yohei Sanada, Toshio Nakamae, Takahiro Harada, Kazunori Imaizumi, Takayuki Akimoto, Shigeru Miyaki, Nobuo Adachi

“…Further, LZTR1, which regulates R-RAS upstream of the ERK1/2 pathway, a signal that promotes myelination, has been identified as a novel target of the miR-23-27-24 cluster in this study.…”
Get full text

Anodal tDCS and virtual reality gait rehabilitation in individuals with chronic stroke: a case series report by Aracely Marks, Shelley Oliveira Barbosa, Daniella Napoli, Susan E. D'Andrea

“…Emerging technologies such as virtual reality (VR) and transcranial direct current stimulation (tDCS) have shown potential to enhance neuroplasticity and functional recovery, suggesting that their combined use could offer a novel pathway for stroke rehabilitation.ObjectiveThis study evaluated the efficacy of an integrated VR and tDCS treadmill training protocol in improving gait and mobility outcomes among individuals with chronic stroke.MethodsFive chronic stroke patients were recruited for this study. …”
Get full text

Effects of Aspirin on Odontogenesis of Human Dental Pulp Cells and TGF-β1 Liberation from Dentin In Vitro by V. Khampatee, C. Zhang, L. Chou

“…This in vitro study demonstrated that ASA, especially in high concentrations, promoted the odontogenesis of HDPCs and TGF-β1 liberation from dentin, showing the potential of being incorporated into the novel pulp capping materials for dental tissue regeneration.…”
Get full text

Application of Extreme Gradient Boosting Based on Grey Relation Analysis for Prediction of Compressive Strength of Concrete by Liyun Cui, Peiyuan Chen, Liang Wang, Jin Li, Hao Ling

“…This study presents a novel predictive system as follows: extreme gradient boosting (XGBoost) based on grey relation analysis (GRA) for predicting the compressive strength of concrete containing slag and metakaolin. …”
Get full text

A Vaginal Inlay for Reduction of Stress Urinary Incontinence: Outcome of a Randomized Clinical Trial and Four User Acceptance Studies by Aino Fianu Jonasson, Karin Bryder, Elisabeth Sthengel

“…A multicenter, randomized, controlled clinical trial and four postmarket user acceptance investigations were carried out to document the safety, performance, and user acceptance of Efemia Bladder Support, a novel vaginal inlay for the temporary reduction of stress urinary incontinence (SUI). …”
Get full text

Cardiovascular Disease Detection through Innovative Imbalanced Learning and AUC Optimization by Karthikeyan Palanisamy, Krishnaveni Krishnasamy, Praba Venkadasamy

“…In this paper, we introduce a novel imbalanced learning approach named Imbalanced Maximizing-Area Under the Curve (AUC) Proximal Support Vector Machine (ImAUC-PSVM), which harnesses the foundational principles of traditional PSVM for the detection of CVDs. …”
Get full text

Isolation and Characterization of Potential Antibiotic-Producing Actinomycetes from Water and Soil Sediments of Different Regions of Nepal by Bhanu Shrestha, Dharmendra Kumar Nath, Alina Maharjan, Anju Poudel, Roshani Nhuchhen Pradhan, Sagar Aryal

“…The water source and soil sediments of Nepal provide suitable environments for actinomycetes towards obtaining a novel antimicrobial agent. The study of actinomycetes from various unexploited areas of Nepal is necessary. …”
Get full text

Evaluation of the Cytotoxicity of Aqueous Extract and Oleo-Essential Oil of Dorema ammoniacum Plant Oleo-Gum Resin in Some Human Cancer Cell Lines by Pardis Mohammadi Pour, Spideh Bidad, Gholamreza Bahrami, Leila Hosseinzadeh, Mahdi Mojarrab, Mohammad Hosein Farzaei

Get full text

The impact of digital transformation on sustainability: a case of the Iranian telecom industry by Jamal Aghayari, Changiz Valmohammadi, Mahmood Alborzi

“…Digital technologies transform markets and create novel paradigms in the industry. In addition, they present new solutions to organizations to cope with sustainability issues. …”
Get full text

Analysis of Arc Re-Ignition in Vacuum Interrupter-Based HVdc Circuit Breakers by Tamer Eliyan, Ali Saeed Almuflih, Z. M. S. Elbarbary, Fady Wadie

“…The results indicate that active L-C branches improve performance, but the multi-injection method outperforms both passive and active designs, achieving the lowest TRV and arcing time. This work provides novel insights into the arc-reignition behavior of VI-HVdc-CBs and offers practical guidelines for optimizing HVdc circuit breaker performance, aiming to minimize arc reignitions, TRV, and arcing time for more reliable HVdc system protection.…”
Get full text

Nutritional safety and suitability of a specific protein hydrolysate manufactured by Fonterra Co‐operative Group Ltd derived from a whey protein concentrate and used in infant form... by EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan de Henauw, Karen‐Ildico Hirsch‐Ernst, Angeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Laurence Castle, Mary Fewtrell, Hildegard Przyrembel, Ariane Titz, Dominique Turck

Get full text

Application of Nano-Titanium Dioxide in Food Antibacterial Packaging Materials by Jiarui Li, Dequan Zhang, Chengli Hou

“…This review aims to provide a whole comprehensive understanding of novel antibacterial packaging systems based on nano-TiO₂.…”
Get full text

Facile Synthesis of Graphene Oxide/Titanate Nanotube Composites and Their Application for Cobalt(II) Removal by Min-Da Xu, Zhen Jin, Wen-Jie Xie, De-Cai Wang, Guang-Song Xu, Ai-Jing Wang, Ran Zhang, Jian Huang

“…In this work, the novel graphene oxide/titanate nanotubes (GTNT) composites were synthesized through a facile and high-yield alkaline hydrothermal method. …”
Get full text

Cognitive asymmetry in rats in response to emergent vs. disappearing affordances by Wojciech Pisula, Klaudia Modlinska, Anna Chrzanowska, Katarzyna Goncikowska

“…Abstract This study examines the effects of novel environmental changes on the behavior of rats in an experimental chamber. …”
Get full text

Loss of SNHG4 Attenuated Spinal Nerve Ligation-Triggered Neuropathic Pain through Sponging miR-423-5p by Xia Pan, Cheng Shen, Yayi Huang, Long Wang, Zhongyuan Xia

“…Therefore, our study indicated SNHG4 as a novel therapeutic target for neuropathic pain via sponging miR-423-5p.…”
Get full text