20-HETE mediates Ang II-induced cardiac hypertrophy via ROS and Ca2+ signaling in H9c2 cells by Jingyi Han, Jiaojiao Li, Lianlian Liu, Kaiyuan Li, Chun Zhang, Yong Han

“…These findings suggested that targeting 20-HETE reduction or blocking its receptor action could offer a novel therapeutic approach for cardiovascular diseases associated with Ang II.…”
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Phenotypic insights into genetic risk factors for immune-related adverse events in cancer immunotherapy by Haochuan Ma, Dili Song, Haibo Zhang, Taidong Li, Xing Jin

“…Results MR-PheWAS identified numerous risk factors for irAEs, encompassing both previously documented and novel associations. Specifically, we identified 105 traits with probable causal relationships to all-grade irAEs and 119 traits with suggestive associations. …”
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Patient Experience of Living With Hemophilia A: A Conceptual Model of Humanistic and Symptomatic Experience in Adolescents, Adults, and Children by Zalmai Hakimi, Rakhee Ghelani, Linda Bystrická, Nana Kragh, Patrick Marquis, Jameel Nazir, Nadine McGale

“…**Conclusion:** Insights gathered through the interviews and resulting conceptual model support development of new therapies to address the physical and social challenges identified by PwHA and highlight a need for novel hemophilia A treatments that can ease treatment administration, provide adequate level of protection, and enable life to be lived normally.…”
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3-DOF Inertial Piezoelectric Actuator for Angular Positioning of the Optical Mirror by Andrius Ceponis, Dalius Mazeika, Regimantas Bareikis

“…Article introduces a novel 3-DOF piezoelectric actuator designed to achieve the high-precision angular motion of a spherical rotor and an optical mirror around three axes. …”
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Studies of the Interaction between Isoimperatorin and Human Serum Albumin by Multispectroscopic Method: Identification of Possible Binding Site of the Compound Using Esterase Activ... by Samira Ranjbar, Yalda Shokoohinia, Sirous Ghobadi, Nooshin Bijari, Saeed Gholamzadeh, Nastaran Moradi, Mohammad Reza Ashrafi-Kooshk, Abbas Aghaei, Reza Khodarahmi

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MicroRNA-29b Suppresses Inflammation and Protects Blood-Brain Barrier Integrity in Ischemic Stroke by Xiaoqing Ma, Ho Jun Yun, Kenneth Elkin, Yunliang Guo, Yuchuan Ding, Guangwen Li

“…Leukocytic miR-29b attenuates inflammatory response by augmenting BBB integrity through C1QTNF6, suggesting a novel miR-29b-based therapeutic therapy for ischemic stroke.…”
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YAP Overexpression in Breast Cancer Cells Promotes Angiogenesis through Activating YAP Signaling in Vascular Endothelial Cells by Yu Yan, Qiang Song, Li Yao, Liang Zhao, Hui Cai

“…YAP-YAP interaction between breast cancer cells and endothelial cells could promote tumor angiogenesis, supporting that YAP is a potential marker and target for developing novel therapeutic strategies against breast cancer.…”
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Preliminary In Vitro Evaluation of the Probiotic Potential of the Bacteriocinogenic Strain Enterococcus lactis PMD74 Isolated from Ezine Cheese by Başar Uymaz Tezel

“…The nonstarter fermented foods serve as sources for the isolation of novel strains. The present study aimed to report the novelty of the bacteriocinogenic Enterococcus lactis PMD74 strain and the in vitro assessment of its potential as a probiotic candidate. …”
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Sternal-Wound Infections following Coronary Artery Bypass Graft: Could Implementing Value-Based Purchasing be Beneficial? by Dominique Brandt, Maximilian Blüher, Julie Lankiewicz, Peter J. Mallow, Rhodri Saunders

“…Mutually beneficial VBP agreements might be one method to promote uptake of novel methods of SWI prevention.…”
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Present and future of cancer nano-immunotherapy: opportunities, obstacles and challenges by Man Wang, Fei Yu, Yuan Zhang

“…Strategies to remove these hindrances mainly focus on the development of combinatorial therapies or the exploitation of novel immunotherapeutic mediations. Nanomaterials carrying anticancer agents to the target site are considered as practical approaches for cancer treatment. …”
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Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Grow... by Alena Chumanevich, Piper Wedman, Carole A. Oskeritzian

“…These studies identify a novel proangiogenic axis encompassing MC/S1P/S1PR2 likely relevant to inflammation.…”
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Papaverine Enhances the Oncolytic Effects of Newcastle Disease Virus on Breast Cancer In Vitro and In Vivo by Sura Akram, Ahmed Majeed Al-Shammari, Hayder B. Sahib, Majid Sakhi Jabir

“…Therefore, we aimed at assessing the novel combination of the AMHA1 strain of Newcastle disease virus (NDV) and nonnarcotic opium alkaloid (papaverine) against breast cancer models in vitro and in vivo. …”
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Repeatability and High-Speed Validation of Supplemental Lead-Extrusion Energy Dissipation Devices by Geoffrey W. Rodgers, J. Geoffrey Chase, John B. Mander

“…They provide significant energy dissipation and force capacity in a small volume, enabling a range of novel low to no damage connections and systems. However, despite several research study tests and a limited range of velocity testing, they have never been tested across a realistic velocity range or for robustness to manufacture and design across several devices. …”
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Adipose Tissue-Specific Deletion of 12/15-Lipoxygenase Protects Mice from the Consequences of a High-Fat Diet by Banumathi K. Cole, Margaret A. Morris, Wojciech J. Grzesik, Kendall A. Leone, Jerry L. Nadler

“…Therefore, deletion of 12/15-LO in adipose tissue can offer local and systemic protection from obesity-induced consequences, and blocking 12/15-LO activity in adipose tissue may be a novel therapeutic target in the treatment of type 2 diabetes.…”
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Semantic-Aware Top-k Multirequest Optimal Route by Shuang Wang, Yingchun Xu, Yinzhe Wang, Hezhi Liu, Qiaoqiao Zhang, Tiemin Ma, Shengnan Liu, Siyuan Zhang, Anliang Li

“…Another problem is that most of the previous studies consider that a POI belongs to a category, and they do not consider that a POI may provide various kinds of services even in the same category. So, we propose a novel top-k optimal route planning algorithm based on semantic perception (KOR-SP). …”
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Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy by Amelia C. McCue, Stephen J. Demarest, Karen J. Froning, Michael J. Hickey, Stephen Antonysamy, Brian Kuhlman

“…Here, we solve the crystal structure of the antigen-binding fragment of a novel anti-CD3 antibody, E10, in complex with its epitope from CD3 and use this information to engineer a masked form of the antibody that can activate by the tumor-enriched protease matrix metalloproteinase 2 (MMP-2). …”
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Upregulated Solute Carrier SLC39A1 Promotes Gastric Cancer Proliferation and Indicates Unfavorable Prognosis by Dan Yu, Yong Chen, Ming Luo, Yanjin Peng, Shengen Yi

“…Therefore, targeting SLC39A1 may provide novel therapeutic insights.…”
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Field apple scab susceptibility of a diverse Malus germplasm collection identifies potential sources of resistance for apple breeding by David Papp, Liqiang Gao, Ranjita Thapa, Dan Olmstead, Awais Khan

“…These accessions are promising for use in future genetic studies to identify novel sources of scab resistance alleles for apple breeding to develop cultivars with durable apple scab resistance.…”
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Effectiveness of Centrality Measures for Competitive Influence Diffusion in Social Networks by Fairouz Medjahed, Elisenda Molina, Juan Tejada

“…We attempt to explain these results by introducing a novel metric, the Early Influence Diffusion (EID) index, which measures the early influence diffusion of a strategy in a non-competitive setting. …”
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Heuristic Forest Fire Detection Using the Deep Learning Model with Optimized Cluster Head Selection Technique by Sengottaiyan N., Ananthi J., Rajesh Sharma R., Hamsanandhini S., Sungheetha Akey, Chinnaiyan R., Ketema Adare Gemeda

“…Their development and implementation represent a crucial aspect of modern disaster risk management and resilience systems. This novel technique introduces a modern approach to forest fire prediction by integrating a deep learning model with an optimized cluster head selection technique. …”
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