HIF-3α-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop by Qiaohui Gao, Zhenghua Ren, Shengyuan Jiao, Juan Guo, Xia Miao, Jin Wang, Junye Liu

“…Taken together, our findings indicate a novel hypoxia-induced HIF-3α and miR-630 regulatory feedback loop contributing to metastasis and progression of cervical cancer cells and suggest that HIF-3α and miR-630 might act as potential biomarkers and therapeutic targets for cervical cancer in the future.…”
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Molecular Hydrogen Modulates T Cell Differentiation and Enhances Neuro-Regeneration in a Vascular Dementia Mouse Model by Dain Lee, Hyunjun Jo, Jong-Il Choi

“…Behavioral assessments using open field and novel object recognition tests revealed that VaD mice exhibited anxiety-deficient behavior and memory impairment, both of which were reversed by H₂ treatment. …”
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Modeling the modulation of beta oscillations in the basal ganglia by dual-target optogenetic stimulation by Xiaomin Wang, Ying Yu, Qingyun Wang

“…The findings unveil effective circuit mechanisms of optogenetic stimulation and provide novel insights for designing precise regulatory strategies for PD.…”
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Metabolomic profiling reveals systemic metabolic disruptions induced by combined exposure to particulate matter and ozone by Yue Ge, Maliha S. Nash, Aimen K. Farraj

“…In conclusion, this study provides new insights into the systemic metabolic effects of air pollutant exposure, identifies novel metabolic targets of pollutant-induced toxicity, highlights the complex interactions resulting from combined exposure to multiple pollutants, and underscores the importance of assessing the combined effects of multiple pollutants in air pollution risk assessments.…”
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Blood-based biomarkers in patients with non-small cell lung cancer treated with immune checkpoint blockade by Yo-Ting Tsai, Jeffrey Schlom, Renee N. Donahue

“…Further research aimed at longitudinal monitoring of circulating biomarkers is also crucial to comprehend immune dynamics and resistance mechanisms and should be used alongside tissue-based methods that interrogate the tumor microenvironment to guide treatment decisions and may inform on the development of novel therapeutic strategies. The data reviewed here reinforce the opportunity to refine patient stratification, optimize treatments, and improve outcomes not only in NSCLC but also in the wider spectrum of solid tumors undergoing immunotherapy.…”
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A Nomogram Based on Apelin-12 for the Prediction of Major Adverse Cardiovascular Events after Percutaneous Coronary Intervention among Patients with ST-Segment Elevation Myocardial... by Enfa Zhao, Hang Xie, Yushun Zhang

“…We established and validated a novel nomogram that can provide individual prediction of MACEs for patients with STEMI after PCI procedures in a Chinese population. …”
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Optimizing Photovoltaic Panel Performance: A Comparative Study of Meta-Heuristic Algorithms by M. Sundar Rajan

“…The centerpiece of this study is the introduction of a novel hybrid algorithm, HPSGWO, which combines Particle Swarm Optimization (PSO) and Grey Wolf Optimizer (GWO) techniques. …”
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Benchmarking protein language models for protein crystallization by Raghvendra Mall, Rahul Kaushik, Zachary A. Martinez, Matt W. Thomson, Filippo Castiglione

“…Starting with 3000 generated proteins and through a step of filtration processes including consensus of all open PLM-based classifiers, sequence identity through CD-HIT, secondary structure compatibility, aggregation screening, homology search and foldability evaluation, we identified a set of 5 novel proteins as potentially crystallizable.…”
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Roles of Copper Transport Systems Members in Breast Cancer by Yichang Chen, Chen Li, Mengxin Li, Bing Han

“…Conclusion By integrating the members of the copper transport system in breast cancer, we offer novel insights for the treatment of breast cancer and copper‐related therapies.…”
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Influence of College Teacher’s Instructional Design on the Development of College Students’ Thinking of Innovation Multi-Algorithms Perspective Analysis by Leilei Wang, Jie Zhou, Xinying Li

“…The results support the following: Compared with the traditional teaching design, the novel network instructional system is more conducive to helping college students cultivate learning interests and enhance their innovative thinking level. …”
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Hypergraph User Embeddings and Session Contrastive Learning for POI Recommendation by Yan Zhang, Bin Wang, Qian Zhang, Sulei Zhu, Yan Ma

“…To address these issues, we propose a novel method called Hypergraph User Embedding and Session Contrastive Learning (HUE-SCL) for next POI recommendation. …”
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Immunoinfiltration Analysis of Mitochondrial Damage‐Related Genes in Lung Adenocarcinoma and Construction of a Classification and Prognostic Model Integrated With WGCNA and Machine... by Jirong Zhang, Lin Lin

“…The gene module and models identified have potential applications in LUAD classification and prognosis, offering novel markers for precision medicine. Conclusion This study uncovers the relationship between mitochondrial damage and immune infiltration in LUAD, paving the way for molecular classification, prognosis prediction, and personalized treatment strategies.…”
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Design and implementation of an asynchronous online course-based undergraduate research experience (CURE) in computational genomics. by Seema B Plaisier, Danielle O Alarid, Joelle A Denning, Sara E Brownell, Kenneth H Buetow, Katelyn M Cooper, Melissa A Wilson

“…We generated custom learning materials and leveraged remotely accessible computational tools to address 2 novel research questions over 2 iterations of the genomics CURE, one testing bioinformatics approaches and one mining cancer genomics data. …”
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Land conversions not climate effects are the dominant indirect consequence of sun-driven CO2 capture, conversion, and sequestration by Moritz Adam, Thomas Kleinen, Matthias M May, Kira Rehfeld

“…Here, we study Earth system impacts of modular, s un-powered process chains, which combine d irect a ir c apture with (electro)chemical c onversion of the captured CO _2 into liquid or solid sink products and subsequent product s torage (sDACCCS). Drawing on a novel explicit representation of CO _2 removal in a state-of-the-art Earth system model, we find that these process chains can be renewably powered and have minimal implications for the climate and carbon cycle. …”
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A temporal knowledge graph reasoning model based on recurrent encoding and contrastive learning by Weitong Liu, Khairunnisa Hasikin, Anis Salwa Mohd Khairuddin, Meizhen Liu, Xuechen Zhao

“…Motivated by these considerations, this work introduces a novel temporal knowledge graph reasoning model, named Temporal Reasoning with Recurrent Encoding and Contrastive Learning (TRCL), which integrates recurrent encoding and contrastive learning techniques. …”
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Learning deep forest for face anti-spoofing: An alternative to the neural network against adversarial attacks by Rizhao Cai, Liepiao Zhang, Changsheng Chen, Yongjian Hu, Alex Kot

“…In this paper, we have proposed a novel solution for FAS against adversarial attacks, leveraging a deep forest model. …”
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Modeling and optimization of dyeing process of polyamide 6 and woolen fabrics with plum-tree leaves using artificial intelligence by Fatemeh Shahmoradi Ghaheh, Milad Razbin, Majid Tehrani, Leila Zolfipour Aghdam Vayghan, Mehdi Sadrjahani

“…In response, this study introduces a novel algorithmic approach that integrates response surface methodology (RSM), artificial neural network (ANN), and genetic algorithm (GA) techniques for the precise fine-tuning of concentration, time, pH, and temperature. …”
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From phenotypic to molecular diagnosis: Insights from a clinical immunology service focused on inborn errors of immunity in Colombia by Mónica Fernandes Pineda, Andrés F. Zea-Vera

“…A broad spectrum of genetic defects, novel and previously reported, were described, including mutations in the following genes: ATM, BTK, ERBIN, MAB21L2, RAG2, SAVI, SH2D1A, STAT1, SYK, and TMEM173. …”
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Bioinformatic Analysis Reveals Central Role for Tumor-Infiltrating Immune Cells in Uveal Melanoma Progression by Mieszko Lachota, Anton Lennikov, Karl-Johan Malmberg, Radoslaw Zagozdzon

“…Therefore, we propose further investigations of IDO1 and metalloproteinases as novel targets for immunotherapy in lymphocyte-rich metastatic UM patients.…”
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The Development and Content of Movement Quality Assessments in Athletic Populations: A Systematic Review and Multilevel Meta-Analysis by Gyan A. Wijekulasuriya, Carl T. Woods, Aden Kittel, Paul Larkin

“…Second, academics could use these results to help design new assessments for novel applications that meet rigour and reliability requirements. …”
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