Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect by Xiyuan Wang, Zhengsheng Zhan, Zhen Wang, Yan Zhang, Kaiyan Zhao, Han Li, Xiaoqian Zhou, Yuting Guo, Fengying Fan, Jian Ding, Meiyu Geng, Xuekui Yu, Wenhu Duan, Zuoquan Xie

“…In conclusion, DW18343 serves as a novel non‐nucleotide STING agonist with systemic antitumor effect through the activation of antitumor immunity.…”
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TIM‐4 increases the proportion of CD4+CD25+FOXP3+ regulatory T cells in the pancreatic ductal adenocarcinoma microenvironment by inhibiting IL‐6 secretion by Ziyao Wang, Zerong Xie, Yu Mou, Ruiman Geng, Chen Chen, Nengwen Ke

“…Analyzing of the role of TIM‐4 in the immune regulation of PDAC can offer novel insights for immune therapy. Methods We analyzed the TIM‐4 expression in tumor specimens from PDAC patients. …”
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NcSWP8, a New Spore Wall Protein, Interacts with Polar Tube Proteins in the Parasitic Microsporidia <i>Vairimorpha (Nosema) ceranae</i> by Pengfei Wang, Dufu Li, Qianmin Hai, Siming Liu, Yueyue Zhang, Jun Zhang, Jinshan Xu, Zhengang Ma, Zeyang Zhou

“…Here, we report the expression and identification of a novel spore wall protein, NcSWP8, with a molecular mass of 21.37 kDa in <i>V. ceranae</i>. …”
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Description of global innovative methods in developing the WHO Community Engagement Package by Jackeline Alger, Don Mathanga, Semeeh Akinwale Omoleke, Noel Juban, Meredith Labarda, Obinna Ikechukwu Ekwunife, Obioma Nwaorgu, Allan Ulitin, Jana Deborah Mier-Alpaño, María Isabel Echavarría, Yolanda Vargas Bayugo, Jose Rene Bagani Cruz, Pauline Marie Padilla Tiangco, Ukam Ebe Oyene, Alberto Ong Jr, Marvinson See Fajardo, Barwani Khaura Msiska, Lorena Abella Lizcano, Natalia Gomez Quenguan, Claudia Ivette Nieto Anderson, Briana Yasmin Beltran, Elsy Denia Carcamo Rodriguez, Eduardo Salomón Núñez, Vera Nkosi-Kholimeliwa, Glory Mwafulirwa-Kabaghe

“…The package comprises four modules organised by major themes such as mobilising communities, strengthening health systems, CE in health emergencies and CE as a driver for health equity.Conclusion After pilot implementation, tools and resources were made available for training and continuous collection of novel CE lessons and experiences from diverse socio-geographical contexts.…”
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LipBengal: Pioneering Bengali lip-reading dataset for pronunciation mapping through lip gesturesHugging Face by Md. Tanvir Rahman Sahed, Md. Tanjil Islam Aronno, Hussain Nyeem, Md. Abdul Wahed, Tashrif Ahsan, R Rafiul Islam, Tareque Bashar Ovi, Manab Kumar Kundu, Jane Alam Sadeef

“…Captured under diverse and uncontrolled conditions, LipBengal stands as the most extensive Bengali lip-reading dataset to date, designed to facilitate robust benchmarking and validation of novel deep learning architectures. Detailed annotations extend from phoneme- level classifications to full sentence constructions, providing a granular and comprehensive dataset. …”
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The Role of Hibiscus sabdariffa L. (Roselle) in Maintenance of Ex Vivo Murine Bone Marrow-Derived Hematopoietic Stem Cells by Zariyantey Abdul Hamid, Winnie Hii Lin Lin, Basma Jibril Abdalla, Ong Bee Yuen, Elda Surhaida Latif, Jamaludin Mohamed, Nor Fadilah Rajab, Chow Paik Wah, Muhd Khairul Akmal Wak Harto, Siti Balkis Budin

“…Conclusively, Roselle shows novel property as potential supplement and genoprotectant against oxidative damage to cultured HSCs.…”
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The solvent effect, preferential solvation of metformin hydrochloride in binary mixed solvents of methanol/ethanol + water mixtures from 278.15 K to 323.15 K by Adel Noubigh, Abdalazeem A. Omar, Manef Abderrabba

“…This study provides a novel quantitative analysis of metformin hydrochloride (MET-HCl) solvation behavior in binary solvents mixtures of methyl alcohol and water, as well as ethyl alcohol and water, addressing critical gaps in understanding its solubility mechanisms for pharmaceutical formulation. …”
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Carboxylated Graphene: An Innovative Approach to Enhanced IgA-SARS-CoV-2 Electrochemical Biosensing by Luciana de Souza Freire, Ariamna María Dip Gandarilla, Yonny Romaguera Barcelay, Camila Macena Ruzo, Barbara Batista Salgado, Ana P. M. Tavares, Francisco Xavier Nobre, Julio Nino de Souza Neto, Spartaco Astolfi-Filho, Ștefan Țălu, Pritesh Lalwani, Niranjan Patra, Walter Ricardo Brito

“…This study presents a novel carboxylation method for synthesizing carboxylated graphene (CG) under acidic conditions, enhancing biosensing capabilities. …”
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Seq2scFv: a toolkit for the comprehensive analysis of display libraries from long-read sequencing platforms by Marianne Bachmann Salvy, Luca Santuari, Emanuel Schmid-Siegert, Nikolaos Lykoskoufis, Ioannis Xenarios, Bulak Arpat

“…To address this methodological gap, we introduce Seq2scFv, a novel open-source toolkit designed for analyzing in vitro display libraries from long-read sequencing platforms. …”
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Engineering p‐Orbital States via Molecular Modules in All‐Organic Electrocatalysts toward Direct Water Oxidation by Li‐Hong Yu, Xue‐Feng Zhang, Zi‐Ming Ye, Hong‐Gang Du, Li‐Dong Wang, Ping‐Ping Xu, Yuhai Dou, Li‐Ming Cao, Chun‐Ting He

“…A variety of spectroscopic techniques and density functional theory (DFT) calculations reveal that the p‐band center of these catalysts can be shifted stepwise to optimize the oxygen intermediate adsorption and lower the reaction energy barrier. This work provides a novel perspective for enhancing the electrocatalytic performance of metal‐free COFs.…”
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Integrating Multilayer Perceptron and Support Vector Regression for Enhanced State of Health Estimation in Lithium-Ion Batteries by Sadiqa Jafari, Jisoo Kim, Wonil Choi, Yung-Cheol Byun

“…This paper presents a novel strategy for tackling the difficulties associated with intricate preprocessing and the demand for extensive data in conventional approaches to SOH measurement. …”
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Hypoxia Promotes Vascular Smooth Muscle Cell (VSMC) Differentiation of Adipose-Derived Stem Cell (ADSC) by Regulating Mettl3 and Paracrine Factors by Jiaying Lin, Qianqian Zhu, Jialyu Huang, Renfei Cai, Yanping Kuang

“…These observations might contribute to novel progress in understanding the role of epitranscriptomic regulation in the VSMC differentiation of ADSCs and provide a promising perspective for new therapeutic strategies for tissue regeneration.…”
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Comprehensive analysis of ESCRT transcriptome-associated signatures and identification of the regulatory role of LMO7-AS1 in osteosarcoma by Shibing Zhao, Dasheng Tian, Fei Huang, Lei Wang, Jinhao Cheng, Zhitao He, Qitian Shen, Shuai Liang, Deliang Gong, Jun Liu, Chengfeng Yi, Chun Zhang, Erbao Bian, Juehua Jing, Tao Wang

“…In conclusion, our ESCRT transcriptome-associated signatures can act as prognostic biomarkers for OS, and LMO7-AS1 is a novel therapeutic target for the treatment of OS.…”
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Biallelic SLC13A1 loss-of-function variants result in impaired sulfate transport and skeletal phenotypes, including short stature, scoliosis, and skeletal dysplasia by Christina G. Tise, Katie Ashton, Lachlan de Hayr, Kun-Di Lee, Omkar L. Patkar, Emma Krzesinski, Jennifer A. Bassetti, Erin M. Carter, Cathleen Raggio, Andreas Zankl, Anas M. Khanshour, Kristhen N. Atala, Jonathan J. Rios, Carol A. Wise, Ying Zhu, Futao Zhang, Tony Roscioli, Michael Buckley, Robert J. Harvey, Paul A. Dawson

“…Conclusion: Biallelic loss-of-function variants in SLC13A1 are a novel cause of skeletal phenotypes in humans with a measurable biomarker. …”
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Fault current handling in large-scale MMC-HVDC systems: an improved approach with DC circuit breaker and fault current limiter by Rashid Hussain Chandio, Madad Ali Shah, Abdul Aziz Memon, Khawaja Haider Ali, Jahangeer Badar Soomro, Basem Alamri, Ahmed Althobaiti, Mohammed Alqarni

“…This paper presents a novel Hybrid FCL for the protection of large scale VSC-HVDC. …”
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Research on Cold-Energy Loss of Long-Distance Sleeve-Type Insulated Pipe for High-Temperature Deep Mines by Lijuan Zhang, Wenlong Wang, Fengtian Yue, Jingsheng Wei, Tao Gao, Yangjie Wang, Yang Zhou

“…Implementing modifications such as increasing the inlet temperature, enhancing the water flow rate, or utilizing materials with lower thermal conductivity can effectively mitigate temperature rises. Additionally, the novel sleeve-type design enhanced the pipe’s pressure-bearing capacity, reduced the required pipe length by 4752 m and minimized energy loss compared to traditional systems. …”
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The Impact of the Coexpression of MET and ESR Genes on Prognosticators and Clinical Outcomes of Breast Cancer: An Analysis for the METABRIC Dataset by Nehad M. Ayoub, Ghaith M. Al-Taani, Amer E. Alkhalifa, Dalia R. Ibrahim, Aymen Shatnawi

“…The expression of the MET/ESR genes could be a novel prognosticator and calls for future studies to evaluate the impact of combinational treatment approaches with MET inhibitors and endocrine drugs in breast cancer.…”
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Machine learning models for predicting interaction affinity energy between human serum proteins and hemodialysis membrane materials by Simin Nazari, Amira Abdelrasoul

“…This study focuses on developing machine learning algorithms that accurately and rapidly predict affinity energy between novel chemical structures of membrane materials and human serum proteins, based on a molecular docking dataset. …”
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Osseointegrated Transcutaneous Device for Amputees: A Pilot Large Animal Model by Brian T. Grisez, Andrew E. Hanselman, Karim W. Boukhemis, Trapper A. J. Lalli, Brock A. Lindsey

“…As a result, we evaluated a novel osseointegrated transcutaneous implant in a large animal. …”
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Numerical parametric study of a Kaplan turbine incorporated with a sub runner considering analysis of hydraulic dissipation by Amirhossein Khoddami, Mojtaba Tahani, Fathollah Pourfayaz, Alireza Riasi, Khalil Allah Sajadian

“…In this paper, a novel approach on Kaplan turbines, proposed and published in a US patent, has been investigated numerically using CFD tool. …”
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