Bayesian calibration and uncertainty quantification for a large nutrient load impact modelZenodoZenodoZenodo by Karel Kaurila, Risto Lignell, Frede Thingstad, Harri Kuosa, Jarno Vanhatalo

“…In this work, we developed a novel Bayesian computational approach for estimating the uncertainties in predictions of the Finnish coastal nutrient load model FICOS. …”
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Utilizing kombucha culture for coffee fermentation and biochemical characteristic analysis by Hayeong Kim, Jihyeon Jeon, Jiyeon Lee, Chaeri Song, Boncheol Gu, Nahyun Mariah Kim, Tae-hui Yang, Sejin Oh, Soochul Park, Kunal Pal, Ghahyun Jeffrey Kim, Doman Kim

“…These results support the feasibility of kombucha fermentation as a novel approach to develop specialty coffees with enhanced flavour and nutritional profiles.…”
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Li-doped C20 nanocage and its derivatives for gas sensing application: A density functional theory study by Poonam Parkar, Mohsen Doust Mohammadi, Ajay Chaudhari

“…We studied the gas-sensing properties of Li-decorated C20 nanocage and its derivatives, presenting these materials as novel candidates for sensing applications. The derivatives of C20 considered are either B-substituted, N-substituted or B and N co-substituted C20 Nanocages. …”
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Expression of VEGF-A, Otx Homeobox and p53 Family Genes in Proliferative Vitreoretinopathy by Claudio Azzolini, Ilaria Stefania Pagani, Cristina Pirrone, Davide Borroni, Simone Donati, Muna Al Oum, Diana Pigni, Anna Maria Chiaravalli, Riccardo Vinciguerra, Francesca Simonelli, Giovanni Porta

“…Individuating the genetic pathways of PVR represents a novel approach to PVR therapies.…”
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MyVivarium: A cloud-based lab animal colony management application with realtime ambient sensing by Robinson Vidva, Mir Abbas Raza, Jaswant Prabhakaran, Ayesha Sheikh, Alaina Sharp, Hayden Ott, Amelia Moore, Christopher Fleisher, Hailey Netherton, Evan Goldstein, Pothitos M. Pitychoutis, Tam V. Nguyen, Aaron Sathyanesan

“…Taken together, MyVivarium is a novel, open-source, cloud-based application template that provides a low-cost, simple, and efficient way to digitally manage research-animal colonies.…”
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Multiepitope Subunit Vaccine Design against COVID-19 Based on the Spike Protein of SARS-CoV-2: An In Silico Analysis by Hamza Arshad Dar, Yasir Waheed, Muzammil Hasan Najmi, Saba Ismail, Helal F. Hetta, Amjad Ali, Khalid Muhammad

“…Researchers around the globe need to design and develop successful therapeutics as well as vaccines against the novel COVID-19 disease. In the present study, we conducted comprehensive computer-assisted analysis on the spike glycoprotein of SARS-CoV-2 in order to design a safe and potent multiepitope vaccine. …”
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Multi-step pre-treatment of rice husk for fractionation of components including silica by Shinnosuke Ishida, Shinji Kudo, Shinji Kudo, Shusaku Asano, Shusaku Asano, Jun-ichiro Hayashi, Jun-ichiro Hayashi

“…This study introduces a novel multi-step pre-treatment process to fractionate these components efficiently, enabling their comprehensive valorization.MethodsThe process begins with hydrothermal treatment, selectively extracting hemicellulose while preserving the structural integrity of other components. …”
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Drastic Improvements in Air Quality in Ecuador during the COVID-19 Outbreak by Rasa Zalakeviciute, Renne Vasquez, Daniel Bayas, Adrian Buenano, Danilo Mejia, Rafael Zegarra, Valeria Diaz, Brian Lamb

“…Abstract In the beginning of 2020, the global human population encountered the pandemic of novel coronavirus disease 2019 (COVID-19). Despite social and economic concerns, this epidemiologic emergency has brought unexpected positive consequences for environmental quality as human activities were reduced. …”
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Compound-Specific Chlorine Isotope Analysis of Organochlorine Pesticides by Gas Chromatography-Negative Chemical Ionization Mass Spectrometry by Jing Zhang, Shenghua Liu, Jianye Gui, Xiaoya Li, Guochen Qi

“…To overcome the mentioned problems, a novel method has been developed for the CSIA-Cl of eight organochlorine pesticides using gas chromatography-negative chemical ionization mass spectrometry (GC-NCI-qMS) in this study. …”
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Deformation behaviour and microstructure characteristics of aluminium alloy cylindrical toothed parts by an innovative crossed-axes helical rolling process by Kun Li, Chao Zhang, Ming Chang, Shengdun Zhao

“…This paper conducts in-depth research on the manufacturing of toothed parts with 6061 aluminium alloy on the basis of the proposed novel crossed-axes helical rolling process. The deformation characteristics during the rolling process were analysed and the formed parts with a complete and full tooth profile were obtained by an experiment. …”
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Pre-injection of exosomes can significantly suppress ovarian cancer growth by activating the immune system in mice by Yuanyuan Wang, Changyi Zhang, Huimin Zeng, Liangliang Wang, Zanhong Wang, Zhiqiang Han

“…But in general, we emphasize that in the case of pre-injection, exosomes have great potential to combat the famous “cold tumor”, ovarian cancer, via targeting omentum and activating anti-tumor immunity, offering a novel avenue for overcoming ovarian cancer.…”
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Targeted therapy for cisplatin‐resistant lung cancer via aptamer‐guided nano‐zinc carriers containing USP14 siRNA by Xinmin Zhao, Xianghua Wu, Huijie Wang, Songtao Lai, Jialei Wang

“…Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. …”
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Role of the androgen receptor in melanoma aggressiveness by Marzia Di Donato, Costanza Maria Cristiani, Mariaelena Capone, Cinzia Garofalo, Gabriele Madonna, Lucia Carmela Passacatini, Margaret Ottaviano, Paolo Antonio Ascierto, Ferdinando Auricchio, Ennio Carbone, Antimo Migliaccio, Gabriella Castoria

“…Abstract Malignant melanoma represents the fifth most common cancer in the world and its incidence is rising. Novel therapies targeting receptor tyrosine kinases, kinases and immune checkpoints have been employed with a significant improvement of the overall survival and long-term disease containment. …”
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Clinical relevance and druggability of sole reciprocal kinase fusions: A large‐scale study by Jiao Feng, Tonghui Ma, Chunyang Wang, Baoming Wang, Qian Liu, Zhengchuang Liu, Houquan Tao, Zaiyuan Ye

“…Conclusion This inaugural multicenter study introduces a novel algorithm for detecting and treating sole reciprocal fusions in advanced cancers, expanding the patient population potentially amenable to KIs.…”
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Prognostic Factors on the Graft-versus-Host Disease-Free and Relapse-Free Survival after Adult Allogeneic Hematopoietic Stem Cell Transplantation by Yao-Chung Liu, Sheng-Hsuan Chien, Nai-Wen Fan, Ming-Hung Hu, Jyh-Pyng Gau, Chia-Jen Liu, Yuan-Bin Yu, Liang-Tsai Hsiao, Tzeon-Jye Chiou, Cheng-Hwai Tzeng, Po-Min Chen, Jin-Hwang Liu

“…The cure of hematologic disorders by allogeneic hematopoietic stem cell transplantation (HSCT) is often associated with major complications resulting in poor outcome, including graft-versus-host disease (GVHD), relapse, and death. A novel composite endpoint of GVHD-free/relapse-free survival (GRFS) in which events include grades 3-4 acute GVHD, chronic GVHD requiring systemic therapy, relapse, or death is censored to completely characterize the survival without mortality or ongoing morbidity. …”
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Biogenic silver nanoparticles produced by Trichoderma reesei inhibit SARS-CoV-2 infection, reduce lung viral load and ameliorate acute pulmonary inflammation by Marcus V.M.V. Amaral, Cláudia B. Carraro, Amanda C.C. Antoniêto, Mariana N. Costa, Thais F.C. Fraga-Silva, Ualter G. Cipriano, Rodrigo P.F. Abuná, Tamara S. Rodrigues, Ronaldo B. Martins, Andreia M. Luzenti, Glaucia R. Caruso, Priscyla D. Marcato, Vania L.D. Bonato, Dario S. Zamboni, Bergman M. Ribeiro, Sônia N. Báo, Joao S. da Silva, Flávio P. Veras, Roberto N. Silva

“…Nonetheless, our findings offer promising insights into the development of novel therapeutic strategies for combating COVID-19 and reducing its associated morbidity and mortality.…”
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Spatial profiling of endoplasmic reticulum stress markers in tumor associated cells predicts patient outcomes in pancreatic cancer by Georgia Porter, Murray D. Norris, Minoti Apte, Angelica M. Merlot

“…The correlation of high ER stress in immune cells with poor patient survival highlights the importance of the TME and the use of spatial analysis for the identification of novel biomarkers.…”
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Comparison of Resampling Methods and Radiomic Machine Learning Classifiers for Predicting Bone Quality Using Dual-Energy X-Ray Absorptiometry by Mailen Gonzalez, José Manuel Fuertes García, María Belén Zanchetta, Rubén Abdala, José María Massa

“…<b>Background/Objectives</b>: This study presents a novel approach, based on a combination of radiomic feature extraction, data resampling techniques, and machine learning algorithms, for the detection of degraded bone structures in Dual X-ray Absorptiometry (DXA) images. …”
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Parameter Optimization for Dissimilar Aluminum Alloys Joined Using Friction Stir Additive Manufacturing: A Screening Study by Senthil Kumaran Selvaraj, Akash L. Manoj, Alan B. Mathew, Akash V. Govind, Govindaswamy Sundaramali, Utkarsh Chadha, Bhaskar Vajipeyajula, Albert E. Patterson

“…These lightweight engineering materials are hard to be joined utilising traditional fusion joining techniques, necessitating the development of alternative joining techniques. The novel friction‐stir additive manufacturing (FSAM) technique, based on the concept of friction stir welding (FSW), can be used to combine aluminum alloys additively in their solid state. …”
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Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer by Der Sheng Sun, Soon Auck Hong, Hye Sung Won, Su Hyun Yoo, Han Hong Lee, Okran Kim, Yoon Ho Ko

“…High expression of tumoral Cav-1 protein in metastatic lymph node is associated with unfavorable prognosis of curative resected GC, indicating the potential of novel prognostic markers.…”
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