The Role of Mean Platelet Volume as a Predictor of Mortality in Critically Ill Patients: A Systematic Review and Meta-Analysis by Pattraporn Tajarernmuang, Arintaya Phrommintikul, Atikun Limsukon, Chaicharn Pothirat, Kaweesak Chittawatanarat

“…An increase in the mean platelet volume (MPV) has been proposed as a novel prognostic indicator in critically ill patients. …”
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Methyl Canthin-6-one-2-carboxylate Inhibits the Activation of the NLRP3 Inflammasome in Synovial Macrophages by Upregulating Nrf2 Expression by Yuanyuan Chen, Zongying Zhang, Yuan Yao, Xiaorong Zhou, Yong Ling, Liming Mao, Zhifeng Gu

“…In this study, we synthesized a novel canthin-6-one alkaloid, namely methyl canthin-6-one-2-carboxylate (Cant), and assessed its effects on NLRP3 inflammasome activation in macrophages. …”
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Smart surgical telementoring system with patch-to-pixel point tracking method by Yanwei Qu, Ling Li, Tongtong Li, Jieyu Zheng, Wentao Tang, Xiaojian Li

“…This system enables the transmission of points marked by remote doctors to grassroots doctors, updating these points’ coordinates in real-time on the local endoscopic video. In this system, a novel method named P2PTracking (Patch-to-Pixel Point Tracking) is implemented. …”
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Enhanced energy storage in electric double-layer capacitors using boron-doped graphene and upcycled carbon quantum dots derived from spent coffee grounds as electrode materials by Grishika Arora, Nuur Syahidah Sabran, Bo Zhang, H.K. Jun

“…In the pursuit of high-efficiency and sustainable energy storage solutions, we investigate a novel electrode material: boron-doped graphene (BG) combined with carbon quantum dots (CQDs) derived from upcycled, medium-roasted local Liberica spent coffee grounds. …”
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Evaluating the impact of drought and water restrictions on agricultural production in irrigated areas through crop water productivity functions and a remote sensing-based evapotran... by Joaquim Bellvert, Magí Pamies-Sans, Jaume Casadesús, Joan Girona

“…Since crop yield is closely linked to the water used (crop actual evapotranspiration, ETcact), this study proposes a novel approach based on using crop water productivity functions and a remote sensing-based surface energy balance model to spatially estimate ETcact. …”
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Prognostic significance of pathological response and lymph node status in neoadjuvant immunotherapy for potentially resectable non-small cell lung cancer by Yuan Xu, Dongjie Ma, Yingzhi Qin, Hongsheng Liu

“…Lymph node involvement adversely affected PFS (p < .01). A novel risk stratification approach based on pathological response and nodal status effectively distinguished prognostic groups, with 3-year PFS rates of 98.9%, 78.9%, and 53.3%. …”
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SS316/CCA laminated metal composite fabricated by additive friction stir deposition: Microstructure and mechanical properties by Ravi Sankar Haridas, Anurag Gumaste, Eric Kusterer, Devin Davis, Supreeth Gaddam, Brandon McWilliams, Kyu C. Cho, Rajiv S. Mishra

“…For the first time, the present study investigated the potential of the novel solid-state additive friction stir deposition (AFSD) technique to additively manufacture an LMC containing SS316 and Fe40Co20Mn20Cr15Si5 complex concentrated alloy (CS-CCA) exhibiting transformation induced plasticity (TRIP). …”
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Using computer modeling to find new LRRK2 inhibitors for parkinson’s disease by María C. García, Sebastián A. Cuesta, José R. Mora, Jose L. Paz, Yovani Marrero-Ponce, Frank Alexis, Edgar A. Márquez

“…The DrugBank screening resulted in three promising drugs—triamterene, phenazopyridine, and CRA_1801—with predicted pIC50 values greater than 7, warranting further investigation as novel PD treatments. Molecular docking and molecular dynamics simulations were performed to provide a comprehensive understanding of the interactions between LRRK2 and the inhibitors in the data set and best molecules of the screening. …”
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3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects by Kai Chen, Fang Wang, Xiumei Sun, Wenwei Ge, Mingjun Zhang, Lin Wang, Haoyu Zheng, Shikang Zheng, Haoyu Tang, Zhengjie Zhou, Guomin Wu

“…This study introduces a novel method for constructing piezoelectric ceramic scaffolds exhibiting outstanding osteogenic, angiogenic, and antibacterial properties under the combined influence of LIPUS, offering a promising treatment strategy for infectious bone defects.…”
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Facile construction of polyoxometalate-modified polyaryletherketone-based hybrid membranes with enhanced proton conductivity by Bo Hu, Qiuchen Du, Yang Yang, Dengdeng Li, Jiawang Fu, Bailing Liu, Hong-Ying Zang, Yangguang Li, Haiming Xie, Zhongmin Su

“…The development of novel proton exchange membranes (PEMs) with high proton conductivity and good mechanical performance as alternatives to Nafion is crucial. …”
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The first multiple center prospective study of rhFSH CTP in patients undergoing assisted reproductive technology in China by Longmei Wu, Huayan Yin, Lingfang Guan, Guanjian Li, Junqiang Zhang, Qunshan Shen, Xiaoqing Ni, Chao Wang, Tianjuan Wang, Hao Geng, Chuan Xu, Yunxia Cao, Xiaojin He, Bing Song

“…Abstract We assessed the safety and efficacy of rhFSH-CTP, a novel long-acting FSH agent, in controlled ovarian hyperstimulation for patients undergoing ART. …”
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Structural Characterizations and Biological Evaluation of a Natural Polysaccharide from Branches of <i>Camellia oleifera</i> Abel by Shengjia Lu, Yali Zhang, Yanghui Ou, Jianghui Xin, Hongliang Yao, Litao Guan

“…This bioactive polysaccharide adds value to waste branches by offering a novel approach to waste recycling and the development of <i>C. oleifera</i>.…”
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Androgen Receptor-Target Genes in African American Prostate Cancer Disparities by Bi-Dar Wang, Qi Yang, Kristin Ceniccola, Fernando Bianco, Ramez Andrawis, Thomas Jarrett, Harold Frazier, Steven R. Patierno, Norman H. Lee

“…Chromatin immunoprecipitation confirmed STAT1, RHOA, ITGB5, MAPKAPK2, CSNK2A,1 and PIK3CB genes as novel AR targets in PCa disparities. Moreover, functional screens revealed that androgen-stimulated AR binding and upregulation of RHOA, ITGB5, and PIK3CB genes were associated with increased invasive activity of AA PCa cells, as siRNA-mediated knockdown of each gene caused a loss of androgen-stimulated invasion. …”
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4-Thiobenzoic acid-functionalized nanocomposite probes for surface-enhanced raman spectroscopy-based detection of CA19-9 in colorectal adenocarcinoma by Yinan Hu, Tao Liu, Bo Guo, Miao Ni, Yanrong Li

“…This study presents a novel surface-enhanced Raman spectroscopy (SERS) method for detecting CA19–9 in colorectal adenocarcinoma using 4-thiobenzoic acid (4-TBA) functionalized gold nanoparticles (nanospheres). …”
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PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling by Koji Hashimoto, Yuji Kamijo, Takero Nakajima, Makoto Harada, Makoto Higuchi, Takashi Ehara, Hidekazu Shigematsu, Toshifumi Aoyama

“…The vast increase of chronic kidney disease (CKD) has attracted considerable attention worldwide, and the development of a novel therapeutic option against a representative kidney disease that leads to CKD, mesangial proliferative glomerulonephritis (MsPGN) would be significant. …”
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Assessing the influence of matcha green tea extract on NF-κB/MAPK signaling pathway activation in rats: A study on irradiation-induced acute hepatic inflammatory response by Noha Sayed Hamed, Eithar K. El Adham, Amal I. Hassan

“…Conclusion: Further research in this area may reveal the underlying mechanisms and pave the way for the development of novel therapies for radiation therapy patients.…”
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Performance Analysis of IRS-Assisted Multi-Link FSO System Under Pointing Errors by Takumi Ishida, Chedlia Ben Naila, Hiraku Okada, Masaaki Katayama

“…Nonetheless, the configuration of IRS-assisted FSO systems remains relatively novel, requiring investigation into optimizing IRS placement to enhance system performance while mitigating interference and obstacles in dynamic environmental conditions. …”
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Digital twin-centered hybrid data-driven multi-stage deep learning framework for enhanced nuclear reactor power prediction by James Daniell, Kazuma Kobayashi, Ayodeji Alajo, Syed Bahauddin Alam

“…This paper introduces a novel hybrid digital twin-focused multi-stage deep learning framework that addresses these limitations, offering a faster and more robust solution for predicting the final steady-state power of reactor transients. …”
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Knockdown of YAP/TAZ Inhibits the Migration and Invasion of Fibroblast Synovial Cells in Rheumatoid Arthritis by Regulating Autophagy by Wei Zhou, Qin Shen, Hui Wang, Jie Yang, Chen Zhang, Zijing Deng, Keyan Wu, Yang Zhou, Jing Zeng, Yu Zhang, Weigan Shen

“…Our experiments preliminarily revealed that YAP/TAZ and autophagy play important roles in the migration and invasion of RA-FLS, which might provide novel targets for the treatment of RA.…”
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Robust <inline-formula><tex-math notation="LaTeX">$H_\infty$</tex-math></inline-formula> Fault-Tolerant Observer-Based PID Path Tracking Control of Autonomous Ground Vehicle With C... by Bor-Sen Chen, Hao-Ting Liu, Ruei-Syuan Wu

“…To simplify the design procedure, a novel path reference-based feedforward linearization scheme is proposed to transform nonlinear dynamic AGV system to an equivalent linear tracking error system with nonlinear actuator signal. …”
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