NF-κB-94ins/del ATTG Genotype Contributes to the Susceptibility and Imbalanced Th17 Cells in Patients with Immune Thrombocytopenia by Jie Yu, Mingqiang Hua, Xueyun Zhao, Rui Wang, Chaoqing Zhong, Chen Zhang, Ruiqing Wang, Guosheng Li, Na He, Ming Hou, Daoxin Ma

“…The NF-κB-94ins/del ATTG genotype might serve as a novel biomarker and potential target for ITP.…”
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Optimal design for six-phase asymmetrical surface mount permanent magnet synchronous motor: An innovative approach considering fault tolerance and load variations for electric vehi... by Mahmoud Y. Mohamed, Ahmed Refaat, Ahmed Kalas, Ayman S. Abdel-Khalik, Shehab Ahmed, Mahmoud Fawzi

“…This research potentially sets a novel technique in PMSM design, steering towards machines that are not only performance-optimized but also inherently resilient to operational abnormalities.…”
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SensorDBSCAN: Semi-Supervised Active Learning Powered Method for Anomaly Detection and Diagnosis by Petr Ivanov, Maria Shtark, Alexander Kozhevnikov, Maksim Golyadkin, Dmitry Botov, Ilya Makarov

“…In this paper, we propose SensorDBSCAN, a novel semi-supervised method for anomaly detection and diagnosis. …”
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Mendelian randomization study of serum uric acid levels and urate-lowering drugs on pulmonary arterial hypertension outcomes by Xiaoling Yao, Xin Cai, Shaoqin Zhang, Yuzheng Yang, Xiangyan Yang, Wukai Ma, Zong Jiang

“…These findings provide a novel reference point for developing future therapeutic strategies for PAH.…”
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Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2 by Stephanie Ghio, Jean-Pierre Brincat, Yuksel Cetin, Frederick Lia

“… Spices and Mediterranean medicinal plants provide a rich resource for novel antiviral drug development. The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic with devastating outcomes, and hence, there is a global need to search for small-molecule inhibitors that can act against this viral pathogen. …”
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Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism by Xin Liu, Junling Wang, Huiyun Zhang, Mengmeng Zhan, Hanqiu Chen, Zeman Fang, Chiyan Xu, Huifang Chen, Shaoheng He

“…In conclusion, provocation of mast cell accumulation by mast cell tryptase suggests a novel self-amplification mechanism of mast cell accumulation. …”
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Forecasting epidemic spread of SARS-CoV-2 using ARIMA model (Case study: Iran) by T.T. Tran, L.T. Pham, Q.X. Ngo

“…Currently, the pandemic caused by a novel coronavirus, namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is one of the most serious issues worldwide. …”
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Blockchain-Assisted Hierarchical Attribute-Based Encryption Scheme for Secure Information Sharing in Industrial Internet of Things by A. Sasikumar, Logesh Ravi, Malathi Devarajan, A. Selvalakshmi, Abdulaziz Turki Almaktoom, Abdulaziz S. Almazyad, Guojiang Xiong, Ali Wagdy Mohamed

“…To address the need to exchange data between logistics networks, we proposed a novel decentralized hierarchical attribute-based encryption (HABE) scheme combining edge computing and blockchain. …”
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Targeted Inhibition of the miR-199a/214 Cluster by CRISPR Interference Augments the Tumor Tropism of Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells under Hypoxic Con... by Yumei Luo, Xuehu Xu, Xiuli An, Xiaofang Sun, Shu Wang, Detu Zhu

“…These findings suggest a novel application of CRISPRi in NSC-based tumor-targeted gene therapy.…”
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Lycium ruthenicum Murr. treatment attenuates APPswE/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model by Min Wang, Tianxiong Xu, Li Gao, Chujun Huang, Piao Xu, Congcong Gong, William Kwame Amakye, Linfeng Liao, Maojin Yao, Jiaoyan Ren

“…Mitochondria morphology in different tissues of a novel mitochondrial outer membrane protein Slc25a46 knockout mouse and a traditional APPSWE/PS1ΔE9 transgenic mouse were examined using transmission electron microscope (TEM). …”
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In Vitro Assessment of Anthelmintic Activities of Rauwolfia vomitoria (Apocynaceae) Stem Bark and Roots against Parasitic Stages of Schistosoma mansoni and Cytotoxic Study by Emmanuel Mouafo Tekwu, Kwabena Mante Bosompem, William Kofi Anyan, Regina Appiah-Opong, Kofi Baffour-Awuah Owusu, Mabel Deladem Tettey, Felicia Amanfo Kissi, Alfred Ampomah Appiah, Veronique Penlap Beng, Alexander Kwadwo Nyarko

“…The reliance on a single drug, praziquantel, is a motivation for the search of novel antischistosomal compounds. This study investigated the anthelmintic activity of the stem bark and roots of Rauwolfia vomitoria against two life stages of Schistosoma mansoni. …”
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HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells by Zhiqi Xie, Jinjin Shao, Zeren Shen, Zhichao Ye, Yoshiaki Okada, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

“…Our findings reveal a novel mechanism of action of HDAC1-3 inhibitors in MDSCs and suggest a potential synergistic immunotherapy strategy for clinical benefit in HCC.…”
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Defect Detection in Concrete Structures Based on Characteristics of Hammer Reaction Force and Apparent Stiffness of Concrete by Koki Shoda, Jun Younes Louhi Kasahara, Qi An, Atsushi Yamashita

“…To address this challenge, we propose a novel method that enhances defect discrimination accuracy by integrating statistical processing and physical property analysis within a machine learning framework designed for force signal characteristics. …”
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Evaluation of the effects of short-term PM2.5 exposure on triglyceride-glucose metrics in a population in eastern China by Zhenpeng Guo, Chenchen Yang, Qiang Zhang, Xinling Shi, Xiaona Li, Qun Zhang, Jianming Wang

“…Abstract Context The triglyceride-glucose (TyG) index, a novel health indicator, has been widely employed to assess insulin resistance (IR). …”
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Gut microbiota dysfunction in Crohn’s disease by Sylvie Buffet-Bataillon, Sylvie Buffet-Bataillon, Gabriela Durão, Isabelle Le Huërou-Luron, Olivier Rué, Olivier Rué, Yann Le Cunff, Vincent Cattoir, Guillaume Bouguen

“…Here, we investigated metagenomic functions using PICRUSt2 during the course of CD to better understand microbiota-related disease mechanisms and provide new insights for novel therapeutic strategies.MethodsWe performed 16S rRNA-based microbial profiling of 567 faecal samples collected from a cohort of 383 CD patients, including 291 remissions (CR), 177 mild-moderate (CM) and 99 severe (CS) disease states. …”
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Current Perspectives on Treatment of Gram-Positive Infections in India: What Is the Way Forward? by Atul P. Kulkarni, Vasant C. Nagvekar, Balaji Veeraraghavan, Anup R. Warrier, Deepak TS, Jaishid Ahdal, Rishi Jain

“…The most important step is development of newer antimicrobial agents with novel mechanisms of action and favourable pharmacokinetic profile. …”
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Ultra‐Broad Emission Copper Halide Scintillator‐Based X‐Ray Imager by Haocheng Lv, Wenyi Shao, Haifeng Chen, Guoyang Zhu, Yao Wang, Zhenzhong Zhang, Hongwei Liang

“…Abstract Lead‐free metal‐halide scintillators are gaining considerable attention as more eco‐friendly and superior alternatives to their lead‐based counterparts. However, novel broad‐emission band scintillators like the state‐of‐the‐art CsI: Tl scintillator, which can generate high signals due to its strong compatibility with the spectral responsivity of regular photodiode arrays, are still less investigated. …”
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Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India by Nabeela Usmani, Mukhtar Ahmad, Saba Khan, Mohammad Mustufa Khan, Haseeb Ahsan, Sadaf Parveen, Roshan Alam

“… Background: Coronavirus disease 2019 (Covid-19) is a novel disease caused by coronavirus-2 that causes severe acute respiratory syndrome (SARS-CoV-2). …”
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3D Localization of FRB 20190425A for Its Potential Host Galaxy and Implications by Da-Chun Qiang, Zhi-Qiang You, Sheng Yang, Zong-Hong Zhu, Ting-Wan Chen

“…In this paper, we introduce a novel approach to identifying potential host galaxies in three-dimensional space. …”
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Informed Design of a Gravity Science Experiment for the Future Geophysical Investigation of the Uranian Moons by Valerio Filice, Gael Cascioli, Sébastien Le Maistre, Rose-Marie Baland, Antony Trinh, Erwan Mazarico, Sander Goossens

“…With a launch window opening in 2029, the Uranus Orbiter and Probe (UOP) mission has been prioritized as a NASA Flagship mission for the next decade (2023–2032) to comprehensively study Uranus and its major moons—Miranda, Ariel, Umbriel, Titania, and Oberon. We define and apply novel mission design principles centered on scientific objectives to UOP's gravity science (GS) experiment. …”
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