Genome‐wide association study of tuberculosis in the western Chinese Han and Tibetan population by Hao Bai, Mengyuan Song, Shikun Lei, Lin Jiao, Xuejiao Hu, Tao Wu, Jiajia Song, Tangyuheng Liu, Wu Peng, Zhenzhen Zhao, Zirui Meng, Binwu Ying

“…Our findings suggest a novel mechanism of the interaction with the HLA class II genes and reinforce the importance of the HLA class II alleles in response to TB.…”
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Three-Dimensional Assessment of Dental Enamel Microcrack Progression After Orthodontic Bracket Debonding Using Optical Coherence Tomography by Ahmed Haj Hamdan, Sm Abu Saleah, Daewoon Seong, Naresh Kumar Ravichandran, Ruchire Eranga Wijesinghe, Sangyeob Han, Jeehyun Kim, Mansik Jeon, Hyo-Sang Park

“…Three-dimensional OCT imaging monitored existing EMCs at higher risk of progression and detected new EMCs following orthodontic bracket debonding. This study provides novel insights into EMC progression regarding the length, width, depth, and number after debonding.…”
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Dysregulation of c-Jun (JUN) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) in obese people and their predictive values for metabolic syndrome by Chenxi Yang, Yi Chen, Guangfeng Tang, Tongtong Shen, Li Li

“…This study aimed to identify new biomarkers for predicting MetS and provide a novel diagnostic approach. Herein, the expression profiles of c-Jun (JUN) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) in individuals with obesity and patients with MetS from the Gene Expression Omnibus database. …”
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FS-DDPG: Optimal Control of a Fan Coil Unit System Based on Safe Reinforcement Learning by Chenyang Li, Qiming Fu, Jianping Chen, You Lu, Yunzhe Wang, Hongjie Wu

“…To address this issue, we propose a novel FCU control method, Fluctuation Suppression–Deep Deterministic Policy Gradient (FS-DDPG). …”
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Albumin as an Effective Auxiliary Agent for the Enriched Extraction of Anthraquinones and Curcumin from Plant Matrices by Chiara Collevecchio, Salvatore Genovese, Francesco Epifano, Lorenzo Marchetti, Serena Fiorito

“…The addition of bovine serum albumin in the processing of plant extracts has been shown to be a novel and a valid alternative, comparing favourably to already reported methodologies. …”
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Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics by George S. Biggs, Emma E. Cawood, Aini Vuorinen, William J. McCarthy, Harry Wilders, Ioannis G. Riziotis, Antonie J. van der Zouwen, Jonathan Pettinger, Luke Nightingale, Peiling Chen, Andrew J. Powell, David House, Simon J. Boulton, J. Mark Skehel, Katrin Rittinger, Jacob T. Bush

“…High-content screening approaches to expand the ligandable proteome offer the potential to expedite the discovery of novel chemical probes to study protein function. …”
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Hydrogen Sulfide Increases Nitric Oxide Production and Subsequent S-Nitrosylation in Endothelial Cells by Ping-Ho Chen, Yaw-Syan Fu, Yun-Ming Wang, Kun-Han Yang, Danny Ling Wang, Bin Huang

“…Elevated gaseous NO levels were observed by a novel and specific fluorescent probe, 5-amino-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid methyl ester (FA-OMe), and quantified by flow cytometry. …”
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NRBF2 plays a crucial role in the acquisition process of learning and memory, independent of the Vps34 complex by Songfen Wu, Songfen Wu, Songfen Wu, Haicai Zhuang, Haicai Zhuang, Haicai Zhuang, Xidan Zhou, Kuan Li, Kuan Li, Kuan Li

“…Our results suggested that NRBF2 deletion impaired memory acquisition through an autophagy-independent pathway and provided novel insights into the role of NRBF2 in the central nervous system.DiscussionThis study offer new insights into the role of NRBF2 and highlight the potential of targeting NRBF2 as a therapeutic strategy for addressing cognitive deficits associated with various disorders.…”
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The first two mitochondrial genomes for the genus Ramaria reveal mitochondrial genome evolution of Ramaria and phylogeny of Basidiomycota by Qiang Li, Lijiao Li, Ting Zhang, Peng Xiang, Qian Wu, Wenying Tu, Zhijie Bao, Liang Zou, Cheng Chen

“…We further found frequent intron loss/gain and potential intron transfer events in Phallomycetidae mitogenomes during the evolution, and the mitogenomes of R. rubella contained a novel intron P44. Phylogenetic analyses using both Bayesian inference (BI) and Maximum Likelihood (ML) methods based on a combined mitochondrial gene dataset obtained an identical and well-supported phylogenetic tree for Basidiomycota, wherein R. cfr. rubripermanens and Turbinellus floccosus are sister species. …”
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Interleaved Landsman Converter with Class Topper Optimized PI Control in Sensorless BLDC Motor Drive for Electric Vehicle by Suresh V., Jahnavi V.G., Manjula D., Lokesh M.

“…In order to achieve the set goals, the following tasks were accomplished: The scientific novelty of this work lies in the design of a novel interleaved Landsman converter along with Class Topper Optimization (CTO) algorithm. …”
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Development and Alpha Testing of EzHifz Application: Al-Quran Memorization Tool by Nor Musliza Mustafa, Zulkifly Mohd Zaki, Khairul Anuar Mohamad, Mokmin Basri, Sedek Ariffin

“…This study contributes to the novel design and evaluation of the Quran memorization application based on the Quran memorization model. …”
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Immune Toxicity with Checkpoint Inhibition for Metastatic Melanoma: Case Series and Clinical Management by Anna J. Lomax, Jennifer Lim, Robert Cheng, Arianne Sweeting, Patricia Lowe, Neil McGill, Nicholas Shackel, Elizabeth L. Chua, Catriona McNeil

“…Immune checkpoint inhibitors (anti-PD-1 and anti-CTLA-4 antibodies) are a standard of care for advanced melanoma. Novel toxicities comprise immune-related adverse events (irAE). …”
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A Semi-Automated Usability Evaluation Framework for Interactive Image Segmentation Systems by Mario Amrehn, Stefan Steidl, Reinier Kortekaas, Maddalena Strumia, Markus Weingarten, Markus Kowarschik, Andreas Maier

“…Nevertheless, publications introducing novel interactive segmentation systems (ISS) often lack an objective comparison of HCI aspects. …”
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Antibacterial Activity of Rationally Designed Antimicrobial Peptides by Marius B. Tincho, Thureyah Morris, Mervin Meyer, Ashley Pretorius

“…Due to these reasons, there is a need to seek and develop novel therapeutic regimens to reduce the rapid scale of bacterial infections. …”
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Specific Immune Responses and Oncolytic Effects Induced by EBV LMP2A-Armed Modified Ankara-Vaccinia Virus Vectored Vaccines in Nasopharyngeal Cancer by Liying Sun, Chao Liu, Junping Peng

“…Here, we constructed a novel MVA-LMP2A recombinant virus and investigated its specific immune response induction and oncolytic effect. …”
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Pilot Trial of the Reboot Online Program: An Internet-Delivered, Multidisciplinary Pain Management Program for Chronic Pain by Regina Schultz, Jessica Smith, Jill M. Newby, Tania Gardner, Christine T. Shiner, Gavin Andrews, Steven G. Faux

“…A prospective, feasibility pilot study was conducted to trial a novel, multidisciplinary online pain management program: the “Reboot Online” program. …”
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Enhancing Thermal Comfort in Historic Buildings by Wind-Driven Ventilation Systems—A Case Study of the Praterateliers in Vienna by Aida Shayegani, Viera Joklova, Katarina Kristianova, Juraj Illes

“…By addressing the unique challenges posed by cultural heritage buildings, such as the Praterateliers’ Pavilions, this research highlights the role of sustainable ventilation strategies in mitigating urban overheating, which is exacerbated by climate change. A novel focus is placed on integrating windcatchers with passive systems like earth tubes and solar ventilation to reduce reliance on mechanical cooling and achieve lower carbon emissions while adhering to heritage preservation regulations. …”
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Probiotic Potential of Lactobacillus Strains with Antifungal Activity Isolated from Animal Manure by Soundharrajan Ilavenil, Hyung Soo Park, Mayakrishnan Vijayakumar, Mariadhas Valan Arasu, Da Hye Kim, Sivanesan Ravikumar, Ki Choon Choi

“…Thus, KCC-25, KCC-26, KCC-27, and KCC-28 could have the survival ability in the harsh condition of the digestive system in the gastrointestinal tract. In conclusion, novel L. plantarum KCC-25, KCC-26, KCC-27, and KCC-28 could be considered as potential antimicrobial probiotic strains.…”
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Masked Modeling-Based Ultrasound Image Classification via Self-Supervised Learning by Kele Xu, Kang You, Boqing Zhu, Ming Feng, Dawei Feng, Cheng Yang

“…Furthermore, to address the challenges posed by hard samples in ultrasound data, we propose a novel hard sample mining strategy. To evaluate the effectiveness of our proposed method, we conduct experiments on two datasets. …”
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Evaluating the relative predictive validity of measures of self-referential processing for depressive symptom severity by Ethel Siew Ee Tan, Hong Ming Tan, Kah Vui Fong, Sheryl Yu Xuan Tey, Nikita Rane, Chong Wei Ho, Zhao Yuan Tan, Rachel Jing Min Ong, Chloe Teo, Jerall Yu, Maxine Lee, An Rae Teo, Sin Kee Ong, Xin Ying Lim, Jin Lin Kee, Jussi Keppo, Geoffrey Chern-Yee Tan

“…Participants completed the standard SRET and its variations, including Likert scales and matrix formats. Both standard and novel SRET measures were calculated and compared for their relative and incremental contribution to their associations with depression, with mean squared error (MSE) used as the primary metric for measuring predictive accuracy. …”
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