A heteropolysaccharide from Rhodiola rosea L.: preparation, purification and anti-tumor activities in H22-bearing mice by Yaru Wu, Qing Wang, Huiping Liu, Lulu Niu, Mengyu Li, Qi Jia

“…In order to explore the influence to hepatocellular carcinoma, a novel cold water-soluble polysaccharide was separated from Rhodiola rosea L. root (RLP) and then its structure and anti-cancer activities were tested. …”
Get full text

YOLOv8s-Longan: a lightweight detection method for the longan fruit-picking UAV by Jun Li, Jun Li, Jun Li, Kaixuan Wu, Meiqi Zhang, Hengxu Chen, Hengyi Lin, Yuju Mai, Linlin Shi

“…To improve the detection accuracy, a crossstage local network structure VOVGSCSPC module is designed, which can help the model better understand the information of the image through multiscale feature fusion and improve the perception and expression ability of the model. Meanwhile, the novel Inner-SIoU loss function is proposed as the loss function of the target bounding box.Results and discussionThe experimental results show that the proposed algorithm has good detection ability for densely distributed and mutually occluded longan string fruit under complex backgrounds with a mAP@0.5 of 84.3%. …”
Get full text

Ellagic acid ameliorates cisplatin-induced acute kidney injury by regulating inflammation and SIRT6/TNF-α signaling by Yuqi Gao, Kezheng Peng, Yida Wang, Yannan Guo, Chenye Zeng, Rui Hua, Qingfei Liu, Xue Li, Ying Qiu, Zhao Wang

“…For this reason, finding novel targeted therapies to attenuate the nephrotoxicity of cisplatin should be pretty significant. …”
Get full text

Synthesis and Spatial Structure of 3-Phenylacrylic Acid Octahydroquinolizin-1-Ylmethyl Ester and 2-(Octahydroquinolizin-1-Ylmethyl)Isoindole-1,3-Dione by Zh.S. Nurmaganbetov, O.A. Nurkenov, S.D. Fazylov, D.M. Turdybekov, Ye.V. Minayeva, G. Khabdolda, A.M. Ibraybekova, Zh.S. Tilla, K.M. Turdybekov

“…The values of chemical shifts, multiplet and integrated intensity of 1H and 13C signals in one-dimensional NMR spectra of the novel compounds were determined. The crystal structures of 3-phenylacrylic acid octahydroquinolizin-1-ylmethyl ester and 2-(octahydroquinolizin-1-ylmethyl)isoindole-1,3-dione were elucidated through X-ray analysis. …”
Get full text

Antimicrobial activity of indigenous Oscillatoria spp. against prevalent bacterial diseases in fish and shellfish by Jannatul Nayeem, Sumit Kanti Dey, Proma Dey, Mohammed Abdullah Ayoun, Dipa Debi, Mohammed Nurul Absar Khan, Helena Khatoon

“…Thus, Oscillatoria spp. contain potential antibacterial substances that facilitate detailed analysis of Oscillatoria spp. bioactive compounds for creating novel antibiotics and benefitting both aquaculture and pharmaceutical industries.…”
Get full text

Schwann Cell‐Specific Ablation of Beclin 1 Impairs Myelination and Leads to Motor and Sensory Neuropathy in Mice by Lisa Gambarotto, Loris Russo, Silvia Bresolin, Luca Persano, Rachele D'Amore, Giulia Ronchi, Federica Zen, Luisa Muratori, Alice Cani, Samuele Negro, Aram Megighian, Sonia Calabrò, Paola Braghetta, Dario Bizzotto, Matilde Cescon

“…By knocking out Beclin 1 in SCs here a novel mouse model (Becn1 cKO) is generated, developing a severe and progressive neuropathy, accompanied by involuntary tremors, body weight loss, and premature death. …”
Get full text

The Effect of Diabetes-Associated Autoantigens on Cell Processes in Human PBMCs and Their Relevance to Autoimmune Diabetes Development by Jana Vcelakova, Radek Blatny, Zbynek Halbhuber, Michal Kolar, Ales Neuwirth, Lenka Petruzelkova, Tereza Ulmannova, Stanislava Kolouskova, Zdenek Sumnik, Pavlina Pithova, Maria Krivjanska, Dominik Filipp, Katerina Stechova

“…Genes involved in Th17 and TGF-beta cascades may represent novel, promising (pre)diabetes biomarkers.…”
Get full text

Bias in Discontinuous Elevational Transects for Tracking Species Range Shifts by Shixuan Li, Jiannan Yao, Yang Lin, Siyu Wu, Zhongjie Yang, Chao Jin, Yuhan Zhang, Zhen Wang, Jinliang Liu, Guochun Shen, Mingjian Yu

“…To address this concern, we utilized species distribution data from a novel continuous elevational transect to evaluate the accuracy of discontinuous transect methods. …”
Get full text

Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages by Qi Wang, Juqing Huang, Yafeng Zheng, Xuefang Guan, Chenchun Lai, Huiying Gao, Chi-Tang Ho, Bin Lin

“…Collectively, our results indicated that Se-TE may have the potential to be used as a novel food ingredient for the development of various anti-inflammatory foods and the treatment and prevention of chronic inflammation-related diseases.…”
Get full text

Identification of Potential Serum Metabolic Biomarkers of Diabetic Kidney Disease: A Widely Targeted Metabolomics Study by Hang Zhang, Jing-jing Zuo, Si-si Dong, Yuan Lan, Chen-wei Wu, Guang-yun Mao, Chao Zheng

“…This study is aimed at determining novel sensitive and specific biomarkers to distinguish DKD from their counterparts effectively based on the widely targeted metabolomics approach. …”
Get full text

Individual-network based predictions of microbial interaction signatures for response to biological therapies in IBD patients by Federico Melograna, Padhmanand Sudhakar, Behnam Yousefi, Behnam Yousefi, Clara Caenepeel, Gwen Falony, Gwen Falony, Gwen Falony, Sara Vieira-Silva, Sara Vieira-Silva, Sara Vieira-Silva, Sreenikhitha Krishnamoorthy, David Fardo, Bram Verstockt, Bram Verstockt, Jeroen Raes, Jeroen Raes, Severine Vermeire, Severine Vermeire, Kristel Van Steen

“…This study introduces a novel approach using Individual Specific Networks (ISNs) derived from faecal microbial measurements of IBD patients across multiple cohorts. …”
Get full text

Microstructure evolution and mechanical properties of ZK61 magnesium alloy fabricated via friction stir additive manufacturing by Yichen Xiao, Lei Shi, Chuansong Wu, Shengli Li, Ji Chen, Wenjian Ren

“…Friction stir additive manufacturing (FSAM) is a novel solid-phase AM method which enables AM of Mg alloy components to achieve excellent mechanical properties. …”
Get full text

Lateral Polydactyly of the Foot: Surgical Outcomes Based on a New Classification by Junko Otsuka, MD, Emiko Horii, MD, Shukuki Koh, MD, Hiroki Takeshige, MD

“…The objective of this study was to propose a novel classification for lateral polydactyly of the foot that integrates both visual appearance and radiographic findings and to delineate surgical techniques and their outcomes based on this classification. …”
Get full text

Psychological Safety in Saudi Arabian Healthcare: A Scoping Review by Yumna Ali, Roaya Alqurashi, Ahmed M. Asfahani, Mark Leonard, Catherine Elisa John, Yasuhiro Kotera

“…Our aim, therefore, is to raise awareness of the potential for novel intervention programs to improve psychological safety. …”
Get full text

Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort Study by Raviraj Menon, Poornima Baby, Anil Kumar V., Sandeep Surendran, Manu Pradeep, Aiswarya Rajendran, Gaayathri Suju, Arathy Ashok

“…Logistic regression analysis indicated that chronic kidney disease (OR = 14.0), CRP >100 IU/L (OR = 6.964), and S. albumin <3 gm/dl (OR = 8.0) were risk factors associated with mortality and can guide in risk stratification. Hypoalbuminemia is a novel mortality risk factor, detected in this study, and requires further investigation to validate its utility as a prognostic marker and reveal possible therapeutic benefits in clinical correction.…”
Get full text

Structural bioinformatics for rational drug design by Soroush Mozaffari, Agnethe Moen, Che Yee Ng, Gerry A.F. Nicolaes, Kanin Wichapong

“…Finally, we summarize relevant data and highlight cases where various computational approaches were successfully applied to develop novel inhibitors, as presented during the ISTH 2024 Congress.…”
Get full text

Hybrid Harmony Search Algorithm Integrating Differential Evolution and L&#x00E9;vy Flight for Engineering Optimization by Feng Qin, Azlan Mohd Zain, Kai-Qing Zhou, Norfadzlan Bin Yusup, Didik Dwi Prasetya, Rozita Abdul Jalil, Zaheera Zainal Abidin, Mahadi Bahari, Yusri Kamin, Mazlina Abdul Majid

“…This paper proposes HSA-DELF, a novel hybrid algorithm that combines differential evolution (DE) and L&#x00E9;vy flight (LF) techniques to enhance the performance of HSA. …”
Get full text

BP-3 exposure at environmentally relevant concentrations induced male developmental reproductive toxicity via ER/CCL27/ROS pathway in mice by Hong-Mei Li, Yan-Rong Gao, Qing Chang, Xiu-Ying Pei, Jia-He Sun, Yu-Jia Lin, Ya-Nan Tian, Qiang-Wang, Bin Zhao, Heidi Qunhui Xie, Hui-Ming Ma, Hai-Ming Xu

“…This study provides a novel perspective understanding the male reproductive toxicity risk caused by BPs exposure at low-doses.…”
Get full text

Potentially commercializable nerve guidance conduits for peripheral nerve injury: Past, present, and future by Chundi Liu, Mouyuan Sun, Lining Lin, Yaxian Luo, Lianjie Peng, Jingyu Zhang, Tao Qiu, Zhichao Liu, Jun Yin, Mengfei Yu

“…The emergence of nerve guidance conduits as novel tissue engineering tools offers a promising alternative strategy. …”
Get full text

Pheromones in Crane Flies: Behaviorally Active Cuticular Compounds in <i>Tipula autumnalis</i> Loew (Diptera: Tipulidae) by Vincas Būda, Violeta Apšegaitė, Laima Blažytė-Čereškienė, Sigitas Podėnas, João Pedro de A. Souza, Paulo H. G. Zarbin, Linas Labanauskas, Tomas Paškevičius, Vilma Baužienė, Sandra Radžiutė

“…Among the semiochemicals, the established stereostructure of (<i>Z</i>, <i>E</i>)-6,9-pentacosadiene and the olfactory/behavioral effects of (<i>R</i>)- and (<i>S</i>)-3-methylheneicosane were novel findings in insects.…”
Get full text