Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention by Rodrigo Fonseca, Yuan Xiao Zhu, Laura A. Bruins, Joseph Ahmann, Cecilia de Bonolo Campos, Esteban Braggio, Xianfeng Chen, Mariano Arribas, Susie Darvish, Seth Welsh, Erin Meermeier, Kiran K. Mangalaparthi, Richard K. Kandasamy, Greg Ahmann, J. Erin Wiedmeier-Nutor, Akhilesh Pandey, Marta Chesi, P. Leif Bergsagel, Rafael Fonseca

“…Abstract Investigating venetoclax (VTX) resistance in multiple myeloma (MM) is crucial for the development of novel therapeutic strategies to tackle resistance. …”
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Waste heat recovery cycles integration into a net-Zero emission solar-thermal multi-generation system; Techno-economic analysis and ANN-MOPSO optimization by Pradeep Kumar Singh, Ali Basem, Rebwar Nasir Dara, Mohamed Shaban, Sarminah Samad, Raymond Ghandour, Ahmad Almadhor, Samah G. Babiker, Iskandar Shernazarov, Ibrahim A. Alsayer

“…This paper presents a novel solar-powered multi-generation system (MGS) integrated with a fuel cell, designed to enhance both sustainability and operational reliability. …”
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Gellan Gum Enhances the Quality of Egg-Based Yoghurt by Changing the Water Phase Distribution and Improving the Gel Texture by Yuanyuan Zhang, Jianwei Zang, Shutong Liu, Bingxu Yan, Daobang Tang, Jiguang Chen, Dongwen Li, Dayong Peng, Zebo Liu, Zhongping Yin

“…Egg-based yoghurt (EBY) is a novel yoghurt fermented by lactic acid bacteria with high nutritional and health values, serving as a potential alternative to milk-based yoghurt. …”
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Tunning valence state of cobalt centers in Cu/Co-CoO1-x for significantly boosting water-gas shift reaction by Xing-Chi Li, Jun-Hao Wang, Tao-Tao Huang, Yang Hu, Xin Li, De-Jiu Wang, Wei-Wei Wang, Kai Xu, Chun-Jiang Jia, Hao Dong, Guangshe Li, Chen Li, Ya-Wen Zhang

“…The results would provide guidance for the construction of novel heterogeneous catalyst with dual active sites and clarify its underlying reactivity enhancement mechanism induced by the tunning of valence state of metal centers for heterogeneous catalytic reactions.…”
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3D Printed Swordfish‐Like Wireless Millirobot by Xingcheng Ou, Yu Sheng, Jiaqi Huang, Dantong Huang, Xiaohong Li, Ran Bi, Guoliang Chen, Weijie Hu, Shuang‐Zhuang Guo

“…Inspired by the efficient swimming capabilities of swordfish, a novel wireless soft swordfish‐like robot with programmable magnetization has been developed, integrating direct‐ink‐writing (DIW) 3D printing and assembly technology. …”
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A Comparative Study of Antibacterial Activity of CuO/Ag and ZnO/Ag Nanocomposites by R. B. Asamoah, E. Annan, B. Mensah, P. Nbelayim, V. Apalangya, B. Onwona-Agyeman, A. Yaya

“…This study presents a novel approach for relative analysis of the performance efficiency of transition metal based nanocomposites.…”
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Laryngeal cancer diagnosis based on improved YOLOv8 algorithm by Xin Nie, Xueyan Zhang, Di Wang, Yuankun Liu, Lumin Xing, Wenjian Liu

“…This study introduces an improved YOLOv8 algorithm named MSEC-YOLO, specifically designed for the detection and classification tasks of laryngeal cancer in endoscopic images. A novel multiscale enhanced convolution module has been introduced to improve the model’s feature extraction capabilities for small-sized targets. …”
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RETRACTED: The role and molecular mechanism of Trop2 induced epithelial‐mesenchymal transition through mediated β‐catenin in gastric cancer by Wei Zhao, Lizhou Jia, Xingwang kuai, Qi Tang, Xiaochen Huang, Tingting Yang, Zhenning Qiu, Jin Zhu, Jianfei Huang, Wenbin Huang, Zhenqing Feng

“…These sets of data reveal a novel regulatory network of Trop2 in EMT and GC metastasis, suggesting Trop2 as a useful marker for inducing EMT and metastasis of GC, which may help to lead a better understanding of the pathogenesis of the GC.…”
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Sensitivity of global solar irradiance to transposition models: Assessing risks associated with model discrepancies by Yasser F. Nassar, Hala J. El-Khozondar, Mohamed M. Khaleel, Abdussalam A. Ahmed, Abdulgader H. Alsharif, Monaem Elmnifi, Mark Amoah Nyasapoh

“…Significant errors can occur when choosing the incorrect TM for feasibility assessments or determining the optimum tilt angles (β) for solar collectors. A novel theory (Risky Index theory) for determining the least risky TM is introduced in this work. …”
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Obtention of stable neuroprotective extracts from orange by-products by gas-expanded liquids extraction (GXLE) and liposomal microencapsulation by Victor M. Amador-Luna, Lidia Montero, Pablo Mendoza-Orbaneja, Elena Ibáñez, Miguel Herrero

“…In this contribution, a process combining gas-expanded liquids extraction together with a novel microencapsulation protocol is studied with the aim to recover and stabilize neuroprotective compounds from orange by-products. …”
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Q11, a CYP2E1 inhibitor, exerts anti-hepatocellular carcinoma effect by inhibiting M2 macrophage polarization by Cunzhen Zhang, Yan Fang, Mengxue Guo, Liming Tang, Yurong Xing, Jun Zhou, Yuanyuan Guo, Yuhan Gu, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao

“…Abstract Despite significant advancements in cancer immunotherapy, many patients continue to respond poorly. Novel therapeutic strategies and drugs are urgently needed. …”
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Enhanced CATBraTS for Brain Tumour Semantic Segmentation by Rim El Badaoui, Ester Bonmati Coll, Alexandra Psarrou, Hykoush A. Asaturyan, Barbara Villarini

“…This paper introduces a novel, fully automated model called Enhanced Channel Attention Transformer (E-CATBraTS) for Brain Tumour Semantic Segmentation; this model builds upon 3D CATBraTS, a vision transformer employed in magnetic resonance imaging (MRI) brain tumour segmentation tasks. …”
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Development and Validation of a Bordetella pertussis Whole-Genome Screening Strategy by Ricardo da Silva Antunes, Lorenzo G. Quiambao, Aaron Sutherland, Ferran Soldevila, Sandeep Kumar Dhanda, Sandra K. Armstrong, Timothy J. Brickman, Tod Merkel, Bjoern Peters, Alessandro Sette

“…Thus, characterizing and defining novel targets associated with T cell reactivity are of considerable interest. …”
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Immunogenic dying cells elicit potent anti-tumor T cell immunity against lung metastasis and tumorigenesis by Min Hu, Xinyu Meng, Tong Wang, Yifan Wang, Xiaodong Chen, Dongliang Xu, Wei He, Hongjia Zhang, Wenzheng Guo, Bo Jing, Siwei Zhang, Jianhua Xu, Beibei Sun, Xueqian Sun, Tingting Liu, Na Ni, Tongtong Zhang, Wenwen Cui, Xiaoyu Wu, Liping Xia, Feng Yao, Fang Zhang, Jing Du, Jiong Deng

“…Conclusion Immunization with the ICD dying tumor cells evokes potent tumor-specific T cell immunity, which provides a novel approach for cancer immunotherapy.…”
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Graph Convolutional Networks for multi-modal robotic martial arts leg pose recognition by Shun Yao, Yihan Ping, Xiaoyu Yue, Xiaoyu Yue, He Chen, He Chen

“…These methods lack the ability to effectively model the nuanced dynamics of joint interactions and temporal progression, leading to limited generalization in recognizing complex actions.MethodsTo address these challenges, we propose PoseGCN, a Graph Convolutional Network (GCN)-based model that integrates spatial, temporal, and contextual features through a novel framework. PoseGCN leverages spatial-temporal graph encoding to capture joint motion dynamics, an action-specific attention mechanism to assign importance to relevant joints depending on the action context, and a self-supervised pretext task to enhance temporal robustness and continuity. …”
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Differential Gene Expression Analysis in a Lumbar Spinal Stenosis Rat Model via RNA Sequencing: Identification of Key Molecular Pathways and Therapeutic Insights by Jin Young Hong, Wan-Jin Jeon, Hyunseong Kim, Changhwan Yeo, Hyun Kim, Yoon Jae Lee, In-Hyuk Ha

“…Conclusions: Our findings provide novel insights into the molecular mechanisms underlying LSS and offer potential avenues for the development of targeted therapies aimed at mitigating disease progression and improving patient outcomes.…”
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Gut microbiota derived DCA enhances FOLFOX efficacy via Ugt1a6b mediated enterohepatic circulation in colon cancer by Qian Fang, Xiaoying Hou, Limei Fan, Yufei Deng, Xiaoxuan Li, Hongyun Zhang, Haiping Wang, Zhengqi Fu, Binlian Sun, Xiji Shu, Hongzhi Du, Yuchen Liu

“…In conclusion, our findings establish that gut microbiota-derived DCA enhances the efficacy of FOLFOX potentially via Ugt1a6b mediated enterohepatic circulation, providing novel insights into a synergistic therapeutic strategy for improving colon cancer treatment.…”
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β-Nicotinamide Mononucleotide Reduces Oxidative Stress and Improves Steroidogenesis in Granulosa Cells Associated with Sheep Prolificacy via Activating AMPK Pathway by Yu Cai, Hua Yang, Hui Xu, Shanglai Li, Bingru Zhao, Zhibo Wang, Xiaolei Yao, Feng Wang, Yanli Zhang

“…These findings also position NMN as a potential novel metabolic biomarker in enhancing ovarian function.…”
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MAEMC-NET: a hybrid self-supervised learning method for predicting the malignancy of solitary pulmonary nodules from CT images by Tianhu Zhao, Tianhu Zhao, Yong Yue, Hang Sun, Jingxu Li, Yanhua Wen, Yudong Yao, Wei Qian, Yubao Guan, Shouliang Qi, Shouliang Qi

“…This study aims to address this diagnostic challenge by developing a novel deep learning model.MethodsThis study proposes MAEMC-NET, a model integrating generative (Masked AutoEncoder) and contrastive (Momentum Contrast) self-supervised learning to learn CT image representations of intra- and inter-solitary nodules. …”
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OCT-based diagnosis of glaucoma and glaucoma stages using explainable machine learning by Md Mahmudul Hasan, Jack Phu, Henrietta Wang, Arcot Sowmya, Michael Kalloniatis, Erik Meijering

“…Leveraging SHapley Additive exPlanations (SHAP)-based global feature ranking and partial dependency analysis (PDA) estimated decision boundary cut-offs on machine learning (ML) models, a novel algorithm was developed to implement an XAI tool. …”
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