Development of an m6A-Related lncRNAs Signature Predicts Tumor Stemness and Prognosis for Low-Grade Glioma Patients by Dahua Xu, Peihu Li, Chunrui Zhang, Yutong Shen, Jiale Cai, Qingchen Wei, Meng Cao, Zhizhou Xu, Deng Wu, Hong Wang, Xiaoman Bi, Bo Wang, Kongning Li

“…We finally provided several potential compounds suitable for specific risk groups, which may aid in LGG treatment. Conclusions. This novel signature presents noteworthy value in the prediction of prognosis and stemness status for LGG patients and will foster future research on the development of clinical regimens.…”
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Finding Neural Biomarkers for Motor Learning and Rehabilitation Using an Explainable Graph Neural Network by J. Han, A. Embs, F. Nardi, S. Haar, A. A. Faisal

“…In response to these challenges, we developed a novel Spatial Graph Neural Network (SGNN) model to predict motor learning outcomes from electroencephalogram (EEG) data using the spatial-temporal dynamics of brain activity. …”
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Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair by Penghui Wang, Zaifeng Chen, Ping Li, Abdullah Al Mamun, Shaoxia Ning, Jinjing Zhang, Chonghui Tang, Tianmiao Sun, Jian Xiao, Xiaojie Wei, Fenzan Wu

“…In this study, we introduce a novel multifunctional liposome hydrogel drug delivery system (QLipTC@HDM), obtained by incorporating liposomes with blood-spinal cord barrier penetration and injury site targeting properties (LipTC) into a dual-network viscous hydrogel (HDM). …”
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Genomic and transcriptomic insights into vitamin A-induced thermogenesis and gene reuse as a cold adaptation strategy in wild boars by Mingpeng Zhang, Aleksei Traspov, Jiawen Yang, Min Zheng, Veronika R. Kharzinova, Huashui Ai, Natalia A. Zinovieva, Lusheng Huang

“…Further pathway and transcriptomic analyses reveal a novel cold resistance mechanism centered on enhanced vitamin A metabolism and catalysis, involving the reuse of UGT2B31 and rhythm regulation by ANGPTL8, RLN3 and ZBTB20. …”
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Inhibition of histone deacetylase in Arabidopsis root calli promotes de novo shoot organogenesis by Qinwei Pan, Ruirui Huang, Qiong Xiao, Xuting Wu, Baoxia Jian, Yanan Xiang, Lijun Gan, Zongrang Liu, Yi Li, Tingting Gu, Huawei Liu, Huawei Liu

“…These findings provide novel insights into the regulatory mechanisms underlying de novo shoot organogenesis and lay a foundation for the improvement of plant transformation technologies.…”
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Offshore Network Development to Foster the Energy Transition by Enrico Maria Carlini, Corrado Gadaleta, Michela Migliori, Francesca Longobardi, Gianfranco Luongo, Stefano Lauria, Marco Maccioni, Jacopo Dell’Olmo

“…Starting from a realistic estimate of the offshore wind power plants (OWPPs) to be realized off the southern coasts in a very long-term scenario, this paper presents a novel optimization procedure for meshed AC offshore network configuration, aiming at minimizing the offshore wind generation curtailment based on the DC optimal power flow approximation, assessing the security condition of the whole onshore and offshore networks. …”
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Multilayer all-polymer metasurface stacked on optical fiber via sequential micro-punching process by Kim Moohyuk, Park Nu-Ri, Yu Aran, Kim Jin Tae, Jeon Minseok, Jeon Seung-Woo, Han Sang-Wook, Kim Myung-Ki

“…Herein, we demonstrate a novel sequential micro-punching process that enables rapid and precise stacking of multiple polymer metasurfaces on the end face of a single-mode optical fiber. …”
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Acupuncture Induces Reduction in Limbic-Cortical Feedback of a Neuralgia Rat Model: A Dynamic Causal Modeling Study by Zhen-Zhen Ma, Ye-Chen Lu, Jia-Jia Wu, Xiang-Xin Xing, Xu-Yun Hua, Jian-Guang Xu

“…Our study for the first time explored the relationship of involved brain regions with dynamic causal modeling. It provided novel evidence for the feature of the organization of the cortical-limbic network and the alteration caused by acupuncture.…”
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Immunization of cattle with a Rhipicephalus microplus chitinase peptide containing predicted B-cell epitopes reduces tick biological fitness by María Martina Esperanza Perez-Soria, Daniel Gustavo López-Díaz, Rafael Jiménez-Ocampo, Gabriela Aguilar-Tipacamú, Massaro W. Ueti, Juan Mosqueda, Ala Tabor

“…An immunological strategy based on vaccines offers an alternative approach to tick control. To develop novel tick vaccines, it is crucial to identify and evaluate antigens capable of generating protection in cattle. …”
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Cecropin AD ameliorates pneumonia and intestinal injury in mice with mycoplasma pneumoniae by mediating gut microbiota by Bowen Li, Mingming Liu, Wenjing Du, Shuaidong Wang, Zekang Xu, Xiaoqian Zhang, Yang Zhang, Song Hua

“…Consequently, this significantly mitigated the morphological and functional damage to the lungs and colons caused by Mccp. The findings offer novel insights and approaches for the clinical management of Mccp infections.…”
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Diagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysis by Cheng Tang, Su-Xia Sun, Chao Gu, Chao-Juan Li, Jin Xu, Ke-Lei Su, Dan-Dan Zhou, Kuai Yu, Qing-Ling Xiao, Xiao-Li Chen

“…Abstract Background Lung cancer (LC) is the leading cause of cancer-related death in humans. tRNA-derived small RNA (tsRNA) is a novel biomarker that plays a crucial role in the genesis and development of LC. …”
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Towards a More Efficient Design of High Temperature Concentrating Solar Power Plant With Cascaded Thermal Energy Storage by Brenda Hernandez Corona, Thomas Fasquelle, Muhammad Abdullah, Nicolas Lopez Ferber, Jean-Francois Hoffmann, Mathieu Martins, Ahmad Mayyas, Nicolas Calvet

“… This work proposes a novel concentrating solar power (CSP) plant configuration aiming at a high operation temperature of 1000°C. …”
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Autophagy is involved in the toxicity of the biocontrol agent GC16 against Tetranychus pueraricola (Acari: Tetranychidae) based on transcriptomic and proteomic analyses by Yanyan He, Guangzu Du, Guang Wang, Huiming Guan, Shusheng Zhu, Bin Chen, Xiahong He, Youyong Zhu

“…Abstract Background GC16 is a novel pesticide with acaricidal properties against the spider mite Tetranychus pueraricola (Ehara & Gotoh). …”
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Network Representation Based on the Joint Learning of Three Feature Views by Zhonglin Ye, Haixing Zhao, Ke Zhang, Zhaoyang Wang, Yu Zhu

“…Based on the above two optimization approaches, we propose a novel network representation learning algorithm, Network Representation learning algorithm based on the joint optimization of Three Features (TFNR). …”
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Unveiling Prevalence, Risk Factors, and Outcomes of Hepatitis D Among Vulnerable Communities in Romania by Liana Gheorghe, Speranta Iacob, Irma Eva Csiki, Mihaela Ghioca, Razvan Iacob, Ileana Constantinescu, Bogdan Chiper, Laura Huiban, Cristina Muzica, Irina Girleanu, Nicoleta Tiuca, Sorina Diaconu, Daniela Larisa Sandulescu, Ion Rogoveanu, Andra Iulia Suceveanu, Florentina Furtunescu, Corina Pop, Anca Trifan

“…Conclusions: This study underscores the urgent need for targeted public health interventions, including enhanced screening, education, and access to novel antiviral therapies like bulevirtide to address the significant burden of HBV/HDV co-infection in Romania.…”
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Quality by Design-Based Methodology for Development of Titanate Nanotubes Specified for Pharmaceutical Applications Based on Risk Assessment and Artificial Neural Network Modeling by Ranim Saker, Géza Regdon, Krisztina Ludasi, Tamás Sovány

“…Furthermore, a reasonable estimation of the factors affecting titanate nanotube preparation and transformation from traditional uses to novel pharmaceutical ones was established with the aid of a quality by design approach and risk assessment tools, mainly an Ishikawa diagram, a risk estimation matrix, and Pareto analysis. …”
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Inovirus-Encoded Peptides Induce Specific Toxicity in <i>Pseudomonas aeruginosa</i> by Juehua Weng, Yunxue Guo, Jiayu Gu, Ran Chen, Xiaoxue Wang

“…Our study reveals that the novel Pf-encoded polypeptide PftP4 has the potential to selectively target and eradicate <i>P. aeruginosa</i>, offering valuable insights for combating <i>P. aeruginosa</i> infections.…”
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Clinical and genetic analysis of epilepsy with myoclonic-atonic seizures caused by SLC6A1 gene variant by Zhen Li, Zhen Li, Changming Han, Hongwei Zhao

“…The identification of this novel mutation enriches the spectrum of known SLC6A1 gene variants.…”
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Fragmenstein: predicting protein–ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding–based methodology by Matteo P. Ferla, Rubén Sánchez-García, Rachael E. Skyner, Stefan Gahbauer, Jenny C. Taylor, Frank von Delft, Brian D. Marsden, Charlotte M. Deane

“…Fragmenstein either takes the atomic coordinates of ligands from a experimental fragment screen and combines the atoms together to produce a novel merged virtual compound, or uses them to predict the bound complex for a provided molecule. …”
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EM Database v1.0: A benchmark informatics platform for data-driven discovery of energetic materials by Xin Huang, Wen Qian, Jian Liu, Jun-hong Zhou, Chao-yang Zhang

“…Large-scale data demonstrates great significance for the discovery of novel energetic materials (EMs). However, the open-source databases of EMs are not readily available. …”
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