Computationally Efficient Minimum-Time Motion Primitives for Vehicle Trajectory Planning by Mattia Piccinini, Simon Gottschalk, Matthias Gerdts, Francesco Biral

“…This paper introduces new motion primitives for autonomous racing, aiming to accurately approximate the minimum-time vehicle trajectories while ensuring computational efficiency. We present a novel neural network, named PathPoly-NN, whose internal architecture is designed to learn the minimum-time vehicle path. …”
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Advancing neutron imaging techniques to highest resolution with fluorescent nuclear track detectors by Abdul Muneem, Junya Yoshida, Takehiko R. Saito, Hiroyuki Ekawa, Masahiro Hino, Katsuya Hirota, Go Ichikawa, Ayumi Kasagi, Masaaki Kitaguchi, Kenji Mishima, Jameel-Un Nabi, Manami Nakagawa

“…Fluorescent nuclear track detectors are reusable solid-state detectors that do not require additional chemical processing. A novel technique combining neutron imaging based on fluorescent nuclear track detectors with a neutron converter layer formed using $$^{10}$$ B $${_4}$$ C was developed with unprecedented resolution. …”
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Metal–Salen‐Incorporated conjugated microporous polymers as robust artificial leaves for solar‐driven reduction of atmospheric CO2 with H2O by Wei Wu, Zhaocen Dong, Mantao Chen, Waner Li, An Liao, Qing Liu, Yachao Zhang, Zhixin Zhou, Chao Zeng, Xuezhong Gong, Chunhui Dai

“…Herein, we report the design of four novel metal–salen‐incorporated conjugated microporous polymers as robust artificial leaves for photoreduction of atmospheric CO2 with gaseous water. …”
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Multi-slotted airfoil design for enhanced aerodynamic performance and economic efficiency by Mohamed A. Aziz, Mohamed A. Khalifa, M. A. Abdelrahman, Haitham Elshimy, Ahmed M. Elsayed

“…The current study focuses on enhancing wind turbine blades’ efficiency by utilizing a novel multi-slot NACA23012C airfoil design as a passive control approach. …”
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A detoxified TLR4 agonist inhibits tumour growth and lung metastasis of osteosarcoma by promoting CD8+ cytotoxic lymphocyte infiltration by Ryunosuke Oyama, Akira Nabeshima, Makoto Endo, Alexey Novikov, Toshifumi Fujiwara, Capucine Phelip, Nobuhiko Yokoyama, Yoshinao Oda, Martine Caroff, Yoshihiro Matsumoto, Jerome Kerzerho, Yasuharu Nakashima

“…Current immunotherapies show limited efficacy, highlighting the need for novel therapeutic approaches. Systemic immune activation by Toll-like receptor 4 (TLR4) immunostimulants has shown great promise; however, current TLR4 agonists’ toxicity hinders this systemic approach in patients with osteosarcoma. …”
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Nootkatone inhibits the progression of glioblastoma by activating the ATF4-CHOP-CHAC1 pathway by Qian Wang, Xiumin Xue, Zhichao Chen, Wei Zhang, Yiming Qian, Danni Chen, Lin Lin, Yinfeng Yuan, Weiqiao Zhao, Zhihui Huang, Yongjie Wang

“…Taken together, our findings show that NKT suppresses the growth and migration of GBM cells by activating the ATF4-CHOP-CHAC1 pathway, which in turn prevents the tumorigenesis of GBMs and provides a novel perspective for the development of drugs against GBM. …”
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MicroVi: A Cost-Effective Microscopy Solution for Yeast Cell Detection and Count in Wine Value Chain by Ismael Benito-Altamirano, Sergio Moreno, David M. Vaz-Romero, Anna Puig-Pujol, Gemma Roca-Domènech, Joan Canals, Anna Vilà, Joan Daniel Prades, Ángel Diéguez

“…We demonstrate that this novel microscopy setup is able to measure the same type of samples as an optical microscopy system, but with smaller size equipment and with automated cell count configuration. …”
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Simultaneous exposure to microplastics and heavy metal lead induces oxidative stress, histopathological damage, and immune dysfunction in marine mussel Mytilus coruscus by Chuanyue Chen, Xueer Wang, Yingrong Jin, Yinchang Yao, Suchang Li, Zhi Liao, Xiaolin Zhang, Xiaojun Yan

“…Furthermore, the TLR/MyD88/NFκB signaling pathway is involved in the immune response of mussels to environmental stress. This study provides novel perspectives on the toxicity of MPs combined with Pb in marine animals, as well as the molecular mechanisms underlying their ecotoxicological effects.…”
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Revisiting the anatomy of inferior extensor retinaculum of foot and ankle, a study based on fifty embalmed adult cadaveric lower extremities by M. Praveen Shenoy, Mangala M. Pai, B.V. Murlimanju, Rajanigandha Vadgaonkar, Latha V. Prabhu, M.D. Prameela

“…Conclusion: Our study is novel in determining the compartment format, deeper connections of IER, and relations with deeper structures along with the anatomical variations, which are clinically important in ankle arthroscopy, tendinoscopy, tendon repairs and foot drop stabilization surgeries.…”
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RatDEGdb: a knowledge base of differentially expressed genes in the rat as a model object in biomedical research by I. V. Chadaeva, S. V. Filonov, K. A. Zolotareva, B. M. Khandaev, N. I. Ershov, N. L. Podkolodnyy, R. V. Kozhemyakina, D. A. Rasskazov, A. G. Bogomolov, E. Yu. Kondratyuk, N. V. Klimova, S. G. Shikhevich, M. A.  Ryazanova, L. A. Fedoseeva, О. Е. Redina, О. S. Kozhevnikova, N. A. Stefanova, N. G. Kolosova, A. L. Markel, M. P. Ponomarenko, Yu. D. Oshchepkov

“…The current release contains information on 25,101 DEGs representing 14,320 unique rat genes that change transcription levels in 21 tissues of 10 genetic rat strains used as models of 11 human diseases based on 45 original scientific papers. RatDEGdb is novel in that, unlike any other biomedical database, it offers the manually curated annotations of DEGs in model rats with the use of independent clinical data on equal changes in the expression of homologous genes revealed in people with pathologies. …”
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Intrusion detection using synaptic intelligent convolutional neural networks for dynamic Internet of Things environments by Hui Chen, Zhendong Wang, Shuxin Yang, Xiao Luo, Daojing He, Sammy Chan

“…The SICNN model leverages the synaptic intelligence (SI) algorithm to optimize the synaptic structure of the convolutional neural network (CNN), significantly mitigating the forgetfulness of the CNN for past detection tasks and simplifying model training. Additionally, a novel loss function is designed to address the class imbalance present in IoT traffic data and to mitigate the gradient vanishing issue observed in traditional loss functions. …”
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Insulin versus Lipid Emulsion in a Rabbit Model of Severe Propranolol Toxicity: A Pilot Study by Martyn Harvey, Grant Cave, Daniel Lahner, Jan Desmet, Gaynor Prince, Gary Hopgood

“…We compare efficacy of the novel antidotes ING, with ILE, in a rabbit model of combined enteric/intravenous propranolol toxicity. …”
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Gli1+ Cells Residing in Bone Sutures Respond to Mechanical Force via IP3R to Mediate Osteogenesis by Xiaoyao Huang, Zihan Li, Peisheng Liu, Meiling Wu, An-qi Liu, Chenghu Hu, Xuemei Liu, Hao Guo, Xiaoxue Yang, Xiaohe Guo, Bei Li, Xiaoning He, Kun Xuan, Yan Jin

“…Furthermore, our results provide novel insights regarding the mechanism of orthodontic treatments of skeletal malocclusion.…”
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Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans by Michela Palmieri, Spyridoula Maraka, Horace J. Spencer, Jeff D. Thostenson, Katherine Dishongh, Micheal Knox, Betty Ussery, Jesse Byrd, Jacqueline K. Kuipers, Sanaz Abedzadeh-Anaraki, Chitharanjan Duvoor, Yuanjie Mao, Lakshmi Menon, James S. Williams, Stavros C. Manolagas, Robert L. Jilka, Elena Ambrogini

“…These results raise the possibility that higher levels of anti-PC IgM in patients with lower BMD reflect exposure to higher levels of PC-OxPLs, which are known to affect bone mass, and could be a novel risk marker for osteoporosis.…”
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Exploring Zinc C295 as a Dual HIV-1 Integrase Inhibitor: From Strand Transfer to 3′-Processing Suppression by Sharif Karim Sayyed, Marzuqa Quraishi, D. S. Prabakaran, Balaji Chandrasekaran, Thiyagarajan Ramesh, Satish Kumar Rajasekharan, Chaitany Jayprakash Raorane, Tareeka Sonawane, Vinothkannan Ravichandran

“…<b>Background</b>: The global AIDS pandemic highlights the urgent need for novel antiretroviral therapies (ART). In our previous work, Zinc C295 was identified as a potent HIV-1 integrase strand transfer (ST) inhibitor. …”
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Conductive supramolecular acrylate hydrogels enabled by quaternized chitosan ionic crosslinking for high-fidelity 3D printing by Lukas A. Bauman, Boxin Zhao

“…To address this limitation, a novel ionic crosslinker consisting of quaternized chitosan complexed with 3-sulfopropyl acrylate was used to form supramolecular 2-hydroxyethyl acrylate organogel precursors. …”
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The Expression Pattern and Functional Analysis of Extracellular Vesicle Long Non-Coding RNAs from Uterine Fluid During Implantation in Pig by Yijun Shang, Qiuping Zhang, Yue Ding, Yongzhong Wang, Shengchen Gu, Xupeng Zang, Zheng Xu, Sixiu Huang, Zicong Li, Zhenfang Wu, Ting Gu, Linjun Hong, Gengyuan Cai

“…Through screening and validation, we discovered that LNC_026212 was highly expressed on day 12 of pregnancy and can promote the proliferation and migration of porcine trophoblast cells (PTr cells). These novel findings contribute to our understanding of the impact of lncRNAs on porcine reproductive processes, offering new research directions to improve the success rate of embryo implantation in pigs.…”
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Restoration of Innate and Adaptive Immune Responses by HCV Viral Inhibition with an Induction Approach Using Natural Interferon-Beta in Chronic Hepatitis C by Y. Kishida, N. Imaizumi, H. Tanimura, Y. Haruna, S. Kashiwamura, T. Kashiwagi

“…This study investigated the hypothesis that an induction approach with nIFN-beta for 24 weeks followed by PEG-IFN-alpha+ribavirin (standard of care: SOC) for 48 weeks (novel combination treatment: NCT) would increase the initial virologic response rate and restore innate and adaptive immune responses in CHC. …”
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Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue by Jieun Shin, Kavita B. Hosur, Kalyani Pyaram, Ravi Jotwani, Shuang Liang, Triantafyllos Chavakis, George Hajishengallis

“…Here we investigated additional novel mechanisms whereby Del-1 could interfere with neutrophil recruitment and inflammation. …”
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Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients by Bridgette M. Cumming, Kelvin W. Addicott, Fernanda Maruri, Fernanda Maruri, Vanessa Pillay, Rukaya Asmal, Sashen Moodley, Beatriz Barreto-Durate, Beatriz Barreto-Durate, Mariana Araújo-Pereira, Mariana Araújo-Pereira, Matilda Mazibuko, Zoey Mhlane, Nikiwe Mbatha, Khadija Khan, Senamile Makhari, Farina Karim, Lauren Peetluk, Alexander S. Pym, Mahomed Yunus S. Moosa, Yuri F. van der Heijden, Yuri F. van der Heijden, Yuri F. van der Heijden, Timothy S. Sterling, Timothy S. Sterling, Bruno B. Andrade, Bruno B. Andrade, Alasdair Leslie, Alasdair Leslie, Alasdair Leslie, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn

“…These findings underscore the importance of metabolic health in combating TB, supporting the need for further investigation of the bioenergetic immunometabolism associated with TB infection for novel therapeutic approaches aimed at bolstering cellular energetics to enhance immune responses and expedite recovery in TB patients.…”
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