Exploring Core Genes Associated with Sepsis and Systemic Inflammatory Response Syndrome Using Single-Cell Sequencing Technology by Shen Y, Leng L, Hu Y

“…The frequency of occurrence is on the rise, but there is a lack of certain indicators for the timely detection and recognition of illnesses.Methods: By virtue of scRNA-seq, this research has analyzed single-cell transcriptome data from samples taken from groups with septic death and systemic inflammatory response syndrome so as to identify the unique markers and patterns in immune response.Results: By revealing the status of twelve cell clusters of four major cell types in blood samples through UMAP cell clustering and the differences of major cell populations between the dead and SIRS patients, the results have elucidated the components of different cells and their marker genes in two disease states, and the response mechanism beneficial to disease diagnosis in blood samples.Conclusion: By establishing a theoretical framework centered on cellular and molecular regulation, the study has introduced a novel approach for diagnosing and treating sepsis death group and SIRS patients early, as well as differentiating and preventing these conditions.Keywords: sepsis, SIRS, single cell sequencing, biomarkers, single cell transcriptome…”
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Differential Expression of Sphingosine-1-Phosphate Receptors in Abdominal Aortic Aneurysms by Z. Qu, Bernice L. Y. Cheuk, Stephen W. K. Cheng

“…Since those newly discovered receptors play an important role in the inflammatory cascade, the modulating of S1P signaling, particularly via S1P2 and S1P3, could represent novel therapeutic targets in future AAA treatments.…”
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An Assay System for Plate-based Detection of Endogenous Peptide:N-glycanase/NGLY1 Activity Using A Fluorescence-based Probe by Hiroto Hirayama, Tadashi Suzuki

“…We recently advanced this approach by producing a novel fluorescence resonance energy transfer (FRET)-based GCP probe (fGCP) and demonstrated its ability to detect endogenous NGLY1 activity across diverse enzyme sources via fluorescence on multiarray plates. …”
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Inferring the energy cost of resistance to parasitic infection and its link to a trade-off by Frédéric Douhard, Carole Moreno-Romieux, Andrea B. Doeschl-Wilson

“…Conclusions Our mechanistic model fitting to experimental data provides novel insights into the link between energy costs and reallocation due to induced resistance within-individual, and trade-offs among individuals of selected lines. …”
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Experimental Study of Fracture Characterizations of Rocks under Dynamic Tension Test with Image Processing by Dihao Ai, Yuechao Zhao, Beijing Xie, Chengwu Li

“…The experimental results indicate that (1) impact velocity plays a critical role in both crack propagation process and dynamic mechanical properties, (2) the crack fractal dimension is positively correlated with crack propagation velocity and has a linear relationship with the proposed morphological feature of crack, (3) mean strain rate and max strain of rocks under SHPB loading both decrease with the increase of crack propagation velocity, and (4) the energy absorbed by the rocks increases with increasing impact velocity and has a strong negative correlation with a proposed novel crack descriptor. Experimental studies pertaining to the measurement of crack propagation path and velocity, in particular, some crack feature extraction approaches, present a promising way to reveal the fracture process and failure mechanisms of rock-like materials.…”
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Adipose-Derived Mesenchymal Stem Cells Promote M2 Macrophage Phenotype through Exosomes by June Seok Heo, Youjeong Choi, Hyun Ok Kim

“…Thus, iMΦ may be used as a novel stem cell-based cell-free therapy for the treatment of immune-mediated inflammatory disorders.…”
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Evaluation of the Water Yield of Coal Roof Aquifers Based on the FDAHP-Entropy Method: A Case Study in the Donghuantuo Coal Mine, China by Yaowen Zhang, Lili Zhang, Haijun Li, Baoming Chi

“…The research results propose a novel method for evaluating the water yield of coal seam roof aquifers and can provide scientific guidance for the prevention and control of water disasters in the no. 8 coal seam roof of the Donghuantuo Coal Mine.…”
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Metformin Facilitates Osteoblastic Differentiation and M2 Macrophage Polarization by PI3K/AKT/mTOR Pathway in Human Umbilical Cord Mesenchymal Stem Cells by Min Shen, Huihui Yu, Yunfeng Jin, Jiahang Mo, Jingni Sui, Xiaohan Qian, Tong Chen

“…As demonstrated by using PI3K-specific inhibitor LY294002, we found that the pathway inhibitor partly reversed osteoinductive activity which was activated by coculture of metformin-treated M2 macrophages. Overall, our novel research illuminated the cooperative and synergistic effects of metformin and M2 macrophages on the dynamic balance of bone metabolism.…”
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Breast Carcinoma, Intratumour Heterogeneity and Histological Grading, Using Geostatistics by Vénus Sharifi‐Salamatian, Anne de Roquancourt, Jean Paul Rigaut

“…If any invariance paradigm representing a stochastic or geostatistic function could be discovered, this might help in solving the grading problem. A novel methodological approach using geostatistics to measure heterogeneity is used. …”
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Gut–brain axis and neuropsychiatric health: recent advances by Ceymi Doenyas, Gerard Clarke, Renáta Cserjési

“…The studies described in this Collection support and expand on the observations from previous preclinical and clinical investigations, while also providing essential novel insights that can drive discovery into previously unexplored avenues of brain-gut-microbiome interactions in health and disease.…”
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Federated Learning Based on Kernel Local Differential Privacy and Low Gradient Sampling by Yi Chen, Dan Chen, Niansheng Tang

“…By combining RFFM-KLDP and modified low-gradient sampling technique, we develop a novel and robust federated learning method for classification in the presence of the noisy text data, which can preserve data privacy and largely improve the accuracy of classification algorithm compared to the existing classifiers in terms of the area under curve and classification accuracy. …”
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An Adverse Outcome Pathway Linking Organohalogen Exposure to Mitochondrial Disease by Brooke McMinn, Alicia L. Duval, Christie M. Sayes

“…The presented AOP is expected to serve as the basis for designing new toxicological tests as well as the characterization of novel biomarkers for disinfectant by-product exposure and adverse health effects.…”
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Therapeutic Implications of a Polymethoxylated Flavone, Tangeretin, in the Management of Cancer via Modulation of Different Molecular Pathways by El-Shaimaa A. Arafa, Noura T. Shurrab, Manal A. Buabeid

“…The purpose of this review is to highlight the protective effects of a novel natural product, tangeretin against chemotherapeutic-induced toxicity. …”
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Association of P2X7 polymorphisms on Type 2 diabetes mellitus susceptibility and diabetic complications. by Guoni Huang, Jing Cheng, Wenfeng Liu, Tong Yang, Tao Ye, Qian Zhang, Qi Chen, Yuzhong Xu

“…<h4>Conclusions</h4>We found that P2X7 polymorphisms are significantly associated with the risk of T2DM and its complications, suggesting that targeting P2X7 may offer a novel therapeutic strategy for the prevention and personal treatment of T2DM.…”
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Unpredictable Malnutrition and Short-Term Outcomes after Single Anastomosis Sleeve Ileal (SASI) Bypass in Obese Patients by Ayman Kamal, Mahmoud El Azawy, Tarik A. A. Hassan

“…The single anastomosis sleeve ileal (SASI) bypass is a novel metabolic/bariatric surgery operation based on minigastric bypass operation and Santoro’s operation. …”
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The Saudi thoracic society guidelines for vaccinations in adult patients with chronic respiratory diseases by Mohammed Al Ghobain, Fayssal Farahat, Mohammed Zeitouni, Waleed Alsowayan, Sultan Al-Awfi, Ali AlBarrak, Shareefah Al-Basheri, Fatmah Alhabeeb, Esam H. Alhamad

“…Additional strategies include maintaining continuous surveillance and advance research to discover novel vaccines. This approach aims to expand the range of preventable diseases and improve overall health and well-being. …”
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Evaluating Batch Imaging as a Method for Non-Lethal Identification of Freshwater Fishes by Conrad James Pratt, Nicholas E. Mandrak

“…While eDNA can provide fish community data through metabarcoding, it is costly and provides little ecological information. A novel, image-based method for taxonomic identification (“batch-image identification”), which addresses the shortcomings of standard and eDNA methods, was tested in this study. …”
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Mobile Integrated Healthcare: Preliminary Experience and Impact Analysis with a Medicare Advantage Population by Daniel J. Castillo, J. Brent Myers, Jonathan Mocko, Eric H. Beck

“…**Background:** Mobile Integrated Healthcare (MIH) is a novel, patient-centered approach to population management. …”
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Chronic Benign Tubular Albuminuria From Compound Heterozygous Variants in : A Case Report by Adam Pietrobon, Mark D. Elliott

“…Outcomes: Kidney biopsy was not pursued for this patient as diagnostic clarification was achieved by non-invasive genetic testing alone. Novel findings: This case highlights several important lessons. …”
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Predictive role of preoperative sarcopenia for long-term survival in rectal cancer patients: A meta-analysis. by Qiutong Su, Jia Shen

“…<h4>Conclusion</h4>Preoperative sarcopenia is significantly related to poor survival in surgical rectal cancer patients and could serve as a novel and valuable predictor of long-term prognosis in these patients.…”
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