Choroidal Vascularity Index as a Biomarker for Visual Response to Antivascular Endothelial Growth Factor Treatment in Diabetic Macular Edema by Ningxin Dou, Shanshan Yu, Ching-Kit Tsui, Boyu Yang, Jianqiang Lin, Xi Lu, Yue Xu, Benjuan Wu, Jinfeng Zhao, Xiaoling Liang

“…DME patients with a higher CVI, higher adjusted EZ reflectivity, the presence of SRF, and the absence of DRIL at baseline were more likely to gain >5 letters in visual acuity after anti-VEGF treatment. CVI may serve as a novel biomarker for visual response to anti-VEGF treatment in DME.…”
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Prostate Cancer Susceptibility Loci Identified in GATA2 and ZMIZ1 in Chinese Population by Hui-Jing Zhang, Zhongyuan Liu, Liang Kan

“…Recently, GWAS were applied to a large Japanese cohort and identified 12 novel susceptibility loci associated with PCa risk. …”
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Takeover Quality: Assessing the Effects of Time Budget and Traffic Density with the Help of a Trajectory-Planning Method by Fabian Doubek, Erik Loosveld, Riender Happee, Joost de Winter

“…This paper proposes a novel method of quantifying how well the driver executed an automation-to-manual takeover by comparing human behaviour to optimised behaviour as computed using a trajectory planner. …”
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Cross fan-shaped roof-cutting blasting technology for preventing rockbursts in gob-side mining roadways by PAN Junfeng, LIU Shaohong, MA Wentao, GAO Jiaming, MA Hongyuan

“…This study provides a novel approach and methodology for preventing and controlling the frequent occurrence of rockbursts during gob-side roadway mining.…”
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A Hybrid Approach Integrating Multiple ICEEMDANs, WOA, and RVFL Networks for Economic and Financial Time Series Forecasting by Jiang Wu, Tengfei Zhou, Taiyong Li

“…Therefore, accurately forecasting economic and financial time series is always a challenging research topic. In this study, a novel multidecomposition and self-optimizing hybrid approach integrating multiple improved complete ensemble empirical mode decompositions with adaptive noise (ICEEMDANs), whale optimization algorithm (WOA), and random vector functional link (RVFL) neural networks, namely, MICEEMDAN-WOA-RVFL, is developed to predict economic and financial time series. …”
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Recent Advances and Perspectives on the Use of Mineralocorticoid Receptor Antagonists for the Treatment of Hypertension and Chronic Kidney Disease: A Review by Kisho Miyasako, Yujiro Maeoka, Takao Masaki

“…MR antagonists (MRAs) have substantial beneficial effects in patients with cardiac and renal conditions; however, their use has been constrained because of adverse effects, such as hyperkalemia and kidney dysfunction. Recently, novel non-steroidal MRAs are more efficacious and have superior safety profiles to steroidal MRAs, making them promising potential components of future treatment strategies. …”
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Challenges and Solutions for Keeping Maternity and Gynecology Services Functioning Comprehensively in Secondary Level Health Care Facility in COVID-19 Pandemic Situation Using a Cl... by Jayanta Kumar Biswas, Pratistha Lall, Soumen Das Poddar, Vikas Srivastava, Ajith Nilakantan

“… OBJECTIVE: With the nationwide lockdown in India, and with a near-exclusive focus on the novel coronavirus disease (COVID-19) there has been a great deal of neglect in the management of other illnesses leading to significant mortality and morbidity. …”
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Diagnostic Value of Systemic Inflammatory Response Index for Catheter-Related Bloodstream Infection in Patients Undergoing Haemodialysis by Jiajia Yang, Hongmei Wang, Qing Hua, Jian Wu, Ying Wang

“…Our results showed SIRI as a novel and efficient indicator for the early diagnosis of CRBSI in patients undergoing haemodialysis.…”
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Investigation and Identification of let-7a Related Functional Proteins in Gastric Carcinoma by Proteomics by Yimin Zhu, Xingyuan Xiao, Lairong Dong, Zhiming Liu

“…The data suggest that these differential proteins are involved in a novel let-7a signal pathway and these findings provide the basis to investigate the functional mechanisms of let-7a in gastric carcinoma.…”
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Estimating the Effect of Adhering to the Recommendations of the 2019 Canada’s Food Guide on Health Outcomes in Older Adults: Protocol for a Target Trial Emulation by Didier Brassard, Nancy Presse, Stéphanie Chevalier

“…An alternative is the target trial emulation framework for causal inference, a novel approach to improve the analysis of observational data. …”
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Integrating PCA and DEA techniques for strategic assessment of network security by Reza Rasinojehdehi, Seyyed Najafi

“…This paper introduces a novel approach to evaluating computer network security using Data Envelopment Analysis (DEA), a mathematical method designed to measure the performance of Decision-Making Units (DMUs) employing identical inputs to yield identical outputs. …”
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Remote Minimally Invasive Surgery – Haptic Feedback and Selective Automation in Medical Robotics by Christoph Staub, Keita Ono, Hermann Mayer, Alois Knoll, Heinz Ulbrich, Robert Bauernschmitt

“…The automation of recurrent tasks and force feedback are complex problems in medical robotics. We present a novel approach that extends human-machine skill-transfer by a scaffolding framework. …”
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Repurposing Drugs in Controlling Recurrent Platinum-Resistant Clear-Cell Ovarian Cancer by Woraporn Sinsuwan, Phawit Norchai

“…This work introduces a novel strategy for the management of recurrent platinum-resistant clear-cell ovarian cancer that needs further evaluation in large-scale studies.…”
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Preparation and photoelectric properties of Si:B nanowires with thermal evaporation method. by Yang Feng, Ping Liang, Ziwen Xia, Weiye Yang, Hongyan Peng, Shihua Zhao

“…SiNWs (Silicon nanowires), as a novel type of nanomaterial, exhibit many outstanding properties, including the quantum confinement effect, quantum tunneling, Coulomb blocking effect, and exceptional electrical and optical properties. …”
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Effective and safe surgery for keratinocyte skin cancer in the elderly over 80 years of age: a single-institution retrospective study of 345 patients over one year by Luca D. Fontana, Clara Richter, Ramon Lang, Christian Greis, Jürg Hafner

“…Of the 26 recorded complications, 15 (58%) concerned wound dehiscence, requiring no further measures. The use of novel oral anticoagulants, lower extremity location, surgical specimen size >2 cm2, and flap repair were found to be independent risk factors associated with a statistically higher incidence of complications.Conclusions This study demonstrated that dermatologic surgery adapted to the geriatric population is relatively safe and effective, even for larger KC of several centimeters in diameter.…”
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Advances in antiviral strategies targeting mosquito-borne viruses: cellular, viral, and immune-related approaches by Ayyaz Khan, Zakirullah, Shahid Wahab, Seong-Tshool Hong

“…Additionally, it explores immunomodulatory therapies to enhance antiviral responses and emphasizes the potential of drug repurposing, bioinformatics, artificial intelligence, and deep learning in identifying novel antiviral candidates. Continued research is crucial in mitigating MBVs’ impact and preventing future outbreaks.…”
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A Climate Simulation Dataset From 11 Overriding Experiments for Analysing Cloud and Air–Sea Feedbacks by Xiao Guo, Biao Feng, Zhiying Zhao, Jian Ma

“…Due to complex cloud physics in air–sea coupling, this contributes to the surface warming pattern formation with significant uncertainty. Here we develop a novel overriding technique for climate projections that substitutes specific variables in control runs to isolate such feedback mechanisms, decoupling thermodynamic, dynamical and radiative responses of the surface ocean to the atmosphere. …”
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Hypoxia Promotes Glioma Stem Cell Proliferation by Enhancing the 14-3-3β Expression via the PI3K Pathway by Weidong Cao, Qiang Zhou, Hongwei Wang, Wei Rao, Gang Cheng, Peng Wang, Shengli Guo, Bin Ren, Jianning Zhang

“…Examination of the numerous biomarkers or cancer-associated genes involved in the development or prevention of glioma may therefore serve the discovery of novel strategies to treat patients with glioma. Hypoxia induced by using CoCl2 application and 14-3-3β protein knockdown by specific small interfering RNA transfection were performed in GSCs both in vitro and in vivo to observe their role in glioma progression and metastasis occurrence by using western blot analysis and MTT assay. …”
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Assessing the Relationship between COVID-19, Air Quality, and Meteorological Variables: A Case Study of Dhaka City in Bangladesh by Md Sariful Islam, Mizanur Rahman, Tanmoy Roy Tusher, Shimul Roy, Mohammad Arfar Razi

“…Abstract The novel coronavirus disease 2019 (COVID-19) has become a serious health concern worldwide for almost a year. …”
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In-Process Quality Inspection of Rolling Element Bearings Based on the Measurement of Microelastic Deformation of Outer Ring by Kuosheng Jiang, Lianghe Li, Liubang Han, Shuai Gou

“…Thus, there are problems about special operating conditions and weak fault severity in quality inspection of bearings, which is quite different from the fault diagnosis of bearings. In this paper, a novel dynamic quality evaluation technique is proposed based on the measurement of Hertz deformations. …”
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