Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Ulcerative Colitis in Mice by Inhibiting Ferroptosis via Nrf2/GPX4 Pathway by Jinke Huang, Jiaqi Zhang, Zhihong Liu, Jing Ma, Fengyun Wang, Xudong Tang

“…Ferroptosis, a form of programmed cell death, is considered a novel target for the treatment of ulcerative colitis (UC). …”
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Design, Synthesis, and Biological Evaluation of Triazolyl- and Triazinyl-Quinazolinediones as Potential Antitumor Agents by Abeer N. Al-Romaizan, Nesreen S. Ahmed, Sherin M. Elfeky

“…Novel 6(3-1H-1,2,4-triazol-1-yl)-3-phenylquinazoline-2,4(1H,3H)-diones (7a–e) were synthesized from different enaminones (6a–e) with 6-hydrazinyl-3-phenylquinazoline-2,4(1H,3H)-dione. 2,6(4-2-Substituted-1,3,5-triazin-1(2H)-yl)-3-phenylquinazoline-2,4(1H,3H)-diones (8a–k) were synthesized from the reaction of 1-(2,4-dioxo-3-phenyl-1,2,3,4-tetrahydroquinazolin-6-yl)thiourea, urea, or guanidine (3a–c) with enaminones (6a–e), and a series from 3-substituted-2-imino-1,3,5-triazin-1(2H)-yl-sulfonyl-phenyl-1-methylquinazoline-2,4(1H,3H)-dione (12a–j) were obtained from the reaction of N-(diaminomethylene)-4-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)benzenesulfonamide (11) with the enaminone (6a–j). …”
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Vitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis by Maryam Mukhtar, Andleeb Batool, Abdul Wajid, Iram Qayyum

“…At the FokΙ site, tryptophan was replaced with arginine due to polymorphism. A novel SNP (GeneBank acc number KT280406) was identified through the sequencing of intron 8, 62 bp downstream from the ApaI polymorphic site, and significantly associated with T1D development. …”
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Driving political issues with political brand storytelling on social media: an online brand persona perspective by Helena van Wyk, Charmaine Du Plessis

“…This article proposes adopting a social identity theory as a novel approach to how political brands could drive political issues on social media. …”
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Identification Method of Highway Accident Prone Sections Under Adverse Meteorological Conditions Based on Meteorological Responsiveness by Yanyang Gao, Chi Zhang, Maojie Ye, Bo Wang

“…To mitigate the prevalence of highway accidents in Southwest China during adverse weather conditions, this study introduces a novel method for identifying accident-prone sections in complex meteorological circumstances. …”
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Zim4rv: an R package to modeling zero-inflated count phenotype on regional-based rare variants by Xiaomin Liu, Yi-Ju Li, Qiao Fan

“…Our package offers two novel models developed by our team: our previously proposed ZIP-b and ZIP-k tests, and the newly derived Negative Binomial Burden and Kernel Test (ZINB-b, ZINB-k). …”
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Alzheimer’s Disease and <i>Porphyromonas gingivalis</i>: Exploring the Links by Ivana Shawkatova, Vladimira Durmanova, Juraj Javor

“…Understanding these interactions could provide critical insights into novel strategies for reducing AD risk through periodontal disease management.…”
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Comparative Evaluation of Antimicrobial and Smear Layer Removal Efficacy of Mangifera indica Kernel Extract as Root Canal Irrigant in Primary Molar: An In Vitro Study by S. Haripriya, Jamaluddin Mohammed Farzan, Parisa Nourouzi Baghkomeh, Sivakumar Nuvvula

“…Extracts from the kernel of Mangifera indica has the potential to be a novel root canal irrigant that has yet to be studied. …”
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Improved Grey Particle Swarm Optimization and New Luus-Jaakola Hybrid Algorithm Optimized IMC-PID Controller for Diverse Wing Vibration Systems by Nailu Li, Hua Yang, Anle Mu

“…To solve this problem, a novel optimization technique, called GNPSO is proposed based on the hybridization of improved grey particle swarm optimization (GPSO) and new Luus-Jaakola algorithm (NLJ). …”
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Excellent Reliability for an Instrumented Test of Ankle Plantarflexion Force by Moez Glaied, Rodney Whiteley

“…Accordingly, the purpose of this study is to describe the reliability, feasibility, and clinimetrics of a novel test of plantarflexion force in a clinical setting # Methods Test-retest reliability of a seated isometric plantar flexion strength test performed a minimum of one day apart (maximum of six) using the maximum value of four trials was investigated using a force plate and custom apparatus in 61 volunteer adults (of varying activity levels (Tegner one to ten). …”
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Peptidoglycan recognition protein PGRP-5 is involved in immune defence and neuro-behavioral disorders in zebrafish embryos. by Xi Li, Guanghua Xiong, Manni Luo, Siwan Mao, Ruiying Zhang, Ziwei Meng, Juan Li, Xinjun Liao

“…Firstly, we identified three PGRPs in zebrafish and phylogenetic analysis suggested that DrPGRP-5 was a novel member of the PGRP superfamily in evolution. …”
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MultiChem: predicting chemical properties using multi-view graph attention network by Heesang Moon, Mina Rho

“…Leveraging this progress, we developed a novel multi-view learning model. Results We introduce a graph-integrated model that captures both local and global structural features of chemical compounds. …”
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Contrast-Invariant Edge Detection: A Methodological Advance in Medical Image Analysis by Dang Li, Patrick Cheong-Iao Pang, Chi-Kin Lam

“…This study provides a novel approach for edge detection within medical images.…”
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A Full-Scale Experimental Study of the Vertical Dynamic and Static Behavior of the Pier-Cap-Pile System by Jianlei Liu, Meng Ma

“…In the present study, a novel full-scale experimental study, including both TRM test and SLT, was performed on an abandoned bridge pier with grouped pile foundation. …”
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Acid-decorated chitosan-magnetic aluminum ferrite as a bionanocomposite catalyst for green synthesis of biologically active [4,3‑d]pyrido[1,2‑a]pyrimidin-6‑ones by Maryam Saberi-Zare, Mohammad Ali Bodaghifard

“…Abstract In this study, a novel hybrid nanostructure consisting of acid-decorated chitosan and magnetic AlFeO3 nanoparticles was fabricated. …”
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GeoTemporal clustering for aquifer delineation: a big data approach to synchronizing and analyzing variable-length groundwater time series by Khalid ElHaj, Dalal Alshamsi

“…This study proposes a novel methodology for aquifer delineation using time-series clustering of groundwater-level data. …”
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IL6 Induces mtDNA Leakage to Affect the Immune Escape of Endometrial Carcinoma via cGAS-STING by Xue Zeng, Xiaosong Li, Yundong Zhang, Chaoxia Cao, Qin Zhou

“…Our findings may provide a novel clue for the development of therapeutic targets for EC.…”
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Public Transit Loyalty Modeling Considering the Effect of Passengers’ Emotional Value: A Case Study in Xiamen, China by Shi-chao Sun

“…To better sustain passengers’ loyalty towards bus service, this paper addressed the modeling of the public transit loyalty by the use of structural equation model. As a novel hypothesis, the emotional value was considered to have effects on the perceived value of bus services in this study, which reflected the degree of passengers’ emotional dependence on the public transit. …”
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SEM-2/SoxC regulates multiple aspects of C. elegans postembryonic mesoderm development. by Marissa Baccas, Vanathi Ganesan, Amy Leung, Lucas R Pineiro, Alexandra N McKillop, Jun Liu

“…SEM-2 is essential for embryonic development, and for specifying the sex myoblast (SM) fate in the postembryonic mesoderm, the M lineage. We have identified a novel partial loss-of-function sem-2 allele that has a proline to serine change in the C-terminal tail of the highly conserved DNA-binding domain. …”
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PilotCareTrans Net: an EEG data-driven transformer for pilot health monitoring by Kun Zhao, Xueying Guo

“…These approaches typically fail to integrate multi-scale features effectively, resulting in suboptimal health intervention decisions, especially in dynamic, high-pressure environments like pilot training.MethodsTo overcome these challenges, this study introduces PilotCareTrans Net, a novel Transformer-based model designed for health intervention decision-making in aviation students. …”
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