Exosome-loading miR-205: a two-pronged approach to ocular neovascularization therapy by Hui-ying Zhang, Qiu-yang Zhang, Qing Liu, Si-guo Feng, Yan Ma, Feng-sheng Wang, Yue Zhu, Jin Yao, Biao Yan

“…Collectively, our findings highlight miR-205 as a promising therapeutic for ocular neovascularization, with exosome delivery offering a novel and efficient strategy for treating vision-threatening vascular diseases. …”
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Electric sampling of soot particles in spreading non-premixed flames: methodology and influence of gravity by Li, Yutao, Bordino, Antoine, Guibaud, Augustin, Montero, David, Citerne, Jean-Marie, Consalvi, Jean-Louis, Torero, Jose, Legros, Guillaume

“…Within this context, a novel technique of soot sampling using electric field is applied to a spreading non-premixed flame at normal and micro-gravity. …”
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Precision Medicine Assessment of the Radiographic Defect Angle of the Intrabony Defect in Periodontal Lesions by Deep Learning of Bitewing Radiographs by Patricia Angela R. Abu, Yi-Cheng Mao, Yuan-Jin Lin, Chien-Kai Chao, Yi-He Lin, Bo-Siang Wang, Chiung-An Chen, Shih-Lun Chen, Tsung-Yi Chen, Kuo-Chen Li

“…This study employed a series of novel image enhancement techniques to significantly improve diagnostic accuracy. …”
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First-Trimester Threatened Abortion: Can Red Blood Cell Distribution Width-Standard Deviation Predict Miscarriage? by Sebnem Karagun, Yusuf Dal, Hamza Yildiz, Sefanur Gamze Karaca, Ahmet Zeki Nessar, Ayhan Coskun

“…CONCLUSION: In this study, we found that RDW-SD, as a novel inflammatory mediator may be a useful marker for miscarriage in first trimester bleeding. …”
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Optimal WSN Deployment to Measure Air Quality in Dynamic Multi-Source Dispersion Scenarios: A Case Study in Arequipa by Alexander Hilario-Tacuri, Alberth Tamo, Marco Pinares-Mamani, Walter Butron, Romel Jimenez

“…Thus, to address this public health challenge, this article introduces a novel dynamic multi-source dispersion model that accounts for variations in wind velocity and direction over time, recognizing that air pollution is influenced by rapidly changing environmental factors. …”
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Employing the Oncolytic Vesicular Stomatitis Virus in Cancer Virotherapy: Resistance and Clinical Considerations by Alaa A. Abdelmageed, Stephen Dewhurst, Maureen C. Ferran

“…Several VSV-based phase I/II clinical trials show promise; however, addressing resistance and developing novel strategies to enhance therapeutic efficacy are essential for realizing the full potential of VSV oncolytic virotherapy. …”
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m6A Reader PRRC2A Promotes Colorectal Cancer Progression via CK1ε‐Mediated Activation of WNT and YAP Signaling Pathways by Xi Wu, Shiyang Wang, Yuwei Pan, Mengzhen Li, Manyu Song, Hanfu Zhang, Min Deng, Xu Yang, Jiuzhi Xu, Shuo Zhang, Jinhua Zhang, Fengchao Wang, Maksim V. Plikus, Cong Lv, Lu Yu, Zhengquan Yu

“…In summary, the work reveals a novel mechanism by which m6A reader PRRC2A promotes colorectal cancer progression via CK1ε and aberrant upregulation of WNT and YAP signaling. …”
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Innovative design and experimental verification of cam shedding for high-speed looms by Haifei Qiu, Ming Chen, Feiyang Li, Yifan Zhang

“…For overcoming space limitations and load-bearing defects of traditional conjugate cam shedding on looms, a novel cam shedding system with double-shaft was developed by incorporating mechanism analysis, theoretical calculations, modeling and simulation, and experimental verification. …”
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TClC effectively suppresses the growth and metastasis of NSCLC via polypharmacology by Jing Lu, Ying Zhang, Chunyan Yan, Jingwen Liu, Dan Qi, Yue Zhou, Qinwen Wang, Juechen Yang, Jing Jiang, Benhao Wu, Meiling Yang, Weiwei Zhang, Xin Zhang, Xiaoyu Shi, Yan Zhang, Kun Liu, Yongcai Liang, Chaoyang Wang, Hanyu Yang, Yuqing Gao, Yuping Sun, Ronghu Ke, Jason H. Huang, Min Wu, Hongbo Wang, Chunlei Li, Shuang Zhou, Bin Guo, Erxi Wu, Guoying Zhang

“…In response, we synthesized a novel bioactive compound, ethyl 6-chlorocoumarin-3-carboxylyl L-theanine (TClC), which significantly inhibited NSCLC growth, epithelial mesenchymal transition (EMT), migration, and invasion in vitro and tumor growth and metastasis in vivo without inducing toxicity. …”
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How does agricultural insurance influence grain production scale? An income-mediated perspective by Dainan Hou, Xin Wang, Xin Wang

“…It further examines the mediating role of farmers’ income in this process, providing novel insights into the complex dynamics between agricultural insurance and production behavior. …”
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Protein Kinase Cα Modulates Estrogen-Receptor-Dependent Transcription and Proliferation in Endometrial Cancer Cells by Alicia M. Thorne, Twila A. Jackson, Van C. Willis, Andrew P. Bradford

“…PKCα-dependent pathways may provide much needed prognostic markers of aggressive disease and novel therapeutic targets in ER positive tumors.…”
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The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltration by Chiara Cencioni, Silvia Malatesta, Virginia Vigiano Benedetti, Valerio Licursi, Livia Perfetto, Federica Conte, Danilo Ranieri, Armando Bartolazzi, Martina Kunkl, Loretta Tuosto, Alberto Larghi, Geny Piro, Antonio Agostini, Giampaolo Tortora, Vincenzo Corbo, Carmine Carbone, Francesco Spallotta

“…Conclusions These results shed light on novel therapeutic options for PDAC patients with metabolic syndrome aimed at PDAC stroma reshape.…”
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Host RNA-Binding Proteins as Regulators of HIV-1 Replication by Sebastian Giraldo-Ocampo, Fernando Valiente-Echeverría, Ricardo Soto-Rifo

“…Targeted studies have been of paramount importance in identifying and understanding the role of RNA-binding proteins that bind to HIV-1 RNAs. However, novel approaches aimed at identifying all the proteins bound to specific RNAs (RBPome), such as RNA interactome capture, have also contributed to expanding our understanding of the HIV-1 replication cycle, allowing the identification of RBPs with functions not only in viral RNA metabolism but also in cellular metabolism. …”
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Microgrid Islanding Detection Using D-PMU and Phase Angle Analysis of Negative Sequence Impedance by Asim Chaulagain, Ramakrishna Gokaraju, Nurul Chowdhury, Krish Narendra

“…This paper describes a novel method for microgrid islanding detection utilizing distribution phasor measurement unit (D-PMU). …”
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Controlling the formation of microstructure at the melt-pool boundaries during directed energy deposition of aluminum alloy with a modified continuous growth restriction factor by Shanshan Xu, Bo Yin, Jiale Wang, Liquan Jin, Yu Yin, Zhenhua Li, David H. StJohn, Petro Pavlenko, Yueling Guo

“…This study fills the gap left by the inability of Q to explain the influence of solutes on the microstructure during DED, and presents a novel approach for analyzing the formation mechanism of solidified microstructure adjacent to the fusion boundary of the melt pool.…”
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Mapping QTL for Root and Shoot Morphological Traits in a Durum Wheat × T. dicoccum Segregating Population at Seedling Stage by Anna Iannucci, Daniela Marone, Maria Anna Russo, Pasquale De Vita, Vito Miullo, Pina Ferragonio, Antonio Blanco, Agata Gadaleta, Anna Maria Mastrangelo

“…Moreover, meta-QTL analysis was performed to compare the QTL identified in the “Simeto” × “Molise Colli” segregating population with those described in previous studies in wheat, with three novel QTL defined. Due to the complexity of phenotyping for root traits, further studies will be helpful to validate these regions as targets for breeding programs for optimization of root function for field performance.…”
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Context-Aware Fine-Grained Product Recognition on Grocery Shelves by Lovre Antonio Budimir, Zoran Kalafatic, Marko Subasic, Sven Loncaric

“…Our work incorporates semantic and spatial context into a novel product recognition method. We take advantage of stores being organized into different sections and aisles, where similar products are placed nearby. …”
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Investigation of Free Vibration in Fluid-Loaded Cylindrical Shells with a Three-Layer Sandwich Wall and an Auxetic Central Layer by Korosh Khorshidi, Saboor Savvafi, Sadegh Zobeid

“…Using novel materials, including auxetic structures, has witnessed significant growth. …”
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Dual Polarized Dual Fed Vivaldi Antenna for Cellular Base Station Operating at 1.7–2.7 GHz by Marko Sonkki, Sami Myllymäki, Jussi Putaala, Eero Heikkinen, Tomi Haapala, Harri Posti, Heli Jantunen

“…The paper presents a novel dual polarized dual fed Vivaldi antenna structure for 1.7–2.7 GHz cellular bands. …”
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Document-level relation extraction via dual attention fusion and dynamic asymmetric loss by Xiaoyao Ding, Dongyan Ding, Gang Zhou, Jicang Lu, Taojie Zhu

“…This paper proposes a novel framework for Document-level RE with two techniques, dual attention fusion and dynamic asymmetric loss. …”
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