Evolution of Alzheimer’s Disease Therapeutics: From Conventional Drugs to Medicinal Plants, Immunotherapy, Microbiotherapy and Nanotherapy by Emma Ortiz-Islas, Pedro Montes, Citlali Ekaterina Rodríguez-Pérez, Elizabeth Ruiz-Sánchez, Talía Sánchez-Barbosa, Diego Pichardo-Rojas, Cecilia Zavala-Tecuapetla, Karla Carvajal-Aguilera, Victoria Campos-Peña

“…Faced with this challenge and in line with advances in the understanding of the pathophysiology of this neurodegenerative condition, various innovative therapeutic strategies have been explored. Here, we review novel approaches inspired by advanced knowledge of the underlying pathophysiological mechanisms of the disease. …”
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Increased N-Ethylmaleimide-Sensitive Factor Expression in Amygdala and Perirhinal Cortex during Habituation of Taste Neophobia by Beatriz Gómez-Chacón, Fernando Gámiz, Thomas C. Foster, Milagros Gallo

“…Twenty-one naïve male Wistar rats were exposed to a saccharin solution (0.4%) during the first (novel), the second (Familiar I), and the sixth presentation (Familiar II). …”
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Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice by Ezgi Özcan, Kristie B. Yu, Lyna Dinh, Gregory R. Lum, Katie Lau, Jessie Hsu, Mariana Arino, Jorge Paramo, Arlene Lopez-Romero, Elaine Y. Hsiao

“…Understanding interactions between diet, microbiome, and host susceptibility to seizures could inform novel microbiome-guided approaches to treat refractory epilepsy.…”
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Understanding the relationship, trends, and integration challenges between lean manufacturing and industry 4.0. A literature review by Tariq Benslimane, Rajaa Benabbou, Salma Mouatassim, Jamal Benhra

“…This research enriches academic and industrial discourse by presenting a novel outlook on the convergence of lean manufacturing and Industry 4.0, highlighting its significance for future works.…”
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Preoperative Thrombocytopenia May Predict Poor Surgical Outcome after Extended Hepatectomy by Mohammad Golriz, Omid Ghamarnejad, Elias Khajeh, Mohammadsadegh Sabagh, Markus Mieth, Katrin Hoffmann, Alexis Ulrich, Thilo Hackert, Karl Heinz Weiss, Peter Schirmacher, Markus W. Büchler, Arianeb Mehrabi

“…Background. It is a novel idea that platelet counts may be associated with postoperative outcome following liver surgery. …”
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Harnessing nanotechnology for cancer treatment by Jiajun Zhu, Jiajun Zhu, HaeJu Lee, HaeJu Lee, Ruotong Huang, Ruotong Huang, Jianming Zhou, Jingjun Zhang, Xiaoyi Yang, Wenhan Zhou, Wangqing Jiang, Shuying Chen

“…Furthermore, nanotechnology-based therapeutic strategies, including photothermal therapy, gene therapy and immunotherapy are offering novel ways to combat cancer by selectively targeting tumor cells and enhancing the immune response. …”
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Validity and Advantages of Three-Dimensional High-Frequency Ultrasound in Dermatological Evaluation by Misaki Kinoshita-Ise, Taiichiro Ida, Tatsuro Iwasaki, Hideaki Iwazaki, Kazuyuki Yokota, Hoshito Taguchi, Manabu Ohyama

“…<b>Conclusions:</b> These findings suggested that this novel technology holds promise as a robust noninvasive tool to diagnose and evaluate various cutaneous diseases.…”
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Robust adaptive optimization for sustainable water demand prediction in water distribution systems by Ke Wang, Jiayang Meng, Zhangquan Wang, Kehua Zhao, Banteng Liu

“…This study introduces a novel approach, the Robust Adaptive Optimization Decomposition (RAOD) strategy, which integrates a deep neural network to address these challenges. …”
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Targeting Glutathione-S Transferase Enzymes in Musculoskeletal Sarcomas: A Promising Therapeutic Strategy by Michela Pasello, Maria Cristina Manara, Francesca Michelacci, Marilù Fanelli, Claudia Maria Hattinger, Giordano Nicoletti, Lorena Landuzzi, Pier Luigi Lollini, Annamaria Caccuri, Piero Picci, Katia Scotlandi, Massimo Serra

“…Recent studies have indicated that targeting glutathione-S-transferase (GST) isoenzymes may be a promising novel strategy to improve the efficacy of conventional chemotherapy in the three most common musculoskeletal tumours: osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma. …”
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PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psor... by Anella Saviano, Bonita Apta, Samantha Tull, Laleh Pezhman, Areeba Fatima, Mustafa Sevim, Antonio Mete, Myriam Chimen, Anna Schettino, Noemi Marigliano, Helen M. McGettrick, Asif J. Iqbal, Francesco Maione, G. Ed Rainger

“…Taken together with other reports on the efficacy of PEPITEM, this study paves the way for the development and translation of a novel class of anti-inflammatory agents which may have utility in a broad range of autoimmune and chronic inflammatory diseases.…”
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Integrated gene expression and alternative splicing analysis in human and mouse models of Rett syndrome by Silvia Gioiosa, Silvia Gasparini, Carlo Presutti, Arianna Rinaldi, Tiziana Castrignanò, Cecilia Mannironi

“…To perform a comparative analysis of publicly available RNA sequencing (RNA-seq) studies and generate novel data resources for AS, we explored 100 human datasets and 130 mouse datasets from Mecp2-mutant models, processing data for gene expression and alternative splicing. …”
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Structural Optimization of the Aircraft NACA Inlet Based on BP Neural Networks and Genetic Algorithms by Zhimao Li, Changdong Chen, Houju Pei, Benben Kong

“…The BP neural networks and genetic algorithms are studied to optimize the design of the ram air inlet system. It is proven to be a novel approach, and the efficiency can be highly improved.…”
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Revealing the potential of ChatGPT for English language teaching: EFL preservice teachers’ teaching practicum experience by I Putu Indra Kusuma, Marianus Roni, Kadek Sintya Dewi, Gede Mahendrayana

“…The potential of ChatGPT as a novel Artificial Intelligence (henceforth, AI)-powered language model for language instruction, particularly for preservice teachers (henceforth, PSTs), remains unclear since earlier studies mainly provided theoretical concepts that have not yet been empirically verified. …”
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Bioactive Characteristics of Wild Berberis vulgaris and Berberis crataegina Fruits by Arzu Yaşar Eroğlu, Özlem Çakır, Mustafa Sağdıç, Enes Dertli

“…There is an increasing trend to find novel sources of products with high antioxidant capacity and wild fruits are very good examples for these sources. …”
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Long-Term Follow-Up after Intravenous Immunoglobulin Therapy in Patients with Severe Ocular Mucous Membrane Pemphigoid Unresponsive to Conventional Therapy by Stefania Leuci, Massimo Amato, Elena Calabria, Raffaele Piscopo, Fausto Tranfa, Gianrico Spagnuolo, Michele Davide Mignogna

“…This new therapy has proven to be effective in stopping ocular pemphigoid, but the data regarding the long-term effect on the disease activity or reactivation are extremely scarce, so the novel scientific aim of this study was to evaluate the clinical outcomes after a 9-year follow-up in 12 eyes (6 patients) affected by MMP with ocular involvement, successfully treated with IVIg therapy, as previously described in our report published in 2008. …”
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Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice by Tatsuhito Himeno, Hideki Kamiya, Keiko Naruse, Zhao Cheng, Sachiko Ito, Taiga Shibata, Masaki Kondo, Jiro Kato, Tetsuji Okawa, Atsushi Fujiya, Hirohiko Suzuki, Tetsutaro Kito, Yoji Hamada, Yutaka Oiso, Kenichi Isobe, Jiro Nakamura

“…These results suggest that transplantation of angioblast like cells induced from embryonic stem cells appears to be a novel therapeutic strategy for diabetic polyneuropathy.…”
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Efficient digital quadratic unconstrained binary optimization solvers for SAT problems by Robert Simon Fong, Yanming Song, Alexander Yosifov

“…To utilize them, we implement a 2-step [3-SAT]-[Max 2-SAT]-[QUBO] conversion procedure and present a novel approach using linear systems and Diophantine equation to calculate the number of both satisfied and violated clauses of the original 3-SAT instance from the transformed Max 2-SAT formulation. …”
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How Do Temporal and Geographical Kernels Differ in Reflecting Regional Disparities? Insights from a Case Study in China by Chunzhu Wei, Xufeng Liu, Wei Chen, Lupan Zhang, Ruixia Chao, Wei Wei

“…Among the models, STWR outperforms others in capturing and interpreting local variations in spatio-temporal disparities, demonstrating its utility in understanding complex regional dynamics. This study provides novel insights into the spatio-temporal determinants of regional economic disparities, offering a robust analytical framework for policymakers to address region-specific variables driving inequality over time and space. …”
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Green Space Planning and Landscape Sustainable Design in Smart Cities considering Public Green Space Demands of Different Formats by Juan Shan, Zhuo Huang, Sibo Chen, Yue Li, Wenli Ji

“…Smart UGS planning is a technical management tool and a human-centered smart application. A novel UGS classification method based on function combinations is proposed in the present work. …”
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A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study by V. P. Diego, L. Almasy, D. L. Rainwater, M. C. Mahaney, A. G. Comuzzie, S. A. Cole, R. P. Tracy, M. P. Stern, J. W. MacCluer, J. Blangero

“…To our knowledge, the putative QTL on chromosome 5p is novel. The possible QTL on chromosome 2q is discussed in relation to a recent report of linkage of a related hemostatic factor to the same location. …”
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