Drug Target Identification and Elucidation of Natural Inhibitors for : An Study by Surya Narayan Rath, Manisha Ray, Animesh Pattnaik, Sukanta Kumar Pradhan

“…Identification of potential drug target and proposing a novel lead compound against the pathogen has a great aid and value. …”
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Coupled Thermo-Hydro-Mechanical-Chemical Modeling of Permeability Evolution in a CO2-Circulated Geothermal Reservoir by Jing Tao, Yu Wu, Derek Elsworth, Pan Li, Yang Hao

“…However, complex thermo-hydro-mechanical-chemical (THMC) interactions may result when CO2 is injected into the geothermal reservoir. We present a novel numerical model to describe the spatial THMC interactions and to better understand the process interactions that control the evolution of permeability and the heat transfer area. …”
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Characterization of the ZDSD Rat: A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes by Richard G. Peterson, Charles V. Jackson, Karen Zimmerman, Willem de Winter, Norman Huebert, Michael K. Hansen

“…ZDSD rats will provide a novel, translational animal model for the study of human metabolic diseases and for the development of new therapies.…”
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A multi-criteria optimization for a radial heat sink with semicircular fins based on the design of experiments approach by Yousif Hashim Hussein, Tahseen Ahmad Tahseen, Abdulrazzak Akroot, M.A.H. Mithu, Ammar M. Abdulateef

“…This study utilized the Nusselt number and thermal resistance, along with an effective regression analysis, to develop a novel predictive model. Key performance indicators included R2, adjusted R2, predicted R2, coefficient of variation (CV), and parameter separation from the best-fit results. …”
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MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy by Yingying Zhang, Siqi Zhao, Depei Wu, Xingmei Liu, Mingjun Shi, Yuanyuan Wang, Fan Zhang, Jing Ding, Ying Xiao, Bing Guo

“…Therefore, our findings indicated that miR-22 may promote TIF by suppressing autophagy partially via targeting PTEN and represents a novel and promising therapeutic target for DN.…”
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Freshwater sponges in the southeastern U.S. harbor unique microbiomes that are influenced by host and environmental factors by Jacqueline G. Keleher, Taylor A. Strope, Noah E. Estrada, Allison M. Griggs Mathis, Cole G. Easson, Cara Fiore

“…Bacterial taxa within the Gammproteobacteria, Alphproteobacteria, Bacteroidota (Flavobacteriia in particular), and Verrucomicrobia, were notable as enriched in the sponge relative to the surrounding water across sponge individuals with diverging microbial communities from the water. These results add novel information on the assembly and maintenance of microbial communities in an ancient metazoan host and is one of few published studies on freshwater sponge microbial symbiont communities.…”
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<i>Epigynum auritum</i>-Derived Near-Infrared Carbon Dots for Bioimaging and Antimicrobial Applications by Wenfeng Shi, Jiahui Li, Junmei Pu, Guiguang Cheng, Yaping Liu, Shanshan Xiao, Jianxin Cao

“…In this study, near-infrared carbon dots (NIR-CDs) with antimicrobial and bioimaging functions were prepared from <i>Epigynum auritum</i> branches and leaves using a novel green synthesis approach. The spectral properties of the synthesized NIR-CDs were characterized by ultraviolet–visible (UV-Vis) absorption and fluorescence spectroscopy. …”
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Perioperative treatment with cilostazol reverses steatosis and improves liver regeneration after major hepatectomy in a steatotic rat model by Sebastian Holländer, Maximilian von Heesen, Gereon Gäbelein, Julie Mercier, Matthias W. Laschke, Michael D. Menger, Matthias Glanemann, Antonios E. Spiliotis

“…Consequently, cilostazol should be evaluated as a novel strategy to reduce the rate of liver failure after PHX in steatotic liver.…”
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Ion‐Permeable Electrospun Scaffolds Enable Controlled In‐Vitro Electrostimulation Assay of Myoblasts by Serafina Pacilio, Francesco Decataldo, Roberta Costa, Tobias Cramer, Beatrice Fraboni, Giovanna Cenacchi, Maria Letizia Focarete

“…However, in‐vitro assays permitting reliable electrical stimulation of cell contractile activity still require technological development. Here, a novel approach to electrically stimulate differentiated muscular cell contractility is reported exploiting the ionic conductivity and mechanical flexibility of 3D nanofibrous scaffolds. …”
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Efficient guided inpainting of larger hole missing images based on hierarchical decoding network by Xiucheng Dong, Yaling Ju, Dangcheng Zhang, Bing Hou, Jinqing He

“…Abstract When dealing with images containing large hole-missing regions, deep learning-based image inpainting algorithms often face challenges such as local structural distortions and blurriness. In this paper, a novel hierarchical decoding network for image inpainting is proposed. …”
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Using RAD-seq to identify and differentiate the medicinal herb Scrophularia ningpoensis and its adulterants by Lei Guo, Xia Wang, Hong Li, Mengli Zhou, Liqin Liu, Ruihong Wang, Pan Li

“…Furthermore, it offers novel insights and methodologies for the identification of medicinal plants.…”
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The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling by Liusong Yin, Xiaoying Chen, Abhinav Tiwari, Paolo Vicini, Timothy P. Hickling

“…In summary, our computational analysis is suggestive of novel insights into the mechanisms underlying aggregate-induced immunogenicity, which could be used to develop mitigation strategies.…”
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Finite element analysis and artificial neural network for stress distribution of an aircraft model in a wind tunnel by Ahmed Al-Mulla Khalaf, Sinan Al-Haddad, Bilal Al-Oubaidi, Naseem Ibrahim, Fawaz Abdulwahed, Athraa Hilal

“…This paper presents a novel enhancement to stress distribution predictions in wind tunnel simulations by combining Finite Element Analysis (FEA) and Artificial Neural Networks (ANN). …”
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STADIUM: Species-Specific tRNA Adaptive Index Compendium by Jonghwan Yoon, Yeun-Jun Chung, Minho Lee

“…To enable easy access to this index, we constructed a novel web database, named STADIUM (Species-specific tRNA adaptive index compendium). …”
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Intelligence Based Controlling Models for Effective Power Tracking and Voltage Enhancement in Grid-PV Systems by I. E. S. Naidu, T. Padmavathi, S. Venkata Padmavathi, Budidi U. Kumar

“…The underlying research work is focused on enhancement in the efficiency and voltage gain for solar PV systems with the help of designing a novel regulating framework that includes advanced converter topologies integrated with intelligent control techniques. …”
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Floquet topological phase transitions in 2D Su–Schrieffer–Heeger model: interplay between time reversal symmetry breaking and dimerization by Adrian Pena, Bogdan Ostahie, Cristian Radu

“…Furthermore, we employ a novel method to show that the four unit cell atoms, in the absence of irradiation, can be interpreted as conserved spin states. …”
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The role of new hepatitis B vaccines in South Africa by G U van Zyl, T Maponga, H Rabie, J Taljaard

“…PreHevbrio, which includes three hepatitis B surface protein domains, instead of one, may also be more immunogenic, although clinical study data are still limited. These two novel vaccines have not yet been investigated in children and licensed in SA. …”
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Identification of emerging harms due to COVID-19 outbreak: a qualitative study in Iran by Sina Ahmadi, Seyed Fahim Irandoost, Neda SoleimanvandiAzar, Marzieh Nojomi, Javad Yoosefi Lebni, Arash Tehrani-Banihashemi

“…Conclusion The COVID-19 crisis has intensified existing social harms and introduced new ones, rendering previous mitigation strategies ineffective. Designing novel policies and guidelines is crucial to address these evolving challenges and reduce the adverse societal impacts of the pandemic.…”
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Graph Deep Active Learning Framework for Data Deduplication by Huan Cao, Shengdong Du, Jie Hu, Yan Yang, Shi-Jinn Horng, Tianrui Li

“…To fill this research gap, we propose a novel graph deep active learning framework for data deduplication, which is based on similarity algorithms combined with the bidirectional encoder representations from transformers (BERT) model to extract the deep similarity features of multi-source data records, and first introduce the graph active learning strategy to build a clean graph to filter the data that needs to be labeled, which is used to delete the duplicate data that retain the most information. …”
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Photothermal inactivation of methicillin‐resistant Staphylococcus aureus : anti‐biofilm mediated by a polypyrrole–carbon nanocomposite by Niloufar Behzadpour, Neda Akbari, Naghmeh Sattarahmady

“…Widespread resistance to antibiotics amongst pathogens has become a tremendous challenge of high morbidity and mortality rates which increases the needs to exploring novel methods of treatment. An efficient antimicrobial procedure to root out pathogenic bacteria is photothermal therapy. …”
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