A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes) by Tamás Visnovitz, Dorina Lenzinger, Anna Koncz, Péter M Vizi, Tünde Bárkai, Krisztina V Vukman, Alicia Galinsoga, Krisztina Németh, Kelsey Fletcher, Zsolt I Komlósi, Csaba Cserép, Ádám Dénes, Péter Lőrincz, Gábor Valcz, Edit I Buzas

“…According to our model, upon fusion of multivesicular bodies with autophagosomes, fragments of the autophagosomal inner membrane curl up to form LC3B positive ILVs of amphisomes, while CD63 positive small EVs are of multivesicular body origin. Our data suggest a novel common release mechanism for small EVs, distinct from the exocytosis of multivesicular bodies or amphisomes, as well as the small ectosome release pathway.…”
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New Biofunctional Loading of Natural Antimicrobial Agent in Biodegradable Polymeric Films for Biomedical Applications by Bakhtawar Ghafoor, Murtaza Najabat Ali, Umar Ansari, Muhammad Faraz Bhatti, Mariam Mir, Hafsah Akhtar, Fatima Darakhshan

“…The study focuses on the development of novel Aloe vera based polymeric composite films and antimicrobial suture coatings. …”
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Linking machine learning and biophysical structural features in drug discovery by Armin Ahmadi, Shivangi Gupta, Vineetha Menon, Jerome Baudry

“…By leveraging pharmacophore descriptors, the AI/ML framework prioritized features uniquely associated with ligand-selected conformations, enabling a mechanism-driven understanding of binding interactions. This novel approach integrates biophysical insights with machine learning, focusing on pharmacophoric properties such as charge, hydrogen bonding, hydrophobicity, and aromaticity.ResultsResults showed significant enrichment of true positive ligands—improving database enrichment by up to 54-fold compared to random selection—demonstrating the robustness of this approach across diverse proteins.ConclusionUnlike conventional structure-based or ligand-based screening methods, this work emphasizes the role of specific protein conformations in driving ligand binding, making the process highly interpretable and actionable for drug discovery. …”
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IS THERE A CAUSAL RELATIONSHIP BETWEEN FINANCIAL PERFORMANCE AND PREMIUM PRODUCTION? EVIDENCE FROM TURKISH INSURANCE INDUSTRY by Murat Belke, Mohsin Shabir, Özcan Işık

“…In the first stage of the analysis, a hybrid model including LOPCOW, SWARA II, and MARCOS methods is proposed to determine companies’ financial performance values. In this stage, a novel integrated weighting method for calculating criterion weights is applied based on objective information and judgements of decision-makers. …”
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Improvement in Brightness Uniformity by Compensating for the Threshold Voltages of Both the Driving Thin-Film Transistor and the Organic Light-Emitting Diode for Active-Matrix Orga... by Ching-Lin Fan, Hao-Wei Chen, Hui-Lung Lai, Bo-Liang Guo, Bohr-Ran Huang

“…This paper proposes a novel pixel circuit design and driving method for active-matrix organic light-emitting diode (AM-OLED) displays that use low-temperature polycrystalline-silicon thin-film transistors (LTPS-TFTs) as driving element. …”
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NuFold: end-to-end approach for RNA tertiary structure prediction with flexible nucleobase center representation by Yuki Kagaya, Zicong Zhang, Nabil Ibtehaz, Xiao Wang, Tsukasa Nakamura, Pranav Deep Punuru, Daisuke Kihara

“…To address this challenge, we developed NuFold, a novel computational approach that leverages state-of-the-art deep learning architecture to accurately predict RNA tertiary structures. …”
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Synergistic enhancement of pseudocapacitance behavior in supercapacitors through porous carbon and lignosulfonate integration by Bingjie Zhou, Yuankai Shao, Weikang Zhu, Shuoyao Yin, Zhenguo Li, Xiaoning Ren, Anqi Dong, Xi Liu, Yatao Liu, Yaodong Hao, Bin Ren, Wei Liu

“…Biomass has emerged as a promising resource for novel energy storage devices. Lignosulfonate, a byproduct of the forestry and pulp industries, contains quinone groups and has enormous potential for electrochemical energy storage. …”
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Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives by Hubo Yang, Xuefeng Zhang, Zongming Jia, He Wang, Jixiang Wu, Xuedong Wei, Yuhua Huang, Wenying Yan, Yuxin Lin

“…Hence deciphering the role of ferroptosis in carcinogenesis would provide novel insights and strategies for precision medicine and personalized healthcare against PCa. …”
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Integrative genetics and multiomics analysis reveal mechanisms and therapeutic targets in vitiligo highlighting JAK STAT pathway regulation of CTSS by Zi-yue Dong, Ming-jie He, Yong-kai Yu, Fang Wang, Peng-yuan Zhao, De-long Ran, De-shuang Fu, Qing He, Run-ping Yang, Jiang-an Zhang

“…Microarray and single-cell RNA-seq data showed differential expression of CTSS and STAT1/3 in vitiligo patients’ blood and skin lesions. Our study offers novel perspectives on vitiligo’s genetic and molecular basis, highlighting the JAK/STAT pathway’s role in regulating CTSS for antigen processing in melanocytes. …”
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In-Plane Instability of Parabolic Arches under Uniformly Distributed Vertical Load Coupled with Temperature Gradient Field by Zhenyu Pan, Deyuan Deng, Changsheng Feng, Hanwen Lu, Zhou Chen, Jinman Zhou, Angfeng Jiang

“…Secondly, the preinstability internal force analysis of the parabolic arch under the linear temperature gradient field and the vertical uniform load is carried out based on the force methods. Novel theoretical solutions for in-plane instability load for fixed steel parabolic arches under the linear temperature gradient field and the vertical uniform load are obtained. …”
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Proteomic Analysis of Lung Tissue in a Rat Acute Lung Injury Model: Identification of PRDX1 as a Promoter of Inflammation by Dongdong Liu, Pu Mao, Yongbo Huang, Yiting Liu, Xiaoqing Liu, Xiaoqing Pang, Yimin Li

“…In conclusion, our findings provide a global alteration in the proteome of lung tissues in the ALI rat model and indicate that PRDX1 may play a critical role in the pathogenesis of ARDS by promoting inflammation and represent a novel strategy for the development of new therapies against ALI.…”
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Mechanism of Repeat-Associated MicroRNAs in Fragile X Syndrome by Karen Kelley, Shin-Ju E. Chang, Shi-Lung Lin

“…FMRP deficiency often causes synapse deformity in the neurons essential for cognition and memory activities, while FMR1 inactivation augments metabotropic glutamate receptor (mGluR)-activated long-term depression (LTD), leading to abnormal neuronal responses in FXS. Using this novel animal model, we may further dissect the etiological mechanisms of TREDs, with the hope of providing insights into new means for therapeutic intervention.…”
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Enhancing Channel Selection in 5G with Decentralized Federated Multi-Agent Deep Reinforcement Learning by Taghi Shahgholi, Keyhan Khamforoosh, Amir Sheikhahmadi, Sadoon Azizi

“…In this paper, we present a comprehensive study on channelization in Cellular Vehicle-to-Everything (C-V2X) communication and propose a novel two-layer multi-agent approach that integrates deep reinforcement learning (DRL) and federated learning (FL) to enhance the decision-making process in channel utilization.Our approach leverages the autonomy of each vehicle, treating it as an independent agent capable of making channel selection decisions based on its local observations in its own cluster. …”
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Dataset and analysis of automated and manual methods to differentiate wide QRS complex tachycardiasDataverse by Sarah LoCoco, Anthony H. Kashou, Abhishek J. Deshmukh, Samuel J. Asirvatham, Christopher V. DeSimone, Krasimira M. Mikhova, Sandeep S. Sodhi, Phillip S. Cuculich, Rugheed Ghadban, Daniel H. Cooper, Thomas M. Maddox, Peter A. Noseworthy, Adam M. May

“…Brugada, Vereckei aVR, and VT Score) to novel automated wide QRS complex tachycardia differentiation algorithms (i.e. …”
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The Role of Pentacyclic Triterpenoids in Non-Small Cell Lung Cancer: The Mechanisms of Action and Therapeutic Potential by Young-Shin Lee, Ryuk Jun Kwon, Hye Sun Lee, Jae Heun Chung, Yun Seong Kim, Han-Sol Jeong, Su-Jung Park, Seung Yeon Lee, Taehwa Kim, Seong Hoon Yoon

“…This underscores the growing need for novel therapeutic strategies to complement existing treatments and improve patient outcomes. …”
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Trypsin-instructed bioactive peptide nanodrugs with cascading transformations to improve chemotherapy against colon cancer by Can Wu, Xiao Wei Zhang, Manman Wang, Jinpan Sun, Jianfei Chen, Yanbin Guan, Xin Pang

“…As the first example of employing trypsin-mediated nanodrugs with cascading transformations to promote chemotherapeutic activity, this work promises a strategy for novel therapies for efficiently combating colon cancer. …”
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Dynamics of a Self-Excited Vibrating Thermal Energy Harvester with Shape Memory Alloys and PVDF Cantilevers by Ivo Yotov, Georgi Todorov, Elitsa Gieva, Todor Todorov

“…This paper discusses the dynamics of a novel energy harvester that converts heat into mechanical vibrations of two polyvinylidene fluoride (PVDF) piezoelectric cantilevers that generate electrical energy using a shape memory alloy (SMA) filament. …”
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Review—Recent Progress in Materials Development for Electrochemical Gas Sensors by Kening Lang, Tianyi Liu, Rishi J. Patel, Mark L. Ballentine, Alan J. Kennedy, Wu-Sheng Shih, Adam Scotch, Jiadeng Zhu

“…The unique properties of novel materials, including metal and metal oxides, carbon materials, conducting polymers, their composites, and others, are discussed in detail. …”
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Impact of COVID-19 pandemic on emergency department visits and infant health: a scoping review protocol by Mark Walker, Shi Wu Wen, Yanfang Guo, Romina Fakhraei, Brenden Osborne, Mélika Moorjani-Houle

“…Introduction The novel SARS-CoV-2 pandemic has provided a set of unique challenges for paediatric patients requiring emergency care across the globe. …”
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Review on recent advancements in the role of electrolytes and electrode materials on supercapacitor performances by Ashutosh Patel, Suresh Kumar Patel, R. S. Singh, R. P. Patel

“…Additionally, the paper delves into the impact of novel bio-based hybrid electrolytes, drawing upon literature data to outline the fabrication of various hybrid electrode materials incorporating conducting polymers like polyaniline and polypyrrole, as well as metal oxides, carbon compounds, and hybrid electrolytes such as ionic liquids, gel polymers, aqueous, and solid polymer electrolytes. …”
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