‘Photodynamic therapy light’: An enhanced treatment protocol for actinic keratoses with minimal pain and optimal clinical outcome by combining laser-assisted low irradiance PDT wit... by Martin T. Braun, Kelly Del Tredici, Anna Wölling, Luitgard Wiest

“…Therefore, we developed a novel off-label PDT protocol: ‘PDT light’. Methods: Laser-assisted low irradiance PDT (li-PDT) was performed beginning in 2014. …”
Get full text

Deletion of bZIP Transcription Factor <i>PratfA</i> Reveals Specialized Metabolites Potentially Regulating Stress Response in <i>Penicillium raistrickii</i> by Anxin Zhang, Shu Zhang, Xinran Xu, Wen-Bing Yin

“…The manipulation of regulatory factors can guide the discovery of novel natural products (NPs).…”
Get full text

Identification of Houge type of X-linked syndromic mental retardation caused by CNKSR2 truncated variants by Si-Hua Chang, Jie-Yuan Jin, Yi-Qiao Hu, Run-Yan Wang, Rong Xiang, Xia Wang

“…Conclusions We identified two novel CNKSR2 variants in MRXSHG families, expanding the variant spectrum of CNKSR2, enriching MRXSHG-related phenotypes, and contributing to genetic counseling for MRXSHG patients.…”
Get full text

The Stability-Indicating Ultra High-Performance Liquid Chromatography with Diode Array Detector and Tandem Mass Spectrometry Method Applied for the Forced Degradation Study of Ritl... by Jelena Kovačić, Daniela Amidžić Klarić, Nikša Turk, Željko Krznarić, Emma Riordan, Ana Mornar

“…Ritlecitinib, a second-generation JAK3 inhibitor, is a novel therapeutic agent for alopecia areata and other autoimmune conditions. …”
Get full text

Nevoid basal cell carcinoma syndrome (Gorlin syndrome): a case report by Noura Abdul Rahman, Fatima Breim, Joud Zakour, Zainab Srouji, Silva Ishkhanian

“…Minimal side effects were observed, highlighting the potential efficacy of this novel approach in managing basal cell carcinomas associated with Gorlin–Goltz syndrome. …”
Get full text

Stock volatility as an anomalous diffusion process by Rubén V. Arévalo, J. Alberto Conejero, Òscar Garibo-i-Orts, Alfred Peris

“…In financial markets, accurately estimating asset volatility—whether historical or implied—is vital for investors.We introduce a novel methodology to estimate the volatility of stocks and similar assets, combining anomalous diffusion principles with machine learning. …”
Get full text

Research Progress on the Potential Pathogenesis of Persistent Postural–Perceptual Dizziness by Chen Qin, Ruyi Zhang, Zhihui Yan

“…Methods To better understand the pathogenesis of PPPD and to aid in the development of novel diagnostic strategies and therapies, we conducted a comprehensive narrative review of the relevant literature. …”
Get full text

Atomized Neutrophil Membrane-coated MOF Nanoparticles for Direct Delivery of Dexamethasone for Severe Pneumonia by Yixiao Yang, Lizhen Yan, Han Zhang, Chuanguang Xiao, Kai Wang

“…Methods: We designed a novel UiO66 metal-organic framework nanoparticle loaded with Dex and coated with neutrophil cell membranes (UiO66-Dex@NMP) for targeted therapy of severe pneumonia. …”
Get full text

Nutritional Quality, Potential Health Promoting Properties and Sensory Perception of an Improved Gluten Free Bread Formulation Containing Inulin, Rice Protein and Bioactive Compoun... by Alessandro Guglielmetti, Beatriz Fernandez-Gomez, Giuseppe Zeppa, Dolores del Castillo

“…The new formulation combines well-known and novel food ingredients. To validate the novel ingredients, we determined the physicochemical characterization, caffeine and chlorogenic acid contents and food safety of coffee silverskin (CSE) and husk (CHE) extracts. …”
Get full text

A two-step machine learning approach for predictive maintenance and anomaly detection in environmental sensor systems by Saiprasad Potharaju, Ravi Kumar Tirandasu, Swapnali N. Tambe, Devyani Bhamare Jadhav, Dudla Anil Kumar, Shanmuk Srinivas Amiripalli

“…Using Environmental Sensor Telemetry Data, this study introduces a novel methodology that combines unsupervised and supervised machine learning approaches to detect anomalies and predict sensor failures. …”
Get full text

Numerical investigation of heat and mass transfer for unsteady multiphase flow in a vented cavity filled with hybrid nanofluid by Muhammad Ashhad Shahid, Mojtaba Dayer, Muhammad Adil Sadiq, Haris Ali, Ishak Hashim

“…The current study investigates the effect of novel combination of unsteady condition and multiphase flow effect on hybrid nanofluid (HNF) convective heat and mass transfer (CHMT) within a vented cavity. …”
Get full text

Safety-Critical Oracles for Metamorphic Testing of Deep Learning LiDAR Point Cloud Object Detectors by Simon Speth, Maximilian Trien, Dominik Kufer, Alexander Pretschner

“…We address this by introducing novel egocentric test oracles based on traffic participants&#x2019; bounding boxes shifted into or out of the ego vehicle&#x2019;s expected lane. …”
Get full text

Raman spectroscopy study of the role of dispersion and interfaces in the improvement of the mechanical properties of epoxy-TiO2 composites by María Fernández-Álvarez, Alberto Moure, Luis Angulo Delgado, Julián J. Reinosa, José F. Fernández

“…To achieve these goals, a novel dispersion method, involving three steps (high-speed stirring, high-shear mixing, and tri-cylinder rolling), was developed. …”
Get full text

Synergistic Enzybiotic Effect of a Bacteriophage Endolysin and an Engineered Glucose Oxidase Against <i>Listeria</i> by David Talens-Perales, José-Antonio Daròs, Julio Polaina, Julia Marín-Navarro

“…Two enzyme-based antimicrobials (enzybiotics) have been combined in a novel treatment against this pathogenic bacterium, resulting in a powerful synergistic effect. …”
Get full text

GFRα1 Promotes Axon Regeneration after Peripheral Nerve Injury by Functioning as a Ligand by Tomoaki Suzuki, Ken Kadoya, Takeshi Endo, Miwako Yamasaki, Masahiko Watanabe, Norimasa Iwasaki

“…These findings reveal a novel role of GFRα1 as a ligand, the molecular mechanism supporting axon regeneration by RSCs, and a novel therapy for peripheral nerve repair.…”
Get full text

Tuberculosis vaccines and therapeutic drug: challenges and future directions by Yajing An, Ruizi Ni, Li Zhuang, Ling Yang, Zhaoyang Ye, Linsheng Li, Seppo Parkkila, Ashok Aspatwar, Wenping Gong

“…The hurdles in TB vaccine and therapeutic development encompass overcoming antigen diversity, enhancing vaccine effectiveness across diverse populations, and advancing novel vaccine platforms. Future initiatives emphasize combinatorial strategies, the development of anti-TB compounds targeting novel pathways, and personalized medicine for TB treatment and prevention. …”
Get full text

Frequency and Texture Aware Multi-Domain Feature Fusion for Remote Sensing Scene Classification by Russo Ashraf, Kang-Hyun Jo

“…Delving into these complexities, the Efficient Spectral Inception Former (ESIF) architecture is proposed, which introduces a novel paradigm to RS scene classification by integrating multi-domain feature fusion of the spatial, texture, and spectral (frequency) domains. …”
Get full text

Improving the Utility, Safety, and Ethical Use of a Passive Mood-Tracking App for People With Bipolar Disorder Using Coproduction: Qualitative Focus Group Study by Laurence Astill Wright, Matthew Moore, Stuart Reeves, Elvira Perez Vallejos, Richard Morriss

“…Principally, people with BD wished to use this novel technology to aid them in self-managing their BD with greater insight and a better understanding of potential triggers. …”
Get full text

Proteomic insights into dual-species biofilm formation of E. coli and E. faecalis on urinary catheters by Kidon Sung, Miseon Park, Ohgew Kweon, Angel Paredes, Alena Savenka, Saeed A Khan

“…Notably, elongated E. faecalis cells were observed in dual-species biofilms, a novel finding in mixed-species biofilm cultures. …”
Get full text

Enhancing paddy leaf disease diagnosis -a hybrid CNN model using simulated thermal imaging by Jagamohan Padhi, Kunal Mishra, Ashoka Kumar Ratha, Santi Kumari Behera, Prabira Kumar Sethy, Aziz Nanthaamornphong

“…This study introduces a novel hybrid Deep Learning approach integrating thermal imaging and model hybridization for early and precise detection of rice leaf diseases. …”
Get full text