Combination PPARγ and RXR Agonist Treatment in Melanoma Cells: Functional Importance of S100A2 by Joshua P. Klopper, Vibha Sharma, Reid Bissonnette, Bryan R. Haugen

“…Nuclear hormone receptors, including RXR and PPARγ, represent novel therapeutic targets in melanoma. We have previously shown that the DRO subline of the amelanotic melanoma A375 responds to rexinoid and thiazolidinedione (TZD) treatment in vitro and in vivo. …”
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Development and Validation of a Wave-Propelled Semi-submersible Unmanned Vehicle by Tian Yingyuan, Li Weijia, Wang Zhigang

“…This study proposes a novel wave-propelled semi-submersible unmanned vehicle (WPSUV) to overcome these disadvantages. …”
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Blinding HT: Hiding Hardware Trojan signals traced across multiple sequential levels by Ying Zhang, Minghui Ge, Xin Chen, Jiaqi Yao, Zhiming Mao

“…As shown in the experimental results, the proposed HTs are hardly detected even by the novel HT detection approach based on machine learning algorithm. …”
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A Proposed Role for Lymphatic Supermicrosurgery in the Management of Alzheimer's Disease: A Primer for Reconstructive Microsurgeons by Joon Pio Hong, Wei F. Chen, Dung H. Nguyen, Qingping Xie

“…The relatively recent discovery of a novel lymphatic system within the brain meninges has spurred interest in how waste products generated by neurons and glial cells—including proteins associated with Alzheimer's disease (AD) pathology such as amyloid beta (Aβ) and tau—are disposed of. …”
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Cell-marking techniques for cell lineage tracing by A. M. Yunusova, N. R. Battulin

“…One chapter of the review describes novel advancements in the field of CRISPR/Cas9-based cellular barcoding.…”
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Synthesis, Characterization, and Antibacterial Activities of 1H-Imidazo [5, 6-f] [1,10] Phenanthroline-2(3H)-Thione and Its Ni(II) and Cu(II) Complexes by Radiet Anbessie Tirkeso, Tilahun Wubalem Tsega, Gebru G/Tsadik Amdemichael

“…As multidrug resistant pathogens are emerging, the search for novel potent drug candidates is ever going. Heterocycles are known by their broad spectrum of biological activities, so a search for a new drug from heterocycles can elevate the chance of success. …”
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Application of deconvolutional networks for feature interpretability in epilepsy detection by Sihao Shao, Yu Zhou, Ruiheng Wu, Aiping Yang, Qiang Li

“…The Fully Convolutional Network (FCN) can provide the model’s interpretability but has not been applied in seizure detection.MethodsTo address these challenges, a novel convolutional neural network (CNN) model, combining SE (Squeeze-and-Excitation) modules, was proposed on top of the FCN. …”
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Machine learning enabled measurements of astrophysical (p,n) reactions with the SECAR recoil separator by P. Tsintari, N. Dimitrakopoulos, R. Garg, K. Hermansen, C. Marshall, F. Montes, G. Perdikakis, H. Schatz, K. Setoodehnia, H. Arora, G. P. A. Berg, R. Bhandari, J. C. Blackmon, C. R. Brune, K. A. Chipps, M. Couder, C. Deibel, A. Hood, M. Horana Gamage, R. Jain, C. Maher, S. Miskovich, J. Pereira, T. Ruland, M. S. Smith, M. Smith, I. Sultana, C. Tinson, A. Tsantiri, A. Villari, L. Wagner, R. G. T. Zegers

“…The SECAR (SEparator for CApture Reactions) recoil separator at FRIB (Facility for Rare Isotope Beams) was originally designed to measure astrophysical reactions that change the mass of a nucleus significantly. We used a novel approach that integrates machine learning with ion-optical simulations to find an ion-optical solution for the separator that enables the measurement of (p,n) reactions, despite the reaction leaving the mass of the nucleus nearly unchanged. …”
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Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche by Alejandro Luarte, Luis Federico Bátiz, Ursula Wyneken, Carlos Lafourcade

“…Neurodegenerative disorders are one of the leading causes of death and disability and one of the biggest burdens on health care systems. Novel approaches using various types of stem cells have been proposed to treat common neurodegenerative disorders such as Alzheimer’s Disease, Parkinson’s Disease, or stroke. …”
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Inhibitory Effect of Matrine on Blood-Brain Barrier Disruption for the Treatment of Experimental Autoimmune Encephalomyelitis by Su Zhang, Quan-Cheng Kan, Yuming Xu, Guang-Xian Zhang, Lin Zhu

“…Taken together, our results identify a novel mechanism underlying the effect of MAT, a natural compound that could be a novel therapy for MS.…”
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Application of loaded graphene oxide biomaterials in the repair and treatment of bone defects: a review by Jinyi Xing, Shuzhong Liu

“…Given their favourable biocompatibility and osteoinductive capabilities, these materials offer a novel therapeutic avenue for bone tissue regeneration and repair. …”
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p-Type Quasi-Mono Silicon Solar Cell Fabricated by Ion Implantation by Chien-Ming Lee, Sheng-Po Chang, Shoou-Jinn Chang, Ching-In Wu

“…The p-type quasi-mono wafer is a novel type of silicon material that is processed using a seed directional solidification technique. …”
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Activating PKC-ε induces HIV expression with improved tolerability. by Alivelu M Irrinki, Jasmine Kaur, Bally Randhawa, Ryan McFadden, Chelsea Snyder, Hoa Truong, Daniel Soohoo, Eric Hu, Helen Yu, Bernard P Murray, Bing Lu, Dmytro Kornyeyev, Ishak Darryl Irwan, Lan Nguyen, Yu-San Yang, Jean-Philippe Belzile, Uli Schmitz, Todd C Appleby, Brian Schultz, Jay Lalezari, Steven Deeks, Tomas Cihlar, Jeffrey P Murry

“…Using structure-based drug design, we developed a novel PKC agonist, C-233, with increased selectivity for PKC-ε. …”
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The use of Platelet Rich Plasmain combination of guided tissue regeneration (chitosan) for bone defects: homogeneity analysis. by Dildar Abdullah Othman, Ziwar Ahmed Saleh, Raid Fahim Salman

“…In this investigation, a novel combination by mixing of Platelet Rich Plasma (PRP) with the chitosan solution has been prepared. …”
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Comprehensive reviews on technological and life cycle environmental aspects of solar–thermal adsorption refrigerator by Jun-Ki Choi, Anup Paudel, Bipin Karki, Katie Bradley, Natalie Quinn, Amy Ciric

“…Finally, we present two novel bench-scale STAR systems, compare their environmental performance to traditional systems, and highlight key design improvements that address scalability challenges.…”
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A first exploratory comparison of the behaviour of wolves (Canis lupus) and wolf-dog hybrids in captivity by Federica Amici, Simone Meacci, Emmeline Caray, Linda Oña, Katja Liebal, Paolo Ciucci

“…In this study, we conducted a first systematic comparison of admixed (N = 11) and non-admixed (N = 14) wolves in captivity, focusing on their reaction to unfamiliar humans and novel objects, and the cohesiveness of their social groups. …”
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A standardized physician-modified endograft workflow utilizing the punch card technique and the Hungaroring reinforcement to treat complex abdominal aortic aneurysms by Csaba Csobay-Novák, MD, PhD, Bendegúz Juhos, PhD, András Szentiványi, MD, Ákos Bérczi, MD, PhD, Artúr Hüttl, MD, Péter Sótonyi, MD, DSc

“…The punch card and the novel reinforcement technique might improve the safety and durability of such repairs.…”
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Curcumin Is an Iconic Ligand for Detecting Environmental Pollutants by T. Devasena, N. Balasubramanian, Natarajan Muninathan, Kuppusamy Baskaran, Shani T. John

“…Nanomaterial-based sensing system has proved to be proficient in sensing environmental pollutants. The development of novel ligands for enhancing the sensing efficiency of nanomaterials has always been a challenge. …”
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Purification and identification of anti-inflammatory peptides from sturgeon (Acipenser schrenckii) cartilage by Li Yuan, Qian Chu, Bei Yang, Wei Zhang, Quancai Sun, Ruichang Gao

“…Five peptide sequences, including four novel peptides, were identified from ethanol-soluble cartilage hydrolysates. …”
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Sparse Regularization With Reverse Sorted Sum of Squares via an Unrolled Difference-of-Convex Approach by Takayuki Sasaki, Kazuya Hayase, Masaki Kitahara, Shunsuke Ono

“…This paper proposes a sparse regularization method with a novel sorted regularization function. Sparse regularization is commonly used to solve underdetermined inverse problems. …”
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