Exploring target selectivity in designing and identifying PI3Kα inhibitors for triple negative breast cancer with fragment-based and bioisosteric replacement approach by Debojyoti Halder, Shreya Mukherjee, R. S. Jeyaprakash

“…PI3Kα selective inhibition can decrease the TNBC by a significant level with minimal off-target effects. Novel compounds with high selectivity towards PI3Kα are crucial for treating TNBC. …”
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miR-126 and miR-126*: New Players in Cancer by Jeannette Meister, Mirko H. H. Schmidt

“…The novel endothelial cell–derived secreted protein epidermal growth factor–like domain 7 (EGFL7) has been suggested to control vascular tubulogenesis. …”
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Integration of transcriptomics and metabolomics data revealed role of insulin resistant SNW1 gene in the pathophysiology of gestational diabetes by Ravi Bhushan, Rimjhim Trivedi, Ritu Raj, Anjali Rani, Sangeeta Rai, Anima Tripathi, Shiv Govind Rawat, Ajay Kumar, Dinesh Kumar, Pawan K. Dubey

“…The lack of complete understanding of its pathophysiological mechanisms and novel regulatory biomarkers makes early diagnosis difficult. …”
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La Mélancolie et l’aspect spatio-temporel de l’identité dans Le pion sur l’échiquier d’Irène Némirovsky by Liudmyla Parfeniuk

“…However, this triggers new mechanisms for the formation of the characters’ identities and the composition of the novel. As these mechanisms are inscribed in the spatial dimension, space becomes an additional device, participating in the configuration of time in the novel and supporting composition where the structuring function of emplotment is weakened. …”
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Altered Protein Structures and Neoepitopes in Lupus Neutrophils From Dysregulated Splicing of Messenger RNA by Rayan Najjar, Xiaoxing Wang, Jose Mario Bello Pineda, Hugh Alessi, Alison Bays, Robert K. Bradley, James N. Jarvis, Tomas Mustelin

“…Besides causing a range of structural changes, 80 mRNA splice variants exclusive to SLE were predicted to translate into novel amino acid sequences. Peptides derived from these novel amino acid sequences were predicted to bind to the individual patients’ class I and II major histocompatibility complex molecules with high affinity. …”
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Rapid changes in plasma corticosterone and medial amygdala transcriptome profiles during social status change reveal molecular pathways associated with a major life history transit... by Tyler M Milewski, Won Lee, Rebecca L Young, Hans A Hofmann, James P Curley

“…We show that mice of all social ranks rapidly establish new stable social hierarchies when placed in novel social groups with animals of equivalent social status. …”
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Chromosome Numbers and Reproductive Life Cycles in Green Plants: A Phylotranscriptomic Perspective by Rijan R. Dhakal, Alex Harkess, Paul G. Wolf

“…In this study, we combine known ideas from existing literature with novel methods, tools, and data to generate fresh insights into an old question. …”
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Performance Evaluation of Compressive Strength Models for SRP and SRG-Confined Concrete Columns by Ehsan Janfada, HamidReza Nasseri, Hashem Jahangir

“…This paper focused on confining effects of externally bonded composites with polymer and grout matrices equipped with steel fibers, respectively named steel reinforced polymer (SRP) and steel reinforced grout (SRG) composites, as novel and effective methods of strengthening structures. …”
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Unlocking the secrets of the immunopeptidome: MHC molecules, ncRNA peptides, and vesicles in immune response by Arpita Balakrishnan, Arpita Balakrishnan, Gabriela Winiarek, Olga Hołówka, Jakub Godlewski, Agnieszka Bronisz

“…This novel research not only challenges conventional views but also opens up new avenues for understanding immune responses. …”
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Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads? by Periyasamy Sivalingam, Kui Hong, John Pote, Kandasamy Prabakar

“…This review covers novel drug leads with antibacterial and cytotoxic activities isolated from deep-sea, desert, cryo, and volcanic environment Streptomyces from 2009 to 2019. …”
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Multilingüismo en la traducción de Zeru horiek (1995) de Bernardo Atxaga al finés y al estonio by Merilin Kotta

“…Zeru horiek (1995, The Lone Woman, English translation by Margaret Jull Costa) is the second most multilingual novel written by Bernardo Atxaga after Obabakoak. …”
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Potential biomarkers for predicting the risk of thyroid cancer in immunosenescence: a population-based and externally validated multi omics study by Qian Li, Yuanyuan Zhao, Jiawei Yan, Chao He

“…This study aims to uncover novel plasma proteins tied to aging, potentially contributing to thyroid cancer, utilizing diverse investigative methodologies.MethodsIn this research, we utilized an integrative omics approach to identify novel plasma proteins associated with immunosenescence in relation to the risk of thyroid cancer. …”
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Decitabine Increases the Transcription of <i>RIG-I</i> Gene to Suppress the Replication of Feline Calicivirus and Canine Influenza Virus by Shaotang Ye, Zhen Wang, Aolei Chen, Ying Chen, Gaoming Lou, Qingmei Xie, Gang Lu, Shoujun Li

“…Developing novel antiviral drugs has always been a significant forefront in biological medicine research. …”
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Mg-Al Mixed Oxide Adsorbent Synthesized Using FCT Template for Fluoride Removal from Drinking Water by Jifa Liu, Ping Zhao, Yue Xu, Xibin Jia

“…To make full use of natural waste, a novel Mg-Al mixed oxide adsorbent was synthesized by the dip-calcination method using the fluff of the chinar tree (FCT) and an Mg(II) and Al(III) chloride solution as raw materials. …”
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State-of-the-Art Management of Complications of Myeloma and Its Treatment by Monique A. Hartley-Brown, Daniel M. Sullivan, Rachid Baz

“…Multiple myeloma is an incurable disease, although patient survival has increased with the availability of novel agents. Both multiple myeloma and its therapies often affect the renal, immune, skeletal, hematologic, and nervous systems. …”
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Hall deflection of spin-current driven skyrmion and its modulation by Yu Wang, Jingguo Hu

“…Skyrmion has been widely studied as a potential novel information carrier due to its particle-like structure and high sensitivity to the external field. …”
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Multiferroic Memories by Amritendu Roy, Rajeev Gupta, Ashish Garg

“…This phenomenon has led to the development of various kinds of materials and conceptions of many novel applications such as development of a memory device utilizing the multifunctionality of the multiferroic materials leading to a multistate memory device with electrical writing and nondestructive magnetic reading operations. …”
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Children's Conceptual Development: A Long-Run Investigation by Yilmaz Saglam, Merve Ozbek

“…The novel conception further is mixed up with the elements from both old and new beliefs leading intermediate structures to emerge. …”
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Information Flow from COVID-19 Pandemic to Islamic and Conventional Equities: An ICEEMDAN-Induced Transfer Entropy Analysis by Ahmed Bossman

“…To the studied equities markets, a novel technique based on a denoised frequency-domain entropy paradigm was applied. …”
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Brigatinib treatment in a patient with advanced NSCLC with XPO1-ALK fusion: a case report by Yang Zhang, Ke-jie Li, Can Wang, Chang-lin Zou, Meng Su

“…In this case report, we provide evidence of a novel ALK fusion, XPO1-ALK (intergenic), identified by next-generation DNA sequencing in a patient with advanced lung cancer. …”
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