Comparative miRNAome combined with transcriptome and degradome analysis reveals a novel miRNA-mRNA regulatory network associated with starch metabolism affecting pre-harvest sprouting resistance in wheat by Longqing Sun, Ting Zhao, Dandan Qin, Jing Dong, Daorong Zhang, Xifeng Ren

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Chichimene field T2 sand: a successful application of cycles in a water injection project on heavy crude oil, enabled by a novel smart selective completion system adapted for water injection by Pedro Luis Solorzano, Carlos Emilio Giosa, Carol Stephanny Rojas, Mónica Andrea Satizabal, Amelia Jhoanna Araque, Luisa Fernanda Falla, Walter Enrique Sanchez, Luis Oswaldo Castañeda, Mónica Alexandra Martínez, Diana Patricia Ahmedt

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A novel ultra-high temperature ceramic composite coating prepared by high-speed laser cladding and pack cementation on Ta–W alloys for higher plasma ablation resistance above 2300 °C by Youjiang Zhang, Qiyao Deng, Yang Li, Pengfei He, Chuan Sun, Wengang Bu, Yue Xing, Yujun Cai, Xiubing Liang

“…To improve the high-temperature ablation resistance properties of Ta(W) refractory alloys, a novel ultra-high-temperature ceramic (UHTC) composite coating was prepared by combining the technological advantages of high-speed laser cladding (HSLC) and pack cementation (PC). …”
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Novel laparoscopic “lateral three-port technique” of extended totally extra peritoneal approach for ventral hernias: Short-term results and technical aspects of 100 consecutive cases from a single center by K. Ganesh Shenoy, Marina Thomas, Ramesh B S, Amol Siddalingappa Jeur, Nawab Jan

“…In this article, we present the technical aspects to perform this procedure by using novel lateral three ports and the short-term results of our experience in this subset of patients. …”
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Enhanced Benefit of STA-MCA Bypass Surgery in Chronic Terminal Internal Carotid and/or Middle Cerebral Artery Occlusion Patients With Impaired Collateral Circulation: Introducing a Novel Assessment Approach for Collateral Compensation by Cheng Qiu, Yanping Zhang, Zhiqiang Yu, Yonghui Xu, Yongjiang Huang, Tianci Huang, Jun Ma, Jinbing Zhao

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Discovery of a Novel Shared Variant Among RTEL1 Gene and RTEL1-TNFRSF6B lncRNA at Chromosome 20q13.33 in Familial Progressive Myoclonus Epilepsy by Sima Chaudhari, Lavanya Prakash Acharya, Dushyanth Babu Jasti, Akshay Pramod Ware, Sankar Prasad Gorthi, Kapaettu Satyamoorthy

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A Novel Lactococcal Vaccine Expressing a Peptide from the M2 Antigen of H5N2 Highly Pathogenic Avian Influenza A Virus Prolongs Survival of Vaccinated Chickens by Kaleb A. Reese, Christopher Lupfer, Rudd C. Johnson, Georgi M. Mitev, Valerie M. Mullen, Bruce L. Geller, Manoj Pastey

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Case report: A novel 11-bp deletion in exon 11 causing a frameshift in the C-terminal of the ALAS2 gene leading to X-linked sideroblastic anemia—a family study by Salam Al kindi, Salam Al kindi, Altaf Al-Mamari, Shoaib Al-Zadjali, Mohamed Al-Rawahi, Ali Al Madhani, Anil V. Pathare

“…It is due to mutations of the erythroid-specific enzyme ALAS2, the first enzyme of the heme biosynthetic pathway. Herein, we report a novel 11-bp deletion in exon 11 leading to a frameshift in the C-terminal region of the ALAS2 gene with a non-functional longer polypeptide of 614 amino acids leading to a loss-of-function mutation manifested as an X-linked sideroblastic anemia phenotype. …”
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Resection and Resolution of Bone Marrow Lesions Associated with an Improvement of Pain after Total Knee Replacement: A Novel Case Study Using a 3-Tesla Metal Artefact Reduction MRI Sequence by Thomas Kurien, Robert Kerslake, Brett Haywood, Richard G. Pearson, Brigitte E. Scammell

“…We present our case report using a novel metal artefact reduction magnetic resonance imaging (MRI) sequence to observe resolution of subchondral bone marrow lesions (BMLs), which are strongly associated with pain, in a patient after total knee replacement surgery. …”
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A novel surgical technique for cranial cruciate ligament repair in dogs using autologous lateral digital extensor muscle tendon graft combined with platelet-rich plasma: A preliminary experimental study by Mousa H. Daradka, Mays A. Malkawi, Zuhair Banni Ismail1, Hanan M. Hammouri, Mahmoud A. Abu-Abeeleh, Saba A. Rihani

“…PRP-treated dogs exhibited faster recovery and enhanced tissue regeneration, with reduced inflammation and improved graft-bone attachment. Conclusion: This novel surgical approach demonstrates significant potential for improving outcomes in CrCL repair by combining autologous tendon grafting with PRP. …”
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Efficacy and safety of SHEN26, a novel oral small molecular RdRp inhibitor for COVID-19 treatment: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial by Jiangtao Bai, Tetsuya Asakawa, Wenfang Yuan, Yuanlong Lin, Hao Ju, Dandan Xu, Mingming Yang, Shuo Li, Guanguan Li, Deyin Guo, Hongzhou Lu, Xumu Zhang

“…These preliminary data on the efficacy and safety provide useful information and a working basis for further verification and development of SHEN26 as a novel oral small-molecule antiviral drug for treating COVID-19.…”
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Reduction of chickens use to perform in vitro pre-screening of novel anticoccidials by miniaturisation and increased throughput of the current Eimeria tenella compound-screening model [version 2; peer review: 2 approved, 1 not approved] by Virginia Marugan-Hernandez, Javier Regidor-Cerrillo, Luis Ortega-Mora, Sara Arias-Maroto, Kelsilandia Aguiar-Martins

“…We have developed an in vitro model for the evaluation of potential anticoccidial properties of novel compounds aimed to control chicken coccidiosis, a costly disease for the poultry industry. …”
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MFBTFF-Net: A Novel Multi-Frequency Brightness Temperature Feature Fusion Network for Global Lunar Surface Oxides Abundance Estimation With Chang'e-2 Lunar Microwave Sounder Data by Yu Li, Zifeng Yuan, Sarah Mazhar, Zhiguo Meng, Yuanzhi Zhang, Jinsong Ping, Ferdinando Nunziata

“…In this article, we propose a novel deep learning model named multifrequency brightness temperature feature fusion network (MFBTFF-Net) for processing Chang'e-2 lunar microwave sounder (CELMS) data and it exploits the thermal radiation features related to various drilling depths to acquire the global lunar oxide abundance maps. …”
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Enhancing corrosion resistance of Mg-Al-Mn-Ca-Y dilute alloy via novel core-shell structured Al8Mn4Y-Al2Ca and controllable solute segregation by Xiaorui Dong, Min Zha, Dawei Wang, Siqing Wang, Yajie Yang, Hailong Jia

“…A novel core-shell structured Al8Mn4Y-Al2Ca phase and controllable solute-segregation are elaborately designed in dilute Mg-0.6Al-0.5Mn-0.1Ca-0.1Y alloy (wt.%), via incomplete peritectic transformation during twin-roll casting. …”
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Characterization and Probiotic Potential of <i>Levilactobacillus brevis</i> DPL5: A Novel Strain Isolated from Human Breast Milk with Antimicrobial Properties Against Biofilm-Forming <i>Staphylococcus aureus</i> by Ivan Iliev, Galina Yahubyan, Elena Apostolova-Kuzova, Mariyana Gozmanova, Daniela Mollova, Iliya Iliev, Lena Ilieva, Mariana Marhova, Velizar Gochev, Vesselin Baev

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Genetic Algorithms in Antennas and Smart Antennas Design Overview: Two Novel Antenna Systems for Triband GNSS Applications and a Circular Switched Parasitic Array for WiMax Applications Developments with the Use of Genetic Algorithms by Stylianos C. Panagiotou, Stelios C. A. Thomopoulos, Christos N. Capsalis

“…Two novel antenna systems are presented to cover the new GPS/Galileo band, namely, L5 (1176 MHz), together with the L1 GPS/Galileo and L2 GPS bands (1575 and 1227 MHz). …”
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Molecular docking and dynamics studies to identify novel active compounds targeting potential breast cancer receptor proteins from an indigenous herb Euphorbia thymifolia Linn [version 3; peer review: 2 approved] by ShamaPrasada K, Reshma Kumarchandra, Vasavi Kumblekar, K Sreedhara Ranganath Pai, Suman Manandhar, Sharada Rai, Rajeshwari Shastry

“…This increased burden demands new targeted therapies with novel compounds either synthetically produced or derived from indigenous plants, which could be a promising approach for the development of drugs. …”
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CLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression by Agapitos Patakas, Bochong Li, Naveen K Mehta, Kristan Meetze, Patrick A Baeuerle, Jennifer S Michaelson, Hannah M Findlay, Timothy B London

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Assessment of a novel unidirectional mid-term absorbable barbed suture versus a competitor barbed suture for vaginal cuff closure after gynaecology surgery, study protocol of a randomized controlled trial - BARHYSTER by Petra Baumann, Lourdes Hinojosa Sánchez, Núria Grané Garcia, Larisa Sologiuc, Amadeus Hornemann

“…The current study investigates the clinical outcome of a novel unidirectional mid-term absorbable barbed suture which differs in its configuration from other barbed sutures. …”
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Design, Synthesis, Antibacterial and Antifungal Activity of Novel 2-[(E)-2-aryl-1-ethenyl]-3-(2-sulfanyl-1H-benzo[d]imidazole-5-yl)-3,4- dihydro-4-quinolinones by Anisetti Ravinder Nath, Malladi Srinivas Reddy

“…The novel 2-[(E)-2-aryl-1-ethenyl]-3-(2-sulfanyl-1H-benzo[d]imidazole-5-yl)-3,4- dihydro-4-quinolinones (4a-j) analogs were synthesized by Knoevenagel condensation of a solution of 2-methyl-3-(2-sulfanyl-1H-benzo[d]imidazole-5-yl)-3,4-dihydro-4-quinazolinone (3) with aromatic aldehyde in presence of catalytic amount of piperidine. …”
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