Association of a novel nutritional index with cognitive impairment in middle-aged and elderly Chinese adults: a cross-sectional analysis from the China Health and Retirement Longitudinal Study by Guotao Liu, Jianyuan Zhang

“…PurposeThe triglyceride-cholesterol-body weight index (TCBI), a novel and easily computable nutritional index, incorporates serum triglyceride (TG), total cholesterol (TC), and body weight (BW). …”
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A novel ddPCR™ assay for eDNA detection and quantification of Greater Amberjack Seriola dumerilli and three congeners in US waters: challenges and application to fisheries independent surveys by P. Joana Dias, Ryan Lehman, Bryan L. Huerta-Beltrán, Ana Wheeler, Crystal L. Hightower, Jessica Heise, Theodore Switzer, Clint Rhode, J. Marcus Drymon, Lynne Stokes, Mark A. Albins, Sean Powers, Nicole Phillips

“…Methods We developed and validated a novel tetraplex ddPCR™ assay able to detect and distinguish between S. dumerili, S. fasciata, S. rivoliana, and S. zonata from seawater eDNA samples. …”
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T3P- A Novel Catalyst for Aza-Diels-Alder Reaction: One-Pot Synthesis of Pyrano[3,2-c]quinolines and furano[3,2-c]quinolines by T. S. R. Prasanna, K. Mohana Raju

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Investigation on high-temperature creep behavior at 300 °C in laser-welded joints of a novel heat-resistant Al alloy of Al–12Ce-0.4Sc by Jie Ning, Chao Feng, Linjie Zhang

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Superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion Vegaven as compared to a mixed-oil lipid emulsion containing fish oil by Eliana Lucchinetti, Phing-How Lou, Alessandro Quaranta, Craig E. Wheelock, Akash Chakravarty, Martin Hersberger, Stefanie D. Krämer, Michael Zaugg

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A Novel Liposome Formulation Carrying Both an Insulin Peptide and a Ligand for Invariant Natural Killer T Cells Induces Accumulation of Regulatory T Cells to Islets in Nonobese Diabetic Mice by Hidetoshi Akimoto, Emi Fukuda-Kawaguchi, Omar Duramad, Yasuyuki Ishii, Kazunari Tanabe

“…Herein, we report that RGI-3100-iB, a novel liposomal formulation carrying both α-galactosylceramide (α-GalCer), which is a representative ligand for invariant natural killer T (iNKT) cells, and insulin B chain 9–23 peptide, which is an epitope for CD4+ T cells, could induce the accumulation of regulatory T cells (Tregs) in islets in a peptide-dependent manner, followed by the remarkable prevention of diabetes onset in nonobese diabetic (NOD) mice. …”
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Thioxopyrimidine in Heterocyclic Synthesis II: Novel Synthesis of Some Triazoles and Triazepine Derivatives with a Pyrimido[3,2:4,5]thieno[2,3-d]pyrimidine Skeleton by Yuh Wen Ho, Se Long Chou

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X-Linked Adrenal Hypoplasia Congenita in a Boy due to a Novel Deletion of the Entire NR0B1 (DAX1) and MAGEB1–4 Genes by Aleksandra Rojek, Maciej R. Krawczynski, Aleksander Jamsheer, Anna Sowinska-Seidler, Barbara Iwaniszewska, Ewa Malunowicz, Marek Niedziela

“…Array CGH was used to confirm the putative copy-number variation of NR0B1 (DAX1) revealing a novel hemizygous deletion encompassing the entire NR0B1 (DAX1) gene together with the MAGEB genes. …”
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Fetal and neonatal cardiac tumor diagnosed as Tuberous Sclerosis associated rhabdomyomas resulting from novel pathogenic missense variant detected in TSC2 gene: A case report by Aya Kawasaki, MD, Hidefumi Tonoki, MD, PhD, Osamu Sasaki, MD, PhD, Yoko Matsushita, MD, PhD, Michiko Watari, MD, PhD, Nobuhiro Takahashi, MD, Satoko Fujieda, MD

“…Once the parents were provided careful genetic counseling, a genetic analysis for TS was performed when the patient was 2 years old that demonstrated a novel pathogenic missense variant: c.1072T>C, p.Trp358Arg in the TSC2 gene with 30% mosaicism. …”
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Protective and immunomodulatory effects of the novel probiotic yeast Pichia kudriavzevii isolated from a home-made kefir during infection in human colon epithelial cells: An exploratory study by Angela Maione, Marianna Imparato, Annalisa Buonanno, Marilena Galdiero, Elisabetta de Alteriis, Marco Guida, Emilia Galdiero

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Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2) Alterations in Low-Grade Gliomas: Report of a Novel Gene Fusion Partner in a Pilocytic Astrocytoma and Review of the Literature by Siobhan S. Pattwell, Eric Q. Konnick, Yajuan J. Liu, Rebecca A. Yoda, Laligam N. Sekhar, Patrick J. Cimino

“…In this report, we describe a novel PML-NTRK2 gene fusion occurring in an adult sporadic pilocytic astrocytoma and review the biology and implications of specific NTRK2 mutations occurring in CNS neoplasms.…”
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Novel nucleophilic addition SN2'–SN2' pathway: utilizing phosphonium salts as electrophilic agents for synthesizing new phosphine oxides of Morita–Baylis–Hillman (MBH) adducts by Elleuch, Haitham, Yaccoubi, Ferid, Ayari, Sami, Saadi, Fatma

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A Novel Mathematical Approach to Define the Genes/SNPs Conferring Risk or Protection in Sporadic Amyotrophic Lateral Sclerosis Based on Auto Contractive Map Neural Networks and Graph Theory by Massimo Buscema, Silvana Penco, Enzo Grossi

“…In this pilot case-control study single nucleotide polymorphism (SNP) in several genes has been evaluated with a novel data mining approach based on an AutoCM. We have divided the ALS dataset into two dataset: Cases and Control dataset; we have applied to each one, independently, the AutoCM algorithm. …”
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Effectiveness of a Novel Contralaterally Controlled Neuromuscular Electrical Stimulation for Restoring Lower Limb Motor Performance and Activities of Daily Living in Stroke Survivors: A Randomized Controlled Trial by Ying Shen, Lan Chen, Li Zhang, Shugang Hu, Bin Su, Huaide Qiu, Xingjun Xu, Guilan Huang, Zhifei Yin, Jinyu Yang, Chuan Guo, Tong Wang

“…Contralaterally controlled neuromuscular electrical stimulation (CCNMES) is a novel electrical stimulation treatment for stroke; however, reports on the efficacy of CCNMES on lower extremity function after stroke are scarce. …”
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Discovery of novel and highly potent small molecule inhibitors targeting FLT3-ITD for the treatment of acute myeloid leukemia using structure-based virtual screening and biological evaluation by Kun Shi, Kun Shi, Ye Hong, Ye Hong, Ye Hong, Huajing Liu, Xiaotian Yang, Fengzhen Wang, Fengzhen Wang, Yanming Zhang

“…In this study, we identified a novel, highly potent small molecule inhibitor, FLIN-4, targeting FLT3 through structure-based virtual screening. …”
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Correction: HISS: Snakemake-based workflows for performing SMRT-RenSeq assembly, AgRenSeq and dRenSeq for the discovery of novel plant disease resistance genes by Thomas M. Adams, Moray Smith, Yuhan Wang, Lynn H. Brown, Micha M. Bayer, Ingo Hein

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Synthesis, Antibacterial and Antioxidant Evaluation of Novel 1-(5,7-Dichloro-1,3-benzoxazol-2-yl)-1H-pyrazolo[3,4-b]quinoline Derivatives by N. D. Jayanna, H. M. Vagdevi, J. C. Dharshan, T. R. Prashith Kekuda

“…Some novel 1-(5,7-dichloro-1,3-benzoxazol-2-yl)-1H-pyrazolo[3,4-b]quinoline derivatives 8(a–f) were synthesized by reacting 5,7-dichloro-2-hydrazino-1,3-benzoxazole 4 and substituted-2-chloro-3-quinoline carbaldehydes using p-toluenesulfonic acid (PTSA) as a catalyst for the cyclisation. …”
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A Novel Multi-Attribute Decision-Making Method for Supplier Selection in the Health Care Industry Using Cosine Similarity Measures of Single-Valued Neutrosophic Cubic Hypersoft Sets by Muhammad Sajid, Khuram Ali Khan, Jaroslav Frnda, Atiqe Ur Rahman

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A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar. by James A Watson, Thomas Lamb, Jane Holmes, David A Warrell, Khin Thida Thwin, Zaw Lynn Aung, Min Zaw Oo, Myat Thet Nwe, Frank Smithuis, Elizabeth A Ashley

“…We will apply the model based design to determine a safe and efficacious dose for a novel lyophilised antivenom to treat Daboia siamensis envenoming in Myanmar.…”
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Two Birds With One Stone: A Novel Nanocomposite Combining Silicon Nanoparticles and Carbon‐Doped Titania as the Fluorescence Probe and Visible Light Photocatalyst for Simultaneous Detection and Removal of Oxytetracycline by Liyun Ma, Zhi Li, Yiyi Shi, Yuchen Xie, Ming Jiang, Xu Yu, Li Xu

“…Abstract The monitoring and removal of environmental pollutants are vital for the sustainable development of society. Herein, a novel nanocomposite combining silicon nanoparticles and carbon‐doped titania, C‐TiO2/SiNPs, is designed as a fluorescence probe and visible‐light photocatalyst to simultaneously monitor and degrade oxytetracycline (OTC). …”
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