A novel data augmentation tool for enhancing machine learning classification: A new application of the higher order dynamic mode decomposition for improved cardiac disease identification by Nourelhouda Groun, María Villalba-Orero, Lucía Casado-Martín, Enrique Lara-Pezzi, Eusebio Valero, Jesús Garicano-Mena, Soledad Le Clainche

Get full text

Novel sequential proximal iliopsoas compartment block: A four-in-one block as a primary anaesthetic technique for intramedullary femoral nailing surgery: A retrospective study by Carlos Rodrigues Almeida

Get full text

Analytical and clinical validation of a novel MeltPlus TB-NTM/RIF platform for simultaneous detection of Mycobacterium tuberculosis complex, Non-Tuberculous Mycobacteria and rifampicin resistance by Zhuo Wang, Yuanwu Zou, Zihan Wei, Guanghong Bai, Xiaolin Wang, Shaoyi Qu, Jie Shi, Yaping Jiang, Cuijiao Gu

“…Sanger sequencing revealed that novel assay correctly classifies 98.6% of study cases as RIF resistant or susceptible, slightly higher that of GeneXpert.DiscussionThese findings indicate that the novel MeltPlus MTB-NTM/RIF platform provides a rapid and accurate method for the simultaneously detecting MTBC, NTM, and RIF resistance, making it a promising tool for clinical TB/NTM diagnosis and management, further multi-center and field studies are recommended to validate its broader applicability.…”
Get full text

Novel type 2 diabetes prediction score based on traditional risk factors and circulating metabolites: model derivation and validation in two large cohort studiesResearch in context by Ruijie Xie, Christian Herder, Sha Sha, Lei Peng, Hermann Brenner, Ben Schöttker

“…Interpretation: Adding 11 metabolites to the clinical CDRS led to a novel type 2 diabetes prediction model, we called UK Biobank Diabetes Risk Score (UKB-DRS), substantially outperformed the clinical CDRS. …”
Get full text

Cost Impact Model of a Novel Multi-mRNA Host Response Assay for Diagnosis and Risk Assessment of Acute Respiratory Tract Infections and Sepsis in the Emergency Department by John E. Schneider, Jonathan Romanowsky, Philipp Schuetz, Ivana Stojanovic, Henry K. Cheng, Oliver Liesenfeld, Ljubomir Buturovic, Timothy E. Sweeney

“…Current diagnostic and prognostic solutions, including procalcitonin, lack required accuracy. A novel blood-based host response test, HostDx™ Sepsis by Inflammatix, Inc., assesses the likelihood of a bacterial infection, the likelihood of a viral infection, and the severity of the condition. …”
Get full text

HISS: Snakemake-based workflows for performing SMRT-RenSeq assembly, AgRenSeq and dRenSeq for the discovery of novel plant disease resistance genes by Thomas M. Adams, Moray Smith, Yuhan Wang, Lynn H. Brown, Micha M. Bayer, Ingo Hein

“…Conclusions HISS provides a user-friendly, portable, and easily customised approach for identifying novel disease resistance genes in plants. It is easily installed with all dependencies handled internally or shipped with the release and represents a significant improvement in the ease of use of these bioinformatics analyses.…”
Get full text

Novel Study of Reaction Kinetics and Mass Transfer in Bioreactor Modelling: Prediction of Bioethanol Fermentation Performance by Saccharomyces cerevisiae on Continuous Fixed Bed Biofilm Plug Flow Reactor by Christian Aslan, Hary Devianto, Vita Wonoputri, Ardiyan Harimawan

Get full text

Design, Synthesis, and Acetylcholinesterase Inhibition Assay of Novel 9-(1-(Substituted-benzyl)piperidin-4-yl)-2-chloro-9H-purin-6-amine Derivatives by Dongwei Kang, Yu'ning Song, Peng Zhan, Qingzhu Zhang, Xinyong Liu

Get full text

A novel gene signature for predicting outcome in colorectal cancer patients based on tumor cell-endothelial cell interaction via single-cell sequencing and machine learning by Lina Pang, Qingxia Sun, Wenyue Wang, Mingjie Song, Ying Wu, Xin Shi, Xiaonan Shi

Get full text

Corrigendum to “Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice” by Sung-Hsun Yu, Szu-Yu Tina Chen, Wei-Shan Li, Navneet Kumar Dubey, Wei-Hong Chen, Jiunn-Jye Chuu, Sy-Jye Leu, Win-Ping Deng

Get full text

A Novel Flip-Filtered Orthagonal Frequency Division Multiplexing-Based Visible Light Communication System: Peak-to-Average-Power Ratio Assessment and System Performance Improvement by Hayder S. R. Hujijo, Muhammad Ilyas

Get full text

Improved Photocatalytic Performance of a Novel Fe3O4@SiO2/Bi2SiO5 Hierarchical Nanostructure with Magnetic Recoverability by Xinxin Zhang, Xiaoli Dong, Baiyu Leng, Hongchao Ma, Xiufang Zhang

“…Magnetic Fe3O4@SiO2/Bi2SiO5 composites with a novel hierarchical nanostructure were synthesized by sol-gel and hydrothermal methods and were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and UV-visible diffuse reflectance spectroscopy (UV-vis DRS). …”
Get full text

Novel platinum nanoclusters (Pt NCs) induce mitochondrial apoptosis and damaging autophagy for the treatment of osteosarcoma—from the perspective of P53 mutation status in different cell lines by Jialin Wang, Haodi Yue, Xin Huang, Hongjian Liu, Mengjun Zhang

“…Abstract This study aimed to investigate the anticancer efficacy and underlying mechanism of novel platinum nanoclusters (Pt NCs) in osteosarcoma cell lines exhibiting distinct P53 expression profiles, namely MG-63 (P53−) and U2-OS (P53+). …”
Get full text

Correction: Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts by Yi Wang, Guihua Chen, Deng Li

Get full text

Communal-based domestic rainwater harvesting system: A novel approach to alternative solutions for increasing water supply and recharging groundwater in Jagakarsa urban area, South Jakarta by Suprapti Suprapti, Muhammad Syahril Badri Kusuma, Hadi Kardhana, Muhammad Cahyono, Imroatul Chalimah Juliana

Get full text

A gut-derived Streptococcus salivarius produces the novel nisin variant designated nisin G and inhibits Fusobacterium nucleatum in a model of the human distal colon microbiome by Garreth W. Lawrence, Enriqueta Garcia-Gutierrez, A. Kate O’Mahony, Calum J. Walsh, Paula M. O'Connor, Máire Begley, Caitriona M. Guinane, Paul D. Cotter

“…Whole-genome sequencing of S. salivarius DPC6487 identified a nisin operon with a novel structural variant designated nisin G. The structural nisin G peptide differs from the prototypical nisin A with respect to seven amino acids (Ile4Tyr, Ala15Val, Gly18Ala, Asn20His, Met21Leu, His27Asn, and His31Ile), including differences that have not previously been associated with a natural nisin variant. …”
Get full text

Probiotic Bacterium-Derived p40, p75, and HM0539 Proteins as Novel Postbiotics and Gut-Associated Immune System (GAIS) Modulation: Postbiotic-Gut-Health Axis by Feray Gençer Bingöl, Duygu Ağagündüz, Ferenc Budán

Get full text

Comparing prediction accuracy for 30-day readmission following primary total knee arthroplasty: the ACS-NSQIP risk calculator versus a novel artificial neural network model by Anirudh Buddhiraju, Michelle Riyo Shimizu, Tony Lin-Wei Chen, Henry Hojoon Seo, Blake M. Bacevich, Pengwei Xiao, Young-Min Kwon

“…This study aims to compare the predictive accuracy of the SRC with a novel artificial neural network (ANN) algorithm for 30-day readmission after primary TKA, using the same set of clinical variables from a large national database. …”
Get full text

Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress Disorder by Ágnes Szabó, Zsolt Galla, Eleonóra Spekker, Mónika Szűcs, Diána Martos, Keiko Takeda, Kinuyo Ozaki, Hiromi Inoue, Sayo Yamamoto, József Toldi, Etsuro Ono, László Vécsei, Masaru Tanaka

Get full text

A novel Na2MoO4@CNT/Al–Zn–Mg–Cu composite with superior corrosion resistance and good mechanical properties: Effect of heat treatment by Jie Yang, Qing Li, Zhixiang Xiao, Zhengbin Wang, Zhenyu Liu, Bolv Xiao, Zongyi Ma, Yugui Zheng

“…In this study, a new strategy of incorporating Na2MoO4 precipitants into bulk Al–Zn–Mg–Cu alloys using the inner cavity of opened carbon nanotubes (CNTs) combined with different heat treatments are employed to develop a novel Na2MoO4@CNT/7075 composite with superior corrosion resistance, high strength and good plasticity. …”
Get full text