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2381
Functionally graded AZ91/WC nanocomposite fabricated via friction stir processing using a novel way
Published 2022-01-01“…In this work, functionally graded AZ91/WC nanocomposites were prepared by a novel multi-step chamber diameter reduction method. …”
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2382
Redefining the greenness of quantitative analytical methods for drugs: A case study of a multipurpose novel janus kinase inhibitor
Published 2025-03-01“…Furthermore, it presents a case study that assesses the greenness of various reported methods and a newly developed systematic infrared spectroscopic method for a novel drug, baricitinib. The designed experiments-oriented infrared method development offered a robust framework for optimizing and validating the method, assuring robustness and reliability of results while minimizing resource demand, overall developmental time, and method failure. …”
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Novel Gallium(III), Germanium(IV), and Hafnium(IV) Folate Complexes and Their Spectroscopic, Thermal Decomposition, Morphological, and Biological Characteristics
Published 2020-01-01“…In this study, we describe novel gallium(III), germanium(IV), and hafnium(IV) folate complexes, including their synthesis and analyses. …”
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2386
Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus
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2387
TAG (Tube and Graft) Sandwich Technique: A Novel Single-Stage Scleral Reinforcement and Aqueous Drainage Tube Implantation
Published 2021-01-01“…In this article, we present a novel “TAG sandwich” single surgical procedure in which thinned sclera is reinforced with a pericardial patch graft (“bottom layer of the sandwich”) allowing safe implantation of the GDD (“the tube sandwich filling”) and then placing another patch graft on top of the tube part of the GDD (“top layer of the sandwich”). …”
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2388
Design, synthesis, and in vitro, in vivo, and in silico evaluation of novel substituted 1,3,4-thiadiazole derivatives as anticonvulsant agents
Published 2025-02-01“…In the present study, a library of ten novel substituted 1,3,4‐thiadiazole derivatives were designed and synthesized using an appropriate synthetic route. …”
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2389
Studies on Novel N4-[4,6-Diaryl-2-pyrimidinyl]-7-chloro-4-quinolinamine and their Microbicidal Efficacy
Published 2009-01-01“…The required chalcones 1a-h were prepared by reaction of substituted acetophenone with different aryl aldehyde, which in turn treated with guanidine nitrate, yielded 4-(substituted phenyl)-6-(substituted phenyl)-2-pyrimidinamine 2a-h. Novel pyrimidine quinoline clubbed molecules 3a-h have been prepared by reaction of 2a-h with 4,7-dichloroquinoline. …”
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2390
Manganese-based immunotherapy synergized with novel supramolecular hydrogel: Advancing localized immune activation strategies in squamous cell carcinoma
Published 2025-02-01“…In this study, we introduce a novel approach employing manganese-based immunotherapy (Mn-IT) for the effective treatment of HNSCC. …”
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Solar Thermochemical Fuel Production: A Novel, Validated Multiphysics Reactor Model for the Reduction–Oxidation of Nonstoichiometric Redox Cycles
Published 2025-01-01“…The implementation of a novel approach was exemplified in the ceria thermochemical cycle for producing solar thermochemical hydrogen, specifically in the H<sub>2</sub>O-driven oxidation step. …”
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A Novel Design of Photovoltaic-Based Charging Station for Battery Vehicles with Dynamic Demand: A Case of Short Runs
Published 2021-01-01“…In this research, a novel design and operation of solar-based charging system for battery vehicle for a 50 km run is proposed. …”
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2394
Targeting the IKZF1/BCL-2 axis as a novel therapeutic strategy for treating acute T-cell lymphoblastic leukemia
Published 2025-12-01“…In vivo studies with cell line-derived xenograft (CDX) and patient-derived xenograft (PDX) models demonstrated that CX-4945 and venetoclax combined therapy provided superior therapeutic efficacy, reducing tumor burden and prolonging survival compared to single-agent treatments.Conclusions IKZF1 represses BCL-2 in T-ALL, and targeting the CK2-IKZF1 axis with CX-4945 and venetoclax offers a promising therapeutic strategy, showing enhanced efficacy and potential as a novel treatment approach for T-ALL.…”
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Screening and evaluation of novel DPP-IV inhibitory peptides in goat milk based on molecular docking and molecular dynamics simulation
Published 2025-01-01“…By evaluating the docking energy and active sites, and by analyzing RMSD, RMSF, and Rg values, two novel peptides, GPFPLL and LPYPY, were successfully screened and identified. …”
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A Novel Approach for Stock Price Prediction Using Gradient Boosting Machine with Feature Engineering (GBM-wFE)
Published 2020-04-01“…This study proposes a novel multiclass classification ensemble learning approach for predicting stock prices based on historical data using feature engineering. …”
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