Misuse of prescription medicines is as prevalent as the use of recreational drugs and novel psychoactive substances in Singapore: an unrecognised public health issue? by Wui Ling Chan, Paul Ivor Dargan, Colleen Michelle Haynes, Jody Lynn Green, Joshua Curtis Black, Richard Charles Dart, David Michael Wood

“…The survey collected information on participant demographics, and their awareness, self-reported lifetime and past-year misuse of commonly available prescription medicines in Singapore as well as the use of a range of recreational drugs and novel psychoactive substances (NPS). Results: Lifetime (6.7%) and past-year (4.8%) misuse of any prescription medicine was comparable to lifetime (6.0%) and past-year (3.0%) use of any recreational drugs/NPS. …”
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A novel ready-to-use loop-mediated isothermal amplification (LAMP) method for detection of Burkholderia mallei and B. pseudomallei by Mitsuru Nakase, Jeewan Thapa, Vanaabaatar Batbaatar, Ochirbat Khurtsbaatar, Batchuluun Enkhtuul, Jugderkhorloo Unenbat, Baasansuren Lkham, Sachiho Fujita, Ai Koshikawa, Apichai Tuanyok, Vannarat Saechan, Hideaki Higashi, Kyoko Hayashida, Yasuhiko Suzuki, Chie Nakajima, Takashi Kimura

“…This primer set did not detect any other Burkholderia species. Using this novel primer set, a dried-format in-house LAMP method with high sensitivity and specificity was developed. …”
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Novel EDAS Methodology Based on Single-Valued Neutrosophic Aczel-Alsina Aggregation Information and Their Application in Complex Decision-Making by Shahzaib Ashraf, Shakoor Ahmad, Muhammad Naeem, Muhammad Riaz, Md. Ashraful Alam

“…To accomplish our goal, we first extend the Aczel-Alsina t-norm and t-conorm to SVN scenarios and introduce a few new SVN operations on which we construct novel SVN aggregation operators. Furthermore, a decision support strategy is built in the SVN framework using the EDAS methodology and the suggested Aczel-Alsina aggregation operators. …”
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Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression by Juan Du, Ruyun Liu, Lin Ma, Yue Liu, Wei Wei, Ning Liu, Qiuhua Cao, Jianqiang Yu

“…We previously identified a novel HDAC5 inhibitor, T2943, with antidepressant properties that promote histone 3 lysine-14 acetylation (H3K14ac) by inhibiting HDAC5 activity. …”
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Exploration of the molecular mechanism behind a novel natural genic male-sterile mutation of 1205A in Brassica napus by Lijing Xiao, Jinze Zhang, Shaomin Guo, Hairun Jin, Qingjing Ouyang, Xu Long, Zhongbin Yan, Entang Tian

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Bearing Fault Diagnosis Using a Novel Classifier Ensemble Based on Lifting Wavelet Packet Transforms and Sample Entropy by Lei Zhang, Long Zhang, Junfeng Hu, Guoliang Xiong

“…Such a feature extraction paradigm is expected to depict complexity, irregularity, and nonstationarity of bearing vibrations. Moreover, a novel classifier ensemble is proposed to alleviate the effect of initial parameters on the performance of member classifiers and to improve classification effectiveness. …”
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The Evaluation of the Efficacy of a Novel Subunit Vaccine in the Prevention of <i>Cryptosporidium parvum</i>-Caused Diarrhoea in Neonatal Calves by Martine Reijnders, Mark van Roosmalen, Hans Holtslag, Susan Arts, Suzanne Pel, Divine Dufé, Marianne Kaashoek, Geert Vertenten, Tine van Werven, Steven Sietsma, Christophe Roy, Nicolas Herman

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Mining the Virgin Land of Neurotoxicology: A Novel Paradigm of Neurotoxic Peptides Action on Glycosylated Voltage-Gated Sodium Channels by Zhirui Liu, Jie Tao, Pin Ye, Yonghua Ji

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A Novel Convex Hull Coverage Algorithm for the Deployment of Electric Taxi Swap Stations Based on Urban Traffic Flow by Xudong Zhu, Lijun Yao, Yuxin Mao, Renjie Wang, Hanxiao Shi, Ji Qi

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Exploratory analysis of a Novel RACK1 mutation and its potential role in epileptic seizures via Microglia activation by Sai Zhang, Zhaofei Dong, Jing Guo, Ze Li, Hong Wu, Linming Zhang, Fuli Min, Tao Zeng

“…In this study, we identified the key gene RACK1 and its novel mutation RACK1-p.L206P as being associated with seizures through single-cell transcriptome sequencing (scRNA-seq) and whole exome sequencing (WES) techniques. …”
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A novel way to use cross-validation to measure connectivity by machine learning allows epilepsy surgery outcome prediction by Karla Ivankovic, Alessandro Principe, Justo Montoya-Gálvez, Linus Manubens-Gil, Riccardo Zucca, Pablo Villoslada, Mara Dierssen, Rodrigo Rocamora

“…To test this hypothesis, we developed a novel method for quantifying connectivity change between network states and applied it to identify surgical resection areas.A network state was represented by random snapshots of connectivity within a defined time interval of an intracranial EEG recording. …”
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Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia by Emmanuel Amabebe, Zheping Huang, Sukanta Jash, Balaji Krishnan, Shibin Cheng, Akitoshi Nakashima, Yitong Li, Zhixong Li, Ruizhi Wang, Ramkumar Menon, Xiao Zhen Zhou, Kun Ping Lu, Surendra Sharma

“…We also highlighted the novel role of the Pin1-cis P-tau-ApoE axis in the development of preE, and propagation of cis P-tau-mediated abnormal protein aggregation (tauopathy) from the placenta to cerebral tissues later in life, leading to neurodegenerative conditions. …”
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A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer by Xin Zhang, Xingda Zhang, Guozheng Li, Yi Hao, Lei Liu, Lei Zhang, Yihai Chen, Jiale Wu, Xinheng Wang, Shuai Yang, Shouping Xu

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Synergistic attenuation of complete freund’s adjuvant-induced inflammation in mice using shinbaro-pelubiprofen: a novel therapeutic complex by Hyunseong Kim, Jin Young Hong, Wan-Jin Jeon, Hyun Kim, Changhwan Yeo, Junseon Lee, Yoon Jae Lee, In-Hyuk Ha

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Computational identification and experimental validation of novel Saccharum officinarum microRNAs along with their targets through RT-PCR approach by Abdul Baqi, Samiullah, Jadoon Khan, Asma Sadiq, Yousaf Khan, Shahid Ali, Syed Nadeem ul Hassan Mohani, Naqeebullah Khan, Tawaf Ali Shah, Khalid S. Almaary, Youssouf Ali Younous, Mohammed Bourhia

“…This study seeks to identify and partially characterize several novel miRNAs in sugarcane using in silico tools, while also offering a preliminary assessment of their functions. …”
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Assessment of energy management and power quality improvement of hydrogen based microgrid system through novel PSO-MWWO technique by Hafiz Ghulam Murtza Qamar, Xiaoqiang Guo, Ehab Seif Ghith, Mehdi Tlija, Abubakar Siddique

“…This study proposed a novel bi-level optimization approach to enhance power quality and cost efficiency of the system. …”
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Reliability of a Novel CBCT-Based 3D Classification System for Maxillary Canine Impactions in Orthodontics: The KPG Index by Domenico Dalessandri, Marco Migliorati, Rachele Rubiano, Luca Visconti, Luca Contardo, Roberto Di Lenarda, Conchita Martin

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Potential value of novel multiparametric MRI radiomics for preoperative prediction of microsatellite instability and Ki-67 expression in endometrial cancer by Zhichao Wang, Yan Hu, Jun Cai, Jinyuan Xie, Chao Li, Xiandong Wu, Jingjing Li, Haifeng Luo, Chuchu He

“…This study aimed to develop a novel hybrid radiomics approach integrating multiparametric magnetic resonance imaging (MRI), deep learning, and multichannel image analysis for predicting MSI and Ki-67 status. …”
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Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma by Douglas A Lauffenburger, Khloe S Gordon, Caleb R Perez, Andrea Garmilla, Maxine S Y Lam, Joey J Y Aw, Anisha Datta, Andrea Pavesi, Michael E Birnbaum

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A Novel Heterozygous De Novo MORC2 Missense Variant Causes an Early Onset and Severe Neurodevelopmental Disorder by Daniel Arbide, Nour Elkhateeb, Ewa Goljan, Carolina Perez Gonzalez, Anna Maw, Soo-Mi Park

“…Here, we report a case of MORC2-related DIGFAN syndrome in a female infant caused by a novel heterozygous de novo variant. The condition was early onset and severe, further expanding the range of genotypes associated with this disorder. …”
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